人物經歷
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韓春生[博士生導師]1990年復旦大學遺傳工程專業本科畢業，1993年獲生殖生物學國家重點實驗室生理學碩士，2000年獲美國密蘇里州立大學生物化學博士學位，2000年至2003年任美國Lexicon Genetics & Pharmaceuticals 公司高級生物信息科學家。國際干擾素與細胞介素協會，美國生物信息學學會會員。中科院動物所生殖生物學國家重點實驗室生物信息學研究員，博士生導師。
研究方向
曾從事包括胚胎著床，干擾素信號傳導，基因製藥以及生物信息學等領域的研究。
主要貢獻
曾在“PNAS”、“Endocrinology”、“Biology of Reproduction”、“Current Opinion in Biotechnology”等雜誌上發表學術論文。目前正在利用生物信息學手段對組織特異表達的基因進行挖掘和功能預測，建立基因相互作用的網路模型，利用分子生物學等手段對基因的表達調控、蛋白質的結構與功能進行深入研究，同時還以精原幹細胞為模型對幹細胞的增殖與分化機理進行研究。目前承擔國家自然科學基金面上項目、海外傑出青年合作基金、“973”等研究課題。
發表論文：
1.Shi YQ, Liao SY, Zhuang XJ, Han CS. Mouse Fem1b interacts with and induces ubiquitin-mediated degradation of Ankrd37. Gene (In press).
2.Liu Z, Lin X, Cai Z, Zhang Z, Han C, Jia S, Meng A, Wang Q. Global identification of SMAD2 target genes reveals a role for multiple co-regulatory factors in zebrafish early gastrulas. J Biol Chem; (In press).
3.Zhuang XJ, Hou XJ, Liao SY, Wang XX, Cooke HJ, Zhang M, Han CS. SLXL1，a novel acrosomal protein, interacts with DKKL1 and is involved in fertilization in mice. PLoS ONE 2011; 6: e20866.
4.Gan H, Lin X, Zhang Z, Zhang W, Liao S, Wang L, Han C. piRNA profiling during specific stages of mouse spermatogenesis. RNA 2011; 17: 1191-1203.
5.Liu H, Wang B, Han C. Meta-analysis of genome-wide and replication association studies on prostate cancer. Prostate 2011; 71: 209-224.
6.Zhang J, Liu Q, Zhang W, Li J, Li Z, Tang Z, Li Y, Han C, Hall SH, Zhang Y. Comparative profiling of genes and miRNAs expressed in the newborn, young adult, and aged human epididymides. Acta Biochim Biophys Sin (Shanghai) 2010; 42: 145-153.
7.Yang Y, Han C. GDNF stimulates the proliferation of cultured mouse immature Sertoli cells via its receptor subunit NCAM and ERK1/2 signaling pathway. BMC Cell Biol 2010; 11: 78.
8.Shi YQ, Li YC, Hu XQ, Liu T, Liao SY, Guo J, Huang L, Hu ZY, Tang AY, Lee KF, Yeung WS, Han CS, Liu YX. Male germ cell-specific protein Trs4 binds to multiple proteins. Biochem Biophys Res Commun 2009; 388: 583-588.
9.Nian H, Zhang W, Shi H, Zhao Q, Xie Q, Liao S, Zhang Y, Zhang Z, Wang C, Han C. Mouse RING finger protein Rnf133 is a testis-specific endoplasmic reticulum-associated E3 ubiquitin ligase. Cell Res 2008; 18: 800-802.
10.Zhang K, Shang Y, Liao S, Zhang W, Nian H, Liu Y, Chen Q, Han C. Uncoupling protein 2 protects testicular germ cells from hyperthermia-induced apoptosis. Biochem Biophys Res Commun 2007; 360: 327-332.
11.Nian H, Fan C, Liao S, Shi Y, Zhang K, Liu Y, Han C. RNF151, a testis-specific RING finger protein, interacts with dysbindin. Arch Biochem Biophys 2007; 465: 157-163.
12.Tao SX, Guo J, Zhang XS, Li YC, Hu ZY, Han CS, Liu YX. Germ cell apoptosis induced by experimental cryptorchidism is mediated by multiple molecular pathways in Cynomolgus Macaque. Front Biosci 2006; 11: 1077-1089.
13.Song XX, Li YC, Shi YQ, Hu XQ, Hu ZY, Han CS, Liu YX. Cloning and characterization of a novel spermiogenesis-related gene, T6441, in rat testis. Front Biosci 2006; 11: 143-150.
獲獎記錄
國家“百人計畫”海外傑出人才。
