人物經歷
學歷
學士. 1983，武漢大學生物系。
碩士. 1986, 武漢大學生物系。
博士. 1991, 美國內華達大學生物化學系。
博士後， 1993－1995，美國弗吉利亞大學。
博士後， 1995－1998，美國華盛頓大學。
主要工作
1998-2005.7， Immunex公司/Amgen公司，美國西雅圖，歷任初級科學家、科學家、高級科學家。
2005.8.– 武漢大學生命科學學院教授。
主講課程
科技英文寫作基礎， 每周2學時，2005年秋季，碩士研究生。生物化學， 每周5學時，2006年秋季，本科生國際班。
研究方向
蛋白質組學
目前主要研究領域和興趣：
本實驗室以蛋白質組學及生物質譜學為主要研究方法，重點研究感染與天然免疫過程中的蛋白組變化以及蛋白質信號傳導通路。
主要貢獻
代表性論文
Zeng, H. L., Rao, X., Zhang, L. K., Zhao, X., Zhang, W. P., Wang, J., Xu, F., and Guo, L. (2014) Quantitative proteomics reveals olfactory input-dependent alterations in the mouse olfactory bulb proteome,J Proteomics109, 125-142。
Yao, Q., Liu, B. Q., Li, H., McGarrigle, D., Xing, B. W., Zhou, M. T., Wang, Z., Zhang, J. J., Huang, X. Y., and Guo, L. (2014) C-terminal Src kinase (Csk)-mediated phosphorylation of eukaryotic elongation factor 2 (eEF2) promotes proteolytic cleavage and nuclear translocation of eEF2,J Biol Chem289, 12666-12678。
Zhao, X., Sidoli, S., Wang, L., Wang, W., Guo, L., Jensen, O. N., and Zheng, L. (2014) Comparative proteomic analysis of histone post-translational modifications upon ischemia/reperfusion-induced retinal injury,J Proteome Res13, 2175-2186。
Yan, J., Tian, H., Wang, S., Shao, J., Zheng, Y., Zhang, H., Guo, L., and Ding, Y. (2014) Pollen developmental defects in ZD-CMS rice line explored by cytological, molecular and proteomic approaches,J Proteomics108C, 110-123。
Zhang, L. K., Chai, F., Li, H. Y., Xiao, G., and Guo, L. (2013) Identification of host proteins involved in Japanese encephalitis virus infection by quantitative proteomics analysis,J Proteome Res12, 2666-2678。
Xing, B., Wang, L., Guo, D., Huang, J., Espenel, C., Kreitzer, G., Zhang, J. J., Guo, L., and Huang, X. Y. (2013) Atypical protein kinase Clambda is critical for growth factor receptor-induced dorsal ruffle turnover and cell migration,J Biol Chem288, 32827-32836。
Wu, Y., Zhao, S., Tian, H., He, Y., Xiong, W., Guo, L., and Wu, Y. (2013) CPK3-phosphorylated RhoGDI1 is essential in the development of Arabidopsis seedlings and leaf epidermal cells,J Exp Bot64, 3327-3338。
Li, X. S., Pan, Y. N., Zhao, Y., Yuan, B. F., Guo, L., and Feng, Y. Q. (2013) Preparation of titanium-grafted magnetic mesoporous silica for the enrichment of endogenous serum phosphopeptides,J Chromatogr A1315, 61-69。
Hou, D., Zhang, L., Deng, F., Fang, W., Wang, R., Liu, X., Guo, L., Rayner, S., Chen, X., Wang, H., and Hu, Z. (2013) Comparative Proteomics Reveal Fundamental Structural and Functional Differences between the Two Progeny Phenotypes of a Baculovirus,J Virol87, 829-839。
Chen, X., Zhao, Y., Li, G.-M., and Guo, L. (2013) Proteomic analysis of mismatch repair-mediated alkylating agent-induced DNA damage response,Cell & Biosciences3, 37。
Xu, H., Zhang, W., Gao, Y., Zhao, Y., Guo, L., and Wang, J. (2012) Proteomic analysis of embryo development in rice (Oryza sativa),Planta235, 687-701。
Liu, G., Tian, H., Huang, Y. Q., Hu, J., Ji, Y. X., Li, S. Q., Feng, Y. Q., Guo, L., and Zhu, Y. G. (2012) Alterations of Mitochondrial Protein Assembly and Jasmonic Acid Biosynthesis Pathway in Honglian (HL)-type Cytoplasmic Male Sterility Rice,J Biol Chem287, 40051-40060。
Kang, X., Chen, X., He, Y., Guo, D., Guo, L., Zhong, J., and Shu, H. B. (2012) DDB1 is a cellular substrate of NS3/4A protease and required for hepatitis C virus replication,Virology。
Chen, C., Wu, D., Zhang, L., Zhao, Y., and Guo, L. (2012) Comparative phosphoproteomics studies of macrophage response to bacterial virulence effectors,J Proteomics77, 251-261。
Yu, J. L., and Guo, L. (2011) Quantitative proteomic analysis of Salmonella enterica serovar Typhimurium under PhoP/PhoQ activation conditions,J Proteome Res10, 2992-3002。
Yao, Q., Li, H., Liu, B. Q., Huang, X. Y., and Guo, L. (2011) SUMOylation-regulated Protein Phosphorylation, Evidence from Quantitative Phosphoproteomics Analyses,J Biol Chem286, 27342-27349。
Xu, H., Zhang, W., Gao, Y., Zhao, Y., Guo, L., and Wang, J. (2011) Proteomic analysis of embryo development in rice (Oryza sativa),Planta。
Wu, J. H., Li, X. S., Zhao, Y., Zhang, W., Guo, L., and Feng, Y. Q. (2011) Application of liquid phase deposited titania nanoparticles on silica spheres to phosphopeptide enrichment and high performance liquid chromatography packings,J Chromatogr A1218, 2944-2953。
Shao, J., Zhang, Y., Yu, J., Guo, L., and Ding, Y. (2011) Isolation of Thylakoid Membrane Complexes from Rice by a New Double-Strips BN/SDS-PAGE and Bioinformatics Prediction of Stromal Ridge Subunits Interaction,PLoS One6, e20342。
Chen, X., Wu, D., Zhao, Y., Wong, B. H., and Guo, L. (2011) Increasing phosphoproteome coverage and identification of phosphorylation motifs through combination of different HPLC fractionation methods,J Chromatogr B Analyt Technol Biomed Life Sci879, 25-34。
Wu, J. H., Zhao, Y., Li, T., Xu, C., Xiao, K., Feng, Y. Q., and Guo, L. (2010) The use of liquid phase deposition prepared phosphonate grafted silica nanoparticle-deposited capillaries in the enrichment of phosphopeptides,J Sep Sci33, 1806-1815。
Wang, R., Deng, F., Hou, D., Zhao, Y., Guo, L., Wang, H., and Hu, Z. (2010) Proteomics of the Autographa californica nucleopolyhedrovirus budded virions,J Virol84, 7233-7242。
Ma, Y., Zhao, Y., Zhao, R., Zhang, W., He, Y., Wu, Y., Cao, Z., Guo, L., and Li, W. (2010) Molecular diversity of toxic components from the scorpion Heterometrus petersii venom revealed by proteomic and transcriptome analysis,Proteomics10, 2471-2485。
Zhou, Z., Fan, J. B., Zhu, H. L., Shewmaker, F., Yan, X., Chen, X., Chen, J., Xiao, G. F., Guo, L., and Liang, Y. (2009) Crowded cell-like environment accelerates the nucleation step of amyloidogenic protein misfolding,J Biol Chem284, 30148-30158。
Deng, M., Li, F., Ballif, B. A., Li, S., Chen, X., Guo, L., and Ye, X. (2009) Identification and functional analysis of a novel cyclin e/cdk2 substrate ankrd17,J Biol Chem284, 7875-7888。
Lin, B., Li, T., Zhao, Y., Huang, F. K., Guo, L., and Feng, Y. Q. (2008) Preparation of a TiO2 nanoparticle-deposited capillary column by liquid phase deposition and its application in phosphopeptide analysis,J Chromatogr A1192, 95-102。
Deng, F., Wang, R., Fang, M., Jiang, Y., Xu, X., Wang, H., Chen, X., Arif, B. M., Guo, L., and Hu, Z. (2007) Proteomics analysis of Helicoverpa armigera single nucleocapsid nucleopolyhedrovirus identified two new occlusion-derived virus-associated proteins, HA44 and HA100,J Virol81, 9377-9385。
