基本信息
性 別: 男
職 稱: 研究員
簡歷
2005年在中國科學院上海藥物研究所獲得有機化學博士學位。2005-2006年在美國猶他大學從事博士後研究,2006-2010年在美國馬里蘭大學任研究助理,2010-2012年在美國馬里蘭大學任助理教授。2012年入選第三批“青年千人計畫”，受聘於上海藥物研究所，擔任課題組長。
研究方向
發展和運用新穎的糖蛋白/糖肽/糖複合物合成方法和功能性糖組學分析方法，在化學和生物學交叉領域，具體在蛋白糖基化與重大疾病的關聯、糖參與的粘附GPCR信號介導、新型糖複合物在生物醫藥中的套用、基於糖結構的藥物及疫苗研發等方向上深入探討研究。
職務
中科院上海藥物研究所研究組長；博士生導師
專家類別
研究員；青年千人
科研成果
1．發展和完善了一套酶催化糖蛋白合成方法並套用於各種功能性糖蛋白的修飾改造
2．完成了單克隆抗體藥物的糖基化最佳化和ADC藥物的最佳化與篩選
承擔科研項目情況
1．NSFC面上項目，酶催化合成多糖作為多功能藥物載體的研究，項目負責人，2014.01-2017.12
2．上海市浦江人才計畫，蛋白糖基化與疾病，項目負責人，2014.01-2015.12
3．中組部青年千人計畫，蛋白糖基化結構與功能 項目負責人，2013.01-2015.12
社會任職
2008- Member, American Chemical Society
2008- Member, Sigma Xi, the Scientific Research Society
2011- Editorial Board, Medicinal Chemistry: Current Research
2011- Editorial Board, Virology & Mycology
2011- Reviewer, Journal of the American Chemical Society
2008- Reviewer, Chemical Communications
2008- Reviewer, Organic and Biomolecular Chemistry
2008- Reviewer, Journal of Organic Chemistry
2008- Reviewer, Journal of Combinatorial Chemistry
2008- Reviewer, ChemMedChem
2008- Reviewer, European Journal of Organic Chemistry
2008- Reviewer, Carbohydrate Chemistry
2010- Reviewer, New Journal of Chemistry
獲獎及榮譽
2001年，中國藥學會年會優秀論文一等獎；
2010年，美國馬里蘭大學“教員發展基金”；
2012年，中組部“青年千人計畫”。
代表論著
Amin, M.N.; McLellan, J.S.; Huang, W.; Orwenyo, J.; Burton, D.R.; Koff, W.C.; Kwong, P.D.; Wang, L.X. (2013) “Synthetic glycopeptides reveal the glycan specificity of HIV-neutralizing antibodies.” Nat. Chem. Biol. In press
Huang, W.; Giddens, J.; Fan, S.-Q.; Toonstra, C.; and Wang, L.-X. (2012) “Chemoenzymatic Glycoengineering of Intact IgG Antibodies for Gain of Functions.” J. Am. Chem. Soc
Zou, G.; Ochiai, H.; Huang, W.; Yang, Q.; Li, C.; and Wang, L.-X. (2011) “Chemoenzymatic Synthesis and Fc Receptor Binding of Homogeneous Glycoforms of Antibody Fc Domain. Presence of a Bisecting Sugar Moiety Enhances the Affinity of Fc to FcIIIa Receptor.” J. Am. Chem. Soc
Amin, M.; Huang, W.; Rahman, M.; Wang, L.-X. (2011) Convergent synthesis of homogeneous Glc1Man9GlcNAc2-protein and derivatives as ligands of molecular chaperones in protein quality control. J. Am. Chem. Soc.
Huang, W., Li, J., and Wang, L.X. (2011). Unusual transglycosylation activity of flavobacterium meningosepticum endoglycosidases enables convergent chemoenzymatic synthesis of core fucosylated complex N-glycopeptides. ChemBioChem
Schwarz, F., Huang, W., Li, C., Schulz, B.L., Lizak, C., Palumbo, A., Numao, S., Neri, D., Aebi, M., and Wang, L.X. (2010). A combined method for producing homogeneous glycoproteins with eukaryotic N-glycosylation. Nature Chem. Biol.
Huang, W.; Yang, Q.; Umekawa, M.; Yamamoto, K.; Wang, L.-X. (2010) Arthrobacter Endo-beta-N-acetylglucosaminidase shows transglycosylation Activity on complex type N-glycan oxazolines. One-pot conversion of ribonuclease B to sialylated ribonuclease C. ChemBioChem
Huang, W., Li, C., Li, B., Umekawa, M., Yamamoto, K., Zhang, X., and Wang, L.X. (2009). Glycosynthases enable a highly efficient chemoenzymatic synthesis of N-glycoproteins carrying intact natural N-glycans. J. Am. Chem. Soc.,
Huang, W., Wang, D.N., Yamada, M, and Wang, L.X. (2009). Chemoenzymatic synthesis and lectin array characterization of a class of N-glycan clusters. J. Am. Chem. Soc.
Ochiai, H., Huang, W., and Wang, L.X. (2008). Expeditious chemoenzymatic synthesis of homogeneous N-glycoproteins carrying defined oligosaccharide ligands. J. Am. Chem. Soc.
Huang, W., Zhang, H., Dayrazou, F., Kutateladze, T.G., Shi, X., Gozani, O., and Prestwich, G.D. (2007). Stabilized phosphatidylinositol-5-phosphate analogues as ligands for the nuclear protein ING2: chemistry, biology and molecular modeling. J. Am. Chem. Soc..
