![廖建[中科院成都生物所任研究員]](/img/6/12e/nBnauM3XzYzN3czM0IDO5ATM1QTM4AzMyQjNzQTNwAzMwIzLygzL1czLt92YucmbvRWdo5Cd0FmL0E2LvoDc0RHa.jpg "廖建[中科院成都生物所任研究員]")
個人履歷
•廖建 博士，研究員，博士生導師。1972年2月生於四川成都。1994年畢業於上海交通大學套用化學系， 2002年在中科院成都有機所獲理學博士學位。2003年至2006年在美國賓州州立大學材料系、化學系從事導電高分子、彈性體材料設計及性能研究和手性膦配體設計及不對稱催化氫化研究。2006年2月回國後被聘為中科院成都有機所研究員，並任不對稱合成與手性技術四川省重點實驗室常務副主任，所學位評定委員會委員。2008年入選中國科學院“西部之光”人才計畫，2009年入選四川省學術和技術帶頭人後備人選。2010年9月調入中科院成都生物所任研究員。2012年入選四川省百人計畫。2014年任天然藥物與臨床轉化實驗室主任。現主要從事新型手性配體設計、發展新不對稱催化方法以及將所發展的方法套用於天然產物合成的研究工作。在國際核心學術刊物（包括J. Am. Chem. Soc., Angew. Chem. Int. Ed., Adv. Catal. & Synth., Macromolecules, Chem. Eur. J.等）上發表學術論著20餘篇，獲準和申請了發明專利近10項。
研究方向
•手性配體的設計及不對稱催化反應方法學、天然產物合成方法學
代表論著
•(31) Liyin Jiang, Tao Jia, Min Wang, Jian Liao, and Peng Cao* “Pd-Catalyzed Enantioselective Hydroalkoxylation of Alkoxyallenes with Phenol for Construction of Acyclic O,O-Acetals” Org. Lett., 2015, 17 ,1070.
•(30) Tao Jia, Peng Cao, Ding Wang, Yazhou Lou, Jian Liao* “Copper-Catalyzed Asymmetric Three-Component Borylstannation: Enantioselective Formation of C-Sn Bond” Chem. Eur. J. 2015, 21, 4918.
•(29) Juanjuan Wang, Bing wang, Peng Cao, Jian Liao* “Rhodium Catalyzed Asymmetric 1,4-Addition of Arylboronic Acids to β,γ-Unsaturated α-Keto Ester Using Chiral tert-Butanesulfinylphosphines Ligands” Tetrahedron Lett. 2014, 55, 3450.
•(28) Juanjuan Wang, Min Wang, Peng Cao, Liyin Jiang, Guihua Chen, Jian Liao* “Rh-Catalyzed Asymmetric Arylation ofβ,γ-Unsaturated α-Ketoamides for the Construction of Nonracemic γ,γ-Diarylcarbonyls” Angew. Chem. Int. Ed. 2014, 53, 6673. (Highlighted bySynfacts, 2014, 1042)
•(27) Le Du, Peng Cao, Jian Liao* “Bifunctional Ligand Promoted Pd-Catalyzed Asymmetric Allylic Etherification/Amination” Acta Chimica Sinica 2013, 71, 1239.
•(26) Le Du, Peng Cao, Junwei Xing, Yazhou Lou, Liyin Jiang, Liangchun Li, Jian Liao* “Hydrogen Bond Promoted Palladium-Catalysis: Allylic Alkylation of Indoles with Unsymmetrical 1,3-Disubstituted Allyl Acetates Using Chiral Bis(sulfoxide) Phosphine Ligands” Angew. Chem. Int. Ed. 2013, 52, 4207.
•(25) Jiangyang Gui, Guihua Chen, Peng Cao, Jian Liao* “Rh(I)-catalyzed asymmetric addition of arylboronic acids to NH isatins” Tetrahedron: Asymmetry 2012, 23,554.
•(24) Junwei Xing, Peng Cao, Jian Liao* “Chiral SO/P hybrid ligands: an enantioselective switch in palladium-catalyzed asymmetric allylic etherifications” Tetrahedron: Asymmetry 2012,23, 527.
•(23) Guihua Chen, Jiangyang Gui, Peng Cao, Jian Liao* “Chiral sulfoxideeolefin ligands: tunable stereoselectivity in Rh-catalyzed asymmetric 1,4-additions” Tetrahedron 2012, 68, 3220.
•(22)Guihua Chen, Junwen Xing, Peng Cao, Jian Liao* “Rh/chiral sulfinylphosphine catalyzed asymmetric 1,4-addition of arylboronic acids to chalcones” Tetrahedron 2012, 68, 5908.
•(21)Junwen Xing, Guihua Chen, Peng Cao and Jian Liao* “Rhodium-Catalyzed Asymmetric Addition of Arylboronic Acids to Indolylnitroalkenes” Eur. J. Org. Chem. 2012, 1230.
•(20) Xiangyang Zhang, Guihua Chen, Peng Cao, Jibing Liu and Jian Liao* “Rhodium-Catalyzed Michael Addition of Arylboronic Acids to 3-Alkylenyloxindoles: Asymmetric Synthesis of Functionalized Oxindoles” Tetrahedron Lett. 2012, 53, 438.
•(19) Guihua Chen, Jiangyang Gui, Liangchun Li and Jian Liao* “Chiral Sulfoxide-Olefin Ligands: Completely Switchable Stereoselectivity in the Rh-Catalyzed Asymmetric Conjugate Additions” Angew. Chem. Int. Ed. 2011, 50, 7681 (hot paper, Highlight bySynfacts, 2011, 1193 ).
•(18) Fuzhong Han,Guihua Chen, Xiangyang Zhang, and Jian Liao* “Chiral Hetero-Disulfoxide Ligands in Rhodium-Catalyzed Asymmetric 1,4-Addition of Arylboronic Acids to Chromenones” Eur. J. Org. Chem. 2011, 2928.
•(17) Feng Lang, Guihua Chen, Liangchun Li, Junwen Xing, Fuzhong Han, Linfeng Cun, and Jian Liao* “Rhodium-Catalyzed Highly Enantioselective Addition of Arylboronic Acids to 2-Nitrostyrenes by tert-Butanesulfinylphosphine Ligand” Chem. Eur. J. 2011, 5242 (Highlight bySynfacts, 2011, 882).
•(16) Jibing Liu, Guihua Chen, Junwei Xing and Jian Liao* “tert-Butanesulfinylthioether ligands: synthesis and application in palladium-catalyzed asymmetric allylic alkylation” Tetrahedron: Asymmetry 2011, 22, 575.
•(15) Xiangyang Zhang, Jun Chen, Fuzhong Han, Linfeng Cun, and Jian Liao*“Rhodium-Catalyzed Enantioselective Conjugate Addition of Sodium Tetraaryl-borates to 2,3-Dihydro-4-Pyridones and 4-Quinolones by Using (R,R)-1,2-bis(tert-butylsulfinyl)benzene as Ligand” Eur. J. Org. Chem. 2011, 1443.
•(14) Fuzhong Han, Jun Chen, Xiangyang Zhang, Jibing Liu, Linfeng Cun, Jin Zhu, Jingen Deng, and Jian Liao* “Rhodium-catalyzed asymmetric addition of arylboronic acids to γ-phthalimido-substituted-α, β-unsaturated carboxylic acid esters: an approach toγ-amino acids” Tetrahedron Lett. 2011, 52, 830.
•(13) Jun Chen, Junmin Chen, Feng Lang, Xiangyang Zhang, Linfeng Cun, Jin Zhu, Jingen Deng and Jian Liao* “AC-Symmetric Chiral Bis-Sulfoxide Ligand in Rhodium-Catalyzed Reaction: Asymmetric 1, 4- Addition of Sodium Tetraarylborates to Chromenones” J. Am. Chem. Soc. 2010, 132，4552. (Highlight bySynfacts, 2010, 790.)
•(12) Feng Lang, Dong Li, Junmin Chen, Jun Chen, Liangchun Li, Linfeng Cun, Jin Zhu, Jingen Deng and Jian Liao* “tert-Butanesulfinylphosphines: Simple Chiral Ligands in Rhodium-Catalyzed Asymmetric Addition of Arylboronic Acid to Electron-Deficient olefins” Adv. Synth & Catal.2010, 352, 843. ( Highlight bySynfacts, 2010, 667)
•(11) 廖建，鄧金根 《不對稱催化新概念與新方法》，（丁奎嶺、范青華主編）第20章：不對稱催化—從學術研究到工業套用（典型案例分析）。2009年，化學工業出版社。
•(10) Peng Wang, Junmin Chen, Linfeng Cun, Jingen Deng, Jin Zhu and Jian Liao* “Aryl tert-Butyl Sulfoxide-Promoted Highly Enantioselective Addition of Allyltrichlorosilane to Aldehydes”Org. Biomol. Chem., 2009, 7, 3741.
•(9) Xiaoyu Guan, Zhangqin Liu, Haoxi Huang, Liping Yang, Jian Liao* and Wenhao Hu* “Novel C–S Bond Formation Through a’,b-Elimination of tert-Butyl Sulfoxonium Ylides: A Facile Approach to Chiral Sulfoxides” Synlett. 2009, 2183. （與華東師大胡文浩教授合作）
•(8) Junmin Chen, Feng Lang, Dong Li, Linfeng Cun, Jin Zhu, Jingen Deng, Jian Liao* “Palladium-catalyzed asymmetric allylic nucleophilic substitution reactions using chiral tert-butanesulfinylphosphine ligands”Tetrahedron: Asymmetry 2009, 20, 1953.(Highlight by Synfact, 2009, 1374).
•(7) Dong Li, Jingen Deng, Jin Zhu, Jian Liao* “Synthesis of 3,3'-Substituted Biphenyl and Binaphthyl-based Phosphoramidite Ligands” Chin. Synth. Chem. 2008, 16, 656.
•(6) Junmin Chen, Dong Li, Haifeng Ma, Linfeng Cun, Jin Zhu, Jingen Deng, Jian Liao* “Catalytic asymmetric synthesis of α- branched chiral amines using a novel chiraltert-butanesulfinylphosphine ligand”Tetrahedron Lett. 2008. 49. 6921.
•(5) P. Harshad; J. Liao; R. Hedden* “Smectic Ordering in Main-Chain Siloxane Polymers and Elastomers Containing p-Phenylene Terephthalate Mesogens” Macromolecules2007, 40, 6206.
•(4) J. Liao; Qing Wang * “Ruthenium-Catalyzed Knoevenagel Condensation: A New Route toward Cyano-Substituted Poly(p-phenylenevinylene)s” Macromolecules 2004, 37, 7061.
•(3) J. Liao; X. X. Sun; X. Cui; K. B. Yu; J. Zhu; J. G. Deng* “Facile optical resolution of tert-butanethiosulfinate by molecular complexation with (R)-BINOL and study of chiral discrimination of the diastereomeric complexes” Chem. Eur. J. 2003, 9, 2611.
•(2) J. Liao; X. H. Peng; J. H. Zhang; K. B. Yu; X. Cui; J. Zhu; J. G. Deng* “Facile resolution of racemic terbutaline and a study of molecular recognition through chiral supramolecules based on enantiodifferentiating self-assembly” Org. & Biomol. Chem. 2003, 1, 1080.
•(1) J. H. Zhang, J. Liao, X. Cui, K. B. Yu, J. Zhu, J. G. Deng*, S. F. Zhu, L. X. Wang, Q. L. Zhou*, L. W. Chung, T. Ye* “Highly Efficient and practical resolution of 1,1’-spirobiindane-7,7’-diol by inclusion crystallization with N-benzylcinchonidinium chloride” Tetrahedron: Asymmetry 2002, 13, 1363.
科研項目
•國家自然科學基金委面上項目4項
•參加國家973計畫子項目1項
•中科院“西部之光”人才計畫1項
•四川省“百人計畫”1項
