姓名:宋淑亮
學歷:碩士研究生
職務:高級實驗師/碩士生導師
研究方向:海洋活性物質開發、藥理學、化妝品配方學
項目:
1、山東省自然科學基金,ZR2017MH040,水蛭肽抑制動脈粥樣硬化中巨噬細胞遷移的信號通路和作用靶點的研究,2017/08-2020/06,14萬元,在研,主持
2、山東省自然科學基金,ZR2015PH050,水蛭活性肽對動脈粥樣硬化中血管平滑肌細胞的藥理作用及其機制研究,2015/07-2016/12,4萬元,已結題,主持
3、威海市科技攻關項目,威海海參資源深加工產品開發的研究,2013/12-2016/12,10萬元,已結題,主持
4、國家自然科學基金面上項目,81371455,岩藻糖基化海參硫酸軟骨素促進神經幹細胞向腦損傷部位遷移的作用及其機制研究, 2014/01-2017/12,70萬元,在研,參加
5、威海市重大科技專項,海藻健康產品技術創新平台,2014/01-2016/12,200萬元,在研,參加
6、國家自然科學基金面上項目,30873198,刺參岩藻多糖對神經前體細胞增殖的作用及其機制研究,2009/01-2011/12,34萬元,已結題,參加。
論文:
(1)Liu C M, Chen X T, Pan Y Y, Liang H, Song S L*, Ji A G *. Antitumor Studies of Earthworm Fibrinolytic Enzyme Component A from Eisenia foetida on Breast Cancer Cell Line MCF-7. Indian Journal of Pharmaceutical Sciences, 2017, 79(3) :361-368.
(2)Li X, Yang L, Wang YS, Liang H, Song SL*, Ji AG*. Fucoidan Induce Apoptosis of HeLa Cells Accompanied by The Induction of Autophagy. Latin American Journal of Pharmacy, 2017, 36(6):1126-1133
(3)Shuaishuai Li, Long Cheng, Dengkun An, Shuliang Song*, Hao Liang, Fulong Chu, Aiguo Ji. Whitmania pigra Whitman extracts inhibit lipopolysaccharide induced rat vascular smooth muscle cells migration and attenuate their adhesion ability to THP-1 and RAW 264.7 cells. Journal of Atherosclerosis & Thrombosis, 2017, 24:301-311
(4)Fulong Chu, Xiaochen Wang, Qianqian Sun, Hao Liang, Sijian Wang, Dengkun An, Chao Cui, Yuchao Chai, Shuaishuai Li, Shuliang Song*, Aiguo Ji*. Purification and characterization of a novel fibrinolytic enzyme from Whitmania pigra Whitman. Clinical & Experimental Hypertension, 2016,38(7):594-601
(5) Shuliang Song, Yuling Wang, Kai Ji, Hao Liang, Aiguo Ji*, Effect of earthworm active protein on fibroblast proliferation and its mechanism. Pharmaceutical Biology, 2016, 54(4):732-739
(6) Shuliang, Song,Lei, Cui,Guangwu, Jing,Changjie, Liu*,Involvement of ubiquitin-conjugating enzyme E2C in proliferation and invasion of prostate carcinoma cells. Oncology Research,2013,21(3):121-127
(7)Cui, Chao,Cui, Ningshan,Wang, Peng, Song, Shuliang,Liang, Hao,Ji, Aiguo(*),Sulfated Polysaccharide Isolated from the Sea Cucumber Stichopus japonicus Against PC12 Hypoxia/Reoxygenation Injury by Inhibition of the MAPK Signaling Pathway. Cellular and Molecular Neurobiology,2015,35(8):1081-1092
(8)Wang Y.,Zhao X.,Wang Y.-S., Song S.-L.,Liang H.,Ji A.-G.,An extract from medical leech improve the function of endothelial cells in vitro and attenuates atherosclerosis in ApoE null mice by reducing macrophages in the lesions. Biochemical and Biophysical Research Communications,2014,455(1-2):119-125
(9)Sheng X.,Li M., Song S.,Zhang N.,Wang Y.,Liang H.,Wang W.,Ji A.(*),Sulfated polysaccharide isolated from the sea cucumber Stichopus japonicus promotes neurosphere migration and differentiation via up-regulation of N-cadherin. Cellular and Molecular Neurobiology,2012,32(3):435-442
專利:
(1) 宋淑亮,吉愛國,一種藥食兩用海參肽組合物、製備方法及其套用,2017.8.22,中國,201510624206.6
(2) 宋淑亮,吉愛國,一種海星酶解提取物及其製備方法和套用,2017.5.3,中國,ZL201510120730.X
(3) 宋淑亮,張娥,一種海參肽穩定製劑及其製備方法與套用,2016.2.29,中國,ZL201410135479.X。
(4)吉愛國, 宋淑亮,梁浩,王秀敏,低分子岩藻聚糖硫酸酯及其對糖尿病腎病的作用,2015.12.30,中國,ZL 201410029573.7。
(5)吉愛國,梁浩, 宋淑亮,聯產岩藻聚糖硫酸酯和海藻肥的方法,2015.10.21,中國,ZL201410029692.2。
(6)吉愛國, 宋淑亮,梁浩,一種化妝品添加劑及其製備方法與套用,2013.7.10,中國,ZL201210007434.5。