鄭曉峰[北京大學生命科學學院教授]

鄭曉峰，教授，博士生導師。 美國賓夕法尼亞州大學博士後研究員，現任北京大學生命科學學院教授。

學習與工作經歷

學習經歷

1994 - 1998 , 理學博士 , 生化與分子生物學 , 東京農工大學

1998 - 2002 , 博士後研究員 , 美國 賓夕法尼亞州大學

工作經歷

2002 - 2008 , 副教授 , 北京大學 生命科學學院

2008 - 至今 , 教授 , 北京大學 生命科學學院

研究內容

鄭曉峰教授和羅明教授課題組對一個新的NADP(H)結合蛋白(HSCARG) 的結構與功能特徵進行了研究。NADP和一氧化氮是兩個重要的具有廣泛調節功能的信號分子，是否存在連線這兩個信號通路的調節蛋白一直是人們關注的問題。

對HSCARG蛋白的晶體結構進行了解析，其最突出的特點是HSCARG能夠形成一個不對稱的二聚體，該蛋白N端的Rossmann摺疊與NADP(H)結合後發生明顯的構象變化。

HSCARG是一個新的NADPH sensor蛋白，它是連線細胞氧化還原狀態與一氧化氮信號通路的一個關鍵的蛋白：HSCARG通過感應細胞內NADP(H)濃度的變化，發生構象的變化來發揮其調節功能。

所獲榮譽

•北京大學優秀班主任 , 2005 [1]

•北京大學東寶教師獎 , 2006 [1]

•北京市優秀輔導員 , 2006 [1]

•談家楨基金生命科學九源導師獎 , 2006 [1]

•北京大學青年教師教學基本功優秀獎 , 2007 [1]

•北京大學東寶教師獎 , 2009 [1]

•北京大學東寶教師獎 , 2013 [1]

•北京大學東寶教師獎 , 2013 [1]

參與學術會議

1. Straightening of bulged RNA by the double-stranded RNA-binding domain from the protein kinase PKR,Second International Conference: Proteins that bind RNA , 2001.2

.2. Activation of the protein kinase PKR by small double-stranded RNAs flanked by single-stranded regions.,The 3rd Annual Meeting of the China RNA Society & 1st International RNA Workshop in China , 2003.7

3. Restructuring of the dinucleotide binding fold in a NADP(H) sensor protein,International Symposium on Synchrotron Radiation and Biology , 2007.11

4. 北京生物化學學會2007年年會 , 2007.12

5. Serum presence of preS antigen in chronic hepatitis B: a significant serological marker in HBV prognosis,Advances in Protein Sciences, Hongkong , 2005.12

發表論文

1. Li, T,T., Guan J., Li, S.Z., Zhang, X.D.,Zheng, X.F.,HSCARG downregulates TNF-induced NF-κB signaling by interacting with USP7 and inhibiting NEMO ubiquitination., Cell Difference & Diseases. , 2014 , 5: e1229.

2. Peng YY, Xu RD,Zheng XF,HSCARG negatively regulates the cellular antiviral RIG-I like receptor signaling pathway by inhibiting TRAF3 ubiquitination via recruiting OTUB1, PLoS Pathogen , 2014 , Accepted

3. Hu B, Li SZ, Zhang XD,Zheng XF,HSCARG, a novel regulator of H2A ubiquitination by downregulating PRC1 ubiquitin E3 ligase activity, is essential for cell proliferation, Nucleic Acid Res , 2014 , Accepted

4. Xiao W, Meng G, Zhao Y, Yuan H, Li T, Peng Y, Zhao Y, Luo M, Zhao, WM, Li Z,Zheng XF,Human SI-CLP aggravates the inflammation of the arthritis and is a potential macrophage inflammatory regulator, Arthritis Rheumatol , 2014 , doi: 10.1002/art.38356

5. Li TT, Guan JH, Huang ZJ, Hu X,Zheng XF,RNF168-mediated H2A neddylation antagonizes its ubiquitination and regulates DNA damage repair, Journal Cell Science , 2014 , Accepted

6. Li G, Qu L, Ma S, Wu Y, J CW,Zheng XF,Structures determination of human Fas Apoptosis Inhibitory Molecule and identification of the critical residues linking the interdomain interaction to the anti-apoptotic activity, Acta crystallgrophy D , 2014 , Accepted

7. Bai, D.M., Zhang, J., Xiao, W.C.,Zheng, X.F,Regulation of the HDM2-p53 pathway by ribosomal protein L6 in response to ribosomal stress., Nucleic Acid Res. , 2014 , 42(3):1799-1811.

8. Zhang JF, Bai DM, Ma XW, Guan JH,Zheng XF,hCINAP is a novel regulator of ribosomal protein-HDM2-p53 pathway by controlling NEDDylation of ribosomal protein S14, Oncogene , 2014 , 33, 246-254. doi: 10.1038/onc.2012.560 ,

9. Meng G, An X, Ye, S, Liu Y, Zhu W, Zhang R,Zheng XF,The crystal structure of LidA, a translocated substrate of the Legionella pneumophila Type IV secretion system, reveals a novel folding, Protein & Cell , 2013 , 4(12):897-900

10. Bai DM, Zhang J, Xiao WC,Zheng XF,Regulation of the HDM2-p53 pathway by ribosomal protein L6 in response to ribosomal stress, Nucleic Acid Res , 2013 , doi: 10.1093/nar/gkt971