人物簡介
女,1977.1出生,微生物與生化藥學博士,副教授.現主要從事微生物和生物製藥的教學和科研工作,研究方向,天然產物的分離純化,藥物治療學的機理研究,與糖尿病有關的藥理學試驗方法和代謝調控機制基本研究工作,對以疾病動物模型為實驗對象的基礎藥物治療學研究有著豐富的實踐經驗。
科研項目
1. 鯊肝S-8300防治糖尿病作用機制及其基因克隆表達,國家自然科學基金資助,批准號30701036
2. 鯊魚肝低分子多肽抗糖尿病活性物質研究,編號211032,中國藥科大學引進人才啟動基金資助
目前主要參與科研項目
1. Ⅰ類抗肝炎新藥鯊肝刺激物質HSS的臨床前研究,國家海洋863計畫資助,批准號. 2005AA624090
2. 三明治式抗腫瘤基因靶向載體技術的研究,國家自然科學基金資助,批准號30672548
3. 重組水蛭素III的新用途與新劑型研究,教育部博士學科點專項基金,批准號20040316005
4. 鯊肝HSS的一級結構、基因克隆與防治肝炎的作用機制,國家自然科學基金資助,批准號. 30171103
論文著述
1. Qian Sheng Pan, Zhi Ping Fang andFeng Jie Huang. Identification, localization and morphology of APUD cells in gastroenteropancreatic system of stomach-containing teleosts. World Journal of Gastroenterology, 2000; 6(6): 842-847
2.FANG Zhi-ping, PAN Qian-sheng, HUANG Feng-jie, LUO Li-ting and HEJie STUDIES ON histology AND SCANNING ELECTRON MICROSCOPE OF digestive TRACT OF CHINESE mitten-HANDED CRAB (ERIOCHEIRSINENSIS). ACTA HYDROBIOLOGICA SINICA,2002; 26(2): 136-141
2. Lü Zheng-Bing, HUANG Feng-Jie, LI Qian, YE Bo-Ping, WU Wu-Tong. Protective Effects of Shark Stimulator Substance (sHSS) against Acute Hepatic Injury Induced by APP in Mice. ACTA BIOCHIMICA et BIOPHYSICA SINICA, 2003; 35(11): 1051
3.HUANG Feng-jie,LI Qian, Lv Zheng-bing,etal. Protective effect of peptide S-8300 from shark liver on acute liver Injury in mice.Chinese Journal of Marine Medicines,2004:23(1):17-20
4. HUANG Feng-jie, WU Wu-tong. Study on Immunoloregulation Effect of Peptide S-8300 from Shark Liver. Chinese Journal of Natural Medicines,2005,3(2):121-123
5.ZHANG Liang, WEI Li-Jun, HUANG Feng-Jie, WU Wu-Tong. Effect of a Proposed Lyoprotectant on the Cytotoxin ACTX-6 Purified from Snake Venom. Journal of China Pharmaceutical University, 2005(2):183
6.Fengjie Huang, Wutong, Wu. Antidiabetic effect of a new peptide from squalus mitsukurii liver (S-8300) in Alloxan-induced diabetes. Clinical and Experimental Pharmacology and Physiology, 2005, 32: 521-525.ISSN:0305-1870
7. ZHANG Liang, WEI Li-Jun,HUANG Feng-Jie, WU Wu-Tong. Effect of a Proposed Lyoprotectant on the Cytotoxin ACTX-6 Purified from Snake Venom. Journal of China Pharmaceutical University, 2005(2):183
8.Fengjie Huang, Wutong, Wu. Antidiabetic effect of a new peptide from squalus mitsukurii liver (S-8300) in Streptozotocin-induced diabetes. Journal of Pharmacy and Pharmacology, 2005,57: 1575-1580. ISSN: 0022-3573
9. Feng-Jie Huang,Zheng-Bing Lv, Qian Li, Li-Jun Wei,Liang Zhang, Wu-Tong Wu. Study on Hepatoprotective Effect of Peptide S-8300 from Shark Liver. World Journal of Gastroenterology, 2005;11(12):1809-1812; ISSN 1007-9327
10.HUANG Feng-Jie, WU Wu-Tong. Development and Market of Chinese Biopharmaceutical Industry. Progress in Pharmaceutical Science. 2006,30(4):185-191
11.HUANG Feng-Jie, HE Shu-Ying,WU Wu-Tong. Discussion on the Necessity of the Name Change from Microbiology&Biochemical Pharmacy to Biophamaceutical Sciences.Pharmaceutical Education,2006,22(5):14-18
12. WU Wu-Tong, HUANG Feng-Jie. Advances in biopharmaceutical technology in china. Chapter 2and Chapter 20, September, 2006, Society for industrial microbiology and BioPlan Associates, Inc.
13.SONG Li-Na,HUANG Xiao-Dong,LEI Hong,LI Qian,OU Yu, HUANG Feng-Jie,WU Wu-Tong. Hepatocyte Proliferation and Damaged B-cell Protective Effect of a New Hepatocyte Stimulate Peptide(sHSP)from Shark Liver.Chin J Nat Med,2007,15 (14):306-311
14. HUANG Feng-Jie, QIAN Jing, WU Wu-Tong. Study on Anti-apoptosis of S-8300 in alloxan-diabetes. CHINESE JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS, 2007,9(12):993-997
15 HUANG Feng-Jie, WU Wu-Tong. Study on the effect of anti-diabetes and cell protection of a new peptide S-8300. CHINESE JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS,2007,11(12):1283-1287
16. HUANG Feng-jie,WU Wu-tong. Study on hypoglycemic mechanism of S-8300 inalloxan-diabete. CHINESE JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS,2008,13(5):494-498
17. LV Li-li, HUANG Feng-jie, WU Wu-tong. The Effect of secretory Recombinant Shark Hepatic Active Proteinon the Hepatic Glucokinase in Vitro. Pharmaceutical Biotechnology,2008,15(6):439-443(Correspondence)
18.JI Jing-xian, QIAN Jing, HUANG Feng-jie, WU Wu-tong, GAO Xiang-dong. Study on the active principles and pharmacological actions of hairy antler. Chinese Journal of Biochemical Pharmaceutic, 2009,30(2):141-143
19. Fengjie Huang and Wutong Wu. Study on the antidiabetic mechanism of a shark liver peptide,S-8300, in alloxan-induced diabetes. Journal of Pharmacy and Pharmacology,2009; 61: 789–794
20. Huang F, Wu W. Purification and characterization of a new peptide (S-8300) from shark liver. J Food Biochem (in press).
專利成果
吳梧桐,黃鳳傑. 一種新的鯊肝活性肽、其製備方法及其治療用途,中國發明專利. 專利號: ZL200510037679.2
吳梧桐,黃鳳傑,錢璟,吉靜嫻. 一種源自鹿花盤的多肽、其製法及其防治糖尿病的用途.申請號: 200810234865.9,公開日:2009.04.08