![李繼喜[復旦大學生命科學學院]](/img/7/0b8/nBnauM3XwUTNwMTMykjN0ETN1UTM1QDN5MjM5ADMwAjMwUzL5YzLzMzLt92YucmbvRWdo5Cd0FmL0E2LvoDc0RHa.jpg "李繼喜[復旦大學生命科學學院]")
研究方向
研究抗感染天然免疫應答及腫瘤免疫相關蛋白質複合物的結構基礎與功能機制。包括：1，細胞程式性壞死及炎症反應相關蛋白的結構生物學研究；2，天然免疫應答與神經退行性疾病互動調控的分子機制。
在Cell、Immunity、Annu Rev Immunol、PNAS等期刊上發表40餘篇SCI論文，申請/授權發明專利11項。目前主持及參加的科研項目包括國家重點研發計畫（2016YFA0500600）、科技部重大研究計畫（2015CB943300）及國家自然科學基金面上項目（31470724、31670878）等。
獲獎情況
國家重點研發計畫“蛋白質機器與生命過程調控”首席科學家（2016）；復旦大學復星醫藥獎教金（特等獎）（2016）；中組部千人計畫（青年項目）（2015）；上海市“東方學者”特聘教授（2014）；哈佛大學華人生命科學年度傑出研究獎（2013）；國家留學基金委惠普獎學金（2005）。
個人論文
1. Kleino A, Ramia N, Bozkurt G, Shen Y, Nailwal H, Huang J, Napetschnig J, Gangloff M, Chan FK, Wu H*, Li J*, Silverman N*. Peptidoglycan-Sensing Receptors Trigger the Formation of Functional Amyloids of the Adaptor Protein Imd to Initiate Drosophila NF-kB Signaling. Immunity 2017 Oct 17; 47:635-647
2. Kuang S, Zheng J, Yang H, Li S, Duan S, Shen Y, Ji C, Gan J, Xu XW, Li J*. Structure insight of GSDMD reveals the basis of GSDMD autoinhibition in cell pyroptosis. Proc Natl Acad Sci U S A. 2017 Sep 19. pii: 201708194. doi: 10.1073/pnas.1708194114.
3. Huo YY, Li S, Huang J, Rong Z, Wang Z, Li Z, Ji R, Kuang S, Cui HL, Li J*, Xu XW*. Crystal structure of Pelagibacterium halotolerans PE8: New insight into its substrate-binding pattern. Sci Rep. 2017 June 30;7: 4422. doi:10.1038/s41598-017-04550-7
4. Cao X, Li C, Xiao S, Tang Y, Huang J, Zhao S, Li X, Li J, Zhang R, Yu W. Acetylation promotes TyrRS nuclear translocation to prevent oxidative damage. Proc Natl Acad Sci U S A. 2017 Jan 24;114(4):687-692.
5. Huang J, Huo YY, Ji R, Kuang S, Ji C, Xu XW*, Li J*. Structural insights of a hormone sensitive lipase homologue Est22. Sci Rep. 2016 Jun 22;6:28550. doi: 10.1038/srep28550.
6. Yin Q, Fu T, Li J*, Wu H*. Structural Biology of Innate Immunity. Annu Rev Immunol. 2015 Mar 21;33:393-416.
7. Li J, Yin Q, Wu H. Structural basis for TNFR mediating signal pathways. Adv Immunol. 2013;119:135-53.
8. Lee J, Yi L, Li J, Schweitzer K, Borgmann M, Naumann M, Wu H. Crystal Structure and Versatile Functional Roles of the COP9 Signalosome Subunit 1. Proc Natl Acad Sci U S A. 2013 Jul 16;110(29):11845-50.
9. Li J, McQuade T, Siemer A, Napetschnig J, Damko E, Hsiao Y, Moquin D, Walz T, Mcdermott A, Chan FK, Wu H. The RIP1/RIP3 Necrosome Forms a Functional Amyloid Signaling Complex Required for Programmed Necrosis. Cell 2012 Jul 20;150(2):339-50. (Highlighted by Nature Reviews Molecular Cell Biology 2012 Aug 1;13(9):540-1)
10. Li J, Wei Z, Zheng M, Gu X, Deng Y, Qiu R, Chen F, Ji C, Gong W, Xie Y, Mao Y. Crystal structure of human Guanosine Monophosphate reductase 2 (GMPR2) in complex with GMP. J Mol Biol. 2006, 355(5):980-988
