教育經歷
1994.09～1998.07 安徽師範大學攻讀 生物技術專業學士學位
1998.09～2001.07 浙江大學生命科學學院攻讀 遺傳學專業碩士學位
2007.07～2010.07 復旦大學攻讀腫瘤學專業博士學位（復旦大學附屬腫瘤醫院）
工作經歷
2013～ 江南大學附屬醫院腫瘤研究所 副研究員/副所長
2012～2013 Northwestern University Feinberg School of Medicine 訪問學者
2010～2012 蘇州大學附屬第四醫院檢驗科
副研究員/科副主任/研究所副所長
2001～2009 蘇州大學附屬第四醫院中心實驗室
助理研究員/技師、主管技師
研究方向 ：
1. 消化道腫瘤發病機理及轉化研究（腫瘤微環境與非編碼RNA）
2. 惡性腫瘤的早期分子診斷
3. 腫瘤化療藥物基因組學的臨床套用研究
主持課題
1. “結直腸癌通過外泌體miRNA調控微環境中巨噬細胞的機制研究” 國家自然科學基金面上項目（81672328，2017-2020），68.4萬
2. “結直腸癌競爭性內源RNA調控網路的構建及驗證研究”江蘇省自然科學基金-傑出青年基金（BK20150004，2015-2017），100萬
3. 江蘇省留學人員科技活動項目擇優資助經費 2015 9萬
4. “長鏈非編碼RNA—LOC154860在結直腸癌發生髮展中的作用及機制研究” 國家自然科學基金面上項目（81272299，2013-2016），70萬
5. “結直腸癌相關新microRNA靶點的功能及機制研究”江蘇省醫學重點人才計畫（RC2011031，2011-2015），50萬
6. “單細胞基因組多態性在胃腸道間質瘤診斷與個體化治療及預後評估中的套用研究”無錫市醫院管理中心醫學科研重大招標項目（YGZXZ1401，2015-2018），50萬
7. “microRNA-139-5p在結直腸癌發生髮展中的作用及其機制研究”國家自然科學基金青年基金（81000867，2011-2013）， 20萬
8. “miR-638在結直腸癌發生髮展中的作用及其機制研究” 江蘇省“六大人才高峰”高層次人才項目（2011-WS-098，2012-2014）3萬
9. “血循環DNA甲基化譜式分析在肝癌早期診斷中的意義”2008年江蘇省自然科學基金（2008-2010）（BK2008114） 8萬
發明專 利
1. 黃朝暉，王周平，吳世嘉，華東 . 發明專利 “基於抗體功能化磁性納米材料磁分離—上轉換螢光納米材料標記檢測癌胚抗原的試劑盒”，2014， 專利號 ZL 2012 1 0062667.5 （證書號1526550）
2. 黃朝暉 . 發明專利 “環脂肽類抗生素及其製備和套用”，2014，專利號 ZL 2012 1 0356785.7
主要論文（第一 / 通訊，IF=2015）
1. Feng Y, Feng L, Yu D, Zou J *, Huang Z *. srGAP1 mediates the migration inhibition effect of Slit2-Robo1 in colorectal cancer. J Exp Clin Canc Res, 2016, 35:191 (IF=4.357).
2. Li X, Guan F, Li D, Tan T, Yang G, Wu Y, Huang Z *. Identification of aberrantly expressed glycans in gastric cancer by integrated lectin microarray and mass spectrometric analyses. Oncotarget ,2016,7(52): 87284-87300 (IF=5.085).
3. Bian Z , Jin L, Zhang J, Yin Y, Quan C, Hu Y, Feng Y, Liu H, Fei B, Mao Y, Zhou L, Qi X, Huang S, Hua D, Xing C, Huang H*. LncRNA—UCA1 enhances cell proliferation and 5-fluorouracil resistance in colorectal cancer by inhibiting miR-204-5p. Sci Rep, 2016, 6:23892 (IF=5.228)
4. Hu Y, Yin Y, Liu H, Feng Y, Bian Z, Yao S, Zhou L, Zhang J, Fei B, Wang Y, Huang H*. Glucose deprivation induces chemoresistance in colorectal cancer cells by increasing ATF4 expression. World J Gastroenterol, 2016,22(27):6235-6245 ( IF=2.787)
5. Liu H, Yin Y, Hu Y, Feng Y, Bian Z, Yao S, Li M, You Q *, Huang H*. miR-139-5p sensitizes colorectal cancer cells to 5-fluorouracil by targeting NOTCH-1. Pathol Res Pract, 2016, 212(7):643-649. ( IF=1.388)
6. Bian Z , Feng Y, Xue Y, Hu Y, Wang Q, Zhou L, Liu Z, Zhang J, Yin Y, Gu B, Huang Z *. Down-regulation of SNX1 predicts poor prognosis and contributes to drug resistance in colorectal cancer. Tumor Biol, 2016, 37(5):6619-6625 ( IF=2.926).
7. Yin Y, Song M ,, Gu B, Qi X, Hu Y, Feng Y, Liu H, Zhou L, Bian Z, Zhang J, Zuo X, Huang Z*. Systematic analysis of key miRNAs and related signaling pathways in colorectal tumorigenesis. Gene. 2016, 578(2):177-184. ( IF=2.319).
8. Huang Z*, Wen P, Kong R, Cheng H, Zhang B, Quan C, Bian Z, Chen M, Zhang Z, Chen X, Du X, Liu J, Zhu L, Fushimi K, Hua D, Wu JY. USP33 mediates Slit-Robo signaling in inhibiting colorectal cancer cell migration. Int J Cancer, 2015, 136(8):1792-1802 ( IF=5.531).
9. Zhang J, Bian Z, Zhou J, Song M, Liu Z, Feng Y, Zhe L, Zhang B, Yin Y, Huang Z*. MicroRNA-638 inhibits cell proliferation by targeting phospholipase D1 in human gastric carcinoma. Protein Cell, 2015, 6(9):680–688 ( IF=3.247).
10. Zhang B, Yin Y, Hu Y, Zhang J, Bian Z, Song M, Hua D, Huang Z*. MicroRNA-204-5p inhibits gastric cancer proliferation by downregulating USP47 and RAB22A. Med Oncol, 2015, 32(1):331 ( IF=2.634).
11. Yin Y, Zhang B, Wang W, Fei B, Quan C, Zhang J, Song M, Bian Z, Wang Q, Ni S, Hu Y, Mao Y, Zhou L, Wang Y, Yu J, Du X, Hua D, Huang Z*. MiR-204-5p inhibits proliferation and invasion and enhances chemotherapeutic sensitivity of colorectal cancer cells by down-regulating RAB22A. Clin Cancer Res, 2014, 20(23): 6187 - 6199 ( IF=8.722).
12. Wang Q, Huang Z, Guo W, Ni S, Xiao X, Wang L, Huang D, Tan C, Xu Q, Zha R, Zhang J, Sheng W, He X, Du X. MicroRNA-202-3p inhibits cell proliferation by targeting ADP-ribosylation factor-like 5A in human colorectal carcinoma. Clin Cancer Res, 2014, 20(5):1146-1157( co-first author, IF=8.722 ）
13. Zhang J, Fei B, Wang Q, Song M, Yin Y, Zhang B, Ni S, Guo W, Wang Y, Liu Z, Bian Z, Quan C, Yu J, Du X, Hua D, Huang Z*. MicroRNA-638 inhibits cell proliferation, invasion and regulates cell cycle by targeting tetraspanin 1 in human colorectal carcinoma. Oncotarget,2014,5(23):12083-12096 ( IF=6.359)
14. Song M, Yin Y, Zhang J, Zhang B, Bian Z, Quan C, Zhou L, Hu Y, Wang Q, Ni S, Fei B, Wang W, Du X, Hua D, Huang Z*. MiR-139-5p inhibits migration and invasion of colorectal cancer by downregulating AMFR and NOTCH1. Protein Cell, 2014, 5(11):851-861 ( IF=3.247).
15. Huang Z, Hu Y, Shou L, Song M. Isolation and partial characterization of cyclic lipopeptide antibiotics produced by Paenibacillus ehimensis B7. BMC Microbiology, 2013, 13:87 ( IF=2.729)
16. Huang Z, Wu S, Duan N, Hua D, Hua Y, Wang Z. Sensitive detection of carcinoembryonic antigen with magnetic nano-bead and upconversion nanoparticles-based immunoassay. J Pharm Biomed Anal, 2012, 66: 225-231（IF=2.979）
17. Zhao Y, Guo S, Sun J, Huang Z , Zhu T, Zhang H, Gu J, He Y, Wang W, Ma K, Wang J, Yu J. Methylcap-seq reveals novel DNA methylation markers for the diagnosis and recurrence prediction of bladder cancer in a Chinese population . PLoS One, 2012, 7(4): e35175 （ co-first author, IF=3.234 ）
18. Huang Z, Hua D, Hu Y, Cheng Z, Zhou X, Xie Q, Wang Q, Wang F, Du X, Zeng Y. Quantitation of plasma circulating DNA using quantitative PCR for the detection of hepatocellular carcinoma. Pathol Oncol Res, 2012.18(2):271-276 (IF= 1.855)
19. Huang Z, Huang S, Wang Q, Liang L, Ni S, Wang L, Sheng W, He X, Du X. MicroRNA-95 promotes cell proliferation and targets sorting nexin 1 in human colorectal carcinoma. Cancer Res, 2011, 71(7): 2582-2589（ IF=8.556）
20. Huang Z, Hu Y, Hua D, Wu YY, Song MX, Cheng ZH. Quantitative analysis of multiple methylated genes in plasma for the diagnosis and prognosis of hepatocellular carcinoma. Exp Mol Pathol, 2011, 91(3): 702-707 ( IF=2.706)
21. Hua D#, Hu Y, Wu YY, Cheng ZH, Yu J, Du X, Huang ZH*. Quantitative methylation analysis of multiple genes using methylation-sensitive restriction enzymes-based quantitative PCR for the detection of hepatocellular carcinoma. Exp Mol Pathol, 2011, 91(1):455-460 ( IF=2.706)
22. Huang Z, Huang D, Ni S, Peng ZL,Sheng WQ, Du X *. Plasma microRNAs are promising novel biomarkers for early detection of colorectal cancer. Int J Cancer, 2010,127(1):118-126 ( IF=5.085)
23. Huang ZH *，Hua D, Du X. Polymorphisms in p53, GSTP1 and XRCC1 predict relapse and survival of gastric cancer patients treated with oxaliplatin-based adjuvant chemotherapy. Cancer Chemother Pharmacol, 2009, 64(5):1001-1007 （ IF=2.769 ）
24. Huang ZH，Hua D, Li LH . The polymorphisms of TS and MTHFR predict survival of gastric cancer patients treated with fluorouracil-based adjuvant chemotherapy in Chinese population. Cancer Chemother Pharmacol, 2009,63(5):911-918 （ IF=2.769 ）
25. Huang ZH，Hua D, Du X, Li LH, Mao Y, Liu ZH, Song MX, Zhou XK. ERCC1 polymorphism, mRNA expression and clinical outcome of oxaliplatin-based adjuvant chemotherapy in patients with gastric cancer. World J Gastroenterol, 2008, 14(41): 6401-6407 （ IF=2.369 ）
26. Huang ZH ，Hua D, Li LH, Zhu JD. Prognostic role of p53 Codon 72 polymorphism in gastric cancer patients treated with fluorouracil-based adjuvant chemotherapy. J Cancer Res Clin Oncol，2008, 134:1129–1134 ( IF=3.081)
27. Huang ZH, Li LH, Yang F, Wang JF. Detection of aberrant methylation in fecal DNA as a molecular screening tool for colorectal cancer and precancerous lesions. World J Gastroenterol, 2007，13(6): 950-954( IF=2.081)
28. Huang ZH, Li LH, Yang F, Wang JF. Hypermethylation of SFRP2 as a potential marker for stool-based detection of colorectal cancer and precancerous lesions. Dig Dis & Sci, 2007, 52(9):2287-2291 ( IF=2.613)
29. Hua D, Huang ZH*, Deng JZ, Mao Y. Thymidylate synthase and thymidine phosphorylase gene expression as predictive parameters for the efficacy of 5-fluorouraci-adjuvant chemotherapy for gastric cancer. World J Gastroenterol. 2007, 13(37): 5030-5034 ( IF=2.081)
30. Huang ZH, Li LH，Hua D. Quantitative analysis of plasma circulating DNA at diagnosis and during follow-up of breast cancer patients. Cancer Letters. 2006, 243(1): 64-70 ( IF=5.621)
