陳衛華[華中科技大學教授、博導]

陳衛華，男，華中科技大學生命科學與技術學院生物信息學教授、博導，青年千人 。

教育和工作經歷

教育經歷

1996- 2000年 河南師範大學生物科學學院，生物學學士

2000-2003年 東北師範大學生命科學院遺傳與細胞研究所，遺傳學碩士

2003-2006年 中國科學院北京基因組研究所，遺傳學博士

工作經歷

2006- 2007年 中國科學院北京基因組研究所，北京，研究助理

2007-2008年 杜塞道夫大學計算機系，德國，博士後

2008-2013年 歐洲分子生物學實驗室，德國，博士後

2014-2016年 瑞士生物信息學研究所/日內瓦大學醫學院，瑞士，博士後

2016年-至今 華中科技大學生命科學與技術學院，生物信息與系統生物學系，教授，博士生導師

研究方向

主要研究興趣是系統生物學和轉化醫學，即用計算生物學和多組學整合方法，鑑定臨床有顯著套用價值的基因（人）和/或微生物（腸道或腫瘤部位），開發新方法改造細菌基因組或原位操縱細菌豐度。研究組主要研究內容包括：1）腸道或腫瘤部位微生物動態變化與疾病的關係，以及對治療效果的影響；2）微生物基因組改造，使之適合作為腫瘤治療或靶向藥物運送工具；3）噬菌體作為操縱腸道微生物豐度的工具研究及套用；4）與腫瘤預後相關基因標記（突變、基因表達豐度）研究；5）用機器學習方法整合/發現基因突變或表達signature，以建立可用於疾病風險預測和診斷的數學模型。

近年的科研項目、專著與論文、專利、獲獎

截止2018年3月，發表第一作者/通訊作者發表文章近20篇，其中包括Science、Molecular Systems Biology、Nature Communications、Molecular Biology and Evolution、Nucleic Acids Research等著名雜誌。H-index為20。曾任美國人類長壽公司（HLI）顧問（2015年），北京基因組學研究所客座研究（2015年）員。

近五年代表性論文

Na L Gao*, C. Zhang*, Z. Zhang, S. Hu, M. J. Lercher, X. M. Zhao, P. Bork#, Z. Liu# andWei-Hua Chen#(2018). "MVP: a microbe-phage interaction database."Nucleic Acids Res.(2017 IF: 11.561)

Wei-Hua Chen#, G. Lu, X. Chen, X. M. Zhao and P. Bork (2017). "OGEE v2: an update of the online gene essentiality database with special focus on differentially essential genes in human cancer cell lines."Nucleic Acids Res45(D1): D940-D944.(2017 IF: 11.561)

He, Z., H. Zhang, S. Gao, M. J. Lercher,Wei-Hua Chen# and S. Hu# (2016). "Evolview v2: an online visualization and management tool for customized and annotated phylogenetic trees."Nucleic Acids Res44(W1): W236-241.(2017 IF: 11.561)

Wei-Hua Chen, G. Lu, P. Bork, S. Hu and M. J. Lercher (2016). "Energy efficiency trade-offs drive nucleotide usage in transcribed regions."Nat Commun 7: 11334. (2017 IF: 12.353)

Chen, W.H., van Noort, V., Lluch-Senar, M., Hennrich, M.L., JA, H.W., Yus, E., Alibes, A., Roma, G., Mende, D.R., Pesavento, C.et al.(2016) Integration of multi-omics data of a genome-reduced bacterium: Prevalence of post-transcriptional regulation and its correlation with protein abundances.Nucleic Acids Res, 44,1192-1202.(2017 IF: 11.561)

Lluch-Senar, M.*, Delgado, J.*,Chen, W.H.*,Llorens-Rico, V., O'Reilly, F.J., Wodke, J.A., Unal, E.B., Yus, E., Martinez, S., Nichols, R.J.et al.(2015) Defining a minimal cell: essentiality of small ORFs and ncRNAs in a genome-reduced bacterium.Molecular systems biology, 11,780.(2017 IF: 8.500)

Chen, W.-H., X.-M. Zhao, V. van Noort and P. Bork (2013). "Human Monogenic Disease Genes Have Frequently Functionally Redundant Paralogs."PLoS Comput Biol 9(5): e1003073.(2017 IF: 3.955)

Schonknecht, G.*,Chen, W.H.*, Ternes, C.M., Barbier, G.G., Shrestha, R.P., Stanke, M., Brautigam, A., Baker, B.J., Banfield, J.F., Garavito, R.M.et al.(2013) Gene transfer from bacteria and archaea facilitated evolution of an extremophilic eukaryote.Science, 339, 1207-1210.(2017 IF: 41.058)

Chen, W.H.,Minguez, P., Lercher, M.J. and Bork, P. (2012) OGEE: an online gene essentiality database.Nucleic Acids Research, 40, D901-906.(2017 IF: 11.561)

Chen, W.-H., Trachana, K., Lercher, M.J. and Bork, P. (2012) Younger Genes Are Less Likely to Be Essential than Older Genes, and Duplicates Are Less Likely to Be Essential than Singletons of the Same Age.Molecular Biology and Evolution, 29, 1703-1706.(2017 IF: 10.217)

1.

Na L Gao*, C. Zhang*, Z. Zhang, S. Hu, M. J. Lercher, X. M. Zhao, P. Bork#, Z. Liu# andWei-Hua Chen#(2018). "MVP: a microbe-phage interaction database."Nucleic Acids Res.(2017 IF: 11.561)

2.

Wei-Hua Chen#, G. Lu, X. Chen, X. M. Zhao and P. Bork (2017). "OGEE v2: an update of the online gene essentiality database with special focus on differentially essential genes in human cancer cell lines."Nucleic Acids Res45(D1): D940-D944.(2017 IF: 11.561)

3.

He, Z., H. Zhang, S. Gao, M. J. Lercher,Wei-Hua Chen# and S. Hu# (2016). "Evolview v2: an online visualization and management tool for customized and annotated phylogenetic trees."Nucleic Acids Res44(W1): W236-241.(2017 IF: 11.561)

4.

Wei-Hua Chen, G. Lu, P. Bork, S. Hu and M. J. Lercher (2016). "Energy efficiency trade-offs drive nucleotide usage in transcribed regions."Nat Commun 7: 11334. (2017 IF: 12.353)

5.

Chen, W.H., van Noort, V., Lluch-Senar, M., Hennrich, M.L., JA, H.W., Yus, E., Alibes, A., Roma, G., Mende, D.R., Pesavento, C.et al.(2016) Integration of multi-omics data of a genome-reduced bacterium: Prevalence of post-transcriptional regulation and its correlation with protein abundances.Nucleic Acids Res, 44,1192-1202.(2017 IF: 11.561)

6.

Lluch-Senar, M.*, Delgado, J.*,Chen, W.H.*,Llorens-Rico, V., O'Reilly, F.J., Wodke, J.A., Unal, E.B., Yus, E., Martinez, S., Nichols, R.J.et al.(2015) Defining a minimal cell: essentiality of small ORFs and ncRNAs in a genome-reduced bacterium.Molecular systems biology, 11,780.(2017 IF: 8.500)

7.

Chen, W.-H., X.-M. Zhao, V. van Noort and P. Bork (2013). "Human Monogenic Disease Genes Have Frequently Functionally Redundant Paralogs."PLoS Comput Biol 9(5): e1003073.(2017 IF: 3.955)

8.

Schonknecht, G.*,Chen, W.H.*, Ternes, C.M., Barbier, G.G., Shrestha, R.P., Stanke, M., Brautigam, A., Baker, B.J., Banfield, J.F., Garavito, R.M.et al.(2013) Gene transfer from bacteria and archaea facilitated evolution of an extremophilic eukaryote.Science, 339, 1207-1210.(2017 IF: 41.058)

9.

Chen, W.H.,Minguez, P., Lercher, M.J. and Bork, P. (2012) OGEE: an online gene essentiality database.Nucleic Acids Research, 40, D901-906.(2017 IF: 11.561)

10.

Chen, W.-H., Trachana, K., Lercher, M.J. and Bork, P. (2012) Younger Genes Are Less Likely to Be Essential than Older Genes, and Duplicates Are Less Likely to Be Essential than Singletons of the Same Age.Molecular Biology and Evolution, 29, 1703-1706.(2017 IF: 10.217)

note:

• * co-first authors; # (co-) corresponding authors; names indark red:current members of the lab;