董晨[清華大學醫學院教授，院長]

董晨，清華大學醫學院教授，院長。

人物經歷

•2017-至今 北京市”慢性疾病的免疫學研究”重點實驗室, 主任

•2016-至今 清華大學醫學院院長

•2015-至今 北大 - 清華生命科學聯合中心副主任（清華）

•2014-至今 清華大學免疫學研究所所長

•2013-2016 清華大學醫學院副院長

•2013-至今 清華大學醫學院教授

•2010-2013 美國德克薩斯大學安德森腫瘤中心講席教授

•2008-2013 美國德克薩斯大學安德森腫瘤中心炎症與腫瘤中心主任

•2008-2013 美國德克薩斯大學安德森腫瘤中心免疫學系終身教授

•2004-2008 美國德克薩斯大學安德森腫瘤中心免疫學系終身副教授

•2000-2004 美國華盛頓大學（西雅圖）免疫學系助理教授

•1997-2000 美國耶魯大學醫學院免疫系博士後

•1990-1996 美國阿拉巴馬大學伯明罕分校細胞及分子生物學專業博士

•1985-1989 中國武漢大學細胞生物學專業學士

科研方向

董教授主要致力於免疫學的研究，重點探討免疫耐受和免疫應答的分子調控機制, 以理解自身免疫和過敏疾病的發病機理, 並探索新型腫瘤免疫治療。董晨教授是 Th17 細胞分化、調節和功能研究領域的奠基者和研究權威之一 , 並在 Tfh 和 Tfr 細胞的發現和研究中，做出了開創性貢獻。他的主要研究領域包括:

1. T淋巴細胞分化與功能

2. 細胞因子在炎症中的功能與信號傳導

3. 免疫耐受和腫瘤免疫

代表性論文

Xu, M., Lu, H., Wu, Y., Liu, K., Shi, Y., An, H., Zhang, J., Wang, X., Lai, Y. and Dong, C. An IL-25-mediated autoregulatory circuit in keratinocytes plays a pivotal role in psoriatic skin inflammation. (2018) Immunity.48(4):787-7982.

Jing Li, Younghee, Lee, Yanjian Li, Yu Jiang, Huiping Lu, Wenjuan Zang, Xiaohong Zhao, Liguo Liu, Yang Chen, Haidong Tan, Zhiying Yang, Michael Q. Zhang, Tak W. Mak, Ling Ni andChen Dong. Co-inhibitory Molecule B7 Superfamily Member 1 Expressed by Tumor-Infiltrating Myeloid Cells Induces Dysfunction of Anti-tumor CD8+ T Cells. (2018) Immunity.48(4):773-7863.

Jiang, Y., Liu, Y., Lu, H., Sun, S.-C., Jin, W., Wang, X. and Dong, C. Epigenetic activation during T helper 17 (Th17) cell differentiation is mediated by Tripartite motif containing 28. (2018) Nature Communications. 9:1424

Weiwei Fu, Xindong Liu, Xiang Lin, Han Feng, Lin Sun, Shuran Li, Hairong Chen, Hong Tang, Liwei Lu, Wei Jin,Chen Dong. Deficiency in T follicular regulatory cells promotes autoimmunity. (2018) Journal of Experimental Medicine.215:815-825

Tao Xu(#), Kelly M. Stewart(#), Xiaohu Wang(#), Kai Liu, Min Xie, Jae Kyu Ryu, Ke Li, Tianhua Ma, Haixia Wang, Lu Ni; Saiyong Zhu, Nan Cao, Dongwei Zhu, Yu Zhang, Katerina Akassoglou,Chen Dong(*), Edward M. Driggers(*), Sheng Ding(*). Metabolic control of TH17 and induced Treg cell balance by an epigenetic mechanism. (2017) Nature. 548:228-233. (* co-correspondent authors)

Xiao Ding，Aibo Wang，Xiaopeng Ma，Maud Demarque，Jin Wei，Huawei Xin, Anne De jean，Chen Dong. Protein SUMOylation is required for regulatory T cell expansion and function. (2016) Cell Reports. 16:1055-1066.

Xindong Liu, Huiping Lu, Tingting Chen, Kalyan C Nallaparaju, Xiaowei Yan, Shinya Tanaka, Kenji Ichiyama, Xia Zhang, Li Zhang, Xiaofeng Wen, Qiang, Tian, Xiu-Wu Bian, Wei Jin, Lai Wei,Chen Dong. Genome-wide analysis identifies Bcl6-controlled regulatory networks during T follicular helper (Tfh) cell differentiation. (2016) Cell Reports. 14:1735-1747

Xindong Liu, Xin Chen, Bo Zhong, Aibo Wang, Xiaohu Wang, Fuliang Chu, Roza I Nurieva, Xiaowei Yan, Ping Chen, Laurens G van der Flier, Hiroko Nakatsukasa, Sattva S Neelapu, Wanjun Chen, Hans Clevers, Qiang Tian, Hai Qi, Lai Wei,Chen Dong. Transcription factor Achaete-Scute homologue 2 initiates T follicular helper cell development. (2014) Nature. 507: 513–518

1.

Xu, M., Lu, H., Wu, Y., Liu, K., Shi, Y., An, H., Zhang, J., Wang, X., Lai, Y. and Dong, C. An IL-25-mediated autoregulatory circuit in keratinocytes plays a pivotal role in psoriatic skin inflammation. (2018) Immunity.48(4):787-7982.

2.

Chen Dong

3.

Jiang, Y., Liu, Y., Lu, H., Sun, S.-C., Jin, W., Wang, X. and Dong, C. Epigenetic activation during T helper 17 (Th17) cell differentiation is mediated by Tripartite motif containing 28. (2018) Nature Communications. 9:1424

4.

Chen Dong

5.

Chen Dong

6.

Chen Dong

7.

Chen Dong

8.

Chen Dong