鄭志永

鄭志永。

基本信息

人物經歷

2001 年畢業於無錫輕工大學,獲發酵工程專業碩士學位,2005年初畢業於浙江大學,獲生物化工專業博士學位,隨後到江南大學工作,2007 年晉升為江南大學副教授,2008 年為碩士生導師。2009 年受國家留學基金資助,在英國Newcastle University upon Tyne 從事訪問學者研究。

研究方向

微生物多糖生物製造。

微生物生理學。

生物反應工程。

生物反應器。

主要貢獻

1. Zheng Z-Y, Lee J W, Zhan X B, Shi Z P, Wang L, Zhu L, Wu J R, Lin C C. Effect of metabolic structures and energy requirements on curdlan production by Alcaligenes faecalis. Biotechnology and Bioprocess Engineering, 2007, 12,(4): 359-365.

2. Zheng Z-Y, Yao S-J, Zhan X, L C C. Improvement of hEGF production with enhanced cell division ability using dissolved oxygen responses to pulsed addition of tryptone, Biotechnology and Bioprocess Engineering, 2009, 14: 52-59.

3. Zheng Z-Y, Yao S-J, Lin D-Q. Using a kinetic model that considers cell segregation to optimize hEGF expression in fed-batch cultures of recombinant Escherichia coli. Bioprocess and Biosystems Engineering, 2005. 27:143-152.

4. Jin H, Zheng Z-Y, Gao M-J, Duan Z-Y, Shi Z-P. Effective induction of phytase in Pichia pastoris fed-batch culture using an ANN pattern recognition model-based on-line adaptive control strategy. Biochemical Engineering Journal, 2007, 37:26-33.

5. Zhang H, Setubal J C, Zhan X, Zheng Z, Yu L, Wu J, Chen D. Component identification of electron transport chains in curdlan-producing Agrobacterium sp. ATCC 31749 and its genome-specific prediction using comparative genome and phylogenetic trees analysis. Journal of Industrial Microbiology and Biotechnology. 2010 Aug 22. Epub ahead of print.

6. Zhang H, Zheng Z, Zhan X, Wu J, Jiang Y. Sequence and transcriptional analysis of the genes responsible for curdlan synthesis in Agrobacterium sp. ATCC 31749 under dissolved oxygen gradients stimulated in a scale-down system. Applied Microbiology and Biotechnology, 2011, accept.

7. Yu L-J, Wu J-R, Zheng Z-Y, Zhan X-B, Lin C C. Involvement of global regulator NtrC in the regulation of curdlan biosynthesis in Agrobacterium sp. ATCC 31749 under nitrogen limited condition. Research in Microbiology, 2011, accept.

8. Yu L-J, Wu J-R, Zhan X-B, Zheng Z-Y, et al. Changes in expression of genes and proteins involved in the adaptation of Agrobacterium sp. ATCC 31749 to the availability of nitrogen source during curdlan fermentation. Applied Biochemistry and Biotechnology, 2011, accepted.

9. Wu J R, Lin Y, Zheng Z Y, Lin C C, Zhan X B, Shen Y Q. Improvement of the CuZn-superoxide dismutase enzyme activity and stability as therapeutic agent by modification with polysialic acids. Biotechnology Letter, 2010, 32:1939-1945.

科研經歷與成果:

1. 獲獎項目:食品級微生物多糖發酵生產關鍵技術, 2010 年度中國食品科學技術學會科技進步三等獎。

2. 承擔國家自然科學基金項目,重組畢赤酵母表達藥物蛋白過程的智慧型模式識別控制,已完成結題。

3. 承擔江蘇省自然科學基金項目,具有共性特徵的、智慧型型模式識別控制的開發及其在重組畢赤酵母表達中的套用,已完成結題。

4. 參與國家自然科學基金項目,微生物多糖熱凝膠生物合成的能量代謝研究,已完成結題。

5. 參與國家自然科學基金項目,氮調控微生物多糖合成的分子機制及信號應答網路,已完成結題。

6. 參與國家高技術研究發展計畫(863)項目,針對微生物多糖的高粘度發酵關鍵技術與裝備,項目已完成結題。

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