個人簡介
張子張Formerly: Xiaoming (Michael) Zhang
最後學歷及畢業學校：理學博士,馬賽二大（現地中海大學,法國馬賽）
麥吉爾大學(McGill)博士後 (加拿大蒙特婁)
Maxygen等生物科技公司研究員（美國加州）
學會會員及學術兼職
中國化學會會員；中英化學聯合會會員；美國化學會會員
國際純粹與套用化學聯合會（IUPAC）會員；
國際純粹與套用化學聯合會有機與生物分子化學委員會“基因組化學—為生命科學設計的化學”項目主席；
特邀編輯Guest Editor，Current Organic Chemistry (Bentham Science Publishers)
評審情況
國家自然科學基金評審專家；教育部新教師基金評審專家；教育部博士點基金評審專家
工作研究領域
張子張博士的主要研究興趣在於生物大分子與化學小分子之間相互作用的機制, 研究分以下三個方面: 基因組化學，生物轉化與催化，不對稱合成 基因組化學(genochemistry） 針對基因組時代生命科學與化學科學研究信息與數據的海量湧現以及由此產生的新的挑戰，張子張博士提出了“基因組化學”的概念並致力於該領域理論體系與方法學的探討和研究，試圖在更加基礎的基因組水平研究物種的基因型及化學表現型之間的關係，期望這種研究能對未來生命科學研究，醫藥研究，疾病診斷及治療等提供更多的科學依據，方法與手段。 生物催化與轉化(Biocatalysis and biotransformation) 張子張博士長期致力於生物催化與轉化中理論與方法學的研究。
比較重要的工作
(1)用同位素示蹤法研究了黑麴黴中單加氧酶(Monooxygenase)催化的非活化雙鍵的不對稱雙羥基化反應機理並發現了其中環氧化物水解酶(Epoxide hydrolase)的存在及其立體選擇性(JOC,1991), 該工作經第三方(H.L.Holland)實驗驗證被收入S.M Roberts編的專著中,同系列文章為多部專著（如：Patel等的專著)整體選用，據報導，該項工作是後來成為生物催化領域熱點的環氧化物水解酶研究的開端； (2)揭示了Chromobacterium viscosum 脂肪酶催化的具非線性光學性能的單體的依序動力學解析中的對映體選擇性、區域選擇性、和化學選擇性的定量關係(JOC,1999)，在此工作基礎上，產生了一系列美國專利(1999)；(3)用對映體選擇性清除戰略(enantioselective scavenging)發現了牧草紅酵母中L-胺基酸氧化酶系(TL,2008)，及杭州土樣中分離的氣單胞細菌中對映體選擇性互補的D-胺基酸氧化酶系(BMCL,2009)，二項發現形成了實用性很強的的製備高對映體純的L-或D-胺基酸衍生物的生物催化製備方法，並鋪平了繼續發現之路。 不對稱合成(Asymmetric synthesis) 張子張博士致力於生物催化在不對稱合成中的套用研究。以生物催化方法為核心，設計、合成理論上有挑戰意義、實際上有經濟價值的天然物質、特殊材料、生物活性物質、醫藥前體、中間體等。 張子張博士疫情期間在北京參與了SARS 病毒的研究（GPB 2003）。
研究論文
Towards Genochemistry: Harnessing the Power of Biocatalysis for Research in Life Sciences, Zizhang Zhang and Att-ur-Rahman Current Organic Chemistry, 2010, 14, 1902-1913
社論: Meeting grand goals
Zizhang Zhang， Current Organic Chemistry, 2010, 14, 1869
Use of whole cell culture of Aeromonas sp. as enantioselective scavenger: A facile preparation of l-amino acid derivatives in high enantiomeric excess
Zizhang Zhang, Bioorganic & Medicinal Chemistry Letters, 2009, 19，1129-1131
Enantioselective Scavenging Using Homogenate of Rhodotorula graminis: A Facile Preparation of D-Amino Acid Derivatives in Enantiopure Form
Zizhang Zhang, Tetrahedron Letters, 2008, 49, 6468-6470
Mechanism and Application of Asymmetric Dihydroxylation of Olefins Catalyzed by Aspergillus niger 黑麴黴催化烯烴的不對稱雙羥基化反應的機理和套用
Zizhang Zhang（張子張）, J. Mol. Cata.（分子催化）， 2008， 1，80
EHPred: an SVM-based method for classification of epoxide hydrolases
Jia Jia, Liang Yang and Zizhang Zhang,* J.Zhejiang Univ SCIENCE B 2006 7 （1）：1-6
Complete Genome Sequences of the SARS-CoV: the BJ Group (Isolates BJ01-BJ04)
Shengli Bi, Ede Qin, Zuyuan Xu, Wei Li, Jing Wang, Yongwu Hu, Yong Liu, Shumin Duan, Jianfei Hu, Yujun Han, Jing Xu, Yan Li, Yao Yi, Yongdong Zhou, Wei Lin, Jie Wen, Hong Xu, Ruan Li, Zizhang Zhang, Haiyan Sun, Jingui Zhu, Man Yu, Baochang Fan, Qingfa Wu, Wei Lin, Lin Tang, Bao'an Yang, Guoqing Li, Wenming Peng, Wenjie Li, Tao Jiang, Yajun Deng, Bohua Liu, Jianping Shi, Yongqiang Deng, Wei Wei, Hong Liu, Zongzhong Tong , Feng Zhang , Yu Zhang , Cui'e Wang , Yuquan Li, Jia Ye, Yonghua Gan, Jia Ji, Xiaoyu Li, Xiangjun Tian, Fushuang Lu, Gang Tan, Ruifu Yang, Bin Liu, Siqi Liu, Songgang Li, Jun Wang, Jian Wang, Wuchun Cao, Jun Yu, Xiaoping Dong, Huanming Yang, Genomics,Proteomics & Bioinformatics, 2003, 3
Evolution and Variation of the SARS-CoV Genome
Jianfei Hu , Jing Wang , Jing Xu , Wei Li , Yujun Han , Yan Li , Jia Ji , Jia Ye , Zhao Xu , Zizhang Zhang , Wei Wei , Songgang Li , Jun Wang , Jian Wang , Jun Yu , Huanming Yang, Genomics,Proteomics & Bioinformatics, 2003, 3
Genome Organization of the SARS-CoV
Jing Xu, Jianfei Hu, Jing Wang, Yujun Han, Yongwu Hu, Jie Wen, Yan Li, Jia Ji, Jia Ye, Zizhang Zhang, Wei Wei, Songgang Li, Jun Wang, Jian Wang, Jun Yu, Huanming Yang, Genomics,Proteomics & Bioinformatics, 2003, 3
The R Protein of SARS-CoV: Analyses of Structure and Function Based on Four Complete Genome Sequences of Isolates BJ01-BJ04
Zuyuan Xu, Haiqing Zhang, Xiangjun Tian, JIA Ji, Wei Li, Yan Li, Wei Tian, Yujun Han, Lili Wang, Zizhang Zhang, Jing Xu, Wei Wei, Jingui Zhu, Haiyan Sun, Xiaowei Zhang, Jun Zhou, Songgang Li, Jun Wang, Jian Wang, Shengli Bi, Huanming Yang, Genomics,Proteomics & Bioinformatics, 2003, 2
First preparation of enantiopure indane monomer, (S)-(-)–and (R)-(+)-2,3-dihydro-3- (4’-hydroxyphenol)-1,1,3-trimethyl-1H-inden-5-ol, via a unique enantio- and regioselective enzymatic kinetic resolution
M.Zhang*, R. Kazlauskas, J. Org. Chem. 1999, 64, 7498-7503
Asymmetric dihydroxylation of remote double bond of geraniol
X.M. Zhang, A. Archelas, R. Furstoss, Biocatalysis for Fine Chemicals Synthesis. 1999, 3:5.16, John Wiley and Sons, Monograph, Edited by: S. M. Roberts
Short chain fatty acid esters synthesis by commercial lipases in low-water systems and by resting microbial cells in aqueous medium
D. Leblanc, A. Morin, D. Gu, X. M. Zhang, J, -G. Bisaillon, M. Paquet and H. Dubeau, Biotechnology letters. 1998, 12, 1127-1131
On-line determination of lipase activity and enantioselectivity using an immobilized enzyme reactor coupled to a chiral stationary phase
X. Zhang, I. Wainer, Tetrahedron Lett. 1993, 34(30), 4731-4734
Microbiological transformation 24. synthesis of chiral building blocks via stereoselective dihydroxylation of citronellol enantiomers
X. M. Zhang, A. Archelas, R. Furstoss, Tetrahedron: Asymmetry, 1992, 3(11), 1373-1376
Microbiological transformation 21. an expedient route to both enantiomers of marmin and epoxyauraptens via microbiological dihydroxylation of 7-geranyloxycoumarin
X.M. Zhang, A. Archelas, A. Méou, R. Furstoss, Tetrahedron: Asymmetry 1991, 2, 247
Microbial transformation 19. asymmetric dihydroxylation of the remote double bond of geraniol: a unique Stereochemical Control Allowing Easy Access to Both Enantiomers of Geraniol-6,7-diol
X.M. Zhang, A. Archelas, R. Furstoss, J. Org. Chem. 1991, 56, 3814-3817
Synthesis of all four stereoisomers of enantiomerically pure etrahydro-2,2,6-trimethyl-6-vinyl-
2H-pyrane-3-ols
A. Méou, N. Bouanah, A. Archelas, X. M. Zhang, R. Gugliélmetti, R. Furstoss, Synthesis 1991, 09, 681-682
Synthesis of all four stereoisomers of enantiomerically pure cis- and trans-linalyl oxide
A. Méou, N. Bouanah, A. Archelas, X.M. Zhang, R. Gugliélmetti, R.Furstoss, Synthesis 1990, 09, 752-753
Patent applications（專利）
1. L-胺基酸衍生物的生物催化製備方法（授權2011）
張子張, 2008 中國國家專利。
2. D- 胺基酸生物催化製備方法（授權2011）
張子張, 2007, 中國國家專利。
3.Method for preparation of enantiomerically pure 2,3-dihydro-3-(4-hydroxyphenyl)-1,1,3-
trimethyl-1H-inden-5-ol
K. J. Kazlauskas, X. M. Zhang, US patent 5,959,159 1999
學術交流（講座報告）
Genochemistry-chemistry designed for life sciences
Zizhang Zhang （張子張）
43 IUPAC 2011 World Chemistry Congress, July 31-August 8, 2011, San Juan, Puerto Rico
Genochemistry: Revitalizing Biocatalysis for the Life Sciences
Zizhang Zhang （張子張）
2 Symposium on Enzymes & Biocatalysis -2011, April 25-30, 2011, Dalian, China
(5). Genochemistry：a new avenue of research in the life sciences through Biocatalysis
Zizhang Zhang （張子張）
第六屆全國化學生物學學術會議， 2009, 10月23-26，廈門大學，廈門
A Perspective: from Biocatalysis to Genochemistry,
Zizhang Zhang （張子張）,
The 5th Sino-US Chemistry Professor Symposium on Organic Chemistry and Chemical Biology, June 28-30, 2009, Lanzhou University, Lanzhou, China
Biocatalyzed enantioselective scavenging: a facile and efficient preparation of amino acid derivatives in high ee,
Zizhang Zhang （張子張）
Chiral China 2008 Symposium, Nov.21-23, 2008, Shanghai, China
A Perspective on Biocatalysis
Zizhang Zhang（張子張）
The 14th National Congress on Catalysis of China, Oct. 14-18, 2008, Nanjing,China
D from Yeast R.g., L from Bacterium A. sp: Deracemization of Amino Acids by Enantioselective Scavengers
Wei Tong（童威）, Tao Niu（牛滔）, Zizhang Zhang（張子張）*
26th Chinese Chemistry Society Congress, 06-O-23, July 13-16, 2008,
Tianjin, China
