![張智[中科大生命科學學院教授]](/img/e/fdf/nBnauM3X3MTMzYDN0ATO0kTO0UTMyITNykTO0EDMwAjMwUzLwkzL0QzLt92YucmbvRWdo5Cd0FmLzE2LvoDc0RHa.jpg "張智[中科大生命科學學院教授]")
人物經歷
2001年畢業於安徽大學並獲生物化學學士學位，2008年獲中國科學技術大學神經生物學博士學位，2008-2012年在美國德克薩斯大學MD Anderson cancer center從事博士後工作。2012年10月起任中國科學技術大學生命科學學院教授。
研究方向
1.慢性疼痛相關的情緒疾病。
2.慢性疼痛產生的表觀遺傳學機制。
3.藥物成癮。
主要貢獻
主要作品
1. Zhang Z, Pan ZZ. Signaling cascades for δ-opioid receptor-mediated inhibition of GABA synaptic transmission and behavioral antinociception. Molecular Pharmacology, 2012 Mar;81(3):375-83.
2.Bie B, Wang Y, Cai YQ, Zhang Z, Hou YY, Pan ZZ. Upregulation of Nerve Growth Factor in Central Amygdala Increases Sensitivity to Opioid Reward. Neuropsychopharmacology. 2012 Aug 8. doi: 10.1038/npp.2012.144. [Epub ahead of print]
3. Zhang Z, Cai YQ, Zou F, Bie B, Pan ZZ. Epigenetic suppression of GAD65 expression mediates persistent pain. Nature Medicine. 2011 Oct 9;17(11):1448-55. Highlighted by:Harrison C, Analgesia: Unravelling epigenetic mechanisms of chronic pain. Nature Reviews Drug Discovery. 2011 Nov 18;10(12):900.
4. Zhang Z, Pan ZZ. Synaptic mechanism for functional synergism between delta- and mu-opioid receptors. Journal of Neuroscience,2010 Mar 31;30(13):4735-45. Highlighted by: Kingwell K. Pain:Moreish analgesics dealt a blow, Nature Reviews Neuroscience, 2010 May 12; 11:374-375.
5.Bie B, Zhang Z, Cai YQ, Zhu W, Zhang Y, Dai J, Lowenstein CJ, Weinman EJ, Pan ZZ. Nerve growth factor-regulated emergence of functional delta-opioid receptors. Journal of Neuroscience 2010 Apr 21;30(16):5617-28.
6.Metzele R, Alt C, Bai X, Yan Y, Zhang Z, Pan Z, Coleman M, Vykoukal J, Song YH, Alt E.Human adipose tissue-derived stem cells exhibit proliferation potential and spontaneous rhythmic contraction after fusion with neonatal rat cardiomyocytes. FASEB J. 2011 Mar;25(3):830-9.
7. Zhang Z, Gong N, Wang W, Xu L, Xu TL.Bell-shaped D-serine actions on hippocampal long-term depression and spatial memory retrieval. Cerebral Cortex . 2008 Oct;18(10):2391-401.
