![黃民[中山大學藥學院院長]](/img/3/98d/nBnauM3X0AzMxcDOyMDM2kTO0UTMyITNykTO0EDMwAjMwUzLzAzL3QzLt92YucmbvRWdo5Cd0FmLwE2LvoDc0RHa.jpg "黃民[中山大學藥學院院長]")
個人歷程
1979.09——1983.06 上海醫科大學本科學習，獲學士學位；
1983.06——1989.11 中山醫科大學臨床藥理教研室助教；
1985.09——1988.06 中山醫科大學藥理學研究生，獲碩士學位；
1989.12——1994.11 中山醫科大學臨床藥理教研室講師；
黃民教授1994.10——1998.08 香港大學獲藥理學博士研究生，1998年獲博士學位（Ph.D.）；
2000.05——2000.10 香港中文大學藥劑學院訪問教授；
1994.12——2000.11 中山醫科大學臨床藥理教研室副教授；
2000.12——現在 中山大學臨床藥理研究所教授；
2002.06——現在 中山大學藥學院常務副院長，中山大學臨床藥理研究所所長、教授。
研究興趣
主要研究興趣為藥理學、臨床藥理學、藥物代謝以及遺傳藥理學與藥物基因組學。從事臨床藥理學的教學與科研工作。在科研中，發現了硫嘌呤甲基轉移酶分布在中國人群中與白種人群中分布的不同；還發現了在體外，接近生理濃度的17β-雌二醇與內源性抗氧化劑的協同作用，可保護LDL不被氧化，這一發現解釋了長期困擾大家的17β-雌二醇體內體外結果不一致的。
近年來對相關藥物代謝酶和轉運蛋白及其上游調控基因的基因多態性及其與臨床藥物療效及不良反應相關性有較為深入的研究；同時在體外細胞、分子水平，在體或離體器官灌流水平，計算機模擬水平發展了一系列的藥代動力學技術模型，並在中藥藥物代謝相互作用及其調控機制、臨床藥物相互作用預測、臨床合理用藥方面有較深入的探討。在國內外重要學術刊物，包括 Curr Drug Metab, J Pharmacol Exp Ther, Drug Metab Dispos, Pharm Res, Br J Clin Pharmacol, Eur J Pharm Sci, Int Immunopharmacol, Clin Chim Acta, Clin Pharmacokinet, J Mass Spectrom, Rapid Commun Mass Spectrom, J Pharm Biomed Anal, J Chromatogr B, Xenobiotica和 Invest New Drugs等發表論文 100余篇（其中被SCI收錄 90余篇），主編或參與出版了有關藥動學專著和教材 9部；已承擔國家“重大新藥創製”重大專項課題、國家自然科學基金、教育部985重點建設專項、省部重大項目等20多項的研究課題；作為負責人已主持完成近百個藥物（其中不少屬於國家一類、二類、三類新藥）的非臨床、臨床評價工作。
科研基金
01、回國人員科研啟動基金（國家教委，20萬，負責，1999）
02、生理濃度雌激素抗低密度脂蛋白氧化機理（中山醫科大學，1.5萬，負責，1999）
03、CMB基金校內分題（1.5萬，負責，1999）
04、 211工程重點學科建設4項（530萬，參與，1999）
05、 硫嘌呤甲基轉移酶在中國南方人群中的基因表型與硫嘌呤類用藥（廣東省高教廳，3萬，負責，2000 編號200032）
06、生理濃度雌激素抗低密度脂蛋白氧化機理（廣東省衛生廳，1萬，負責，2000 編號A2000139）。
07、 TPMT基因多態性與硫嘌呤類毒性和療效關係（國家自然科學基金，16萬，負責，2001 編號30171098）
08、西藏林芝產丹參的綜合性開發研究 （廣州市重大項目，100萬，參與，2002年 編號2002Z1-E5011）
09、 臨床試驗關鍵技術及平台研究（863）（國家科技部，150萬，分題負責，2002年）
10、套用硫嘌呤甲基轉移酶基因型預測嘌呤類藥物毒性療效 (廣東省自然科學基金重點項目，15萬，負責，2003年)
11、中華民族硫嘌呤甲基轉移酶基因多態性研究（教育部博士點基金，6萬圓，2003年，項目編號20030558081）
12、廣州新藥臨床前評價研究技術平台（廣州市重大項目，500萬圓，2004年，項目編號2004Z1-E4051）
13、創新藥物研究篩選與評價科技創新平台建設（教育部II期985重點建設專項，2200萬圓，2005年，平台負責人）
14、 器官移植患者相關基因單倍型多態性與免疫抑制劑個體化作用（廣東省科技計畫項目基金，4 萬圓，2007年，項目編號2007B031511001）
15、 相關代謝酶基因多態性與環磷醯胺在SLE病人中療效和不良反應相關性研究（國家自然科學基金，32 萬圓，2009.01～2011.12，項目編號30873124）
16、新藥臨床評價研究技術平台.（國家“重大新藥創製”科技重大專項1200 萬圓，負責166萬圓，2008.01～2010.12，項目編號2008ZX09312）
17、多基因 “網路”調控作用下環孢素/他克莫司個體化用藥研究.（國家自然科學基金，37萬圓，2011.01～2013.12，項目編號81072708）
18、個體化用藥相關重要生物技術標誌物及其新型檢測試劑盒研發關鍵技術（十二五重大專項，500萬圓，2012.01~2015.12，項目編號2012ZX09506001-004）
19、紅豆杉口服抗腫瘤5類新藥的開發研究（廣東省重大科技專項，150萬圓2013.01-2014.04，項目編號2012A080202013）
20、基於藥物基因組學及表觀遺傳調控的環孢素/他克莫司個體化用藥研究(（國家自然國際合作項目，280萬圓，2014.01-2018.12，項目編號81320108027）
個人成績
發表的論文和著作（1995年以來）
01、龍啟才，王建華，周晏，黃民，趙香蘭:七年制學生和研究生學習能力的比較研究 醫學教育1995;9:18－21
02、何潔英，黃民，趙香蘭: 環丙沙星三種製劑在62名健康志願者體內動力學研究 中國抗生素雜誌1995;20:105-109
03、何潔英，黃民，趙香蘭：6種頭孢克肟製劑的人體藥動學特徵及比較 中國新藥雜誌 1996；5(2)：11-14
04、蔡葵花，譚丙炎，李章旺，陳紅英，黃民，趙香蘭，姜文奇：氣質聯用(GC/MS)研究嗎啡控釋片的藥代動力學 藥物分析雜誌 1996；16(2)：89-92
05、蔡葵花，譚丙炎，馮智英，李章旺，黃民，趙香蘭：人體血中美百樂鎮濃度的氣相色譜/質譜測定法 色譜 1996；14(2)：121-123
06、Min Huang， Susan W.S. Leung， Jiping Li， Kathryn C.B. Tan and Ricky Y.K. Man. Effect of oxidized low density lipoprotein from diabetic patients on endothelium-dependent relaxation. Journal of Molecular and Cellular Cardiology 1997;29(2):A181
07、 Min Huang， Y.L. Lau and M.Y. Chan. Interethnic difference in thiopurine methyltransferase (TPMT) activity in Chinese and Caucasian populations in Hong Kong. IXth Southeast Asian Drug Metabolism Workshop. April 13-15， 1998. Kuala Lumpur， Malaysia.
08、Jiping Li， Min Huang， Hwee Teoh and Ricky Y.K. Man. Interations between Panax quinquefolium saponin and vitamin C and vitamin E are observed in vitro. Journal of Molecular and Cellular Cardiology 1998;30(7):A261
09、Kuei F. Ting， Jiping Li， Min Huang， Micheal H.W. Koon， Patrica Sullivan， Karmin O and Ricky Y.K. Man. Impairment of endothelium-dependent relaxation by oxidized high density lipoprotein and effect of 17β-estradiol. Journal of Molecular and Cellular Cardiology 1998;30(7):A259
10、Jiping Li， Min Huang and Ricky Y.K. Man. Protective effects of Panax quinquefolium saponin on oxidized low density lipoproteins. Naunyn-Schmiedeberg’s Archives of Pharmacology 1998;358(1) (Suppl 1):R227
11、Min Huang， Jiping Li， Hwee Teoh and Ricky Y.K. Man. Low concerntrations of 17β-estradiol may potentiate antioxidant effects of vitamin C and vitamin E on low low density lipoprotein oxidation. Naunyn-Schmiedeberg’s Archives of Pharmacology 1998;358(1) (Suppl 1):R211
12、Jiping Li， Min Huang， Hwee Teoh and Ricky Y.K. Man. Panax quinquefolium saponin protects low density lipoproteins from oxidation. Life Sciences 1999;64(1):53-64
2006年至今發表論文：
1.Jiang Yi-ming, Fan Xiao-mei, Wang Ying, Chen Pan, Zeng Hang, Tan Hua-sen, Gonzalez Frank J, Huang Min, Bi Hui-chang*. Schisandrol B Protects Against Acetaminophen-Induced Hepatotoxicity by Inhibition of CYP-Mediated Bioactivation and Regulation of Liver Regeneration. Toxicol Sci. 2015 Jan;143(1):107-15.
2.Li Jia, Shen Feihai, Guan Cuiwen, Wang Wen-wen, Sun Xiaozhe, Fu Xinlu, Huang Min, Jin Jing*, Huang Zhi-ying*. Activation of Nrf2 protects against triptolide-induced hepatotoxicity.PLoS One. 2014 Jul 2;9(7):e100685.
3.Fan Xiao-mei, Chen Pan, Jiang Yi-ming, Wang Ying, Tan Hua-sen, Zeng Hang, Wang Yong-tao, Qu Ai-juan, Gonzalez Frank J,Huang Min, Bi Huichang*. Therapeutic Efficacy of Wuzhi Tablet (Schisandra Sphenanthera Extract) on Acetaminophen-induced Hepatotoxicity through a Mechanism Distinct from N-acetylcysteine. Drug Metab Dispos. 2015 Mar;43(3):317-24.
4.Fan Xiao-mei, Jiang Yi-ming, Wang Ying, Tan Hua-sen, Zeng Hang, Wang Yong-tao, Chen Pan, Qu Ai-juan, Gonzalez Frank J,Huang Min, Bi Hui-chang*. Wuzhi tablet (Schisandra Sphenanthera extract) protects against acetaminophen-induced hepatotoxicity by inhibition of CYP-mediated bioactivation and regulation of NRF2-ARE and p53/p21 pathways. Drug Metab Dispos. 2014 Dec;42(12):1982-90.
5.Li Mei-mei, Wang Wei-peng, Wu Wen-juan,Huang Min*, Yu Ai-Ming*.Rapid production of novel pre-microRNA agent hsa-mir-27b in Escherichia coli using recombinant RNA technology for functional studies in mammalian cells. Drug Metab Dispos. 2014 Nov;42(11):1791-5.
6.Fan Xiao-mei, Chen Pan, Tan Hua-sen, Zeng Hang, Jiang Yi-ming, Wang Ying, Wang Yong-tao, Hou Xiang-yu, Bi Hui-chang,Huang Min*. Dynamic and coordinated regulation of KEAP1-NRF2-ARE and p53/p21 signaling pathways is associated with acetaminophen injury responsive liver regeneration. Drug Metab Dispos. 2014 Sep;42(9):1532-9.
7.Yu Tao, Wang Yong-tao, Chen Pan, Li Yu-hua, Chen Yi-xin, Zeng Hang, Yu Ai-ming,Huang Min,Bi Hui-chang*. Effects of Nicotinamide N-methyltransferase on PANC-1 cells proliferation, metastatic potential and survival under metabolic stress. Cellular Physiology and Biochemistry. 2014 Dec 02, accepted.
8.Ou Zhi-min, Jiang Meng-xi, Hu Bing-fang, Huang Yi-xian, Xu Mei-shu, Ren Song-rong, Li Song, Liu Su-huan, Xie Wen*,Huang Min*. Transcriptional regulation of human hydroxysteroid sulfotransferase SULT2A1 by LXRα.Drug Metab Dispos. 2014 Oct;42(10):1684-9.
9.Chen Pan, Zeng Hang, Wang Yong-tao, Fan Xiao-mei, Xu Chen-shu, Deng Rong-rong, Zhou Xu-nian, Bi Huichang*,Huang Min*. Low dose of oleanolic acid protects against lithocholic acid-induced cholestasis in mice: potential involvement of nuclear factor-E2-related factor 2-mediated upregulation of multidrug resistance-associated proteins.Drug Metab Dispos. 2014 May;42(5):844-52.
10.Qin Xiao-ling, Chen Xiao, Wang Ying, Xue Xin-ping, Wang Ying, Li Jia-li, Wang Xue-ding, Zhong Guo-ping, Wang Chang-xi, Yang Hui,Huang Min,Bi Hui-chang*. In vivo to in vitro effects of six bioactive lignans of Wuzhi tablet (Schisandra sphenanthera extract) on the CYP3A/P-glycoprotein-mediated absorption and metabolism of tacrolimus.Drug Metab Dispos. 2014 Jan;42(1):193-9.
11.Li Yu-hua, Huang Ling, Zeng Xue-zhen, Zhong Guo-ping, Ying Meng-jia,Huang Min,Bi Hui-chang*. Down-regulation of P-gp expression and function after Mulberroside A treatment: potential role of protein kinase C and NF-kappa B.Chem Biol Interact. 2014 Apr 25;213:44-50.
12.Wang Ying, Jiang Yi-ming, Wang Yong-tao, Kang Jun-wei, Yu Tao, Zhao Hai-yu, Bian Bao-lin,Huang Min,Bi Hui-chang*. Inhibiton of cytochrome P450 isoenzymes and P-gp activity by multiple extracts of Huang-Lian-Jie-Du decoction. J Ethnopharmacol. 2014 Oct 28;156:175-81.
13.Qin Xiao-ling, Chen Xiao, Zhong Guo-ping, Fan Xiao-mei, Wang Ying, Xue Xin-ping, Wang Ying,Huang Min, Bi Hui-chang*. Effect of Tacrolimus on the pharmacokinetics of bioactive lignans of Wuzhi tablet (Schisandra sphenanthera extract) and the potential roles of CYP3A and P-gp.Phytomedicine. 2014 Apr 15;21(5):766-72.
14.Jin Jing, Xiong Tian-qin, Hou Xiang-yu, Sun Xiao-zhe, Liao Jia-yi, Huang Zhi-ying,Huang Min, Zhao Zhong-xiang*. Role of Nrf2 activation and NF-κB inhibition in valproic acid induced hepatotoxicity and in diammonium glycyrrhizinate induced protection in mice. Food Chem Toxicol. 2014 Nov;73:95-104.
15.Hong Lan, Xu Cong, ONeal Stefanie, Bi Hui-chang,Huang Min, Zheng Wei, Zeng Su. Roles of P-glycoprotein and multidrug resistance protein in transporting para-aminosalicylic acid and its N-acetylated metabolite in mice brain. Acta Pharmacol Sin. 2014 Dec;35(12):1577-85.
16.Li Yu-hua, Bi Hui-chang, Huang Ling, Jin Jing, Zhong Guo-ping, Zhou Xu-nian,Huang Min*. Phorbol 12-myristate 13-acetate inhibits P-glycoprotein-mediated efflux of digoxin in MDCKII-MDR1 and Caco-2 cell monolayer models.Acta Pharmacol Sin. 2014 Feb;35(2):283-91.
17.Chen Xin-meng, Jin Jing, Chen Yao-bin, Peng Ling-ling, Zhong Guo-ping, Li Jia-li, Bi Hui-chang, Cai Ye-feng,Huang Min*.Effect of scutellarin on the metabolism and pharmacokinetics of clopidogrel in rats. Biopharm Drug Dispos. 2014 Sep 25.
18.Cai Yi-ke, Xu Chen-shu, Chen Pei-yi, Hu Jin-qing, Hu Rong,Huang Min, Bi Hui-chang*. Development, validation, and application of a novel 7-day Caco-2 cell culture system.J Pharmacol Toxicol Methods. 2014 Sep-Oct;70(2):175-81.
19.Deng Rong-rong, Xu Chen-shu, Chen Xiao, Chen Pan, Wang Yong-tao, Zhou Xu-nian, Jin Jing, Niu Lu, Ying Meng-jia,Huang Min, Bi Hui-chang*. Resveratrol suppresses the inducible expression of CYP3A4 through the pregnane X receptor. J Pharmacol Sci. 2014;126(2):146-54.
20.Qin Xiao-ling, Chen Xiao, Wang Ying, Xue Xin-ping, Wang Ying, Li Jia-li, Wang Xue-ding, Zhong Guo-ping,Huang Min*, Bi Hui-chang*. In vivo to in vitro effects of six bioactive lignans of Wuzhi tablet (Schisandra Sphenanthera extract) on the CYP3A/P-gp mediated absorption and metabolism of tacrolimus. Drug Metabolism and Disposition. 2014;42(1):193-199
21.Qin Xiao-ling, Chen Xiao*, Zhong Guo-ping, Fan Xiao-mei, Wang Ying, Xue Xin-ping, Wang Ying,Huang Min, Bi Hui-chang*. Effect of Tacrolimus on the pharmacokinetics of bioactive lignans of Wuzhi Tablet (Schisandra sphenanthera extract) and the potential roles of CYP3A and P-gp. Phytomedicine. 2014 Apr 15;21(5):766-72
22.Ou Zhi-min , Shi Xiong-jie , Richard K. Gilroy, Levent Kirisci, Marjorie Romkes, Caitlin Lynch,Wang Hong-bing ,Xu Mei-shu ,Jiang Meng-xi ,Ren Song-rong , Roberto Gramignoli, Stephen C. Strom,Huang Min* , Xie Wen* . Regulation of the Human Hydroxysteroid Sulfotransferase (SULT2A1) by ROR alpha and ROR gamma and Its Potential Relevance to Human Liver Diseases. Molecular Endocrinology. 2013;21(1):106-115
23.Qin Xiao-ling, Yu Tao, Li Lin-jue, Wang Ying, Gu Hao-min, Wang Yong-tao,Huang Min,Bi Hui-chang*. Effect of long-term co-administration of Wuzhi tablet(Schisandra sphenanthera extract) and prednisone on the pharmacokinetics of tacrolimus. Phytomedicine. 2013;20(3-4);375-379
24.Huang Ling,Huang Min, Li Yu-hua, Li Rui-ming, Zeng Yu, Kuang Shao-yi, Zhang Li, Wang Yi-tao, Bi Hui-chang*. Up-regulatation of CYP3A expression through pregnent X receptor by praeruptorin D isolated from Peucedanum praeruptorum Dunn. Journal of Ethnopharmacology .2013;148(2):596-602
25.Chen Si-yang, Li Jia-li , Meng Fan-hang, Wang Xue-ding, Liu Tao, Li Jun, Liu Long-shan, Fu Qian,Huang Min*,Wang Chang-xi*. Individualization of tacrolimus dosage basing on cytochrome P450 3A5 polymorphism - a prospective, randomized, controlled study. Clin Transplant.2013;27(3):272-281
26.Li Yu-hua, Bi Hui-chang, Huang Ling, Jin Jing, Zhong Guo-ping*,Zhou Xu-nian,Huang Min*.Phorbol 12-myristate 13-acetate inhibits P-glycoprotein-mediated efflux of digoxin in MDCKII-MDR1 and Caco-2 cell monolayer models. Acta Pharmacologica Sinica.2013 Dec 23. doi: 10.1038/aps.2013.157.
27.Zhang Yu, Li Jia-li ,Fu Qian, Wang Xue-ding, Liu Long-shan, Wang Chang-xi, Xie Wen, Chen Zhuo-jia, Shu Wen-ying,Huang Min*. Associations of ABCB1, NFKB1, CYP3A, and NR1I2 polymorphisms with cyclosporine trough concentrations in Chinese renal transplant recipients. Acta Pharmacologica Sinica . 2013;34(4):555-560
28.Huang Ling, Bi Hui-chang, Li Yu-hua, Zhang Jun-qing, Kuang Shao-yi, Zhang Li, Wang Yi-tao,Huang Min*. Regulation of Human Pregnane X Receptor and its Target Gene Cytochrome P450 3A by Praeruptorin A Isolated from the Herbal Medicine Peucedanum praeruptorum. Planta Medica.2013;79(16):1509-1515
29.Zhou Xu-nian, Bi Hui-chang*, Jin Jing, Niu Lu, Cai Da-ke, Deng Rong-rong, Li Yu-hua, Wang Yong-tao,Huang Min*,Effects of praeruptorin A and praeruptorin C, a racemate isolated from Peucedanum praeruptorum Dunn, on MRP2 through CAR pathway. Planta Med. 2013 ;79(17):1641-7
30.Jin Jing, Cai Da-ke, Bi Hui-chang, Zhong Guo-ping, Zeng Hang, Gu Lian-quan,Huang Zhi-ying,Huang Min*. Comparative pharmacokinetics of paclitaxel after oral administration of Taxus yunnanensis extract and pure paclitaxel to rats. Fitoterapia .2013;90:1-9
31.Xue Xin-ping, Qin xiao-ling, Xu chen-shu, Zhong Guo-ping, Wang Ying,Huang Min,Bi Hui-chang*. Effect of Wuzhi Tablet (Schisandrasphenantheraextract) on the Pharmacokinetics of CyclosporinA in Rats. Phytotherpy Research. 2013;27(8):1255-1259
32.Chen Si-yang, Li Jia-li , Meng Fan-hang, Wang Xue-ding, Liu Tao, Li Jun, Liu Long-shan, Fu Qian,Huang Min*, Wang Chang-xi*. Individualization of tacrolimus dosage basing on cytochrome P450 3A5 polymorphism - a prospective, randomized, controlled study. Clinical Transplantation . 2013;27(3):272-281
33.Li Yu-hua, Bi Hui-chang, Zhong Guo-ping, Huang Ling, Li Ge-lin, Xia Yan-zhe, Chen Xiao,Huang Min*.Effect of Phorbol 12-Myristate 13-Acetate on Function and Gene Expression of P-Glycoprotein in Adriamycin-Resistant K562/ADM Cells. Pharmacology.2013;92(3-4):121-130
34.Deng Xiao-ying, Wang Chang-xi, Wang Xue-ding, Bi Hui-chang, Chen Xiao, Li Jia-li*,Huang Min*.Genetic polymorphisms of UGT1A8, UGT1A9, UGT2B7 and ABCC2 in Chinese renal transplant recipients and a comparison with other ethnic populations. Pharmazie. 2013 ;68(4):240-244.
35.Ding Liang, Zhang Fang-bin, Liu Hui, Gao Xiang, Bi Hui-chang, Wang Xue-ding, Chen Bai-li, Zhang Yu, Zhao Li-zi, Zhong Guo-ping, Hu Pin-jin, Chen Min-hu,Huang Min*.Hypoxanthine guanine phosphoribosyltransferase activity is related to 6-thioguanine nucleotide concentrations and thiopurine-induced leukopenia in the treatment of inflammatory bowel disease. Inflamm Bowel Dis. 2012;18(1):63-73.
36.Yuan Yue-mei, Gao Jing-wen, Zhan Shi, Huang Ping,Huang Min. Herb-drug pharmacokinetic interaction between radix astragali and pioglitazone in rats. Journal of Ethnopharmacology 2012;144(2):300–304.
37.Zeng Wu-tao, Zheng Qi-Shan,Huang Min,Cen Han-jing, Lai Yong, Ceng Wei-yan, Zhao Li-zi, Leng Xiu-yu. Genetic polymorphisms of VKORC1, CYP2C9, CYP4F2 in Bai, Tibetan. Chinese. Pharmazie. 2012;67(1): 69-73.
38.Lai Yong,Huang Min, Li Hui, Wang Xue-ding, Li Jia-li*. Distinct genotype distribution and haplotype profiles in MDR1 gene among Chinese Han, Bai, Wa and Tibetan ethnic groups. Pharmazie. 2012 ;67(11):938-41.
39.Chen Zhuo-jia, Wang Xue-ding, Wang Hong-sheng, Chen Shu-da, Zhou Lie-min, Li Jia-li , Shu Wen-ying , Zhou Jue-qian , Fang Zi-yan, Zhang Yu,Huang Min *.Simultaneous determination of valproic acid and 2-propyl-4-pentenoic acid for the prediction of clinical adverse effects in Chinese patients with epilepsy. Seizure.2012; 21(2): 110–117.
40.Jin Jing, Liu Jing, Chen Jiang-ying, Zhao Li-zi, Ma Zhong-fu, Chen Xiao,Huang Min, Zhong Guo-ping *. Bioequivalence evaluation of 2 tablet formulations of entecavir in healthy chinese volunteers: a single-dose, randomized-sequence, open-label crossover study. Arzneimittelforschung. 2012;62(3):113-116.
41.Shu Wen-ying, Wang Xue-ding, Yang Xiu-yan, Liang Liu-qin, Li Jia-li, Chen Zhuo-jia, Chen Xiao, Jin Jing, Li Rui-ming, Zhao Li-zi,Huang Min*.Simultaneous determination of cyclophosphamide and 4-hydroxycyclophosphamide in human plasma by high-performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry – application to Chinese systemic lupus erythematosus patients. Clin Chem Lab Med 2011;49(12):1-9.
42.Chen He-Ping, He Ming*, Mei Zhu-Jun, Huang Qi-Ren, Peng Wei-jie,Huang Min**. Anion Exchanger 3 Is Required for Sasanquasaponin to Inhibit Ischemia/Reperfusion-Induced Elevation of Intracellular Cl_ Concentration and to Elicit Cardioprotection. J Cell Biochem. 2011;112(10):2803–2812.
43.Chen Jiang-Ying, Wang Xue-Ding, Zhong Guo-Ping, Qin Xiao-Ling, Li Jia-Li, Huang Zhi-Ying, Zhu Xun, Li Meng-Feng,Huang Min.Development and validation of a highly rapid and sensitive LC–MS/MS method for determination of SZ-685C, an investigational marine anticancer agent, in rat plasma – Application to a pharmacokinetic study in rats. J Chromatogr B Analyt Technol Biomed Life Sci. 2011; 879(22):2127-2134.
44.Huang Ling, Bi Hui-chang, Liu Ya-he, Wang Yi-Tao, Xue Xin-Ping,Huang Min*.CAR-mediated Up-regulation of CYP3A4 Expression in LS174T Cells by Chinese Herbal Compounds. Drug Metab Pharmacokinet. 2011;26(4):331-340.
45.Xue Xin-ping,Huang Min, Xiao Huan-yu, Qin Xiao-ling, Huang Ling, Zhong Guo-ping, Bi Hui-chang ?. Rapid and simultaneous measurement of midazolam, 1_-hydroxymidazolam and digoxin by liquid chromatography/tandem mass spectrometry: Application to an in vivo study to simultaneously measure P-glycoprotein and Cytochrome P450 3A activity. J Pharm Biomed Anal. 2011;55(1):187-193.
46.Zhong Guo-Ping, Chen Jiang-Ying, Bi Hui-chang, Qin Xiao-Ling, DaiChang-liang, Liu Jing, Chen Xiao, Zeng Gui-xiong, Huang Zhi-Ying,Huang Min*. Determination of HS270, a new histone deacetylase inhibitor, in rat plasma by LC-MS/MS--application to a preclinical pharmacokinetic study. J Chromatogr B Analyt Technol Biomed Life Sci. 2011; 879(30):3452-3458.
47.Ding Liang, Zhang Fang-Bin, Liu Hui, Gao Xiang, Bi Hui-chang, Wang Xue-ding, Chen Bai-li, Zhang Yu, Zhao Li-zi, Zhong Guo-ping, Hu Pin-jin, Chen Min-hu,Huang Min.Hypoxanthine guanine phosphoribosyltransferase activity is related to 6-thioguanine nucleotide concentrations and thiopurine-induced leukopenia in the treatment of inflammatory bowel disease. Inflamm Bowel Dis. 2012;18(1):63-73.
48.Jin Jing, Bi Hui-chang, Hu Jin-qing, Zeng Hang, Zhong Guo-ping, Zhao Li-zi, Huang Zhi-ying,Huang Min*.Effect of Wuzhi Tablet (Schisandra sphenanthera extract) on the Pharmacokinetics of Paclitaxel in rats. Phytother Res. 2011;25(8):1250-1253.
49.Lai yong,Zhang Jing,Wang Yi-xi,Wang XD,Li JL,Wang YinHui,Zeng YanJun,Huang Min*. CYP3A5*3 and MDR-1 C3435T single nucleotide polymorphisms in six Chinese ethnic groups. Pharmazie 2011; 66 (2): 136-40.
50.Li Jia-li, Wang Xue-ding, Chen Si-yang, Liu Long-shan, Fu Qian, Chen Xiao,Teng Li-chen,Wang chang-Xi,Huang Min*. Effects of diltiazem on pharmacokinetics of tacrolimus in relation to CYP3A5 genotype status in renal recipients: from retrospective to prospective. Pharmacogenemics J. 2011;11(4):300-306.
51.Li Xin, Pan Yu-Zhuo, Gail M. Seigel, Hu Zi-Hua,Huang Min, Yu Ai-Ming *. Breast cancer resistance protein BCRP/ABCG2 regulatory microRNAs hsa-miR-328, -519c and -520h) and their differential expression in tem-like ABCG2+ cancer cells. Biochem Pharmacol.2011;81(6):783-792.
52.Alice C. Rodrigues, Li Xin, Laura Radecki, Pan Yu-Zhuo, Jerrold C. Winter,Huang Min,Yu ai-Ming *. MicroRNA expression is differentially altered by xenobiotic rugs in different human cell lines. Biopharm. Drug Dispos. 2011;32(6): 355–367.
53.Ou Zhi-min,Huang Min, Xie Wen. MicroRNA hsa-miR-613 targets the human LXRα gene and mediates a feed-back loop of LXRα autoregulation. MolEndocrinol. 2011;25(4):584-96.
54.Liu Ya-he, Mo Sui-lin, Bi Huichang[共同第一作者], Hu Bin-fang, Li Chun-guang, Wang Yi-tao, Huang Ling,Huang Min, Zhou Shu-feng. Regulation of human pregnane X receptor and its target gene cytochrome P450 3A4 by Chinese herbal compounds and a molecular docking study. Xenobiotics, 2011, 41(4):259-280.
55.Li Bei, Zhong L, Yang XL, Andersson T,Huang Min, Tang SJ. WNT5A Signaling Contributes to A beta-Induced Neuroinflammation and Neurotoxicity. Plos One. 2011; 6 (8):e22920.
56.Zhang Bin, Cheng Qiu-qiong, Ou Zhi-min, Lee Junghoon, Xu M, Kochhar U, Ren S,Huang Min,Pflug BR, Xie Wen. Pregnane X Receptor As a Therapeutic Target to Inhibit Androgen Activity. Endocrinology. 2010;151(12):5721-5729.
57.Ou Zhi-min,Huang Min, Zhao Li-zi, Xie Wen. Use of transgenic mice in UDP-glucuronosyltransferase (UGT) studies. Drug Metab Rev. 2010;42(1):119-27.
58.Sun Hai-yan, Bi Hui-chang,Huang Min, Liu D, Qin Z. Absorption of CH330331, a novel 4-anilinoquinazoline inhibitor of epidermal growth factor receptor tyrosine kinase: comparative studies using in vitro, in situ and in vivo models. Biopharm Drug Dispos. 2010;31(8-9)486-494.
59.Jin Jing, Bi Hui-chang, Hu Jin-qing, Zhong Guo-ping, Zhao Li-zi, Huang Zhi-ying,Huang Min*.Enhancement of oral bioavailability of paclitaxel after oral administration of Schisandrol B in rats. Biopharm Drug Dispos. 2010;31(4):264-268.
60.He Lin, He Fan, Bi Hui-chang, Li Jia-li, Zeng Su, Luo Hai-bin,Huang Min.Isoform-selective inhibition of chrysin towards human cytochrome P450 1A2. Kinetics analysis, molecular docking, and molecular dynamics simulations. Bioorg Med Chem Lett. 2010;20(20):6008-6012.
61.Cen Hen-jing, Zeng Wutao, Leng Xiu-yu,Huang Min,Chen Xiao, Li Jia-li, Huang Zhi-ying, Bi Hui-chang, Wang Xue-ding, He Yyan-ling, He Fan, Zhou Rui-na, Zheng Qi-shan, Zhao Li-zi. CYP4F2 rs2108622: a minor significant genetic factor of warfarin dose in Han Chinese patients with mechanical heart valve replacement. Br J Clin Pharmacol. 2010;70(2):234-240.
62.Yuan Fang, Chen Jie, Wu Wen-jin, Chen Su-zhen, Wang Xue-ding, Su Zeng,Huang Min*. Effects of Matrine and Oxymatrine on Catalytic Activity of Cytochrome P450s in Rats. Basic Clin Pharmcol Toxicol. 2010;107(5):906 – 913.
63.Qin Xiao-ling, Bi Hui-chang, Wang Xueding, Li Jiali, Wang Ying, Xue Xinping, Xu Lejia, Chen Xiao, Wang Changxi, Wang Yitao,Huang Min*.Mechanistic understanding of the different effects of Wuzhi Tablet (Schisandra sphenanthera extract) on the absorption and first-pass intestinal and hepatic metabolism of Tacrolimus (FK506). Int J Pharm. 2010, 389(1-2):114-121.
64.Qin Xiao-ling, Bi Hui-chang, Wang Changxi, Li Jiali, Wang Xueding, Liu Longshan, Chen Xiao,Huang Min*.Study of the effect of Wuzhi tablet (Schisandra sphenanthera extract) on tacrolimus tissue distribution in rat by liquid chromatography tandem mass spectrometry method. Biomed Chromatogr. 2010, 24(4):399-405.
65.Wang Xue-Ding, Li Jia-Li, Su Qi-Biao, Guan Su, Chen Jie, Du Jun, He Yu-wen, Zeng Jun, Zhang Jin-xin, Chen Xiao,Huang Min*, Shu-feng Zhou. Impact of the haplotypes of the human pregnane X receptor gene on the basal and St Johns wort-induced activity of cytochrome P450 3A4 enzyme. Brit J Clin Pharmaco, 2009;67(2): 255-261.
66.Wang Yixi, Wang Changxi, Li Jiali, Wang Xueding, Zhu Genglong, Chen Xiao, Bi Huichang,Huang Min*. Effect of genetic polymorphisms of CYP3A5 and MDR1 on Cyclosporine concentration during the early stage after renal transplantation in Chinese Patients co-treated with diltiazem. Euro J Clin Pharmaco, 2009, 65(3):239-247.
67.Tang Cheng, Bi Hui-chang, Zhong Guo-ping, Chen Xiao, Huang Zhi-ying,Huang Min*. Simultaneous determination of mifepristone and monodemethyl-mifepristone in human plasma by liquid chromatography-tandem mass spectrometry method using levonorgestrel as an internal standard: application to a pharmacokinetic study. Biomed Chromatogr. 2009; 23(1):71-80.
68.Deng Ying, Bi Hui-chang, Zhao Li-zi, He Fan, Liu Yan-qing, Yu Jia-jun, Ou Zhi-min, Ding Liang, Chen Xiao, Huang Zhi-ying, Zhou Shu-feng,Huang Min*.Induction of cytochrome P450s by terpene trilactones and flavonoids of the Ginkgo biloba extract EGb 761 in rats. Xenobiotica. 2008;38(5):382-398.
69.Li Jia-li, Wang Xue-ding, Wang Chang-xi, Fu Q, Liu LS,Huang Min*,Zhou Shu-feng. Rapid and simultaneous determination of tacrolimus (FK506) and diltiazem in human whole blood by liquid chromatography-tandem mass spectrometry: Application to a clinical drug-drug interaction study. J Chromatogr B. 2008; 867(1):111-118.
70.Pan Ying, Bi Hui-chang, Zhong Guo-ping, Chen Xiao, Zuo Zhong, Zhao Li-zi, Gu Lian-quan, Liu Pei-qing, Huang Zhi-ying, Zhou Shu-feng,Huang Min*. Pharmacokinetic characterization of hydroxylpropyl-beta-cyclodextrin-included complex of cryptotanshinone, an investigational cardiovascular drug purified from Danshen (Salvia miltiorrhiza). Xenobiotica. 2008;38(4):465-481.
71.Bi Hui-chang, Zuo Zhong, Chen Xiao, Xu Chen-shu, Wen Ying-ying, Sun Hai-yan, Zhao Li-zi, Pan Ying, Deng Ying, Liu Pei-qing, Gu Lian-quan, Huang Zhi-ying, Zhou Shu-feng,Huang Min*.Preclinical factors affecting the pharmacokinetic behaviour of tanshinone IIA, an investigational new drug isolated from Salvia miltiorrhiza for the treatment of ischaemic heart diseases. Xenobiotica, 2008; 38(2): 185-222.
72.Wang Xue-Ding, Deng Xiao-Ying, Chen Jie, Li Jia-Li, Chen Xiao, Zhao Li-zi, Lu Yan, Chowbay Balram,Su Qi-Biao,Huang Min*, Zhou Shu-Feng. Single nucleotide polymorphisms of the pregnane x receptor gene in han chinese and a comparison with other ethnic populations. Pharmacology. 2008;81(4):350-354.
73.Zhao Li-Zi, Zhong Guo-Ping, Bi Hui-Chang, Ding Liang, Deng Ying, Guan Su, Chen Xiao, Huang Zhi-ying,Huang Min*.Determination of levonorgestrel in human plasma by liquid chromatography-tandem mass spectrometry method: application to a bioequivalence study of two formulations in healthy volunteers. Biomed Chromatogr, 2008; 22(5):519-26.
74.Su Qi-Biao, He Fan, Wang Xue-Ding, Guan Su, Xie Zhi-Yong, Wang Lai-You, Lu Yu-Jing, Gu Lian-Quan, Huang Zhi-Shu, Chen Xiao,Huang Min*,Zhou Shu-Feng. Biotransformation and pharmacokinetics of the novel anticancer drug, SYUIQ-5, in the rat. Invest New Drugs, 2008; 26(2):119-137.
75.Wang Xue-Ding, Li Jia-Li, Su Qi-Biao, Deng Xiao-Ying, Lu Yan, Chen Jie, Zhang Jin-Xin, Zhao Li-Zi, Zuo Zhong, Chan Eli, Chen Xiao, Chowbay Balram, Xue Charlie C,Huang Min*, Zhou Shu-Feng. A pharmacogenetic study of pregnane X receptor (NR1I2) in Han Chinese. Curr Drug Metab, 2007; 8(8): 778-786.
76.Chen He-Ping, He Ming, Huang Qi-Ren, Liu Dan andHuang Min*,Sasanquasaponin protects rat cardiomyocytes against oxidative stress induced by anoxia-reoxygenation injury. Eur J Pharmacol, 2007; 575(1-3): 21-27.
77.Sun Hai-Yan, Guan Su, Bi Hui-Chang, Su Qi-Biao, Huang Wei-Lin, Chowbay B,Huang Min*, Chen Xiao, Li Chun-Guang, Zhou Shu-Feng. Determination of CH330331, a novel 4-anilinoquinazoline inhibitor of epidermal growth factor receptor tyrosine kinase, in human Caco-2 monolayers by high performance liquid chromatography with ultraviolet detection: Application to a trans-epithelial transport study. J Chromatogr B Analyt Technol Biomed Life Sci. 2007; 854(1-2):320-327.
78.He Fan, Bi Hui-Chang, Xie Zhi-Yang, Zuo Zhong, Li Jian-Kang, Li Xin, Zhao Li-Zi, Chen Xiao,Huang Min*.Rapid determination of six metabolites from multiple cytochrome P450 probe substrates in human liver microsome by liquid chromatography/mass spectrometry: application to high-throughput inhibition screening of terpenoids. Rapid Commun Mass Spectrom. 2007;21(5):635-643.
79.Su Qi-Biao, He Fan, Guan Su, Lu Yu-Jing, Gu Lian-Quan, Huang Zhi-Shu, Chen Xiao,Huang Min*,Li Chun-Guang, Chowbay Balram, Zhou Shu-Feng. High performance liquid chromatography with ultraviolet detection for the determination of SYUIQ-5, a novel telomerase inhibitor for cancer therapy: application to an enzyme kinetic study in rat liver microsomes. J Chromatogr B Analyt Technol Biomed Life Sci, 2007. 854(1-2): 332-337.
80.Bi Hui-Chang, Law FC, Zhong Guo-Ping, Xu Chen-Shu, Pan Ying, Ding Liang, Chen Xiao, Zhao Li-Zi, Xu Qiong,Huang Min*. Study of tanshinone IIA tissue distribution in rat by liquid chromatography-tandem mass spectrometry method. Biomed Chromatogr. 2007;21(5):473-479.
81.Wang Xue-Ding, Li Jia-Li, Lu Yan, Chen Xiao,Huang Min*,Chowbay Balram, Zhou Shu-Feng. Rapid and simultaneous determination of nifedipine and dehydronifedipine in human plasma by liquid chromatography-tandem mass spectrometry: Application to a clinical herb-drug interaction study. J Chromatogr B Analyt Technol Biomed Life Sci. 2007;852(1-2):534-544.
82.Wang Xue-Ding, Chan E, Chen Xiao, Liao Xiao-Xing, Tang Cheng, Zhou ZW,Huang Min*, Zhou Shu-Feng. Simultaneous and rapid quantitation of benazepril and benazeprilat in human plasma by high performance liquid chromatography with ultraviolet detection. J Pharm Biomed Anal. 2007;44(1):224-230.
83.Chen Jie, Yang XX,Huang Min*, Hu Zhe-Ping, He M, Duan W, Chan E, Sheu FS, Chen Xiao, Zhou Shu-Feng. Small Interfering RNA-Mediated Silencing of cytochrome P450 3A4 Gene. Drug Metab Dispos. 2006; 34(9): 1650-1657.
84.Zhang Jing,Huang Min*, Guan Su, Bi Hui-Chang, Pan Ying, Duan Wei, Chan SY, Chen Xiao, Hong YH, Bian JS, Yang HY, Zhou Shu-Feng. A Mechanistic Study of the Intestinal Absorption of Cryptotanshinone, the Major Active Constituent of Salvia miltiorrhiza. J Pharmacol Exp Ther. 2006;317(3):1285-1294.
85.Zhao Li-Zi, Zhou Shu-Feng, Yang HY, Hong YH, Chen Jie, Chan SY, Chen Xiao,Huang Min*. Induction of propranolol metabolism by Ginkgo biloba extract EGb 761 in rats. Curr Drug Metab.2006; 7(6): 577-587.
86.Zhong Shi-Long,Huang Min*, Yang X, Liang L, Wang Y, Romkes M, Duan W, Chan E, Zhou Shu-Feng. Relationship of glutathione S-transferase genotypes with side-effects of pulsed cyclophosphamide therapy in patients with systemic lupus erythematosus. Br J Clin Pharmacol. 2006 ;62(4):457-472.
87.Guan Su,Huang Min*,Li Xin, Chen Xiao, Chan E, Zhou Shu-Feng. Intra- and Inter-ethnic Differences in the Allele Frequencies of Cytochrome P450 2B6 Gene in Chinese. Pharm Res. 2006; 23(9): 1983-1990.
88.Guan Su,Huang Min*,Chan E, Chen Xiao, Duan W, Zhou Shu-Feng. Genetic polymorphisms of cytochrome P450 2B6 gene in Han Chinese. Eur J Pharm Sci. 2006;29(1):14-21.
89.Zhong Shi-Long, Zhou Shu-Feng, Chen Xiao, Chan SY, Chan E, Ng KY, Duan W,Huang Min*. Relationship between genotype and enzyme activity of glutathione S-transferases M1 and P1 in Chinese. Eur J Pharm Sci. 2006;28(1-2):77-85.
90.Bi Hui-Chang, Zhao Li-Zi, Zhong Guo-Ping, Zhou Shu-Feng, Li Bo, Deng Ying, Chen Xiao,Huang Min*. High-throughput determination of carbocysteine in human plasma by liquid chromatography/tandem mass spectrometry: application to a bioequivalence study of two formulations in healthy volunteers. Rapid Commun. Mass Spectrom. 2006; 20: 1153-1160.
91.Zhong Shi-Long, Zhou Shu-Feng, Chen Xiao,Huang Min*. Rapid determination of common mutations in glutathione S-transferase gene by PCR-based methods in healthy Chinese. Clin Chim Acta 2006;364(1-2):205-208.
92.Zhang Jian-Ping, Zhou Shu-Feng, Chen Xiao,Huang Min*.Determination of intra-ethnic differences in the polymorphisms of thiopurine S-methyltransferase in Chinese. Clin Chim Acta. 2006;365(1-2):337-341.
93.Zhong Guo-ping, Bi Hui-chang, Zhou Shu-feng, Chen Xiao,Huang Min*. Simultaneous determination of metformin and gliclazide in human plasma by liquid chromatography-tandem mass spectrometry: application to a bioequivalence study of two formulations in healthy volunteers. J Mass Spectrom. 2005; 40(11):1462-1471.
94. Bi Hui-chang, Zhong Guo-ping, Zhou Shu-feng, Chen Xiao,Huang Min*. Determination of adefovir in human plasm by liquid chromatography-tandem mass spectrometry method:application to a pharmacokinetic study. Rapid Communication in Mass Spectrometry 2005,19.2911-2917.
95.Wei Hong, Zhou Shu-feng, Li C, Zhang Jian-Ping, Wu Jue-heng,Huang Min*.Phenotyping and genotyping studies of thiopurine s-methyltransferase in kazaks. Pharmaceutical Research 2005,22(10).1762-1766.
96.Zhang Jian-Ping, Guan Yong-yuan, Wu Jue-heng, Xu An-long,Huang Min*.Phenotyping and genotyping study of thiopurine S-methyltransferase in healthy Chinese children: A comparison of Han and Yao ethnic group. British Journal of Clinical Pharmacology. 2004:58(2)163-168.
97.Zhang Jian-Ping, Guan Yong-yuan, Xu An-long, Zhou Shu-Feng, Wu Jue-heng, Wei Hong,Huang Min*.Gene mutation of thiopurine S-methyltransferase in Uygur Chinese. European Journal of Clinical Pharmacology. 2004;60 (1):1-3.
