黃曉華[南京師範大學化學院教授]

黃曉華[南京師範大學化學院教授]

黃曉華,從事化學與生物學交叉研究領域,主要研究方向為生物無機化學,即將生物物理化學研究手段、細胞化學方法與細胞生物學技術最佳化組合,研究稀土元素、重金屬離子、醫用納米材料對細胞及其生物酶分子的結構、功能及其微觀化學過程的影響。

基本信息

在研項目

(1)稀土對辣根的劑量效益評價及其研究(GFZ20612108,2007-2009)

(2)重金屬Tb作用於植物細胞膜的微觀化學行為研究(2009-2012)

(3)聚氨酯無機仿生表面構建的關鍵技術及生物醫用研究(2009-2012)

(4)稀土作用於辣根細胞膜的若干生物無機化學行為研究(2010-2012)

成果介紹

作為項目主持人近三年來, 完成中美合作項目、國家自然科學基金、國家發改委、江蘇省高技術及教育部重點項目等8項、在研項目3項。在J.Biol.Inorg.Chem., J.Phys.Chem., Dalton Transactions, Ecotoxicology and Environmental Safety, Annals of Botany,Electrochimica Acta., J. Electro. Chem.,J. Mater. Chem.等學術期刊上合作發表SCI論文60餘篇(其中第一及通信作者42篇)。被國外SCI期刊如Journal of Physical Chemistry(B、C), Dalton Transactions, International Journal of Biological Sciences, Biological Trace Element Research, Langmuir, Ecotoxicology and Environmental Safety, Annals of Botany, Environmental Chemistry Letters等他引223次,單篇最高引用17次。2007年應邀在 “13th International Conference on Biological Inorganic Chemistry(ICBIC13,維也納)”會上報告;2009年又收到“ICBIC14,日本”會議報告的邀請。獲得1項美國專利及6項中國(授權)發明專利。其中,一項特色研究成果用於出口經濟作物,05-07連續三年該產品獲得歐盟生態證書及出口美國、加拿大、丹麥、德國等國家和地區,淨增經濟效益96萬美元。

研究項目

(1)稀土生態轉光膜分子設計及研製(BG2005040. 2005-2007);

(2)稀土離子對辣根植物過氧化酶的結構和生物活性影(20471030, 2005-2007);

(3)稀土離子對辣根植物過氧化酶的毒害機理(IFZ2051210,2006-2008);

研究成果

(1) Huang, X.H., Zhou, Q., Lu,T.H., Guo, S.F (2009). Design and preparation of plant growth regulator of rare earth element-amino acid-vitamine, United States Patent(EFSID;4978659;PCT/CN07/01912).

(2) Guo , X.Y., Yin,W.Q., Sun, X.H., Huang, X.H.*,. Lu, T.H.(2009). Study on intreaction between Eu(III) and thermosensitive microsphere. Polym.Bull. 62:337-344.

(3) Guo, S.F., Cao, R., Lu, A.H., Zhou, Q., Lu, T.H., Ding, X.L., Li, C.J., Huang, X.H.* (2008) One of the Possible Mechanisms for the Inhibition Effect of Tb (III) on Peroxidase Activity in Horseradish (Armoracia Rusticana) Treated with Tb (III). Journal of Biological Inorganic Chemistry. 13(4): 587-597.

(4) Guo, S.F., Zhou, Q., Lu, T.H., Ding, X.L., Huang, X.H.* (2008) Inhibition Mechanism of Tb-III on Horseradish Peroxidase Activity. Chemistry & Biodiversity. 5(10): 2050-2059.

(5) Ye, Y.X., Wang, L.H., Huang, X.H.*, Lu, T.H., Ding, X.L., Zhou, Q.*, Guo, S.F. (2008) Subcellular Location of Horseradish Peroxidase in Horseradish Leaves Treated with La(III), Ce(III) and Tb(III). Ecotoxicology and Environmental Safety. 71(3): 677-684.

(6) Wang, L.H., Huang, X.H.*, Zhou, Q.* (2008) Effects of Rare Earth Elements on the Distribution of Mineral Elements and Heavy Metals in Horseradish. Chemosphere. 73(3): 314-319.

(7) Liu, H.K. *, Huang, X.H.*, Lu, T.H., Wang, X.J., Sun, W.Y., Kang, B.S. (2008) Discrete and Infinite 1d, 2d/3d Cage Frameworks with Inclusion of Anionic Species and Anion-Exchange Reactions of Ag3l2 Type Receptor with Tetrahedral and Octahedral Anions. Dalton Transactions. (24): 3178-3188.

(8) Guo, S.F., Zhou, Q., Lu, T.H., Ding, X.L., Huang, X.H.* (2008) Spectroscopic Studies of Interactions Involving Horseradish Peroxidase and Tb3+. Spectrochimica Acta Part A-Molecular and Biomolecular Spectroscopy. 70(4): 818-823.

(9) Zhou, H., Lu, T.H., Shi, H.X., Dai, Z.H., Huang, X.H.* (2008) Direct Electrochemistry and Electrocatalysis of Catalase Immobilized on Multi-Wall Carbon Nanotubes Modified Glassy Carbon Electrode and Its Application. Journal of Electroanalytical Chemistry. 612(2): 173-178.

(10) Guo, X.Y., Lu, T.H., Huang, X.H.* (2008) Eu(III)-Modified Properties of Thermosensitive Core-Shell Microspheres. Colloid and Polymer Science. 286(4): 469-473.

(11) Guo, X.Y., Chen, M.Q., Lu, T.H., Huang, X.H.* (2008) Effect of Tb(III) on the Properties of P(Nipam-Co-St) Copolymer Microspheres. Journal of Polymer Research. 15(2): 141-145.

(12) Guo, S.F., Zhou, Q., Lu, T.H., Ding, X.L., Huang, X.H.* (2007)Inhibition Effect of Tb(III) on Horseradish Peroxidase Activity. Journal of Biological Inorganic Chemistry. 12, (S1): S203.

(13) Guo, X.S., Zhou, Q., Zhu, X.D., Lu, T.H., Huang, X.H.* (2007) Migration of a Rare Earth Element Cerium(III) in Horseradish. Acta Chimica Sinica. 65(17): 1922-1924.

(14) Guo, X.S., Zhou, Q., Lu, T.H., Fang, M., Huang, X.H.* (2007) Distribution and Translocation of Ce-141 (III) in Horseradish. Annals of Botany. 100(7): 1459-1465.

(15) Guo, S.F., Zhou, Q., Lu, T.H., Ding, X.L., Huang, X.H.* (2007) Interaction between La3+ and Mp-11 in the Physiological Solution. Electrochimica Acta. 52(5): 2032-2038.

(16) Zhao, B.*, Rong, Y.Z., Huang, X.H., Shen, J.S. (2007) Experimental and Theoretical Study on the Structure and Electronic Spectra of Imiquimod and its Synthetic Intermediates. Bioorganic & Medicinal Chemistry Letters. 17(17): 4942-4946.

(17) Huang, X.H.*, Guo, S.F., Zhou, Q., Lu, T.H.*, Ding, X.L. (2007) Effect of La3+ on Structure and Electrochemical Reaction of Microperoxidase-11 in Imitated Physiological Solution. Journal of Electroanalytical Chemistry. 600(2): 227-235.

(18) Yin, W.Q., Chen, M.Q., Lu, T.H., Akashi, M., Huang, X.H.* (2007) Properties of Complex of Tb(III) and Poly(N-Isopropylacrylamide)-G-Poly(N-Isopropylacrylamide-Co-Styrene) Core-Shell Nanoparticles. Journal of Alloys and Compounds. 432(1-2): L18-L21.

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