Topographical Features
Cantharides was born to the head, feet and wings of the dried body, which has a substantially elongated circular shape, and the back section 3 have a yellow or brownish streaks Cantharides was born to the head, feet and wings of the dried body, which has a substantially elongated circular shape, and the back section 3 have a yellow or brownish streaks . of the thorax and abdomen black, the special odor of volatile constitunts between stir - baked with rice of the thorax and abdomen black, the special odor of volatile constitunts between stir - baked with rice .
cantharis micro hanging tint, gloss, slight odor cantharis micro hanging tint, gloss, slight odor . generally has a length of about 15 to 22 mm, a width of 5 to 8 mm, often inhabiting Caprifoliaceae and Oleaceae plants over generally has a length of about 15 to 22 mm, a width of 5 to 8 mm, often inhabiting Caprifoliaceae and Oleaceae plants over .
joints which can secrete a yellow liquid pungency of Cantharidin, Cantharides Camphor contains at most 5% of cantharidin joints which can secrete a yellow liquid pungency of Cantharidin, Cantharides Camphor contains at most 5% of cantharidin . mylabris phalerata pallas, reach a length of 15 - 30 mm mylabris phalerata pallas, reach a length of 15 - 30 mm .
. All is black head rounded triangular, with dense spines point All is black head rounded triangular, with dense spines point .
eyes big,slightly kidney - shaped feeler eyes big,slightly kidney - shaped feeler . 1 and 1 and .
pronotal length slightly greater than that of the wide elytral pronotal length slightly greater than that of the wide elytral . end wider than the base, and the lines and black end wider than the base, and the lines and black .
each fin have determined it is a large 2 in the macula, the central fin behind the yellow corrugated transverse band each fin have determined it is a large 2 in the macula, the central fin behind the yellow corrugated transverse band . finned surface engraved black portions are densely arranged, the yellow portion of the engraved, very coarse finned surface engraved black portions are densely arranged, the yellow portion of the engraved, very coarse .
Mylabris cichorii Fabr, has a profile on a similar species, are small (10 - 15 mm long and ecological distribution of Mylabris cichorii Fabr, has a profile on a similar species, are small (10 - 15 mm long and ecological distribution of . on on .
species species.
Living Habits
Xi cluster roosting and foraging, often inhabiting Caprifoliaceae and Oleaceae plants over Xi cluster roosting and foraging, often inhabiting Caprifoliaceae and Oleaceae plants over . can secrete a kind of yellow liquid pungency that genistein, cantharadin contains at most 5% of genistein, is able to stimulate tissue of the animal while it is pressed using the can secrete a kind of yellow liquid pungency that genistein, cantharadin contains at most 5% of genistein, is able to stimulate tissue of the animal while it is pressed using the .
baking powder, bright pink, and pale yellowish brown to olive, taste bitter, foul - smelling baking powder, bright pink, and pale yellowish brown to olive, taste bitter, foul - smelling . larvae eat ground - dwelling bees honey made by larvae eat ground - dwelling bees honey made by .
complex metamorphosis, the larva has 6 instars, the larva 4 to 5 month infesting plants, buds and flowers, 7 - 8 months is the most fierce, more damage to soybean, peanut, cotton, eggplant, etc.
Species Distribution
is mainly produced in Henan, Guangxi, Anhui, Jiangsu, Hunan, Guizhou, Xinjiang Provinces, etc.
Cantharidin
Physicochemical Properties
mylabris phalerata pallas main containing cantharidin (ca - C10H12O4) 0.427% ~ 1. 452% Furthermore, 12% fat) containing oil, resin, formic acid, a pigment, etc.
Mylabris cichorii Fabr containing cantharidin 0. 564% ~ 2. 163% cantharidin is an effective antitumor agent, is also characteristic of insects of the order of Cantharis vesicatoria defensive attack 163% cantharidin is an effective antitumor agent, is also characteristic of insects of the order of Cantharis vesicatoria defensive attack .
cantharidin is a colorless crystalline substance, insoluble in cold water, slightly soluble in hot water, soluble in acetone, chloroform, melting point 218 C. .
about 110 DEG C (12mmHg, 3 to 5 mm in the distance) may be sublimed about 110 DEG C (12mmHg, 3 to 5 mm in the distance) may be sublimed . i.e. anhydride cantharidin and cantharis,with strong odor and foaming property, a portion of the magnesium in the form of salts, are present in the soft tissue, by the foot of joint secretion at
mylabris phalerata pallas, removal of the head, feet and wings of a phosphorus - containing 23. 785mg / g, magnesium 7. 114 mg / g, calcium 1. 691mg / g and containing iron, aluminum, zinc, chromium, manganese, cadmium, strontium and copper on scorpion and its head, feet, wings and other parts also include the amount of the above element and lead element scorpion and its head, feet, wings and other parts also include the amount of the above element and lead element .
in the Pharmacopoeia of the People's Republic of China "(1995) with the requirements of the product containing cantharidin and not less than 0. 35% 
Determination Of The Content
3 g of powdered ligusticum, adding 20 ml of chloroform, shaken for 2 hours, then filtered, the filtrate is evaporated and the residue is triturated with petroleum ether (30 ~ 60. degree. C.), and three times with 5 ml each time, carefully removing the supernatant, the residue in 1ml of chloroform to dissolve as the test solution into another piece of cantharidin reference sample, add chloroform to prepare 5 mg of the solution as reference solution reference sample, add chloroform to prepare 5 mg of the solution as reference solution .
According to thin layer chromatography (Appendix VI B), tests of each of the above two solutions, each point on the same silica gel G thin layer plate with chloroform - acetone (98: 2), take out and dry,sprayed with 0.1% of bromocresol green in ethanol, heated to spot clear in the chromatogram obtained with the corresponding position and same colour of the spots in the chromatogram obtained with the corresponding position and same colour of the spots .
. according to gas chromatography for the determination of chromatographic condition and system adaptability test, methyl silicone rubber (SE - 30 stationary liquid, the coating concentration is 3. 5%;Column temperature was 175 c 10 c
The theoretical plate number of cantharidin content determination was 2600 The theoretical plate number of cantharidin content determination was 2600 . Preparation of reference solution Weigh cantharidin reference chloroform to prepare 1mg / ml baicalin reference solution can be diluted as necessary ( Preparation of reference solution Weigh cantharidin reference chloroform to prepare 1mg / ml baicalin reference solution can be diluted as necessary (.
) of the test solution for the preparation of a crude powder of the product of about 1g, precisely measure it in a conical flask, add 30 ml of chloroform, shaken for 15 minutes, 6 hours, filtered, the filtrate in a 50ml volumetric flask, wash the residue with chloroform and the washings into the same volumetric flask, add chloroform to volume and mix well.i.e. Measurement: Lof the reference solution and test solution 2, injecting into the gas chromatograph, and calculate Measurement: Lof the reference solution and test solution 2, injecting into the gas chromatograph, and calculate .
History Of Species
ancient Greek physician Hippocrates described in early Spanish Fly, but the beetle wings were used to subsidise develop blisters of the plaster, and is used as a counterirritant ancient Greek physician Hippocrates described in early Spanish Fly, but the beetle wings were used to subsidise develop blisters of the plaster, and is used as a counterirritant . in ancient China, the world appeared the first recorded stink stink bombs (a bomb, these insects cantharides, arsenic mixed radix aconiti carmichaeli and a proper amount of human feces into in ancient China, the world appeared the first recorded stink stink bombs (a bomb, these insects cantharides, arsenic mixed radix aconiti carmichaeli and a proper amount of human feces into .
In Sang (Ignacio), these cantharis is used as incense making In Sang (Ignacio), these cantharis is used as incense making . cantharides, while more is already a world famous aphrodisiac, founding the Roman emperor Octavian's wife, Wei Ya, the dispersion is mixed with the guests of the winter diet, luring guests with their own light and thin,and then extort cantharides, while more is already a world famous aphrodisiac, founding the Roman emperor Octavian's wife, Wei Ya, the dispersion is mixed with the guests of the winter diet, luring guests with their own light and thin,and then extort .
Harington, Holy Roman Emperor Henry IV (1050 - 1106); it is also due to the use of cantharides detriment to health Harington, Holy Roman Emperor Henry IV (1050 - 1106); it is also due to the use of cantharides detriment to health . 1572, French doctors surgery Barre Ambroise (Par), reported a man taking a certain amount of astaxanthin and canthaxanthin Nettle (Urticaceae), a kind of 'the most terrible of fornication " 1572, French doctors surgery Barre Ambroise (Par), reported a man taking a certain amount of astaxanthin and canthaxanthin Nettle (Urticaceae), a kind of 'the most terrible of fornication ".
1670 in the 1970s, French sorcerer and La Voisin, blends with the mole - rats and bats (moles) of blood, infiltration of Louis XIV's food,to maintain a Louis XIV by his mistress, Mrs Monty spangle (Françoise - Ath na THRICE;, the marquis de) Mehdi 1670 in the 1970s, French sorcerer and La Voisin, blends with the mole - rats and bats (moles) of blood, infiltration of Louis XIV's food,to maintain a Louis XIV by his mistress, Mrs Monty spangle (Françoise - Ath na THRICE;, the marquis de) Mehdi . cantharis insects in Europe in the 18th century prevalent in France, referred to as" the Richelieu ", the Marquis de Sade is more fingers in 1771, to taking prostitutes (anise) flavor of fragrant anchorage and Spanish Fly, forcible sodomy and sex with prostitutes, the Marquis de Sade was sentenced to death, but after an appeal and given probation cantharis insects in Europe in the 18th century prevalent in France, referred to as" the Richelieu ", the Marquis de Sade is more fingers in 1771, to taking prostitutes (anise) flavor of fragrant anchorage and Spanish Fly, forcible sodomy and sex with prostitutes, the Marquis de Sade was sentenced to death, but after an appeal and given probation .
at the same time, Spanish flies will also be used as an abortifacient,(For in stimulants can cause insomnia and nervousness), poison and even, if in the form of pulverulent ooze is imperceptible Italian food at the same time, Spanish flies will also be used as an abortifacient,(For in stimulants can cause insomnia and nervousness), poison and even, if in the form of pulverulent ooze is imperceptible Italian food . the Medici family, a woman la Comtesse poisons" (Aqua di Napoli) ", is by taking white arsenic and Spanish Fly the Medici family, a woman la Comtesse poisons" (Aqua di Napoli) ", is by taking white arsenic and Spanish Fly .
reportedly mixed in water and added dropwise to 4 - 6, after the number of hours within a painless death reportedly mixed in water and added dropwise to 4 - 6, after the number of hours within a painless death . To prove lethal efficacy of the stunning Spanish Fly, that they will carry on the test and one way is to poison the dead entrails exploded in the oil, painted in the rabbit's face,to observe the rabbit for symptoms of blisters To prove lethal efficacy of the stunning Spanish Fly, that they will carry on the test and one way is to poison the dead entrails exploded in the oil, painted in the rabbit's face,to observe the rabbit for symptoms of blisters .
Medical Application
Effectiveness And Role
Activating blood and eliminating, corrosion, foaming conducted Activating blood and eliminating, corrosion, foaming conducted . genera subordinate classification of blood - activating and stasis - eliminating drugs genera subordinate classification of blood - activating and stasis - eliminating drugs .
break blood break blood.
Clinical Application
dosage 0. 03 ~ 0. 06 g, Halitum people, pills, powders with for topical use, which are ground or brandy, vinegar treated with external smearing for topical use, which are ground or brandy, vinegar treated with external smearing .
zhengjia masses from years of intractable tinea, scrofula, warts, ulcer or no ulcer zhengjia masses from years of intractable tinea, scrofula, warts, ulcer or no ulcer .
Main Component
main containing cantharidin 1% ~ 2%, fat 12%, formic acid, a pigment and a resin or the like main containing cantharidin 1% ~ 2%, fat 12%, formic acid, a pigment and a resin or the like . Cantharidin has anti - tumor effect on mouse ascites type liver cancer inhibitory activity;cantharides decoction on mice sarcoma S - 180 sarcoma and L2 network quality to some extent an inhibitory effat of ebeelen Cantharidin has anti - tumor effect on mouse ascites type liver cancer inhibitory activity;cantharides decoction on mice sarcoma S - 180 sarcoma and L2 network quality to some extent an inhibitory effat of ebeelen .
cantharis: infusion (1: 4) in the cuvettes to Trichophyton etc., skin fungi in Furthermore, immunity enhancing, increasing leukocytes and resisting hepatitis Furthermore, immunity enhancing, increasing leukocytes and resisting hepatitis .
effect of norcantharidin on angiogenesis of the skin, the mucosa has strong irritation to the effect of norcantharidin on angiogenesis of the skin, the mucosa has strong irritation to the . results of animal experiments, cantharidin can cause various parenchymal viscera of pathological change;cantharis oral toxicity is rather large, can cause gastritis, enteritis, nephritis etc. symptom
1 1.
