學科方向
生物學
科研概況
自2001年起開始致力於神經退行性和突發性疾病包括帕金森症、老年痴呆症和癲癇症的研究，科研成果發表於Neuron 《神經元》、Cell 《細胞》、Proceedings of the National Academy of Sciences, USA 《美國國家科學院院刊》和 Journal of Neurophysiology 《神經生理雜誌》等國際知名學術期刊，引用次數已超過700 。 在帕金森症研究領域中其成果處於國際前沿。
2009年被福州大學以“閩江學者”特聘教授引進，參與籌建福州大學嶄新的生命科學研究所。將繼續致力於器官發育發病老化機理的研究、幹細胞工程、再生醫學及組織工程以及腫瘤生物學的探索和實踐。
代表性論文
1. Parkin suppresses dopaminergic neuron-selective neurotoxicity induced by PaelR in Drosophila (Y. Yang, I. Nishimura, Y. Imai, R. Takahashi & B. Lu NEURON 37: 911, 2003)
2. PAR-1 kinase plays an initiator role in a multisite sequential phosphorylation process that confers Tau neurotoxicity in Drosophila (I. Nishimura, Y. Yang & B. Lu CELL 116: 671, 2004)
3. Inactivation of Drosophila DJ-1 leads to impairments of oxidative stress response and phosphatidylinositol 3-kinase/Akt signaling (Y. Yang, S. Gehrke, M.E. Haque, Y. Imai, J. Kosek, L. Yang, M. F. Beal, I. Nishimura, K. Wakamatsu, S. Ito, R. Takahashi & B. Lu PNAS USA 102: 13670, 2005)
4. Mitochondrial pathology and muscle and dopaminergic neuron degeneration caused by inactivation of Drosophila Pink1 is rescued by Parkin (Y. Yang, S. Gehrke, Y. Imai, Z. Huang, Y. Ouyang, J. Wang, L. Yang, M. F. Beal, H. Vogel & B. Lu PNAS USA 103: 10793, 2006)
5. GABAA receptor-mediated IPSCs and a1 subunit expression are not reduced in the substantia nigra pars reticulata of gerbils with inherited epilepsy (S. Kumar, X. Wen, Y. Yang & P. Buckmaster J. NEUROPHYSIOL. 95: 2446, 2006)
6. Pink1 regulates mitochondrial dynamics through interaction with fission/fusion machinery (Y. Yang, Y. Ouyang, L. Yang, M. F. Beal, A. McQuibban, H. Vogel & B. Lu PNAS USA , 105: 7070, 2008)
7.Mitochondrial morphogenesis, distribution and Parkinson's disease: insights from PINK1 ( Y. Yang & B. Lu J. Neuropathol. Exp. Neurology. 68(9):953-63, 2009)
8.Neuroprotective effects of compounds with antioxidant and anti-inflammatory properties in a Drosophila model of Parkinson's disease ( K. Faust, S. Gehrke, Y. Yang , L. Yang, M.F. Beal and B. Lu BMC Neurosciences 10:109, 2009)
