主要業績
目前負責國家“973”項目子課題1項,中國科學院知識創新工程重要方向項目子課題1項和大連市科技計畫項目1項。完成國家自然科學基金(執行)、遼寧省科學技術基金(負責)和中科院大連化學物理研究所博士探索基金(負責)各1項,國家 “863”項目2項(骨幹)。發表論文40篇,其中在Biomaterials(IF5.196)、Molecular Therapy(IF5.841)、Journal of Materials Chemistry(IF4.287)等雜誌發表SCI論文20篇;申請國家發明專利4項,授權2項,申請美國專利1項;參編著作章節4章。
代表成果
1. XD Liu, KA. Howard, MD Dong, et al. The influence of polymeric properties on chitosan/siRNA nanoparticle formulation and gene silencing. Biomaterials, 2007, 28, 1280-1288 .(SCI)
2. XD Liu, WT Yu, JZ Lin, et al. Diffusion of acetic acid across oil/water interface in emulsification/internal gelation process for the preparation of alginate gel beads. Chemical Research in Chinese Universities, In press. (SCI)
3. 劉袖洞,於煒婷,王為,等. 海藻酸鈉和殼聚糖聚電解質微膠囊的研究與生物醫學套用. 化學進展(Progress in Chemistry),接受. (SCI)
4. 劉袖洞,馬小軍,袁權. 藥物釋放系統. 化工學報,2005, 56(6): 955-961. (EI)
5. XD Liu, WM Xue, Q Liu, et al, Swelling behaviour of alginate–chitosan microcapsules prepared by external gelation or internal gelation technology. Carbohydrate Polymers, 2004, 56, 459-464. (SCI)
6. XD Liu, DC Bao, WM Xue, et al, Preparation of uniform calcium alginate gel beads by membrane emulsification coupled with internal gelation. Journal of Applied Polymer Science, 2003, 87(5), 848-852. (SCI)
7. XD Liu, WY Yu, Y Zhang, et al, Characterization of structure and diffusion behaviour of Ca-alginate beads prepared with external or internal calcium sources. Journal of Microencapsulation, 2002, 19(6), 775-782. (SCI)
8. SL Xu, MD Dong, XD Liu, et al. Direct force measurements between siRNA and chitosan molecules. Biophysical Journal, 2007, 93, 952-959. (SCI)
9. KA Howard, UL Rahbek, XD Liu, et al. RNA Interference in Vitro and in Vivo Using a Novel Chitosan/siRNA Nanoparticle System. Molecular Therapy, 2006, 14(4), 476-484. (SCI)
W Wang, XD Liu, YB Xie, et al. Microencapsulation using natural polysaccharides for drug delivery and cell implantation. Journal of Materials Chemistry, 2006, 16, 3252-3267. (SCI)