瀋陽興華肛腸醫院副院長
聶廣軍曾任瀋陽市肛腸醫院業務副院長、東北地區中西醫結合大腸肛門疾病學會副主任委員、遼寧省肛腸學會副主任委員、瀋陽市醫學會醫療鑑定專家庫成員。2008年9月經各中醫學會推薦，肛腸分會組織綜合專家組評審，中華中醫藥學會審查批准，被授予“全國中醫肛腸學科名專家”榮譽稱號。從事本專業二十餘年，精通各種常見和疑難的肛門疾病的診斷治療,大腸癌的診斷和治療。最近總結多年臨床經驗，自行設計了專門治療直腸黏膜內脫垂的器械肛腸高位點注射槍，獲國家專利及瀋陽市推廣新技術獎，現已批量投入生產。曾發表國際和國家級論文二十餘篇。主持進行的“直腸肛管周圍膿腫切開引流術切口改進‘T自行切口確立的研究”等3項科研項目獲獎。
中國科學院國家納米科學中心研究員
基本信息
姓 名: 聶廣軍
性 別: 男
職 務: 無
職 稱: 研究員
簡歷
國家納米科學中心研究員，博士生導師，課題組長；獲中國科學院“百人計畫”海外傑出人才擇優支持；科技部973（納米重大研究計畫）首席科學家。2002年於中國科學院生物物理所獲博士學位，之後在加拿大McGill大學從事博士後研究。2008年加入國家納米科學中心。回國以來在Adv Mater, Angew Chem Int Ed, Biomaterials, Blood, Brit J Haematol, J Am Chem Soc, J Biol Chem和Small等國際學術期刊上發表學術論文50餘篇。
研究領域
結合分子生物學、醫學、化學和材料學等交叉學科的方法，以生理和病理的視角研究在納米尺度上新型材料與生物體的相互作用等納米生物醫學中的基本問題。
主要的研究方向
1．基於腫瘤微環境調控的抗腫瘤納米材料設計和抗腫瘤機制的研究；
2．生物分子指導的功能性納米材料合成及其在生物醫學上的套用；
3．細胞膜囊泡系統及其在納米材料生物效應中的分子機制；
4．血細胞分化及其相關疾病的病理機制。
代表論著
Tianjiao Ji, Ying Zhao, Yanping Ding and Guangjun Nie, Using nanotechnology to target and regulate the tumor microenvironment: diagnostic and therapeutic applications, Advanced Materials, doi:
Yanping Ding, Suping Li & Guangjun Nie, Nanotechnological strategies for therapeutic targeting and imaging of tumor vasculature, Nanomedicine
Xin Tian, Motao Zhu, Libo Du, Jing Wang, Zhenlin Fan, Jun Liu Yuliang Zhao and Guangjun Nie, Intrauterine inflammation alters size-dependent materno-fetal transfer of nanoparticles in murine pregnancy, Small, doi:
Tianjiao Ji, Ying Zhao, Jing Wang, Xin Zheng, Yanhua Tian, Yuliang Zhao and Guangjun Nie, Tumor fibroblast specific activation of hybrid ferritin nanocage-based optical probe for tumor microenvironment imaging, Small
Shishuai Su, Hai Wang, Xiaoguang Liu, Yan Wu, Guangjun Nie, iRGD-coupled responsive fluorescent nanogel for targeted drug delivery, Biomaterials,
Hai Wang, Yan Wu, Ruifang Zhao and Guangjun Nie, Engineering the assemblies of biomaterial nanocarriers for delivery of multiple theranostic agents with enhanced antitumor efficacy, Advanced Materials,
Motao Zhu, Sarah, Perrett and Guangjun Nie, Understanding the Particokinetics of Engineered Nanomaterials for Safe and Effective Therapeutic Applications, Small
Hui Yang, Cuiji Sun, Zhenlin Fan, Xin Tian, Liang Yan, Libo Du, Yang Liu, Chunying Chen, Xing-jie Liang, Gregory J. Anderson, Jeffrey A. Keelan, Yuliang Zhao, Guangjun Nie, Effects of gestational age and surface modification on materno-fetal transfer of nanoparticles in murine pregnancy, Scientific Report
Wendi Zhang, Chi Wang, Zhenzhen Lu, Jun-Jie Yin, Yu-Ting Zhou, Xingfa Gao, Ying Fang, Guangjun Nie, Yuliang Zhao, Unraveling Stress-induced Toxicity Properties of Graphene Oxide and the Underlying Mechanism, Advanced Materials
Motao Zhu, Xin Tian, Xiao Song, Yanhua Tian, Yuliang Zhao, and Guangjun Nie, Nanoparticle-Induced Exosomes Target Antigen-Presenting Cells to Initiate Th1-Type Immune Activation, Small
Gang Liu, Shiwen Niu, Ailian Dong, Hao Cai, Gregory J Anderson, Bing Han and Guangjun Nie, A Chinese family carrying novel mutations in the SEC23B and HFE2 genes, British Journal of Haematology
Xin Tian, Motao Zhu, Yanhua Tian, Ramm A. Grant, Yuliang Zhao, Guangjun Nie, A membrane vesicle-based dual vaccine against melanoma and Lewis lung carcinoma, Biomaterials
Motao Zhu, Yiye Li, Jian Shi, Weiyue Feng, Guangjun Nie, and Yuliang Zhao, Cellular Responses to Nanomaterials: Exosomes as Extrapulmonary Signaling Conveyors for Nanoparticle-Induced Systemic Immune Activation, Small
Bo Ning, Gang Liu, Yuanyuan Liu, Xiufen Su, Gregory J Anderson, Xin Zheng, Yanzhong Chang, Mingzhou Guo, Yuanfang Liu, Yuliang Zhao and Guangjun Nie, 5-aza-2'-deoxycytidine activates iron uptake and heme biosynthesis by increasing c-Myc nuclear localization and binding to the E-boxes of TfR1 and ferrochelatase genes, J Biol Chem,
Hai Wang, Ying Zhao, Yan Wu, Kaihui Nan, Guangjun Nie and Hao Chen, Enhanced antitumor efficacy by co-delivery of doxorubicin and paclitaxel with amphiphilic methoxyPEG-PLGA copolymer nanoparticles, Biomaterials
Yiye Li, Yunlong Zhou, Hai-Yan Wang, Sarah Perrett, Yuliang Zhao, Zhiyong Tang, Guangjun Nie, Chirality of Glutathione Surface Coating Affects the Toxicity of Quantum Dots, Angew Chem Int Ed
Cuiji Sun, Hui Yang,Yi Yuan, Xin Tian, Liming Wang, Yi Guo, Li Xu, Jianlin Lei, Ning Gao, Gregory J. Anderson, Xing-jie Liang, Chunying Chen, Yuliang Zhao, Guangjun Nie, Controlling assembly of paired gold clusters within apoferritin nanoreactor for in vivo kidney targeting and biomedical imaging, J Am Chem Soc,
Jia Fan, Jun-Jie Yin, Bo Ning, Xiaochun Wu, Ye Hu, Mauro Ferrari, Gregory J. Anderson, Jingyan Wei, Yuliang Zhao and Guangjun Nie, Direct evidence for catalase and peroxidase activities of ferritin-platinum nanoparticles, Biomaterials
Guangjun Nie, Guohua Chen, Alex D. Sheftel, Kostas Pantopoulos and Prem Ponka. In Vivo Tumor Growth is Inhibited by Cytosolic Iron Deprivation Caused by the Expression of Mitochondrial Ferritin, Blood,
Guangjun Nie, Alex Sheftel, Songwon Kim, Prem Ponka. Overexpression of Mitochondrial Ferritin Causes Cytosolic Iron Depletion and Changes Cellular Iron Homeostasis. Blood
承擔科研項目情況
基於腫瘤微環境調控的抗腫瘤納米材料設計和機制研究 (國家重點基礎研究發展計畫973計畫項目)，首席科學家
中國科學院“百人計畫”海外引進傑出人才擇優支持，項目負責人
