ABT[一種化學品，細胞色素酶抑制劑]:一些藥理藥代實驗中對 1-氨基苯 -百科知識中文網

這是一個細胞色素抑制劑。請知悉！

英文同義詞:ABT;TIMTEC-BB SBB004208;RARECHEM AQ NN 0550;1-BENZOTRIAZOLAMINE;1-AMINOBENZOTRIAZOLE;1-Benzotriazolylamine;Benzotriazol-1-ylamine;1H-Benzotriazol-1-amine;1-Aminobenzotriazole 97%;1-Amino-1H-benzotriazole

One hour following intravenous pretreatment of rats with 50 mg/kg of the cytochrome P-450 suicide substrate 1-aminobenzotriazole (ABT), the metabolism of phenacetin to acetaminophen is inhibited completely [B. A. Mico et al., Drug Metab. Dispos. 15, 274 (1987)]. Here we report an examination of the time-course of inhibition of phenacetin elimination by ABT, a demonstration of dose-dependent inhibition of phenacetin and antipyrine clearances by ABT, and an examination of the acute toxicity of ABT in rats, as well as the effect of ABT on phenacetin metabolism in beagles. After a 1-, 12-, 24- or 36-hr pretreatment of rats with ABT (50 mg/kg, i.v.), the clearance of phenacetin was decreased 85, 88, 81 and 48%, respectively, from control values. Twelve hours after intraperitoneal pretreatment of rats with 0.3, 1.0, 5.0, 20, and 50 mg/kg of ABT, the total systemic clearance of phenacetin was suppressed 39, 47, 60, 75, and 79%, respectively, from control values. The clearance of intravenously administered antipyrine was decreased 38 and 66% after a 12-hr intraperitoneal pretreatment of rats with 10 or 50 mg/kg of ABT. In rats, no hematological, clinical chemistry, macroscopic, or microscopic abnormalities were detected 1, 2, 3, and 9 days after a single i.v. dose of ABT (50 mg/kg). A 1-hr pretreatment of beagles with ABT (20 mg/kg) decreased the clearance of intravenous phenacetin 50% and completely prevented the formation of acetaminophen. These results demonstrate that ABT pretreatment causes long-lasting inhibition of oxidative drug metabolism without disruption of normal physiological processes. Profound inhibition of oxidation in two species suggests that ABT may have general utility as an inhibitor of oxidative drug metabolism in biochemical pharmacology and toxicology studies.

CAS號: 1614-12-6

英文名稱: 1-Aminobenzotriazole

英文同義詞: ABT;TIMTEC-BB SBB004208;RARECHEM AQ NN 0550;1-BENZOTRIAZOLAMINE;1-AMINOBENZOTRIAZOLE;1-Benzotriazolylamine;Benzotriazol-1-ylamine;1H-Benzotriazol-1-amine;1-Aminobenzotriazole 97%;1-Amino-1H-benzotriazole

中文名稱: 1-氨基苯並三唑

中文同義詞: 1-苯並三唑胺;1-氨基苯並三唑;1-氨基苯並三氮唑

CBNumber: CB9185384

分子式: C6H6N4

分子量: 134.14

MOL File: 1614-12-6.mol

CAS號:1614-12-6

英文名稱:1-Aminobenzotriazole

中文名稱:1-氨基苯並三唑

中文同義詞:1-苯並三唑胺;1-氨基苯並三唑;1-氨基苯並三氮唑

CBNumber:CB9185384

分子式:C6H6N4

分子量:134.14

MOL File:1614-12-6.mol

CAS號:1614-12-6

英文名稱:1-Aminobenzotriazole

中文名稱:1-氨基苯並三唑

中文同義詞:1-苯並三唑胺;1-氨基苯並三唑;1-氨基苯並三氮唑

CBNumber:CB9185384

分子式:C6H6N4

分子量:134.14

MOL File:1614-12-6.mol

CAS號: 1614-12-6

英文名稱: 1-Aminobenzotriazole

英文同義詞: ABT;TIMTEC-BB SBB004208;RARECHEM AQ NN 0550;1-BENZOTRIAZOLAMINE;1-AMINOBENZOTRIAZOLE;1-Benzotriazolylamine;Benzotriazol-1-ylamine;1H-Benzotriazol-1-amine;1-Aminobenzotriazole 97%;1-Amino-1H-benzotriazole

中文名稱: 1-氨基苯並三唑

中文同義詞: 1-苯並三唑胺;1-氨基苯並三唑;1-氨基苯並三氮唑

CBNumber: CB9185384

分子式: C6H6N4

分子量: 134.14

MOL File: 1614-12-6.mol

CAS號:1614-12-6

英文名稱:1-Aminobenzotriazole

中文名稱:1-氨基苯並三唑

中文同義詞:1-苯並三唑胺;1-氨基苯並三唑;1-氨基苯並三氮唑

CBNumber:CB9185384

分子式:C6H6N4

分子量:134.14

MOL File:1614-12-6.mol

1-氨基苯並三唑化學性質

熔點:81-84°C(lit.)

水溶解性:slightly soluble

CAS 資料庫:1614-12-6(CAS DataBase Reference)

熔點: 81-84°C(lit.)

熔點:81-84°C(lit.)

水溶解性: slightly soluble

水溶解性:slightly soluble

CAS 資料庫: 1614-12-6(CAS DataBase Reference)

CAS 資料庫:1614-12-6(CAS DataBase Reference)

安全信息

危險品標誌:Xi

危險類別碼:36/37/38

安全說明:26-36-37/39

WGK Germany:3

Hazard Note:Irritant

危險品標誌: Xi

危險品標誌:Xi

危險類別碼: 36/37/38

危險類別碼:36/37/38

安全說明: 26-36-37/39

安全說明:26-36-37/39

WGK Germany: 3

WGK Germany:3

Hazard Note: Irritant

Hazard Note:Irritant

ABT[一種化學品，細胞色素酶抑制劑]

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