張邦治

張邦治, 副教授.
科研方向：
1、多肽藥物的設計與合成
2、抗腫瘤多肽藥物的構效關係、生理藥理活性和作用機制研究
榮譽稱號及獎勵：
甘肅省自然科學一等獎，2008年
個人簡歷
張邦治，男，1977年生，副教授。
1999年於蘭州大學生命科學學院生物化學專業獲學士學位，
2005年於蘭州大學生命科學學院生物化學與分子生物學專業獲博士學位，
2005至2010年任蘭州大學生命科學學院講師。
主要研究方向
多肽藥物分子設計，多肽藥物合成，抗腫瘤多肽藥物構效關係、生理藥理活性和作用機制研究。
成果：
作為項目組主要成員完成了科技部“863”課題一項，蘭州大學“985工程”第二批特色研究方向“多肽科學”學科項目建設，蘭州大學“985工程”醫學子平台建設。主持一項教育部博士點新教師基金、一項甘肅省新藥臨床前研究重點實驗室開放基金和一項蘭州大學校內基金；作為第一或主要作者已發表多篇SCI論文，已獲國家發明專利授權一項，申請國家發明專利一項，研究工作在國際會議進行報告和牆報展示。
發表論文：
1. 王銳、張邦治、倪京滿，“放線菌素D的類似物”，國家發明專利，專利號：
2. Zhang Bangzhi, Wang KR, Yan JX, Zhang W, Song JJ, Ni JM, Wang Rui* In vitro and in vivo antitumor effects of novel actinomycin D analogs with amino acid substituted in the cyclic depsipeptides. Peptides, 2010,31(4): 568-573(SCI)
3. 張邦治*、王凱榮、王則周、李欣檑、王小麗、倪京滿，放線菌素D新類似物的設計、合成與體外抗腫瘤活性研究，高等學校化學學報, 2010, 31(7): 1346-1352(SCI)
4. Zhang W, Li J, Liu LW, Wang KR, Song JJ, Yan JX, Li ZY, Zhang Bangzhi*, Wang Rui* A novel analog of antimicrobial peptide Polybia-MPI, with thioamide bond substitution, exhibits increased therapeutic efficacy against cancer and diminished toxicity in mice. Peptides, 2010, 31(10): 1832-1838(SCI)
5. Jiang XX, Zhang Bangzhi, Zhang YF, Lin L, Yan WJ, Wang Rui* Direct asymmetric Michael addition of thioether-based aryl sulfanyl-propan-2-one to nitroalkenes catalyzed by a chiral amine-thiourea bifunctional organocatalyst. Chirality. 2010, 22(7): 625�634(SCI)
6. Wang KR, Yan JX, Zhang Bangzhi, Song JJ, Jia PF, Wang Rui* Novel mode of action of polybia-MPI, a novel antimicrobial peptide, in multi-drug resistant leukemic cells.Cancer Lett., 2009, 278, 65-72(SCI)
7. Hong L, Wang L, Chen C, Zhang Bangzhi, Wang Rui* An efficient enantioselective method for asymmetric Friedel-Crafts alkylation of indoles with α,β-unsaturated aldehydes. Adv. Synth. Catal., 2009, 351, 772-778(SCI)
8. Wang KR, Zhang Bangzhi, Zhang W, Yan JX, Li J, Wang Rui* Antitumor effects, cell selectivity and structure-activity relationship of a novel antimicrobial peptide polybia-MPI. Peptides, 2008, 29, 963-968(SCI)
9. Wang KR, Zhang Bangzhi, Zhang W, Yan JX, Li XL, Wang Rui* Potent antitumor effects of a novel actinomycin D analog LeuAMD. Cancer Lett., 2008, 268, 38-45(SCI)
10. Chen C, Hong L, Zhang Bangzhi, Wang Rui* Catalytic asymmertric addition of alkynyl zinc reagents to ketones using polymer-supported chiral Schiff-base amino alcohols. Tetrahedron-Asymmetry, 2008, 19, 191-196(SCI)
11. Liu HM, Zhang Bangzhi, Liu XF, Wang CL, Ni JM, Wang Rui* Endomorphin-1 analogs with enhanced metabolic stability and systemic analgesic activity: design, synthesis, and pharmacological characterization. Bioorg. Med. Chem.,2007, 15, 1694-1702 (SCI)
12. Wang Q, Zhang BangZhi, Hu GW, Chen C, Zhao QY, Wang Rui* Asymmetric addition of 1-ethynylcyclohexene to both aromatic and heteroaromatic ketones catalyzed by a chiral Schiff base�zinc complex. Org. Biomol. Chem., 2007, 5, 1161-1163 (SCI)