個人簡介
朱鋼國，男，1978年10月生，浙江省金華市金東區人，現為浙江師範大學化學與生命科學學院教授、碩士生導師
學習經歷
1996.9-2000.7 浙江師範大學化學系獲理學學士，化學專業
2000.9-2005.7 中科院上海有機化學研究所獲理學博士，有機化學專業
2005.9-2007.10 美國普渡大學諾貝爾獎得主Negishi小組博士後研究
2007.11-2008.10 美國印第安納大學化學系博士後研究
工作簡歷
2008.12-至今 浙江師範大學化學與生命科學學院任教，教授（2011.12）
人才榮譽
浙江省“151”人才第三層次培養對象（2009.6）
浙江省高校中青年學科帶頭人(2013.6)
研究領域及成果
主要從事金屬有機化學專業領域的研究，發表Chem. Commun.、Org. Lett.、Chem. Eur. J.、Adv. Synth. Catal.、J. Org. Chem.等SCI論文30多篇，著作章節1篇，其中以通訊作者或第一作者發表影響因子大於4論文19篇。
代表論著
1. Pd-catalyzed addition of boronic acids to ynol ethers: a highly regio- and stereoselective synthesis of trisubstituted vinyl ethers. Bai, Y.; Yin, J.; Kong, W.; Mao, M.; Zhu, G.* Chem. Commun.
2. A Regio- and Stereoselective Entry to ,-Disubstituted Vinyl Ethers via the Sequential Hydroboration/Suzuki–Miyaura Coupling of Ynol Ethers. Cui, W.; Mao, M.; He, Z.; Zhu, G.* J. Org. Chem.
3. Palladium-Catalyzed Direct Alkenylation of 2-Oxazolones: An Entry to 3,4,5-Trisubstituted 2-Oxazolones, Lu, Z.; Luo, F.; Wang, L.; Zhu, G.* J. Org. Chem.
4. Highly stereoselective synthesis of (Z)-1,2-dihaloalkenes by a Pd-catalyzed hydrohalogenation of alkynyl halides. Zhu, G.*; Chen, D.; Wang, Y.; Zheng, R. Chem. Commun.
5. Preparation of 3,4,5-Trisubstituted Oxazolones by Pd-Catalyzed Coupling of N-Alkynyl tert-Butyloxycarbamates with Aryl Halides and Related Electrophiles. Lu, Z.; Cui, W.; Xia, S.; Bai, Y.; Luo, F.; Zhu, G.* J. Org. Chem.
6. Palladium-catalyzed haloallylation of aromatic ynol ethers with allyl chlorides: a highly regio- and stereoselective approach to (1E)--chloroenol ethers. Cai, H.; Yuan, Z.; Zhu, W.; Zhu, G.* Chem. Commun.
7. Palladium-catalyzed highly regio- and stereoselective synthesis of (1E)- or (1Z)-1,2-dihalo-1,4-dienes via haloallylation of alkynyl halides. Chen, X.; Kong, W.; Cai, H.; Kong, L.; Zhu, G.* Chem. Commun.
8. Palladium-Catalyzed Dienylation of Haloalkynes Using 2,3-Butadienyl Acetates: A Facile Access to (1Z)-1,2-Dihalo-3-vinyl-1,3-dienes. Chen, D.; Chen, X.; Lu, Z.; Cai, H.; Shen, J.; Zhu, G.* Adv. Synth. Catal
9. Synthesis of Multisubstituted Enamides via Pd-Catalyzed Chloroallylation of Ynamides. Lu, Z.; Kong, W.; Yuan, Z.; Zhao, X.; Zhu. G.* J. Org. Chem
10. Palladium-Catalyzed Coupling of Haloalkynes with Allyl Acetate: A Highly Regio- and Stereoselective Synthesis of (Z)--Haloenol Acetates. Chen, X.; Chen, D.; Lu, Z.; Kong, L.; Zhu, G.* J. Org. Chem
11.Palladium-Catalyzed Hydroarylation, Hydroalkenylation, and Hydrobenzylation of Ynol Ethers with Organohalides: A Regio- and Stereoselective Entry toα,β- andβ,β-Disubstituted Alkenyl Ethers, Cui, W.; Ying, J.;Zheng, R.; Cheng, C.; Bai, Y. Zhu, G.* J. Org. Chem. 2014, 79, 3487-3493.
12.An unprecedented Pd-catalyzed trans-addition of boronic acids to ynamides. Yang, Y.; Wang, L.; Zhang, J.; Jin, Y.; Zhu, G.* Chem. Commun. 2014, 50, 2347-2349.
13.Synthesis of cis-1,2-dichlorovinylsulfones via Fe-catalyzed regio- and stereoselective addition of sulfonyl chlorides to aromatic chloroalkynes. Wang, L.; Zhu, H.; Che, J.; Yang, Y.*; Zhu, G.* Tetrahedron Lett. 2014, 55, 1011-1013.
14.Synthesis of ( Z)-1-Thio- and ( Z)-2-Thio-1-alkenyl Boronates via Copper-Catalyzed Regiodivergent Hydroboration of Thioacetylenes: An Experimental and Theoretical Study. Zhu, G.*; Kong, W.; Feng, H.; Qian, Z.* J. Org. Chem. 2014, 79, 1786-1795.
15.A regio- and stereoselective entry to ( Z)-β-halo alkenyl sulfides and their applications to the access of stereodefined trisubstituted alkenes. Liu, G.; Kong, L.; Shen, J.; Zhu, G.* Org. Biomol. Chem. 2014, 12, 2310-2321.
2013 年
16.Palladium-Catalyzed Direct Alkenylation of 2-Oxazolones: An Entry to 3,4,5-Trisubstituted 2-Oxazolones, Lu, Z.; Luo, F.; Wang, L.; Zhu, G.* J. Org. Chem. 2013, 78, 10894-10901.
17.Pd-catalyzed addition of boronic acids to ynol ethers: a highly regio- and stereoselective synthesis of trisubstituted vinyl ethers. Bai, Y.; Yin, J.; Kong, W.; Mao, M.; Zhu, G.* Chem. Commun. 2013, 49,7650-7652.
18.Regioselective and Stereoselective Entry to β,β-Disubstituted Vinyl Ethers via the Sequential Hydroboration/Suzuki–Miyaura Coupling of Ynol Ethers. Cui, W.; Mao, M.; He, Z.; Zhu, G. * J. Org. Chem. 2013, 78, 9815-9821.
19.Copper-catalyzed direct thiolation of xanthines and related heterocycles with disulfides. He, Z.; Luo, F.;*Li, Y.; Zhu, G.* Tetrahedron Lett. 2013, 54, 5907-5910.
20.An operationally simple approach to ( E)-α-halo vinyl sulfides and their applications for accessing stereodefined trisubstituted alkenes.Yang, Z.(本科生); Chen, X.; Kong, W.; Xia, S.; Zheng, R.; Luo, F.; Zhu, G.* Org. Biomol. Chem. 2013, 11, 2175-2185.
2012 年
21.Highly stereoselective synthesis of ( Z)-1,2-dihaloalkenesby a Pd-catalyzed hydrohalogenation of alkynyl halides. Zhu, G. *;Chen, D.; Wang, Y.; Zheng, R. Chem. Commun. 2012, 48,5796-5798.
22.Preparation of 3,4,5-Trisubstituted Oxazolones by Pd-Catalyzed Coupling of N-Alkynyl tert-Butyloxycarbamates with Aryl Halides and Related Electrophiles. Lu, Z.; Cui, W.; Xia, S.; Bai, Y.; Luo, F.; Zhu, G.* J. Org. Chem. 2012, 77, 9871-9877.
23.A Facile Access to 3,5-Disubstituted Oxazolones Featuring a Cu-catalyzed Cyclization of N-Alkynyl tert-Butyl Carbamates. Lu, Z.; Yang, Z.; Cui, W.; Zhu, G. * Chem. Lett. 2012, 41, 636-638.
24.Approach to highly functionalized oxazolones by a Pd-catalyzed cyclization of N-alkynyl tert-butyloxycarbamates. Lu, Z.; Xu, X.; Yang, Z.; Kong, L.*; Zhu, G. * Tetrahedron Lett. 2012, 53,3433-3436.
25.A Facile Method for the Synthesis of 3-Alkyloxindole. Du, T.; Zhu, G. *; Zhou, J. * Lett. Org. Chem. 2012, 9, 225-232.
代表性科研項目
1.2012－2015,國家自然科學基金面上項目－“基於1,2-雙官能團化烯烴的偶聯反應選擇性合成多取代烯烴”；
2.2012－2014,浙江省傑出青年基金-“1-鹵-1-硫代烯烴的立體選擇性合成及其三取代烯烴的構建”；
3.2010－2012,國家自然科學基金青年項目-“偶極烯丙基鈀的環加成反應研究”，已結題；
4.2010－2012,浙江省錢江人才計畫項目-“抗禽流感藥物達菲的合成工藝研究”，已結題。
成果獲獎
“雜原子取代炔烴的親核鈀化反應方法學研究”獲2012年浙江省高等學校科研成果獎一等獎。
近三年教學情況
為本科生主講課程有《有機化學》、《有機化學實驗》、《有機合成化學》，指導本科生論文10餘篇；為研究生開設《金屬有機化學》等課程，指導培養碩士研究生4名，獲校優秀碩士論文2篇。
專利申請
1、順式-1-鹵-2-氯代烯烴及其製備方法和套用，朱鋼國、陳東旭，專利號：ZL 201210004757.9。
2、一種莽草酸的合成方法，朱鋼國、崔偉劍、夏思苑、何祖鶯，專利號：ZL 201210094437.7。
3、一種3,4,5-三取代噁唑-2-酮的合成方法，朱鋼國、盧增輝、劉鴿、羅芳、夏思苑，專利號：ZL 201210283568.X。
4、一種利用順式-1-鹵-2-氯代烯烴合成維生素A的方法，朱鋼國，陳東旭，專利號：ZL201310350098.9。
5、一種替馬羅汀的合成方法，朱鋼國、李英龍、金雅麗、金髮根、吳平、樓益義，專利號：ZL 201310362839.5。
6、一種奧司他韋的合成方法，朱鋼國、杜思全、章潔妮、程存歸，專利申請號：ZL 201410102788.7。
指導學生
1、夏思苑等，指導教師：朱鋼國，雜原子取代炔烴的氫鹵化反應研究及其套用，第十三屆大學生“挑戰杯”競賽浙江省一等獎；
2、夏思苑等，指導教師：朱鋼國，高效綠色合成抗禽流感藥物“達菲”原料的技術研究，第十三屆大學生“挑戰杯”競賽全國二等獎。
