個人簡介
David Kaplan，1953年3月生，理學博士，教授，博士生導師。本科1975年畢業於美國Albany大學，1979畢業於美國Syracuse大學，現任美國Tufts 大學Stern Family Endowed 終身榮譽教授， 生物醫學系系主任兼化學工程系教授，美國國立衛生研究院（NIH）組織工程研究中心主任，在生物材料、組織工程研究領域，尤其是絲蛋白生物材料的研究領域有很深的造詣和極高的學術地位，承擔多項美國國立衛生研究院、美國自然科學基金委的多項重大科研課題。在Nature雜誌發表論文4篇，在Biomaterials、Biomicromolecular、Advanced Materials、Soft Materials、Tissue Engineering等高水平學術期刊發表論文400多篇，並同時擔任Biomicromolecular副主編，Advanced Materials，Biomaterials，Tissue Engineering，Soft Materials等10多種高水平學術期刊編輯。已獲得美國及世界專利20餘項，並創辦了三家以上高科技企業。David Kaplan教授積極與中國的科研人員展開合作，已於2011年受聘蘇州大學現代絲綢國家工程實驗室擔任講座教授，聯合建立實驗室，定期回國講學並指導科研工作。主要論文
Sengupta, S., S. Park, K. Lee, D. L. Kaplan. 2010. Quantifying osteogenic cell degradation of silk biomaterials. Biomacromolecules. 11(12):3592-3599Serban, M., D. L. Kaplan. 2010. pH sensitive ionomeric particles via chemical conjugation of silk with poly-amino acids. Biomacromolecules. 11(12): 3406-3412
Serban, M., D. L. Kaplan. 2010. Modular elastic biomaterial patches – mechanical and biological functions. Biomacromolecules. 11(9): 2230-2237
Subramanian, B., D. Rudym, C. Cannizzaro, R. Peronne, J. Zhou, D. L. Kaplan. 2010. Tissue engineered 3D in vitro models for normal and diseased kidney. Tissue Engineering Part A, 16(9): 2821-2831
Vepari, C., D. Matheson, L. Drummy, R. Naik, D. L. Kaplan. 2010. Surface modification of silk fibroin with poly(ethylene glycol) for anti-adhesion and antithrombotic applications. J. Biomedical Materials Research. 93(2): 595-606
Wang, X., T. Yucel, Q. Lu, D. L. Kaplan. 2010. Silk nanospheres and microspheres from silk PVA blend films for drug delivery. Biomaterials 31(6):1025-1035
Wang, X., L. Sun, M. V. Maffini, A. Soto, C. Sonnenschein, D. L. Kaplan. 2010. A complex 3D human tissue culture system based on mammary stromal cells and silk scaffolds for modeling breast morphogenesis and function. Biomaterials. 31(14):3920-3929
Wang, X, M. R. Reagan, D. L. Kaplan. 2010. Synthetic adipose tissue models for studying mammary gland development and breast tissue engineering. Journal of Mammary Gland Biology and Neoplasia. 15(3): 365-376
Yadov, V., B. J. Paniliatis, H. Shi, K. Lee, P. Cebe, D. L. Kaplan. 2010. A novel in vivo degradable cellulose-chitin copolymer from metabolically engineered Gluconacetobacter xylinus. Applied Environmental Microbiology. 76(18): 6257-6265
Yucel, T., N. Kojic, G. G. Leisk, T. J. Lo, D. L. Kaplan. 2010. Non-equilibrium silk fibroin adhesives. Journal Structural Biology 170(2):406-412
Choi, J. H., E. Bella, G. Vunjak-Novakovic, D. L. Kaplan. 2011. Adiopogenic differentiation of human adipose-derived stem cells on 3D silk scaffolds. Methods Molecular Biology. 702: 319-330 Choi, J. H., E. Bellas, J. M. Gimble, G. Vunjak-Novakovic, D. L. Kaplan. 2011. Lipolytic function of adipocyte/endothelial cell cocultures. Tissue Engineering Part A, 17(9-10): 1437-1444.
Choi, J. H., J. M. Gimble, G. Vunjak-Novakovic, D. L. Kaplan, 2011, Effects of hyperinsulinemia on lipolytic function of three dimensional adipocyte/endothelial co-cultures. Tissue Engineering Part C. Methods. 702:319-330
Gil, E. S., J. A. Kluge, D. N. Rockwood, R. Rajkhowa, L. Wang, X. Wang, D. L. Kaplan. 2011. Mechanical improvements to reinforced porous silk scaffolds. J. Biomaterial Materials Research A. 99(1): 16-28.
Gomes, S.C, I B. Lenore, J. F. Mano, R. L. Resis, D. L. Kaplan. 2011. Antimicrobial functionalized genetically engineered spider silk. Biomaterials. 32(18): 4255-4266.
Gomes, S. C., K. Numata, I. B. Lenor, J. F. Mano, R. L. Reis, D. L. Kaplan. 2011. AFM study of morphology and mechanical properties of a chimeric spider silk and bone sialoprotein for bone regeneration. Biomacromolecules 12(5): 1675-1685.
Gomes, S. C., K. Numata, I. B. Lenor, J. F. Mano, R. L. Reis, D. L. Kaplan. 2011. Spider silk-bone sialoprotein fusion proteins for bone tissue engineering. Soft Matter. In press.
Guziewicz, N., A. Best, B. Perez-Ramierez, D. L. Kaplan. 2011. Lyophilized silk fibroin hydrogels for the sustained local delivery of therapeutic monoclonal antibodies. Biomaterials, 32(10): 2642-2650.
Hines, D. J., D. L. Kaplan. 2011. Mechanisms of controlled release from silk fibroin films. Biomacromolecules. 12(3): 804-812
House, M., J. Daniel, K. Elstad, S. Socrate, D. L. Kaplan. 2011. Oxygen tension and formation of cervical like tissue in two dimensional and three dimensional culture. Tissue Eng. Part A. Nov 1, ahead of print.
Hronik-Tupaj, M., D. L. Kaplan. 2011. A review of the responses of 2D and 3D engineered tissues to electric fields. Tissue Engineering Part B. Reviews. Nov 3, ahead of print
Hu, X., K. Shmelev, L. Sun, E.S. Gil, S. H. Park, P. Cebe, D. L. Kaplan. 2011. Regulation of silk material structure by temperature controlled water vapor annealing. Biomacromolecules. 12 (5):1686-1696
Hu, X., S. H. Park, E. S. Gil, X. Xia, A. S. Weiss, D. L. Kaplan. 2011. The influence of elasticity and surface roughness on myogenic and osteogenic differentiation of cells on silk elastin biomaterials. Biomaterials. 32(34): 8979-8989.
Karve, K. A., E. S. Gil, S. P. McCarthy, D. L. Kaplan. 2011. Effect of beta sheet crystalline content on mass transfer in silk films. J. Membrane Science 383(1-2):44-49.
Kluge, J., G. Leisk, R. Cardwell, A. Fernandes, A. Ward, L. Dorfmann, D. L. Kaplan. 2011. Bioreactor system for biomaterial design studies utilizing real time mechanical loading control and noninvasive imaging. Annals of Biomedical Engineering. 39(5): 1390-1402
Krishnaji, S. T., W. Huang, O. Rabotyagova, E. Kharlampieva, I. Choi, V. V. Tsukruk, R. Naik, P. Cebe, D. L. Kaplan. 2011. Thin film assembly of spider silk like block copolymers. Langmuir 27(3): 1000-1008
Lovett, M.; G. Eng, J. A. Kluge, C. Cannizzaro, G. Vunjak-Novakovic, D. L. Kaplan. 2011. Tubular silk scaffolds for small diameter vascular grafts. Organogenesis 6(40): 217-224.
Lu, Q, X. Wang, H. Zhu, D. L. Kaplan. 2011. Surface immobilization of antibody on silk fibroin through conformational transition. Acta Biomaterialia. 7(7): 2782-2786.
Lu, Q., Y. Huang, M. Li, B. Zuo, S. Lu, J. Wang, H. Zhu, D. L. Kaplan. 2011. Silk fibroin electrogelation mechanisms. Acta Biomaterialia. 7(6): 2394-2400.
Mandal, B. B., S. H. Park, E. S. Gil, D. L. Kaplan. 2011. Multilayered silk scaffolds for meniscus tissue engineering. Biomaterials 32(2) 639-651
Mandal, B. B., S. H. Park, E. S. Gil, D. L. Kaplan, 2011. Stem cell based meniscus tissue engineering. Tissue Engineering Part A. 17(21-22): 2749-2761.
Mauney, J. R., G. M. Cannon, M. L. Lovett, E. M. Gong, D. Di Vizio, P. Gomez 3rd, D. L. Kaplan, R. M. Adam, C. R. Estrada Jr. 2011. Evaluation of gel spun silk-based biomaterials in a murine model of bladder augmentation. Biomaterials 32(3): 808-818
Mieszawska, J. J., J. G. Llamas, C. A. Vaiana, M. P. Kadakia, R. R. Naik, D. L. Kaplan. 2011. Clay enriched silk biomaterials for bone formation. Acta Biomaterialia. 7(8): 3036-3041.
Nectow, A. R., K. G. Marra, D. L. Kaplan. 2011. Biomaterials and the development of peripheral nerve guidance conduits. Tissue Engineering Part B, Reviews. Sep 23 ahead of print.
Numata, K., D. L. Kaplan. 2011. Differences in cytotoxicity of beta-sheet peptides originated from silk and amyloid beta. Macromolecular Bioscience 11(1): 60-64
Numata, K., D. L. Kaplan. 2011. Silk-based gene carriers with cell membrane-destabilizing peptides. Biomacromolecules. Oct 13, ahead of print
Numata, K., A. J. Mieszawska-Czajkowska, L. A. Kvenvold, D. L. Kaplan. 2011. Silk-based nanocomplexes with tumor homing peptides for tumor specific gene delivery. Macromolecular Bioscience. Nov. 3, ahead of print.
Numata, K., M. R. Reagan, R. H. Goldstein, M. Rosenblatt, D. L. Kaplan. 2011. Spider silk based gene carriers for tumor cell specific delivery. Bioconjugate Chemistry. 22(8): 605-1610.
Oliverira, A. L. L. Sun, H. J. Kim, X. Hu, W. Rice, J. Kluge, R. L. Reis, D. L. Kaplan. 2011. Aligned silk based 3D architectures for contact guidance in tissue engineering. Acta Biomaterialia Dec 16, ahead of print.
Park, S. H., A. Tofighi, X. Wang, M. Strunk, T. Richketts, J. Chang, D. L. Kaplan. 2011. Calcium phosphate combination biomaterials as human mesenchymal stem cell delivery vehicles for bone repair. J. Biomedical Materials Research B. Applied Biomaterials. 97(2): 235-244.
Park, S. H., E. S. Gil, H. Cho, B. B. Mandal, L. W. Tien, B. H. Min, D. L. Kaplan. 2011. Intervertebral disk tissue engineering using biphasic silk composite scaffolds. Tissue Engineering Part A, Oct 26, ahead of print.
Park, S. H., H. Cho, E. S. Gil, B. B. Mandal, B. H. Min, D. L. Kaplan. 2011. Silk fiboin hyaluronic acid composite gels for nucleus pulposus tissue regeneration. Tissue Engineering Part A, Aug 23, ahead of print.
Pritchard, E. M., T. Valentin, D. Boison, D. L. Kaplan. 2011. Incorporation of proteinase inhibitors into silk-based delivery devices for enhanced control of degradation and drug release. Biomaterials 32(3): 909-918
Pritchard, E. M., D. L. Kaplan. 2011. Silk fibroin biomaterials for controlled release drug delivery. Expert Opinion Drug Delivery, 8(6): 797-811.
Qin, G., D. L. Kaplan. 2011. Silk biomaterials, in An Introduction to Biomaterials, Second Edition. In press.
Qin, G., A. Rivkin, S. Lapidot, X. Hu, I. Presis, S. B. Arinus, O. Dgany, O. Shoseyov, D. L. Kaplan. 2011. Recombinant exon encoded resilins for elastomeric biomaterials. Biomaterials 32(35): 9231-9243.
Rabotyagova, O. S., P. Cebe, D. L. Kaplan. 2011. Protein-based block copolymers. Biomacromolecules. 12(2): 269-289
Reagan, M. R., D. L. Kaplan. 2011. Concise Review: mesenchymal stem cell tumor-homing: detection methods in disease model systems. Stem Cells. 29(6): 920-927.
Rockwood, D. N., E. S. Gil, S. H. Park, J. A. Kluge, W. Grayson, S. Bhumiratana, R. Rajkhowa, X. Wang, S. J. Kim. G. Vunjak-Novakovic, D. L. Kaplan. 2011. Ingrowth of human mesenchymal stem cells into porous silk particle reinforced silk composite scaffolds: an in vitro study. Acta Biomaterialia, 7(1): 144-151
Rockwood, C. Preda, T. Yucel, X. Wang, M. Lovett, D. L. Kaplan. 2011. Materials fabrication from Bombyx mori silk fibroin. Nature Protocols 6(10): 1612-1631.
Serban, M. A., B. Panilaitis, D. L. Kaplan. 2011. Silk fibroin and polyethylene glycol based biocompatible tissue adhesives. J. Biomaterials Materials Research A. 98(4): 567-575.
Sun, L., M. R. Reagan, D. L. Kaplan. 2011. Role of cartilage forming cells in regenerative medicine in cartilage repair. Orthopedic Research and Reviews 2:1-10. In press.
Sun, L., X. Wang, D. L. Kaplan. 2011. A 3D cartilage inflammatory cell culture system for the modeling of human osteoarthritis. Biomaterials 32(24): 5581-5589.
Tigli, R. S., C. Cannizaro, M. Gumusderelioglu, D. L. Kaplan. 2011. Chondrogenesis in perfusion bioreactors using porous silk scaffolds and hESC-derived MSCs. J. Biomedical Materials Research A 96(1): 21-28
Wang, X., D. L. Kaplan. 2011. Functionalization of silk fibroin with NeutrAvidin and biotin. Macromolecular Bioscience 11(1): 100-110
Wray, L. S., X. Hu, J. Gallego, I. Georgakoudi, F. G. Omenetto, D. Schmidt, D. L. Kaplan. 2011. Effect of processing on silk-based biomaterials: reproducibility and biocompatibility. J. Biomedical Materials Research, Part B: Applied Biomaterials. 99(1): 89-101.
Xia, X., Q. Xu, X. Hu, G. Qin, D. L. Kaplan. 2011. Tunable self-assembly of genetically engineered silk-elastin-like protein polymers. Biomacromolecules. 12(11): 3844-3850.
（以上資料摘自蘇州大學紡織與服裝工程學院官網）
成就榮譽
2010 波士頓New England Baptist 醫院學術委員會成員2009 北美組織工程協會常務理事
2007 美國生物材料協會 Clemson 獎金獲得者
2003 美國醫學和生物工程學會常務理事
2000 Biomacromolecules雜誌副總編
