人物經歷
1990.09-1994.07在西北大學有機合成專業獲學士學位，1996.09-1999.07西北大學有機化學專業獲碩士學位，2003.09-2006.06第四軍醫大學藥物化學專業獲博士學位。2004.06-2004.12赴澳大利亞悉尼大學學習交流。2007.02-2008.10赴香港大學化學系楊丹教授課題組從事博士後研究。擔任《ChemicalCommunication》、《Green Chemistry》等國際知名化學期刊審稿人。
研究方向
主要研究方向：（1）手性催化劑、不對稱催化反應方法學的研究，並將方法學研究成果用於生物活性分子的全合成研究；（2）新藥設計合成及工藝研究；（3）功能有機分子的合成及性能研究；（4）天然產物中活性單體化合物的分離、純化、結構改造、質量標準及生物活性研究 。
主要貢獻
目前作為課題負責人承擔“十二五”國家重大新藥創製課題1項、國家自然科學基金課題3項、陝西省科技統籌計畫重點項目1項、陝西省自然科學基金1項，分題負責國家重大新藥創製項目2項。申請發明專利5項，獲授權3項。
論文著作：
1)Nan Ji, Jiani Yuan, Miaoxi Liu, Ting Lan and Wei He*. Novel chiral Schiff base/Ti(IV) catalysts for the catalytic asymmetric epoxidation of N-alkenyl sulfonamides. Chem. Commun., 2016,52, 7731-7734。
2)Nan Ji, Jiani Yuan, Shanshan Xue, Junna Zhang, Wei He*. Novel chiral thiourea organocatalysts for the catalytic asymmetric oxaziridination. Tetrahedron, 2016, 512-517。
3)Yu Wei, Wei He*,Yulong Liu, Peng Liu, Shengyong Zhang. Highly enantioselective Nitro-Mannichreaction catalyzed by cinchonaalkaloids and N-benzotriazole derivedammonium salts. Org. Lett., 2012, 14(3), 704-707.
4）Hua Li, Xu Zhang((co-first author), Xin Shi, Nan Ji, Wei He*, Shengyong Zhang,Bangle。Zhang*.Modularbifunctional chiral thioureas as versatile organocatalysts for highlyenantioselective Aza-Henry reaction and Michael addition. Adv Synth.Catal.,2012,354, 2264-2274。
5）Xiao-Liang Sun, Shi-Yu Wang, Zhi-Min Qi, Ning Wan, Bang-Le Zhang, Wei He*. Design, synthesis, and biological evaluation of novel Tempol derivatives as effective antitumor agents. Res Chem Intermed. 2016, 42:7659–7673。
6）Minghua Li, Nan Ji,Ting Lan, Wei He*, Rui Liu *. Construction of chiral quaternarycarbon center via catalytic asymmetric aza-Henry reaction withα-substitutednitroacetates. RSC Adv., 2014, 4, 20346-20350。
7) Yulong Liu, XieWang, Xiaoyun Wang, Wei He*. Highly enantioselective Michael addition ofdiethyl malonate to chalcones catalyzed by cinchonaalkaloids-derivatived bifunctional tertiaryamine-thioureas bearing multiplehydrogen-bonding donors. Org. Biomol. Chem., 2014, 12,3163- 3166. (COVER IMAGE)。
8)Meiyu Liu, XieWang, Xiaoliang Sun, Wei He*.Highly selective N-allylation of anilinesunder microwave irradiation. Tetrahedron Lett., 2014, 55, 2711-2714。
9) Nan Ji, LinYao, Wei He*, Yurong Li*. Bifunctional Schiff base/Ti(IV) catalysts forenantioselective cyanoformylation of aldehydes with ethyl cyanoformate. Appl.Organometal. Chem., 2013, 27, 209-213。
10) TianyiZhang , Wei He, Xingyu Zhao, Ying Jin*.Asymmetric oxaziridination catalyzed by cinchonaalkaloid derivativescontaining sulfide. Tetrahedro n, 2013, 69,7416-7422。
11)Lin Yao, Yu Wei, Pingan Wang, Wei He*,Shengyong Zhang*.Promotion ofHenry reactions using Cu(OTf)and a sterically hindered Schiffbase: access to enantioenriched β-hydroxynitro alkanes. Tetrahedron, 2012, 68(44), 9119-9124。
12)Pingan Wang,Wei He, SikunCheng, Shengyong Zhang*. Efficient synthesis of unnatural dipeptides based oncis-2,5-disubstituted pyrrolidine.Amino Acids,2012,42,2121-2127。
13)Yu Wei, Lin Yao,Bangle Zhang, Wei He, Shengyong Zhang. NovelSchiff base ligands derived from cinchonaalkaloids for Cu(II)-catalyzedasymmetric Henry reaction. Tetrahedron, 2011, 67(44),8552-8558。
14)Xin Shi,Wei He*, Hua Li, Xu Zhang, ShengyongZhang. Highly efficient and enantioselective Michael addition of acetylacetoneto nitroolefins catalyzed by chiral bifunctional organocatalyst bearingmultiple hydrogen-bonding donors.Tetrahedron Lett.,2011,52(25), 3204-3207。
15)Yu Wei, Bangle Zhang,Peng Liu, Wei He*, Shengyong Zhang. The application of chiral Schiffbase in asymmetric catalysis. Mini-Rev. Org. Chem., 2011, 8,66-90。
16)Peng Liu, Wei He,Xiangyang Qin, Xiaoli Sun, Shengyong Zhang*. Synthesis and application of a novelsingle-isomermono-6-deoxy-6-((2S,3S)-(+)-2,3-O-isopropylidene-1,4-Tetra -methylenediamine)- β-cyclodextrin as chiral selector in capillary electrophoresis. Chirality, 2010, 22, 914-921。
17)Bangle Zhang *, Wei He, Xin Shi, Menglei Huan, Qiuju Huang,Siyuan Zhou*. Synthesis and biological activity of the calcium modulator3-methyl 5-pentyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate. Bioorg. Med. Chem. Lett., 2010, 20, 805-808。
18) Wei He, Quanjun Wang, Qiaofeng Wang, BangleZhang, Xiaoli Sun and Shengyong Zhang*. Synthesis of novel chiralphase-transfer catalysts and their application to asymmetric synthesis ofα-Amino acids derivatives. Synlett., 2009, 8,1311-1314。
19)Wei He, Kai-Tai Yip, Nianyong Zhu, Dan Yang*.Pd(II)/ Bu-quinolineoxazoline: an air-stable and modularchiral catalyst system for enantioselective oxidative cascade cyclization. Org.Lett., 2009, 11(24), 5626-5628。
獲獎記錄
多次獲學校嘉獎，2005年獲學校“學術新人”基金獎勵，2007年獲陝西省科學技術獎一等獎，2009年獲得學校“精英人才”（第一層次）基金獎勵，2010年獲“藥學精品年會”優秀論文金獎，同年獲第四軍醫大學“精品教員”稱號，2011年榮立個人三等功，指導的研究生2012年獲全軍優秀碩士學位論文獎。2014年被評為總後優秀教師、學校“雙十佳精品課”教員，獲得總後院校育才獎銀獎。
