個人經歷
1983年畢業於中國醫科大學醫療系本科，1989獲得醫學碩士學位後任大連醫科大學講師，1992年赴日本群馬大學攻讀博士學位（文部省獎學金資助），1997獲醫學博士學位。在日本學術振興會（JSPS）獎學金資助下做博士後兩年，之後就職於日本理化學研究所任研究員。2000年底辭職，以“引進人才”到南開大學任教授，新組建蛋白質生化研究室。回國後先後主持國家自然科學基金5項（在研2項）、天津市科技發展計畫重點項目（3項）和教育部基金（2項）。參加973項目1項(骨幹)和國家自然科學基金2項。培養博士後1人，培養博士生7人，碩士生17人。已獲得國家發明專利2項，申請國家發明專利11項。在Genbank登入新基因2個。2005年在天津市“巾幗發明家”活動中獲“優秀髮明者”稱號,2007年榮獲天津市智慧財產權系統“十大女傑”稱號，2008年在天津市“巾幗發明家”活動中獲“巾幗發明家創新獎”稱號。承擔博士生《分子生物學前沿講座》和碩士生《高級生化II》的必修課程，擔任本科生《生命科學前沿講座》。迄今在國際權威雜誌PNAS和JBC等雜誌上發表論文120篇，其中SCI論文40篇，總影響因子大於100，他人引用總計200餘次。應美國Nova科學出版社邀請，編寫並出版B型肝炎病毒專著2部。多次應邀在國內外學術會議上作大會發言，並。
論文成果
SCI論文:
1.Zhang X, You X, Wang Q, Zhang T, Du Y, Lv N, Zhang Z, Zhang S, Shan C, Ye LH*, Zhang XD. Hepatitis B virus X protein promotes cell migration via multiple cross-talk cascade loops involving 5-LOX, NF-κB, OPN and Capn4. PLoS One, 2012;7(2):e31458. (IF=4.3)
2.Zhang W, Kong G, Zhang J, Wang T, Ye LH*, Zhang XD. MicroRNA-520b inhibits growth of hepatoma cells by targeting MEKK2 and Cyclin D1. PLoS One 2012;7(2): e31450. (IF=4.3)
3.Cui W, Zhao Y, Shan C, Kong G, Hu N, Zhang Y, Zhang S, Zhang W, Zhang XD, Ye LH*. HBXIP upregulates CD46, CD55 and CD59 through ERK1/2/NF-κB signaling to protect breast cancer cells from complement attack. FEBS Letters, doi:10.1016/j.febslet.2012.01. 0392012, Jan 27. [Epub ahead of print] (IF=2.7)
4.Zhao Y, Wang W, Wang Q, Zhang XD, Ye LH*. Lipid metabolism enzyme 5-LOX and its metabolite LTB4 are capable of activating transcription factor NF-κB in hepatoma cells. Biochem Biophys Res Commun. 2012; 418(4):647-651 (IF=2.7)
5.Wang Q，Zhang T，Ye LH，Wang WH，Zhang XD. Analysis of hepatitis B virus X gene (HBx) mutants in tissues of patients suffered from hepatocellular carcinoma in China. Cancer Epidemiol. 2011 Dec 16. [Epub ahead of print] (IF=1.4)
6.Zhang S, Shan CL, Kong GY, Du YM, Ye LH*, Zhang XD*.MicroRNA-520e Suppresses Growth of Hepatoma Cells by Targeting the NF-κB-inducing Kinase (NIK). Oncogene, 2011 Nov 21. doi: 10.1038/onc.2011.523. [Epub ahead of print](IF=7.4)
7.Kong GY, Zhang JP, Zhang S, Shan CL, Ye LH*, Zhang XD. Hepatitis B virus X protein promotes hepatoma cell proliferation via upregulation of MEKK2. Acta Pharmacol Sin. 2011;32:1173-1180 (IF=1.9)
8.Kong G, Zhang J, Zhang S, Shan C, Ye LH*, Zhang X. Upregulated MicroRNA-29a by Hepatitis B Virus X Protein Enhances Hepatoma Cell Migration by Targeting PTEN in Cell Culture Model. PLoS One. 2011;6(5):e19518.(IF=4.3)
9.Shan C, Zhang S, Cui W, You X, Kong G, Du Y, Qiu L, Zhang Z, Ye LH*, Zhang XD. HBx activates CD59 through indirectly binding to the region of the CD59 promoter and down-regulating Let-7i. Carcinogenesis. 2011;32 (8):1190-7 (IF=5.4)
10.張烜，葉麗虹*，張曉東.骨橋蛋白通過NF-kB上調鈣蛋白酶小亞基1促進肝癌細胞遷移。生物化學與生物物理進展.2010；37(5): 534-539.
11.張學智, 山長亮, 葉麗虹*,張曉東. RNA干擾在抗B肝治療中的套用及其研究進展. 生物化學與生物物理進展. 2008;35(6):631-636
12.王鳳澤，沙麗，喬玲，吳蓮英，張曉東，葉麗虹*.B肝病毒X蛋白結合蛋白（HBXIP）增強肝癌細胞NF-кB轉錄活性的實驗研究. 生物化學與生物物理進展2007;34(11):1-5
13.喬玲, 徐治立, 譚旭, 葉麗虹*, 張曉東.間充質幹細胞釋放Dkk-1抑制乳腺癌細胞Wnt/β-catenin途徑的實驗研究. 生物化學與生物物理進展2007;34(7): 702-708
14.葉麗虹,尤嘉琮,張曉東,蔡娜,喬玲,王長曄.劉毅 吳晶輝 吳蓮英 王洪輝套用基因表達譜晶片從不同轉移能力的乳腺癌細胞中篩選轉移相關基因. 生物化學與生物物理進展2005;32(5): 421-428
著作：
1.《Progress in Hepatitis B Research》 (ISBN: 1-60021-687-0) Editors: Dorothy V. Denyer. Nova publishers of America. Published in Dec. 2007.
Xiaodong Zhang, Weiying Zhang and Lihong Ye wrote the Chapter V - Hepatitis B Virus Research Focus; pp. 113-201
2.《Hepatitis B Virus Research Focus》(ISBN: 978-1-60456-299-6) Writers: Xiaodong Zhang, Weiying Zhang, Lihong Ye. Nova publishers of America. Published in Nov 2008.
主要學術論文::
張曉東;東楠; 張航; 尤嘉琮; 王洪輝; 葉麗虹. Effects of hepatitis B virus X protein on human telomerase reverse transcriptase expression and activity in hepatoma cel. JOURNAL OF LABORATORY AND CLINICAL MEDICINE
王鳳澤; 沙麗; 喬玲;吳蓮英; 張曉東; 葉麗虹. Promotion of transcriptional activity of NF-kappa B mediated by HBXIP in hepatoma cells. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS
秦宵然; 張航; 周曉雷; 王長曄; 張惠中; 張曉東; 葉麗虹. Proliferation and migration mediated by Dkk-1/Wnt/beta-catenin cascade in a model of hepatocellular carcinoma cells. TRANSLATIONAL RESEARCH
張曉東; 張偉英; 葉麗虹. Pathogenesis of hepatitis B virus infection. FUTURE VIROLOGY 1-5-637-647. 2007-1-1
喬玲; 徐治立; 譚旭; 葉麗虹;張曉東. Investigation of inhibition of Wnt/beta-catenin pathway in breast cancer cells mediated by Dkk-1 released from human mesenchymal stem cells. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS
王鳳澤; 沙麗; 張偉應;吳蓮英; 喬玲; 李楠; 張曉東; 葉麗虹. Involvement of hepatitis B X-interacting protein (HBXIP) in proliferation regulation of cells. ACTA PHARMACOLOGICA SINICA
張曉東; 張航; 吳蓮英; 沙麗; 劉樹業; 邵新華; 葉麗虹. Anti-HBx in sera is a potential marker of development from hepatitis B (HB) to liver cirrhosis (LC) and hepatocellular carcinoma (HCC). JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY 21--A133-A133.
葉麗虹; 蔡娜; 東楠; 李楠; 張偉英; 張航; 張烜; 吳蓮英; 張曉東. Interference of RNA targeting hepatitis B virus x (HBx) gene reduces the tumorigenicity of hepatoma cells and HBx-transformed human liver cells. JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY 21--A159-A159.
張曉東; 蔡娜; 李楠; 張偉英;張航; 張烜; 吳蓮英; 齊眾; 葉麗虹. Transformation of human normal liver L-O2 cells induced by hepatitis B virus X protein, enhanced by highly expression level of survivin as a co-factor. JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY 21--A179-A180.
Zhang, XD; Zhang, H; Ye, LH. Effects of hepatitis B virus X protein on the development of liver cancer. JOURNAL OF LABORATORY AND CLINICAL MEDICINE
Zhang H, Wu LY, Zhang S, Qiu LY, Li N, Zhang X, Zhang XZ, Shan SL, Ye LH, Zhang XD*. Anti-hepatitis B Virus (HBV) X protein (HBx) in sera is one of the markers of development of liver c. J Biomed Biotechnol
Zhang WY, Cai N, Ye LH, Zhang XD. Transformation of human liver L-O2 cells mediated by stable HBx transfection.. Acta Pharmacol Sinica.
Zhang WY, Xu FQ, Shan CL, Xiang R, Ye LH, Zhang XD. Gene expression profiles of human liver cells mediated by hepatitis B virus X protein. Acta Pharmacologica Sinica
You J, Mi D, Zhou X, Qiao L, Xu S, Zhang X, Ye LH. Positive feedback between activated ERK and COX/LOX contributes to breast cancer cell proliferation . Endocrinology 1
Zhou X, Liu Y, You J, Zhang X, Ye LH. Myosin light-chain kinase contributes to the proliferation and migration of breast cancer cells through cross-talk with activated ERK1/2. . Cancer Letters
Qiao L, Xu ZL, Zhao TJ, Ye LH, Zhang XD. Dkk-1 secreted by mesenchymal stem cells inhibits growth of breast cancer cells via depression of Wnt signalling. Cancer Letters
張學智, 山長亮, 葉麗虹,張曉東. RNA干擾在抗B肝治療中的套用及其研究進展. . 生物化學與生物物理進展
Qiao L, Xu Z, Zhao T, Zhao Z, Shi M, Zhao C, Ye L, Zhang X. Depression of tumorigenesis mediated by human mesenchymal stem cells in a model of hepatoma cells.. Cell Res
Ye LH, Dong N，Wang Q，Xu ZL，Cai N，Wang HH，Zhang X. Progressive changes in hepatoma cells stably transfected with hepatitis B virus X gene. Intervirology
Zhang H, Shan C, Li N, Zhang X, Zhang X, Xu F, Zhang S, Qiu L, Ye L, Zhang X. Identification of a natural mutant of HBV X protein truncated 27 amino acids at COOH-terminal and it. Acta Pharmacologica Sinica
Qiao L, Zhao T, Wang F, Shan C, Ye L, Zhang X. NF-κB downregulation maybe involved the depression of proliferation of tumor cells mediated by human mesenchymal stem cells. . Acta Pharmacologica Sinica
Wang F, Sha L, Ye L*, Zhang X. Promotion of cell proliferation by HBXIP via upregulation of human telomerase reverse transcriptase in human mesenchymal stem cells. . Acta Pharmacologica Sinica
張烜，葉麗虹，張曉東. 骨橋蛋白通過NF-kB上調鈣蛋白酶小亞基1促進肝癌細胞遷移. 生物化學與生物物理進展
Cui WJ, Liu Y, Zhou XL, Wang FZ, Zhang XD, Ye LH. Myosin light chain kinase is responsible for high proliferative ability of breast cancer cells via anti-apoptosis involving p38 pathway. Acta Pharmacol Sin.
Zhang X, Ye LH, Zhang XD. A mutant of hepatitis B virus X protein (HBx?127) enhances cell migration via osteopontin (OPN) invo. Acta Pharmacol Sin.
Zhang F, Wang Q, Ye LH, Feng YM, Zhang XD. Hepatitis B virus X protein upregulates expression of calpain small subunit 1 via nuclear factor-kap. J Med Virol. 82-5-920-928. 2010-5-1
Shan C, Xu FQ, Zhang S, You JC, You XN, Qiu LY, Zheng J, Ye LH, Zhang XD. Hepatitis B virus X protein promotes liver cell proliferation via a positive cascade loop involving arachidonic acid metabolism and p-ERK1/2. Cell Res.
Wang Q, Zhang WY, Ye LH, Zhang XD. A mutant of HBx (HBxΔ127) promotes hepatoma cell growth via sterol regulatory element binding protein 1c involving 5-lipoxygenase. Acta Pharmacol Sin.
Wang Q, Zhang W, Liu Q, Zhang X, Lv N, Ye L, Zhang XD. A Mutant of Hepatitis B Virus X Protein (HBxDelta127) Promotes Cell Growth through A Positive Feedba. Neoplasia.
Zhou XL, Qin XR, Zhang XD, Ye LH. Downregulation of Dickkopf-1 is responsible for high proliferation of breast cancer cells via losing control of Wnt/β-catenin signaling. Acta Pharmacol Sin.
Cui WJ, Zhang YW, Hu N, Shan CL, Zhang S, Zhang WY, Zhang XD, Ye LH. MiRNA-520b and miR-520e sensitize breast cancer cells to complement attack via directly targeting 3′. Cancer Biol Ther.張烜，葉麗虹，張曉東. B肝病毒X蛋白通過骨橋蛋白OPN促進肝癌細胞遷移. 中國生化與分子生物學學報
周曉雷，張曉東, 葉麗虹. DKK-1通過上調nm23表達抑制乳腺癌細胞遷移。. 中國生化與分子生物學學報Wang Q, Zhang T, Ye LH*, Wang WH, Zhang XD.. Analysis of hepatitis B virus X gene (HBx) mutants in tissues of patients suffered from hepatocellular carcinoma in China. Cancer Epidemiology --
Zhang S, Shan CL, Kong GY, Du YM, Ye LH*, Zhang XD*. MicroRNA-520e suppresses growth of hepatoma cells by targeting the NF-κB-inducing kinase (NIK). Oncogene 2011--1-14. Kong G, Zhang J, Zhang S, Shan C, Ye LH*, Zhang XD*. Upregulated MicroRNA-29a by Hepatitis B Virus X Protein Enhances Hepatoma Cell Migration by Targetin. PLoS One 6-5-e19518. Kong GY, Zhang JP, Zhang S, Shan CL, Ye LH*, Zhang XD*.. Hepatitis B virus X protein promotes hepatoma cell proliferation via upregulation of MEKK2. Acta Pharmacol Sin.
張煊; 葉麗虹*; 張曉東*. Osteopontin(OPN) Upregulates Calpain Small Subunit 1(Capn4) via Nuclear Facter-kappa B in Promotion of Hepatoma Cell Migration. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS尤嘉琮，米達，周曉雷，喬玲，張航，張曉東*，葉麗虹*. A Positive Feedback between Activated Extracellularly Regulated Kinase and Cyclooxygenase/Lipoxygenase Maintains Proliferation and Migration of Breast Cancer Cells. ENDOCRINOLOGY Zhang Xue-Zhi; Shan Chang-Liang; Ye Li-Hong; Zhang Xiao-Dong. Advantages of RNA interference in anti-hepatitis B virus therapy. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS Nan HU, Yu LI, Yu ZHAO, Qi WANG, Jia-cong YOU, Xiao-dong ZHANG, Li-hong YE. A novel positive feedback loop involving FASN/p-ERK1/2/5-LOX/LTB4/FASN sustains high growth of breast cancer cells. ACTA PHARMACOLOGICA SINICA?? Changliang Shan, Shuai Zhang, Wenjing Cui, Xiaona You, Guangyao Kong, Yumei Du, Liyan Qiu, Lihong Yeand Xiaodong Zhang. Hepatitis B virus X protein activates CD59 involving DNA binding and let-7i in protection of hepatoma and hepatic cells from complement attack. Carcinogenesis
Hu N, Zhang J, Cui W, Kong G, Zhang S, Yue L, Bai X, Zhang Z, Zhang W, Zhang X, Ye L.. miR-520b Regulates Migration of Breast Cancer Cells by Targeting Hepatitis B X-interacting Protein and Interleukin-8. J Biol Chem張濤, 張俊萍, 由曉娜, 劉遷, 杜玉梅, 高玉恩, 山長亮, 孔光耀, 葉麗虹，張曉東. Hepatitis B Virus X Protein (HBx) Modulates Oncogene YAP via CREB to Promote Growth of Hepatoma Cells. . Hepatology 杜玉梅, 孔光耀 由曉娜, 張帥，張濤, 葉麗虹, 張曉東. Up-regulated long non-coding RNA HULC by HBx enhances growth of hepatoma cells via down-regulating p18.. J Biol Chem. --.
Zhang X, You X, Wang Q, Zhang T, Du Y, Lv N, Zhang Z, Zhang S, Shan C, Ye LH, Zhang XD. Hepatitis B virus X protein promotes cell migration via multiple cross-talk cascade loops involving . PLoS One 2012;7
Zhang W, Kong G, Zhang J, Wang T, Ye LH, Zhang XD. MicroRNA-520b inhibits growth of hepatoma cells by targeting MEKK2 and Cyclin D1. PLoS One 2012;7(2): e3Cui W, Zhao Y, Shan C, Kong G, Hu N, Zhang Y, Zhang S, Zhang W, Zhang XD, Ye LH. HBXIP upregulates CD46, CD55 and CD59 through ERK1/2/NF-κB signaling to protect breast cancer cells . FEBS Letters
Zhao Y, Wang W, Wang Q, Zhang XD, Ye LH. Lipid metabolism enzyme 5-LOX and its metabolite LTB4 are capable of activating transcription factor. Biochem Biophys Res Commun. Zhang X, You XN, Li N, Zhang WY, Gagos S, Wang Q, Banos A, Cai N, Zhang HK, Zhang H, Zhang XZ, Shan CL, Qiu LY, Zhang S, Lv N, Chen MS, Du YM, Xia JC, Ye LH*, Zhang XD*. Involvement of hepatitis B virus X gene (HBx) integration in hepatocarcinogenesis via a recombination of HBx/Alu core sequence/subtelomeric DNA. FEBS Letters
Liu SP, Li LL, Zhang YY, Zhang YW, Zhao Y, Lin ZH, Zhang XD*, Ye LH*. HBXIP upregulates s100a4 via stat4 and pten to promote growth and migration of breast cancer cells. J Biol Chem
