個人簡歷
上海交通大學“盛毓綬”冠名講席教授，中組部“千人計畫”入選者。1987年獲英國愛丁堡大學分子遺傳學專業博士學位，先後在美國賓夕法尼亞大學擔任高級研究員、康奈爾大學擔任終身教授，長期從事探索免疫學領域的基礎研究，在揭示免疫反應細胞和分子作用機制及開創新的探測技術方法手段方面取得了突出成績。在Nature Immunology、Immunity、J. Experimental Medicine, J.Immunology等高水平國際期刊雜誌發表SCI論文80餘篇，相關研究成果的獨特與創新性被Nature和Cell、Nature Reviews Immunology等進行專題報導和評論。曾榮獲Young Investigators Award by International Cytokine Society、Howard Temin Award (NCI/NIH)等獎勵。
發表論文
Original research articles
1. Yin, F, Banerjee, R, ThoMas, B, Zhou, P, Qian, L, Jia, T, Ma, X, Ma, Y, Iadecola, C, BEAL, MF, Nathan, Cand Ding, H. 2010. Exaggerated Inflammation, Impaired Host Defense and Neuropathology in Progranulin-Deficient Mice. J. Exp. Med. 207(1):117-128.
2. Jiao, X., Katiyar, S., Willmarth, NE, Liu, M., Flomenberg, N., Ma, X., Lisanti, MP, Pestell, RG. 2010. C-jun induces mammary epithelial cellular invasion and breast cancer stem cell expansion. J. Biol. Chem. 285(11):8218-8226.
3. Kang, X, Kim, HJ, Ramirez, M, Salameh, S, Ma, X. 2010. The septic Shock-associated IL-10 -1082 A>G Polymorphism Mediates Allele-specific Transcription via Poly ADP-ribose Polymerase 1 in Macrophages Engulfing Apoptotic Cells. J. Immunol. 184:3718-3724.
4. Zhang, Y. Ma, X. 2010. Triptolide Inhibits IL-12/IL-23 Gene Expression in Antigen-presenting Cells via CCAAT/enhancer-Binding Protein Alpha. J. Immunol. 184:3866-3877.
5. Noguchi, E., Homma, Y., Kang, X., Netea, MG, and Ma, X. 2009. A Crohn’s disease–associated NOD2 mutation suppresses transcription of human IL10 by inhibiting activity of the nuclear ribonucleoprotein hnRNP-A1. Nature Immunology. 10(5):471-479.
6. Leavenworth JW, Ma X, Mo YY, Pauza ME. SUMO conjugation contributes to immune deviation in nonobese diabetic mice by suppressing c-Maf transactivation of IL-4. 2009. J Immunol. 2009 Jul 15;183(2):1110-1119.
7. Jayakumar, A., Widenmaier, R., Ma, X., and McDowell, MA. 2008. Transcriptional inhibition of interleukin-12 promoter activity in leishmania spp.-infected macrophages. J. Parasitol.,94(1):84–93.
8. Chung, E., Liu, J., HOMA, Y., Zhang,Y., Brendolan, A., Saggese, M., Han, J., Silverstein, R., Selleri, L., . 2007. Interleukin-10 Expression in Macrophages during Phagocytosis of Apoptotic Cells Is Mediated by homeoproteins Pbx-1 and Prep-1. Immunity.27:952-964.
9. Liu, J., Guan, X., X. Ma. 2007. Regulation of IL-27 p28 gene expression in macrophages through MyD88- and Interferon-g-mediated pathways. J Exp Med. 204:141-152.
10. Park-Min, K., Serbina, N., Yang, W., X. Ma, Krystal, G., Neel, BJ, Nutt, SL, Hu, X., and Ivashkiv, LB. 2007.FcγRIII-Dependent Inhibition of Interferon-γ Responses Mediates Suppressive Effects of Intravenous Immune globulin. Immunity. 26, 67-78.
11. Chung, EY, Liu, J., Zhang, Y., and X. Ma. 2007. Differential Expression in Lupus-associated IL-10 Promoter Single-nucleotide Polymorphisms Is Mediated by Poly(ADP-ribose) Polymerase 1. Genes & Immunity. 8(7):577-589.
12.Homma, Y., Cao, S., Shi, X., and X. Ma. 2007. The Th2 transcription factor c-Maf inhibits IL-12p35 gene expression in activated macrophages by targeting NF-kB nuclear translocation. J. Interferon & Cytokine Res. 27(9):799-808.
13.Werts, C., le Bourhis, L., Liu, J., Magalhaes, JG., Fritz, JH., Stockinger, S., Decker, T., Philpott, DJ., Ma, X., and Girardin. SE. 2007. Nod1 and Nod2 induce CCL5/RANTES through the NF-κB pathway. Eur. J. Immunol. 37(9):2499-2508.
