於燁

於燁，男，1977年11月出生，理學博士，現任上海交通大學醫學院醫學科學研究院研究員,蛋白質結構與功能研究組組長。1997-2001，湖南農業大學理學院生物工程系生物工程專業，理學學士； 2001-2006，蘭州大學生命科學學院，多肽生物化學與藥物化學博士；2006-2010，中國科學院上海生命科學學院、神經科學研究所博士後；2011年-至今，上海交通大學醫學院/醫學科學研究院研究員,課題組長。
近年來一直從事蛋白質/多肽的結構和功能研究，擅長利用化學生物學、生物物理、分子藥理、分子生物學、計算生物學等多學科交差的技術研究蛋白的結構與功能的關係及其相關的分子發現，取得了一系列較為重要的成果。已在Neuron, PLoS Biol., J Biol Chem, Cell Res., Mol Pain, Biochem Pharm., ChemMedChem, Peptides, J Neurosci., Neurosci., BBA Mol. Res., J Pharmacol Exp. Ther 等國際知名學術雜誌上發表SCI論文20篇，其中第一作者14篇（含共同第一作者），篇均影響因子約5。主持完成國家自然科學基金委青年科學基金項目、“中國博士後科學基金”項目、“中國科學院王寬誠基金”資助項目、中國科學院上海生命科學研究院優秀青年人才領域前沿項目各1項。曾獲蘭州大學“香港求是基金會”研究生獎，中國博士後科學基金一等獎，中國科學院上海生命科學研究院優秀青年人才獎勵，賽諾菲-安萬特優秀青年人才獎勵。
申請人代表性論文或者專利：
1. Yu, Y.*, #, Li, W.G.* ,Chen, Z.*, Jiang, H.L., Xu, T.L. et al. (2011). (*Co-first author). Atomic Level Characterization of the Nonproton Ligand-sensing Domain of ASIC3 Channel. J Biol Chem, 286(28):24996-5006
2. Yu, Y.*, Chen, Z.*, Li, W.G.*, Jiang, H.L., Xu, T.L. et al. (2010). (Co-first author). A non-proton ligand sensor of acid-sensing ion channels. Neuron 68(1):61-72.
Commented in “Small molecule ion channel match making: a natural fit for new ASIC ligands”, Bagriantsev, S.N. and Minor, D.L. Jr.Neuron.68(1):1-3.
3. Yang, H.Y.*, Yu, Y.*, Xu, T.L., Jiang H.L. et al. (2009). (Co-first author). Inherent dynamics of the acid-sensing ion channel 1 correlates with the gating mechanism. PLoS Biol.Jul;7(7) ):e1000151
4. Yang, H.Y.*, Yu, Y.*, Xu, T.L., Jiang H.L. et al. (2009). (Co-first author). Conformational sampling on acid-sensing ion channel 1 (ASIC1): implication for a symmetric conformation.Cell Res. 19(8):1035-7.
5. Duan. B.;Wang, Y.Z.,Yang, T.,Chu, X.P.;Yu,. Y., Xu ,T.L. et al. (2011). Extracellular Spermine Exacerbates Ischemic Neuronal Injury through Sensitization of ASIC1a Channels to Extracellular Acidosis. J Neurosci. 31: 2011-12.
6. Li, W.G.*;Yu, Y.*; Zhang, Z.D.;Cao, H.;Xu, T.L. (2010).(Co-first author).ASIC3 Channels Integrate Agmatine and Multiple Inflammatory Signals through the Nonproton Ligand Sensing Domain.Mol. Pain. 6 (1):88
7. Wang, C. L., Yao, J.L., Yu, Y., Wang. R. et al. (2008). Structure-activity study of endomorphin-2 analogs with C-terminal modifications by NMR spectroscopy and molecular modeling.Bioorg Med Chem. 16(12):6415-22.
8. Yu, Y.,Shao,X., Wang, R. et al. (2007). Structure-activity study on the spatial arrangement of the third aromatic ring of endomorphins 1 and 2 using an atypical constrained C-terminus. ChemMedChem 2(3): 309-17.
9. Yu, Y., Shao,X., Cui, Y., Wang, R. et al. (2007). In vitro and in vivo characterization of opioid activities of endomorphins analogs with novel constrained C-terminus: Evidence for the important role of proper spatial disposition of the third aromatic ring. Peptides;28(4):859-70.
10. Yu, Y., Cui, Y., Wang, R. et al. (2007). In vitro characterization of the effects of endomorphin 1 and 2, endogenous ligands for mu-opioid receptors, on mouse colonic motility. Biochem Pharmacol73(9):1384-93.
11. Wang, C.L., Yu., Y, Wang, R. et al. (2007) (Co-first author) Cardiovascular responses to intrathecal administration of endomorphins in anesthetized rats. Peptides28(4):871-7.
12. Yu, Y., Wang, C. L., Wang, R. et al. (2006). C-terminal amide to alcohol conversion changes the cardiovascular effects of endomorphins in anesthetized rats.Peptides 27(1): 136-43.
13. Yu, Y., Cui, Y., Wang, R. et al. (2006). Endomorphin1 and endomorphin2, endogenous potent inhibitors of electrical field stimulation (EFS)-induced cholinergic contractions of rat isolated bronchus. Peptides27(7): 1846-51.
14. Yu, Y., Wang, X., Wang, R. et al. (2006). Abnormal modulation of cholinergic neurotransmission by endomorphin 1 and endomorphin 2 in isolated bronchus of type 1 diabetic rats. Peptides 27(11): 2770-7.
15. Liu, J., Yu, Y., Wang, R. et al. (2005). (Co-first author). Cardiovascular effects of endomorphins in alloxan-induced diabetic rats. Peptides 26(4): 607-14.
16. Xu, P. H., Cheng, Q., Li, H. F., Yu, Y., Wang, R. et al.(2005) The relaxant effect of dobutamine on porcine coronary arterial ring segments. Pharmazie. 60(5):375-7.
17. Fan, Y. Z., Chang, H., Yu, Y., Wang, R. et al. (2006). Thymosin alpha1 suppresses proliferation and induces apoptosis in human leukemia cell lines. Peptides27(9): 2165-73.
18. Fan, Y. Z., Chang, H., Yu, Y., Wang, R. et al. (2006). Thymopentin (TP5), an immunomo- dulatory peptide, suppresses proliferation and induces differentiation in HL-60 cells. Biochim Biophys Acta 1763(10): 1059-66.
19. Liu, H. M., Liu, X. F., Yao, J. L. Wang, C.L, Yu, Y., Wang, R. et al. (2006). Utilization of combined chemical modifications to enhance the blood-brain barrier permeability and pharmacological activity of endomorphin-1. J Pharmacol Exp Ther 319(1): 308-16.
20. Wang, W., Yu, Y., Xu, T.L. et al. (2007). Modulation of acid-sensing ion channels by Cu in cultured hypothalamic neurons of the rat. Neuroscience145(2):631-641.
國家發明專利：
1.Wang, R., Yu, Y., Liu, H.M. C-terminus modified analogs of endomorphin-1 (No. 200410073159.2.).
2. Wang, R., Yu, Y., Liu, H.M. C-terminus modified analogs of endomorphin-2 (No. 200710147468.3.).
3. Wang, R., Fan, Y.Z., Yu, Y., Chang, H. A new usage of polyhexose isolated from pumpkin (200710017285X.)