Overview
Stevens - Johnson syndrome, also known as' Stevens (Stevens - Johnson syndrome) Stevens - Johnson syndrome, also known as' Stevens (Stevens - Johnson syndrome) . is considered a severe skin and mucosal allergies is considered a severe skin and mucosal allergies .
also in iatrology is identified as a susceptibility factor for severity of erythema also in iatrology is identified as a susceptibility factor for severity of erythema . While most cases of being primary, known mainly from medication caused in the next, is infected by disease germs and cancer (rarely the case) the trigger of the current multi - While most cases of being primary, known mainly from medication caused in the next, is infected by disease germs and cancer (rarely the case) the trigger of the current multi - .
symptoms caused by the drug of known as Stevens - Johnson syndrome,produced by viruses of the symptoms is referred to as a susceptibility factor for erythema symptoms caused by the drug of known as Stevens - Johnson syndrome,produced by viruses of the symptoms is referred to as a susceptibility factor for erythema . Stevens - Johnson syndrome it will cause skin cell death like a snake shedding Stevens - Johnson syndrome it will cause skin cell death like a snake shedding .
patients as a result of the illness will scar all over his body and had a severe case of conjunctivitis, eventually can cause blindness and oral infection, and diet affect their patients as a result of the illness will scar all over his body and had a severe case of conjunctivitis, eventually can cause blindness and oral infection, and diet affect their .
By To
Steven Johnson syndrome is due to two American pediatrician, Albert Mason Stevens and Frank Chambliss Johnson, who in 1922 in the "American Journal of Diseases of Children", published a paper on "disorder", as there is life Steven Johnson syndrome is due to two American pediatrician, Albert Mason Stevens and Frank Chambliss Johnson, who in 1922 in the "American Journal of Diseases of Children", published a paper on "disorder", as there is life . 3 4 3 4.
Epidemiology
Steven Johnson syndrome is a rare disease, there are around 1, 000, 000 degrees divided by 2. 6 5 - 6. 1 6 cases in the United States, there are around 300 new 6 cases in the United States, there are around 300 new .
compared with children, in many cases occur in adults, while prevalent in women than in men, the gender ratio of 3: 2 6 compared with children, in many cases occur in adults, while prevalent in women than in men, the gender ratio of 3: 2 6 . is usually triggered by adverse reactions to medication, the mortality was about 15% 2 is usually triggered by adverse reactions to medication, the mortality was about 15% 2 .
Classification
In the medical literature has a protocol means the Steven Johnson Syndrome (SJS) can be thought of as toxic epidermal necrosis (TEN) Toxic epidermal / of a milder form of the "In the medical literature has a protocol means the Steven Johnson Syndrome (SJS) can be thought of as toxic epidermal necrosis (TEN) Toxic epidermal / of a milder form of the "." in the case for the first time in 1992 is acknowledged " in the case for the first time in 1992 is acknowledged .
6 both disorders can be mistaken for erythema multiforme 6 both disorders can be mistaken for erythema multiforme . Steven - Johnson syndrome is sometimes caused by drug reaction, but more often is a fourth type of hypersensitivity reaction (most commonly caused by herpes simplex) and a relatively benign though Steven - Johnson syndrome is sometimes caused by drug reaction, but more often is a fourth type of hypersensitivity reaction (most commonly caused by herpes simplex) and a relatively benign though .
SJS and TEN are caused by infection,Most commonly they are adverse drug reactions (ADRs) SJS and TEN are caused by infection,Most commonly they are adverse drug reactions (ADRs) . their potential consequences are more dangerous than erythema multiforme their potential consequences are more dangerous than erythema multiforme .
Symptoms
Stevens - Johnson syndrome is characterized by a first appear flu - like symptoms, including fever, sore throat, headache, and then the presence of the coin size circular whorl (target symptoms), the area is gradually increased, then the Stevens - Johnson syndrome is characterized by a first appear flu - like symptoms, including fever, sore throat, headache, and then the presence of the coin size circular whorl (target symptoms), the area is gradually increased, then the . and blisters on the diseased part of body surface area in excess of 30 percent or more, and is referred to as toxic epidermal necrolysis or Lyell syndrome symptoms (Lyell syndrome) and blisters on the diseased part of body surface area in excess of 30 percent or more, and is referred to as toxic epidermal necrolysis or Lyell syndrome symptoms (Lyell syndrome) .
Genesis
Infection
It may be caused by infection, usually following the infection, e.g.: herpes simplex virus (herpes simplex virus), influenza (influenza), mumps (multi -), (cat - scratch - scratch fever, and histoplasmosis (), Human Herpesvirus 4 HHV - 4) (Epstein - Barr virus), pneumonia mycoplasma pneumonae () or similar infection 
Drug
Because drug allergies (e.g. penicillin, barbiturates, sulfonamides, acetaminophen, anti - epileptic drug, etc.) 7 or because of conditions such as cancer, but some unexplained 7 or because of conditions such as cancer, but some unexplained .
also there is cases reported, some herbs such as ginseng, allergy, or drugs such as cocaine also there is cases reported, some herbs such as ginseng, allergy, or drugs such as cocaine . 8 8.
Genetic
In some East Asian populations studied (Han Chinese and Thai), carbamazepine and phenytoin to themedium () () and HLA - B * 1502 (HLA - B75) will lead to the Steven Johnson Syndrome have reacted strongly to HLA - B serotype a broader serotype HLA - B15 In some East Asian populations studied (Han Chinese and Thai), carbamazepine and phenytoin to themedium () () and HLA - B * 1502 (HLA - B75) will lead to the Steven Johnson Syndrome have reacted strongly to HLA - B serotype a broader serotype HLA - B15 . 9 10 11 in a European study suggests that the index (marker genes) are just east of the Asian people related to the 12 9 10 11 in a European study suggests that the index (marker genes) are just east of the Asian people related to the 12 .
13 according to the discovery of Asian people,In Europe a similar study showed that 61% of xanthine induced the Steven Johnson Syndrome / toxic epidermal necrolysis in patients with HLA - B58 (B * 5801 alleles - dominant frequency representative of the Europeans to have 3% 13 according to the discovery of Asian people,In Europe a similar study showed that 61% of xanthine induced the Steven Johnson Syndrome / toxic epidermal necrolysis in patients with HLA - B58 (B * 5801 alleles - dominant frequency representative of the Europeans to have 3% . a study concluded that even when the HLA - B allele is the high risk factors for allopurinol, they are neither sufficient nor necessary to explain away the disease a study concluded that even when the HLA - B allele is the high risk factors for allopurinol, they are neither sufficient nor necessary to explain away the disease .
Treatment
The first step in treatment is to stop the cause of the allergy drug it The first step in treatment is to stop the cause of the allergy drug it . disposal principle and Burn / Scald of similar treatment, comprising administering an intravenous supplement moisture, which is applied to the treatment of pain (such as disposal principle and Burn / Scald of similar treatment, comprising administering an intravenous supplement moisture, which is applied to the treatment of pain (such as .
, etc.) from its position and there is no effective treatment may be, steroid use is still controversial, but it may cause secondary infections in recent years have proposed the use of the chemical drug treatment of the proposal, but has not yet agree with chemical drug treatment of the proposal, but has not yet agree with .
Furthermore if eye also has the disease, the association to seek the ophthalmologist should be consulted by Furthermore if eye also has the disease, the association to seek the ophthalmologist should be consulted by .
After Cure
Stevens - Johnson syndrome is a roughly 5 percent of fatal rate Stevens - Johnson syndrome is a roughly 5 percent of fatal rate . currently to Schickel Walden (index scale) in the prognosis of mortality can be estimated approximately 14 currently to Schickel Walden (index scale) in the prognosis of mortality can be estimated approximately 14 .
other complications including multiple organ failure, and blindness - cornea - other complications including multiple organ failure, and blindness - cornea - .
Case
'Padma Lakshmi, the Indian actress, model, television personality, and cookbook author 'Padma Lakshmi, the Indian actress, model, television personality, and cookbook author . Laguna Beach's music television programs of Laguna Beach's music television programs of .
Tessa Keller says Sabrina Johnson, Steven Johnson syndrome after blindness, the family cannot successfully sued Omnicare, "Children's" of the manufacturer's Tessa Keller says Sabrina Johnson, Steven Johnson syndrome after blindness, the family cannot successfully sued Omnicare, "Children's" of the manufacturer's . 16 Manute Bol, a former professional basketball player and NBA Washington Bullets, Golden State Warriors, Philadelphia 76ers, 16 Manute Bol, a former professional basketball player and NBA Washington Bullets, Golden State Warriors, Philadelphia 76ers,.
Miami Heat players because he died of kidney failure on June 19, 2010 Miami Heat players because he died of kidney failure on June 19, 2010 . Julie Williams, Steven Johnson syndrome foundation founder Jean's daughter, Julie Williams, Steven Johnson syndrome foundation founder Jean's daughter, .
SJS survivors' 17 December 2013, the British 7 - year - old boy Oakley due to prescription drug carbamazepine allergy but rare of Stevens - Johnson syndrome (SJS), Systemic skin shedding SJS survivors' 17 December 2013, the British 7 - year - old boy Oakley due to prescription drug carbamazepine allergy but rare of Stevens - Johnson syndrome (SJS), Systemic skin shedding . his grief - stricken parents have been told by the doctor that her son was only 65 per cent chance of survival his grief - stricken parents have been told by the doctor that her son was only 65 per cent chance of survival .
2 2.
