張奇[南開大學教授]

張奇 Qi

張奇性別：男職稱：南開大學藥學院副教授學科方向：生物技術藥物
招生方向：微生物與生化藥學
教師簡介[1]
1998年9月至2002年7月就讀於南開大學生命科學學院微生物學系，2002年9月考入南開大學微生物學系攻讀研究生，2007年6月獲得理學博士學位後留校任教，主要從事藥學、免疫學及分子生物學等研究，甘氨酸及其衍生物產業技術創新戰略聯盟專家委員。主持國家自然科學基金2項，天津市自然科學基金1項，橫向基金1項；參加包括“973”、國家科技重大專項、國家自然科學基金、天津市科技支撐計畫、天津市自然科學基金等在內的10餘項自然科學基金項目。主要開展腫瘤糖蛋白相關研究、胺基酸類醫藥中間體的生物合成及病原微生物的檢測技術開發以及微生物代謝產物藥物和肽類藥物的開發工作。共發表國內外學術論文及會議論文60餘篇，其中SCI收錄23篇；申請專利14項，授權2項，參編教材2部。
發表文章
1）PangPengwei,QiZhang*,JieHou,FangBai,Mei-rongCao,TingSun,QianShi,GangBai.Cellsurfaceglycoproteinprofilingofcancercellsbasedonbioorthogonalchemistry,AnalBioanalChem(2012)403(6):1661–1670(通訊作者)
2)DuanJingjing,QiZhang*,HongzhiZhao,JunDu,FangBai,GangBai.Cloning,expression,characterizationandapplicationofatcA,atcBandatcCfromPseudomonassp.QR-101,BiotechnologyLetters,(2012)34:1101–1106(通訊作者)
3)PengWeiPan,QiZhang*,FangBai,JieHou,andGangBai,ProfilingandcomparativeanalysisofglycoproteinsinHs578BSTandHs578Tandinvestigationofprolyl4-hydroxylasealphapolypeptideIIexpressionandinfluenceinbreastcancercells,Biochemistry(Moscow)2012,77(5),539-545(通訊作者)
4)JunDu,QiZhang*,JingjingDuan,ChunqinLiu,YangshengYu,JieHou,FangBai,NingChen,GangBai,EnzymaticsynthesisofL-tryptophanfromD,L-2-amino-Δ2-thiazoline-4-carboxylicacidandindolebyPseudomonassp.TS1138ATChydrolase,S-carbamyl-L-cysteineamidohydrolase,andEscherichiacoliL-tryptophanase,AppliedofBiochemistryandMicrobiology,2012,48(2):159-166(通訊作者)
5)LiMing,YangJie,QuHan,QiZhang*,FangBai,GangBai.NovelImmobilizationofArginaseIviaCelluloseBindingDomainandApplicationinProducingofL-Ornithine,BiotechnologyLetters,AppliedofBiochemistryandMicrobiology(Acceptted)(通訊作者)
6)ZhangQi,WangBin,LiXia,HouJie,FangBai,SunDan,BaiGang,EstablishmentandApplicationofImmunofluorescenceDetectionMethodDependingonClickChemistry,ChemicalJournalofChineseUniversities,2011,32(2):287-291
7）JieHou,QiZhang,XiaLi,YuTang,FangBai,QianShi,Mei-rongCao,Cui-hongYang,De-lingKong,GangBaiSynthesisofnovelfolateconjugatedfluorescentnanoparticlesfortumorimaging,JBiomedicalMaterialsRes,PartA,2011,99(4)684-9
8）CaoMei-Rong,HouJie,ZhangQi,FangBai,BaiGang,HyaluronicAcid-QuantumDotConjugateforTumorImaging,ChemicalJournalofChineseUniversities,2012,33(03):437-441
9）PengMeng,YuanqiangGuo,QiZhang,JieHou,FangBai,PengGeng,GangBai,Anovelamino-oligosaccharideisolatedfromthecultureofStreptomycesstrainPW638isapotentinhibitorofα-amylase,CarbohydrateResearch,2011,346(13),1898-1902
10）FangBai,HaijinXu,QiZhang,XizhenQi,RuiMou,GangBai,andMingqiangQiao,FunctionalcharacterizationofpfminproteinsecretionandlunginfectionofPseudomonasaeruginosa,Can.J.Microbiol.,2011,57,829-837
11)YuTang,QiZhang,LongWang,Peng-WeiPan,GangBai.Preparationofcellulosemagneticmicrosphereswith“thesmallestcriticalsize”andtheirapplicationformicrobialimmunocapture,Langmuir,2010,26(13),11266–11271
12)ZhihuiGao,QiZhang*,YuCao,PengweiPan,FangBai,GangBai,Preparationofnovelmagneticcellulosemicrospheresviacellulosebindingdomain-streptavidinlinkageanditsusefortheisolationofmRNAfromeukaryoticcellsandtissues,JournalofChromatographyA,2009,1216(45):7670-7676(通訊作者)
13)PengGeng,GangBai,QianShi,LeiZhang,ZhihuiGao,QiZhang,TaxonomyoftheStreptomycesstrainZG0656thatproducesacarviostatinα-amylaseinhibitorsandanalysisoftheireffectsonbloodglucoselevelsinmammaliansystems,JournalofAppliedMicrobiology,2009,106:525–533
14)ZhihuiGao,GangBai,JiaqiChen,QiZhang,PengweiPan,FangBai,PengGeng,Development,Characterization,andEvaluationofaFusionProteinofaNovelGlucagon-likePeptide-1(GLP-1)AnalogueandHumanSerumAlbumininPichiapastoris,Biosci.Biotechnol.Biochem.,2009,73(3):688-694
15)WangBin,WangShuai,ZhangZhen-Xin,YangPin,TianYe,ZhangQi,BaiGang,ChenRu-Yu,Alkynyl-ModifiedNaphthalimide:Synthesis,CrystalStructureandFluorescenceSpectrum,ChineseJournalofStructuralChemistry,2009,28(8):1008-1012
16)QianShi,ZeLiu,YangYang,PengGeng,Yuan-yuanZhu,QiZhang,FangBai,GangBai,Identificationofanti-asthmaticcompoundsinPericarpiumcitrireticulataeandevaluationoftheirsynergisticeffects,ActaPharmacolSin,2009,30(5):567-567
17)ZhihuiGao,YuTang,JiaqiChen,RuBai,QiZhang,YuanyuanHou,YaxinLu,GangBai,AnovelDPP-IV-resistantanalogofglucagon-likepeptide-1(GLP-1):KGLP-1aloneorincombinationwithlong-actingPLGAmicrospheres,peptide,2009,30:1874–1881
18)GangBai,YangYang,QianShi,ZeLiu,QiZhang,Yuan-yuanZhu,IdentificationofhigenamineinRadixAconitiLateralisPreparataasabeta2-adrenergicreceptoragonist,ActaPharmacolSin,2008,29(10):1187–1194
19)QiZhang,GangBai,JiaqiChen,etal.Identificationofantiviralmimeticpeptideswithinterferonα-2blikeactivityfromarandompeptidelibraryusinganovelfunctionalbio-panningmethod.ActaPharmacologicaSinica,2008,29(5):634-640
20)ZhangQi,BaiGang,LiHaiyan,etal.ThePathogenicCellulaseAssayofthePineWiltDiseaseandtheImmunologicalLocalization,Biosci.Biotechnol.Biochem.,2006,70(11):2727-2732
21)ZhangQi,BaiGang,ChenJiaqi,etal.UseofanEnhancedGreenFluorescenceProteinlinkedtoaSingleChainFragmentVariableAntibodytoLocalizeBursaphelenchusxylophilusCellulase,Biosci.Biotechnol.Biochem.,2007,71(6):1514-1520
22)CaoYu,ZhangQi,WangChao,etal.PreparationofnovelimmunomagneticcellulosemicrospheresviaCBD-proteinAlinkageanditsusefortheisolationofinterferonalpha-2b,JournalofChromatographyA,2007,1149(2):228-235
23)JiaqiChen,GangBai,YuCao,ZhihuiGao,QiZhang,etal.One-StepPurificationofaFusionProteinofGlucagon-LikePeptide-1andHumanSerumAlbuminExpressedinPichiapastorisbyanImmunomagneticSeparationTechnique,Biosci.Biotechnol.Biochem.,2007,71(11):2655-2662