個人簡介
1993年在蘭州大學獲得有機化學專業有機合成方向博士學位(導師:李裕林教授)。李瀛教授長期從事有機化學的教學和科研工作,已合作出版《有機化學》、《有機化學實驗》、《有機化學質疑暨考研指導》、《有機化學簡明教程》教材四部。主講的“有機化學”課程獲2005年度甘肅省精品課程,2009年度甘肅省高等教育教學成果二等獎。李瀛教授的研究領域為具有生物活性的複雜天然產物的全合成以及新藥合成路線和藥物中間體的研製與開發。曾主持和完成國家自然科學基金項目五項;國家重點實驗室基金和省自然科學基金課題及企業合作多項。李瀛教授已在J. Am. Chem. Soc.,Angew. Chem. Int. Ed.,Org. Lett., Synlett 等國內外高水平雜誌上合作發表研究論文150餘篇。
研究方向
● 具有重要生物活性天然產物的全合成;
● 構築螺環縮酮及虎皮楠生物鹼骨架的方法學研究;
● 基於新藥開發為導向的有機合成基礎與套用研究。
榮獲獎項
國家科技進步二等獎一項(2009);
教育部科技進步一等獎一項(2008),二等獎二項(1994,2001);
廣西壯族自治區科技進步三等獎一項(2004);
1997年榮獲寶鋼教育獎學金優秀教師獎;
2005年享受國務院政府特殊津貼。
發表論文
1. Wenjing Wang, Jijun Xue, Tian Tian, Jie Zhang, Liping Wei, Jidong Shao, Zhixiang Xie, and Ying Li*. Total Synthesis of (±)-δ-Rubromycin.Org. Lett., 2013,15, 2402–2405.
2. Wanchun Gong, Yun Liu, Jie Zhang, Yingdong Jiao, Jijun Xue,* and Ying Li*. Regio- and Stereoselective [4+3] Cycloaddition Towards Fused 5,7,6-Tricyclic Skeletons.Chem. Asian J., 2013,8, 546–551.
3. Jie Zhang, Liqi Li, Yongxiang Wang, Wenjing Wang, Jijun Xue* and Ying Li*. A Novel, Facile Approach to Frondosin B and 5-epi-Liphagalvia a New [4 + 3] Cycloaddition.Org. Lett., 2012,14, 4528–4530.
4. Bo Zhang, Yao Wang, Sheng-Ping Yang, Yu Zhou, Wen-Bin Wu, Wei Tang, Jian-Ping Zuo, Ying Li*. and Jian-Min Yue*. Ivorenolide A, an Unprecedented Immunosuppressive Macrolide from Khaya ivorensis: Structural Elucidation and Bioinspired Total Synthesis.J. Am. Chem. Soc., 2012,134, 20605–20608.
5. Wei Wei, Yao Wang, Jianpeng Yin, Jijun Xue,* and Ying Li*. Construction of Aromatic [5,5] Spiroketals via Hypoiodite-Catalyzed Etherification Combined in Relay Cascades.Org. Lett., 2012,14, 1158–1161.
6. Xin Li, Jijun Xue, Chusheng Huang, and Ying Li*. Copper(I)-Catalyzed Hydroalkoxylation/Hydrogen-Bonding-Induced Asymmetric Hetero- Diels–Alder Cycloaddition Cascade: An Approach to Aromatic Spiroketals.Chem. Asian J., 2012,7, 903–906.
7. Wei Wei, Liqi Li, Xiaohong Lin, Haifeng Li, Jijun Xue* and Ying Li*. New fluoride-promoted hypoiodite-catalytic oxidative cycloetherification to aromatic spiroketals.Org. Biomol. Chem., 2012,10, 3494–3499.
8. Xin Li, Jijun Xue*, Rui Chen, Ying Li*. A New Copper(I)-Catalyzed Cycloetherification/Acid-Catalyzed Allylic Nucleophilic Substitution for One-Pot Synthesis of 2-Substituted Benzofurans.Synlett, 2012,23, 1043–1046.
9. Xiaolong Zhao, Jie Liu, Zhixiang Xie*, Ying Li*. A One-Pot Synthesis of Aurones from Substituted Acetophenones and Benzaldehydes: A Concise Synthesis of Aureusidin.Synthesis, 2012,44, 2217–2224.
10. Liping Wei, Jijun Xue,* Hongbiao Liu, Wenjing Wang, and Ying Li*. Synthesis of γ-Rubromycin via a New Hypoiodite-Catalytic Oxidative Cycloetherification.Org. Lett., 2012,14, 5302–5305.
11. Zhijun Xin, Yuan Zhang, Hua Tao, Jijun Xue*, Ying Li*. Dramatic Base-Oriented Chemoselective Tandem Wacker Cyclizations: Synthesis of Bisbenzannelated Spiroketals and 2-Substituted Chromans.Synlett, 2011,7, 1579–1584.
12. Deping Zheng, Wanchun Gong, Zuodong Ma, Bingzhen Ma, Xiaolong Zhao, Zhixiang Xie*, Ying Li *. Unexpected Prins cyclization: iron-promoted cyclization/hydrationof alkynyl-dimethyl acetals.Tetrahedron Letters, 2011,52, 314–317.
13. Deping Zheng, Zuodong Ma, Wanchun Gong, Zhixiang Xie*. Ying Li*, FeCl Promoted One-step Synthesis of Spiro[4,5]decane Derivatives.Synlett, 2010,14, 2169–2173.
14. Chao Du, Liqi Li, Ying Li, Zhixiang Xie*. Construction of Two Vicinal Quaternary Carbons by Asymmetric Allylic Alkylation: Total Synthesis of Hyperolactone C and (-)-Biyouyanagin A.Angew. Chem. Int. Ed.; 2009,48, 7853–7856.
15. Yuan Zhang, Jijun Xue, Zhijun Xin, Zhixiang Xie, Ying Li*. Gold-Catalyzed Double Intramolecular Alkyne Hydroalkoxylation: Synthesis of the Bisbenzannelated Spiroketal Core of Rubromycins Synthesis of the Biusbenzannelaated Spirokental Core of Rubromycins.Synlett, 2008, (6), 940–944.
16. Degang Liu, Jijun Xue, Zhixiang Xie, Liping Wei, Xianshu Zhang, Ying Li*. Formal Total Synthesis of Benzylpedamide: The Right Half of (+)-Pederin.Synlett, 2008,10, 1526–1528.
17. Guanglian Zhou, Jianrong Zhu, Zhixiang Xie,* and Ying Li*. An Efficient Synthesis of Highly Functionalized [5,6] Aromatic Spiroketals by Hetero-Diels-Alder Reaction.Org. Lett., 2008,10(5), 721–724.