項榮[中南大學生命科學學院副院長，教授]

項榮，女，博士，中南大學生命科學學院教授，博士生導師。現任中南大學生命科學學院副院長。 2006年畢業於武漢大學獲微生物病毒專業博士學位，2007至2009年在中南大學湘雅二醫院心內科，從事動脈粥樣硬化疾病發病機制的博士後研究工作，並被評為優秀在站博士後。先後在美國克利夫蘭醫學研究中心、香港科技大學進行神經生物學方向的訪學研究。 近年，主持和參與包括國家自然科學基金面上項目、國家科技重大專項子課題、863子課題、軍口項目子課題、省自然科學基金等在內的各級科研項目20餘項；在CIRCULATION、J NEUROSCI、EUR HEART J、INT J CARDIOL、ATHEROSCIEROSIS等雜誌上發表SCI論文30餘篇；參與申請發明專利10餘項，已授權4項。 主編教材1部，參編國家級規劃教材2部；參與教改課題4項；指導國家級、省級大學生創新課題5項，指導大學生國家級競賽一等獎2項、三等獎2項，省級競賽一等獎1項、二等獎1項、三等獎1項；連續獲校教學質量優秀獎3次、校級教學成果一等獎1次、教學“三十佳”1次；被評為中南大學優秀共產黨員、學科競賽優秀指導教師、優秀班導師，湖南省“挑戰杯”優秀指導老師、長沙市大學生科創大賽優秀指導教師等。

研究方向

目前主要開展 兩個方面的研究：

（1）運用新一代測序、色譜、細胞免疫等技術，從基因、分子、細胞、模式動物及人體水平探討動脈粥樣硬化、高血脂、心肌病等心血管相關疾病的發病機理，並結合臨床篩選相關疾病的早期檢測診斷分子和預後標誌物；

（2）研究病原微生物感染、腫瘤、原發性多囊腎等疾病發生過程中相關細胞器、細胞信號轉導、細胞物質運輸、細胞代謝等細胞結構和功能的異常。

近五年論文發表情況

[1] Xiang R, Fan L L, Huang H, et al. Increased RTN3 Leads to Obesity and Hypertriglyceridemia by Interacting with HSPA5[J]. Circulation, 2018.

[2] Guo S, Fan X F, Jin J Y, et al. A novel proximal 3q29 chromosome microdeletion in a Chinese patient with Chiari malformation type II and Sprengel’s deformity[J]. Molecular Cytogenetics, 2018, 11(1):8.

[3] Ding D B, Fan L L, Xiao Z, et al. A novel mutation of dipeptidyl aminopeptidase-like protein-6 in a family with suspicious idiopathic ventricular fibrillation[J]. QJM: An International Journal of Medicine, 2018.

[4] Huang H, Ding D B, Fan L L, et al. Whole-exome sequencing identifies a Novel SCN5Amutation (C335R) in a Chinese family with arrhythmia[J]. Cardiology in the Young, 2018, 28(5):1-4.

[5] Li J J, Chen Y, Fan L L, et al. Microduplication of 10q26. 3 in a Chinese hypertriglyceridemia patient[J]. Molecular and cellular probes, 2018, 37: 28-31.

[6] Fan L L, Huang H, Jin J Y, et al. Whole exome sequencing identifies a novel mutation (c. 333+ 2T> C) ofTNNI3Kin a Chinese family with dilated cardiomyopathy and cardiac conduction disease[J]. Gene, 2018, 648: 63-67.

[7] Huang H, Chen Y Q, Fan L L, et al. Whole-exome sequencing identifies a novel mutation of GPD1L(R189X) associated with familial conduction disease and sudden death[J]. Journal of cellular and molecular medicine, 2018, 22(2): 1350-1354.

[8] Xiang R, Du R, Guo S, et al. Microduplications of 10q24 Detected in Two Chinese Patients with Split-hand/foot Malformation Type 3[J]. Annals of Clinical & Laboratory Science, 2017, 47(6): 754-757.

[9] Xiang R, Fan L L, Lin M J, et al. The genetic spectrum of familial hypercholesterolemia in the central south region of China[J]. Atherosclerosis, 2017, 258: 84-88.

[10] Liu J S, Fan L L, Li J J, et al. Whole-Exome Sequencing Identifies a Novel Mutation of Desmocollin 2 in a Chinese Family With Arrhythmogenic Right Ventricular Cardiomyopathy[J]. American Journal of Cardiology, 2017, 119(9): 1485-1489.

[11] Liu J S, Fan L L, Zhang H, et al. Whole-exome sequencing identifies two novel TTNmutations in Chinese families with dilated cardiomyopathy[J]. Cardiology, 2017, 136(1): 10-14.

[12] Xiang R, Fan L L, Huang H, et al. Whole-exome sequencing identifies a novel mutation of DSG2(Y198C) in a Chinese arrhythmogenic right ventricular cardiomyopathy patient[J]. International journal of cardiology, 2016, 214: 1-3.

[13] Wu P F, Guo S, Fan X F, et al. A novel ZRSmutation in a Chinese patient with preaxial polydactyly and triphalangeal thumb[J]. Cytogenetic and genome research, 2016, 149(3): 171-175.

[14] Du R F, Huang H, Fan L L, et al. A Novel Mutation of FOXC1(R127L) in an Axenfeld–Rieger Syndrome Family with Glaucoma and Multiple Congenital Heart Diseases[J]. Ophthalmic genetics, 2016, 37(1): 111-115.

[15] Chen Y, Wu Z, Zhao S, et al. Chemical chaperones reduce ER stress and adipose tissue inflammation in high fat diet-induced mouse model of obesity[J]. Scientific reports, 2016, 6: 27486.

[16] Fan L, Lin M, Chen Y, et al. Novel mutations of low-density lipoprotein receptor gene in China patients with familial hypercholesterolemia[J]. Applied biochemistry and biotechnology, 2015, 176(1): 101-109.

[17] Xiang R, Fan L L, Huang H, et al. A novel mutation of GATA4(K319E) is responsible for familial atrial septal defect and pulmonary valve stenosis[J]. Gene, 2014, 534(2): 320-323.

[18] Yu B, Xiang R, Hu D, et al. A novel MYH7 mutation in a family with cardiomyopathy presenting with restrictive physiology and varying degrees of left ventricle hypertrophy[J]. European heart journal, 2014, 36(3): 178-178.

[19] Shi Q, Ge Y, Sharoar M G, et al. Impact of RTN3 deficiency on expression of BACE1 and amyloid deposition[J]. Journal of Neuroscience, 2014, 34(42): 13954-13962.

[20] 項榮, 丁棟博, 范亮亮, 等. 稀土氧化鋅晶須抗菌效能及安全性研究[J]. 功能材料, 2013, 44: 186-191+ 197.

[21] 杜然, 范亮亮, 黃皓, 等. 原發性厚皮性骨膜病的遺傳學研究進展[J]. 中華醫學遺傳學雜誌, 2016 (2016 年 01): 105-107.

[22] 陳雨, 周帥鋒, 孫倩萊, 等. 2012-2014 年湖南省感染性腹瀉哨點醫院兒童諾如病毒感染及基因型別分析[J]. 實用預防醫學, 2016, 23(7): 773-776.

[23] 范亮亮, 馬立寧, 彭元亮, 等. PI3K/AKT 信號通路與心力衰竭[J]. 生命科學研究, 2015, 19(1): 85-90.

[24] 黃皓, 范亮亮, 項榮. HIV-1 輔助蛋白負性調節因子下調細胞膜表面分子的研究進展[J]. 細胞與分子免疫學雜誌, 2015 (6): 848-852.

[25] 項榮, 丁棟博, 范亮亮, 等. 氧化鋅的抗菌機制及其安全性研究進展[J]. 中國組織工程研究, 2014, 18(3): 470-475.

[26] 項榮, 嚴經緯, 范亮亮, 等. 動脈粥樣硬化中炎性反應與內質網應激的相互作用[J]. 基礎醫學與臨床, 2014, 34(2): 253-256.

[27] 曹貝貝, 范亮亮, 項榮. 動脈粥樣硬化中自噬與凋亡在內質網的交叉對話[J]. 生物物理學報, 2013 (12): 911-918.

[28] 項榮, 胡艷, 曹貝貝. β-Arrestins 參與 GPCRs 信號通路的分子機制[J]. 中國生物化學與分子生物學報, 2013, 29(2): 122-127.