個人簡歷
男,博士,副教授。2005年4月畢業於上海交大生命學院生化與分子生物學專業,獲理學博士學位,同年留校工作,07年12月起擔任副教授。目前主要從事抗生素合成等微生物次級代謝的分子調控機理與代謝工程、微生物活性物質的基礎及套用等方面的研究。作為負責人主持完成863探索導向課題(2007AA02Z215)、國家自然科學基金(30800009)各一項。相關研究成果在Journal ofbacteriology、Gene、Journal of Biotechnology等期刊上發表SCI收錄學術論文20多篇。參與研究的“微生物源農藥申嗪黴素”項目獲得2007年度上海市科技進步一等獎、2011年度高等學校科技進步二等獎。2008年,入選上海交通大學晨星青年學者獎勵計畫與上海高校選拔培養優秀青年教師。參與編寫全國工程碩士核心教材1本,《基因工程:原理、方法與套用》(清華大學出版社,2008年)。
研究方向
(1)抗生素合成等微生物次級代謝的分子調控機理與代謝工程研究;
(2)微生物活性物質的基礎及套用研究
發表論文
[1] Wang GH 1, huang XQ 1, *, Li SN, Huang JF, Wei X, Li YQ, Xu YQ*. (2012) The RNA chaperone Hfq regulates antibiotic biosynthesis in the rhizobacterium Pseudomonas aeruginosa M18. Journal of Bacteriology (In press) (*Corresponding authors, 1Co-first authors)
[2] Wu DQ, Ye J, Ou HY, Wei X, Huang XQ, He YW, Xu YQ (2011) Genomic analysis and temperature-dependent transcriptome profiles of the rhizosphere originating strain Pseudomonas aeruginosa M18. BMC Genomics 12:438.
[3] Li YQ, Du XL, Lu ZJ, Wu DQ, Zhao YL, Ren B, Huang JF, Huang XQ, Xu YH, Xu YQ (2011) Regulatory Feedback Loop of Two phz Gene Clusters through 5 '-Untranslated Regions in Pseudomonas sp M18. PLoS One 6: e19413.
[4] Lu JS 1, Huang XQ 1, *, Li K, Li SN, Zhang MY, Wang Y, Jiang HX, Xu YQ* (2009) LysR family transcriptional regulator PqsR asRepressorof pyoluteorin biosynthesis and activator of phenazine-1-carboxylic acid biosynthesis in Pseudomonas sp. M18. Journal of Biotechnology 143(1): 1-9. (*Corresponding authors, 1Co-first authors)
[5] Lu JS, Huang XQ *, Zhang MY, Li SN, Jiang HX, Xu YQ (2009) The distinctquorumsensing hierarchy of las and rhl in Pseudomonas sp. M18. Current Microbiology 59(6): 621-627 (*Corresponding authors)
[6] Huang JF, Xu YQ, Zhang HY, Li YQ, Huang XQ, Ren B, Zhang XH (2009) Temperature-dependent expression of phzM with its regulatory genes lasI and ptsP in rhizosphere isolated Pseudomonas sp. strain M18. Applied and Environmental Microbiology 75(20): 6568-6580.
[7] Huang XQ, Zhang XH, Xu YQ (2008) PltR expression modulated by the global regulators GacA, RsmA, LasI and RhlI in Pseudomonas sp. M18. Research in Microbiology 159(2): 128-136.
[8] Huang XQ, Zhang XH, Xu YQ (2008) Positive regulation of pyoluteorin biosynthesis in Pseudomonas sp. M18 by quorum-sensing regulator VqsR. J Microbiol Biotechnol 18: 828-836.
[9] Yan A, Huang XQ, Liu HM, Dong DX, Zhang DB, Zhang XH, Xu YQ (2007) An rhl-like quorum-sensing system negatively regulates pyoluteorin production in Pseudomonas sp. M18. Microbiology-SGM 153(1): 16-28.
[10] Huang XQ, Yan A, Zhang XH, Xu YQ (2006) Identification and characterization of a putative ABC transporter PltHIJKN required for pyoluteorin production in Pseudomonas sp. M18. Gene 376(1): 68-78.
[11] Huang XQ, Zhu DH, Ge YH, Hu HB, Zhang XH, Xu YQ (2004) Identification and characterization of pltZ, a gene involved in the repression of pyoluteorin biosynthesis in Pseudomonas sp. M18. FEMS Microbiol Lett 232: 197-202.