個人簡介
1997－2001年就讀于山東大學生命科學院，獲微生物學學士學位
2001－2004年就讀于山東大學生命科學院，獲微生物學碩士學位
2004－2009年就讀於清華大學生命科學院，獲生物物理學博士學位
2009－2012年在耶魯大學從事博士後研究
2012－2014年在威斯康星大學麥迪遜分校從事博士後研究
2014－2016年在加州大學伯克利分校從事博士後研究
2016年7月加入上海科技大學，在iHuman研究所任PI（Research Associate Professor），在生命科學與技術學院任助理教授
研究方向
冷凍電子顯微學，膜分子生物學
研究內容
主要研究內容是利用冷凍電子顯微學作為主要技術手段研究蛋白與膜相互作用系統，並結合生物化學，螢光超分辨成像，X-射線晶體學以及分子動態模擬來深刻理解蛋白與膜相互作用的機制；同時，利用胞內系統進一步驗證所得到的作用機制。希望通過這些研究來加深理解重要蛋白與膜系統的分子機制，為解決蛋白與膜系統紊亂引起的疾病提供堅實的結構生物學基礎。
主要集中在以下幾個方向：
1.轉運必需內體複合體（ESCRT）剪下膜系統的分子機制
2.G蛋白偶聯受體（GPCR）的結構生物學研究
3.嵌合於脂雙層的膜蛋白結構冷凍電鏡解析方法的開發與套用
代表論文
1. Lars-Anders Carlson, Qing-Tao Shen, Mark Remec Pavlin, James H. Hurley (2015) ESCRT filaments as spiral springs. Developmental Cell, 35(4): 397-398
2. Qing-Tao Shen, Xuefeng Ren, Rui Zhang, II-Hyung Lee, James H. Hurley (2015) HIV-1 Nef hijacks clathrin coats by stabilizing AP-1:Arf1 polygons. Science, 350(6259): aac5137 (Faculty 1000 recommended)
3. Bei Yang, Goran Stjepanovic, Qing-Tao Shen, Andreas Martin, James H. Hurley (2015) The AAA+ ATPase dissembles ESCRT-III by global unfolding and pore translocation. Nature Structural & Molecular Biology, 22(6): 492-498
4. Qing-Tao Shen, Amber L. Schuh, Yuqing Zheng, Marisa S Otegui, Paul Alquist, Qiang Cui, Anjon Audhya (2014) Structural analysis and modeling reveals new mechanisms governing ESCRT-III spiral filament assembly. Journal of Cell Biology (Cover Story), 206(6):763-777 (Highlighted in Journal of Cell Biology 206(5)) (Faculty 1000 recommended)
5. Zi-Chao Yu, Xiu-Lan Chen, Qing-Tao Shen, Dian-Li Zhao, Bai-Lu Tang, Hai-Nan Su, Zhao-Yu Wu, Qi-Long Zhao, Bin-Bin Xie, Xiying Zhang, Yong Wu, Bai-Cheng Zhou, Bo Chen, Yu-Zhong Zhang (2014) Filamentous phages prevalent in Psuedoalteromonas spp. confer properties advantageous to host survival in Arctic sea ice. ISME Journal, 1-11
6. Lei Shi, Kevin Howan, Qing-Tao Shen, Yong Jian Wang, James E Rothman, Frederic Pincet (2013) Preparation and characterization of SNARE-containing nanodiscs and direct study of cargo release through fusion pores. Nature Protocols, 8:935-948
7. Qing-Tao Shen, Peter Hsiue, Charles V. Sindeler, Matthew D. Weltch, Ken G. Campellone, Hong-Wei Wang (2012) Structural insights into WHAMM-mediated cytoskeletal coordination during membrane remodeling. Journal of Cell Biology (Cover Story), 199(1): 111-124(In focus by Journal of Cell Biology 199(1))
8. Lei Shi, Qing-Tao Shen, Alexander Kiel, Jing Wang, Hong-Wei Wang, Thomas J. Melia, James E. Rothman, Frederic Pincet (2012) SNARE Proteins: One to Fuse and Three to Keep the Nascent Fusion Pore Open. Science, 335(6074):1355-1359
9. Xiaoyang Wu, Qing-Tao Shen, Daniel S. Oristian, Catherine P. Lu, Qinsi Zheng, Hong-Wei Wang and Elaine Fuchs (2010) Skin Stem Cells Orchestrate Directional Migration by Regulating Microtubule-ACF7 Connections through GSK3β. Cell, 144(3):341-352
10. Qing-Tao Shen, Xiao-Chen Bai, Lei-Fu Chang, Yi Wu, Hong-Wei Wang, Sen-Fang Sui (2009) Bowl-shaped oligomeric structures on membranes as DegP's new functional forms in protein quality control. Proc. Natl. Acad. Sci. USA, 106:4858-4863
11. Xiao-Yan Song, Qing-Tao Shen, Shu-Tao Xie, Xiu-Lan Chen, Cai-Yun Sun, Yu-Zhong Zhang (2006) Broad-spectrum antimicrobial activity and high stability of Trichokonins from Trichoderma koningii SMF2 against plant pathogens. FEMS Microbial Lett., 260(1):119-125
12. Chang-Zhen Liu, Li He, Qing-Tao Shen, Xiang-Hui Li, Sen-Fang Sui (2005) Leucine zipper domain is important for actin binding of p57. Progress in Biochemistry and Biophysics, 32(8):718-725
13. Qing-Tao Shen, Xiu-Lan Chen, Cai-Yun Sun, Yu-Zhong Zhang (2004) Dissecting and exploiting nonribosomal peptide synthetases. Acta Biochim Biophys Sin (Shanghai), 36(4):243-249
