主要學歷及工作經歷:
1983 武漢大學病毒學學士
1986 武漢大學病毒生化碩士
1986-1989 中山醫科大學助教、講師
1990-1992 University of California-San Francisco 研究學者
1992-1997 美國恩尼克斯生物製藥有限公司助理科學家
1997 Utrecht University 細胞與分子生物學博士
1998-2000 University of California-Berkeley 博士後
2000-2002 美國寇山生命科學有限公司科學家
2003-2006 美國北進緣有限公司總裁
2006-今 大連理工大學教授、博士生導師
分子靶向抗腫瘤新藥的研製;藥物作用機制和信號傳導研究;細胞的生長和極性調控及癌變機理研究;藥物基因組學及藥物新靶點的發現;多藥耐藥性的分子機理研究
主要在研課題:
1.國家863計畫目標導向專題:組合生物合成技術開發新型埃博黴素抗腫瘤新藥。2007.1-2010.12
2.北京市海淀區科技項目:蛋白磷酸酶I特異性抑制劑TMC作為抗癌藥的研製2006.1-2007.12;
3.中美合資企業合作資金:國家一類抗癌新藥UTD1的開發及臨床研究。2003-;
指導碩、博士生研究方向:
藥物作用機制及信號傳導;
藥物基因組學;
小GTPases與細胞生長和細胞極性的調控
出版著作和論文:
在國內外權威學術期刊上發表論文30餘篇,影響因子總和超過200,被他人引用3000多次。論文所發期刊包括Nature, Cell, Curr. Biol.,Genes & Dev., PNAS, Mol. Cell. Biol., JBC等。
1. P. Li, Z. Deng, Z. Hu and R.-G. Qiu: In Vivo and In Vitro Studies for Evaluating Metabolic Interaction of a Anticancer Drug Candidate UTD1 on Dog and Human Cytochrome P450 Isoforms, Accepted,Academic J. Shanghai Jiaotong University, 2007
2. L. Tang, R.-G. Qiu, Y. Li, and L. Katz: Generation of Novel Epothilone Analogs with Cytotoxic Activity by Biotransformation, J. Antibiotics 56:16-23, 2003
3. R. Arslanian, L. Tang, S. Blough, R.-G. Qiu, L. Katz and J. R. Carney: A New Cytotoxic Epothilone From Modified Polyketide Synthases Heterologously Expressed in Myxococcusxanthus, J. Nat. Prod. 65:1061-1064, 2002.
4. N. Malecz, P. McCabe, C. Spaargaren, R.-G. Qiu and M. Symons: Synaptojanin 2, a Novel effector that Regulates Clathrin-mediated Endocytosis, Curr. Biol. 10: 1383-1386, 2000
5. M. Ahram, M. Sameni, R.-G. Qiu, D. Kirn and B. Sloane: Rac1-induced Invasion: Intracellular Proteolysis of Extracellular Matrix, Exp. Cell Res. 260: 292-303, 2000
6. R.-G. Qiu, A. Abo and G. S. Martin: A Human Homologue of the C. elegans Polarity Determinant Par-6 Links Rac and Cdc42 to PKCz Signaling and Cell Transformation, Curr. Biol. 10: 697-707, 2000
7. B. Anand-Apte, B. Zetter, A. Viswanathan, R.-G. Qiu, R. Ruggieri, J. Chen and M. Symons: PDGF and Fibronectin-stimulated Migration Are Differentially Regulated by the Rac and ERK Pathways, J. Biol. Chem. 272: 30688-30692, 1997
8. R.-G. Qiu, A. Abo, F. McCormick and M. Symons: Cdc42 Regulates anchorage-independent Growth and Is Necessary for Ras Transformation, Mol. Cell. Biol. 17: 3449-3458, 1997
9. R.-G. Qiu: All the Roads Leading to Rho: Rho-like GTPases and Cell Signaling (a review), in The Role of Rho-like GTPases in Cell Proliferation and Ras Transformation, p13-73, Published by FEBO-druk, Enschede, the Netherlands, 1997
10. M. Falasca, A. Carvelli, C. Iurisci, R.-G. Qiu, M. Symons and D. Corda: Fast Receptor-induced Formation of Glycerophosphoinositol-4-phosphate, a Putative Novel Intracellular Messenger in the Ras Pathway, Mol. Biol. Cell. 8: 443-453, 1997
11. J. A. Hess, A H. Ross, R.-G. Qiu, M. Symons and J. Exton: Role of Rho Family Proteins in Phospholipase D Activation by Growth Factors, J. Biol. Chem. 272: 1615-1620, 1997
12. M. Hart, S. Sharma, N. elMastry, R.-G. Qiu, P. McCabe, P. Polakis and G. Bollag: Cloning of a Novel GDP/GTP Exchange Factor for Rho GTPase, J. Biol. Chem. 271: 25452-25458, 1996
13. M. Peppelenbosch, L. Tertoolen, A. Vries-Smits, R.-G. Qiu, M. Symons, S. de Laat, and J. Bos: Rac-dependent and -independent Pathways Mediate Growth Factor Induced Ca2+ influx, J. Biol. Chem. 271: 7883-7886, 1996
14. R.-G. Qiu, J. Chen, F. McCormick, and M. Symons: A Role for Rho in Ras Transformation, Proc. Natl. Acad. Sci. USA 92: 11781-11785, 1995
15. M. Peppelenbosch, R.-G. Qiu, A. de Vries-Smits, L. Tertoolen, S. de Laat, F. McCormick, A. Hall, M. Symons, and J. Bos: Rac Mediates Growth Factor-Induced Arachidonic Acid Release, Cell 81: 849-856, 1995
16. P. Hawkins, A. Eguinoa, R.-G. Qiu, D. Stokoe, F. Cooke, R. Walters, S. Wennstrom, L. Claesson-Welsh, T. Evans, M. Symons, and L. Stephens: PDGF Stimulates an Increase in GTP-Rac via Activation of Phosphoinositide 3-Kinase, Curr. Biol. 5: 393-403, 1995
17. A. Siddiqi, J. Smith, A. Ross, R.-G. Qiu, M. Symons, and J. Exton: Regulation of Phospholipase D in HL60 Cells: Evidence for a Cytosolic Phospholipase D, J. Biol. Chem. 270: 8466-8473, 1995
18. R.-G. Qiu, J. Chen, D. Kirn, F. McCormick, and M. Symons: An Essential Role for Rac in Ras Transformation, Nature 374: 457-459, 1995
19. K. Malcom, A. Ross, R.-G. Qiu, M. Symons, and J. Exton: Activation of Rat Liver Phospholipase D by the Small GTP-binding Protein RhoA, J. Biol. Chem. 269: 25951-25954, 1994
20. C. van Genderen, R. okamura, I. Farinas, R.-G. Qiu, T. Parslow, L. Bruhn, and R. Grosschedl: Development of Several Organs That Require Inductive Epithelial-mesenchymal Interactions Is Impaired in LEF-1 Deficient Mice, Genes & Dev. 8: 2691-2703, 1994
21.A. Milatovich, R.-G. Qiu, R. Grosschedl, and U. Francke: Gene for a Tissue-specific Transcriptional Activator (EBF or Olf-1), Expressed in early B Lymphocytes, adipocytes, and olfactory Neurons, Is Located on Human Chromosome 5, Band q34, and Proximal Mouse Chromosome 11, Mamm. Genome 5: 211-215, 1994
22. T. Jenuwein, W. Forrester, R.-G. Qiu, and R. Grosschedl: The immunoglobulin m Enhancer Core Establishes Local Factor Access in Nuclear chromatin Independent of Transcriptional Stimulation, Genes & Dev. 7: 2016-2032, 1993
科研成果及所受獎勵:
其它獎勵:
2000-2002 美國癌症學會Diane Beardsley 研究獎
1998-1999 美國衛生研究院(NIH)博士後研究獎(NRSA)
在讀碩士、博士人數:n