簡介
鍾志遠 男1974年2月生於江西省安遠縣，蘇州大學特聘教授，國家傑出青年基金獲得者，江蘇特聘教授，德國亥姆霍茲國家究中心生物材料研究所洪堡客座教授，柏林自由大學洪堡客座教授。蘇州大學生物醫用高分子材料重點實驗室主任，江蘇省先進功能高分子材料設計及套用重點實驗室副主任。1995年吉林工業大學（現吉林大學）獲學士學位，1998年中國科學院長春套用化學研究所獲碩士學位（導師：景遐斌研究員），2002年荷蘭屯特大學(University of Twente) 獲博士學位（導師：Jan Feijen 教授）。2002-2007年荷蘭屯特大學任助理教授。2004年9-11月美國猶他大學藥學院訪問學者。2007年4月起受聘為蘇州大學特聘教授。2011-2012年擔任蘇州工業園區生物產業發展有限公司（蘇州生物納米園）副總裁。
擔任Journal Controlled Release (Elsevier)，Journal of Materials Chemistry B (RSC)，Biomacromolecules （ACS），Journal Biomaterials Science, Polymer Edition (Talor & Francis)等國際著名期刊編委，《中國科學：化學》英文刊SCIENCE CHINA Chemistry（Springer）青年工作委員會委員，《藥學學報》英文刊Acta Pharmaceutica Sinica B (Elsevier) 編委，Journal of Controlled Release客座主編，第一、第二和第三屆新型高分子材料與控制釋放國際會議（SIPCD 2010，2012，2014）執行組委會主席，美國材料研究學會2013年春季年會“多功能生物材料分會”共同主席，國家自然科學基金委員會專家評審組專家，中國材料研究學會高分子材料與工程分會常務理事等學術兼職。
在國際主流期刊如 Prog. Polym. Sci., Nano Today, Angew. Chem. Int. Ed., J. Am. Chem. Soc., Biomaterials, J. Control. Release, Macromolecules, Biomacromolecules, J. Mater. Chem., Nanomedicine 等上發表論文120多篇，2篇論文入選“中國百篇最具影響國際學術論文”，論文共被引用 5800多次，H-因子 41。近幾年，應邀在國際學術會議上做邀請報告40多次。現主持3項國家自然科學基金項目和2項國際公司合作項目。獲得的榮譽獎勵包括：美國化學會期刊部和高分子委員會頒發的“2014年生物大分子/大分子青年研究者獎”、德國洪堡基金會“貝塞爾研究獎”（2013）、日本藥物釋放系統學會和美國控制釋放學會共同頒發的“亞洲藥物釋放系統突破技術獎”（2013）、江蘇特聘教授（2013）、江蘇省333工程第二層次培養對象（2013）、蘇州市十佳魅力科技人物（2013）、國家傑出青年科學基金獲得者（2012）等。
學習和工作經歷
1991.09—1995.07 吉林工業大學（現吉林大學）套用化學系
1995.09—1998.07 中國科學院長春套用化學研究所碩士生（導師：景遐斌研究員）
1998.10—2002.10 荷蘭屯特大學(University of Twente) 博士生（導師：Jan Feijen 教授）
2002.10—2007.04 荷蘭屯特大學(University of Twente)生物醫學技術研究所及高分子化學和生物材料系助理教授
2004.09—2004.11 美國猶他大學（University of Utah) 藥學院 訪問學者（Sung Wan Kim教授研究組）
2007.04—至今蘇州大學生物醫用高分子材料重點實驗室蘇州大學特聘教授、實驗室主任:
2010.12—至今江蘇省先進功能高分子材料設計及套用重點實驗室副主任
2011.09—2012.08蘇州工業園區生物產業發展有限公司（蘇州生物納米園）副總裁
學術和社會兼職
1. 首屆新型高分子材料與控制釋放國際會議（Symposium on Innovative Polymers for Controlled Delivery， SIPCD 2010, 2010年9月14-17日, 蘇州）執行組委會主席.
2. 第二屆新型高分子材料與控制釋放國際會議（2 Symposium on Innovative Polymers for Controlled Delivery， SIPCD 2012, 2012年9月11-14日, 蘇州）執行組委會主席.
3. 第三屆新型高分子材料與控制釋放國際會議（3 Symposium on Innovative Polymers for Controlled Delivery， SIPCD 2014, 2014年9月16-19日, 蘇州）執行組委會主席
4.美國材料化學學會2013年春季年會“Multifunctional Biomaterials” Symposium (MRS Spring 2013 Meeting, April 1-5, 2013, San Francisco, USA)共同主席.
5. Journal of Controlled Release客座主編（( J. Control. Release, Volume 152, Issue 1, 30 May 2011).
6. Journal of Controlled Release客座主編（ J. Control. Release, Volume 169, Issue 3, 10 August 2013）.
7. 美國化學會期刊 Biomacromolecules編委(2011.1-).
8. Elsevier期刊 Journal of Controlled Release編委(2012.5-).
9. Journal of Biomaterials Science, Polymer Edition編委(2012.8-).
10. 英國皇家化學會期刊 Journal of Materials Chemistry B顧問(2014.1-).
11. 《中國科學-化學》英文刊 SCIENCE CHINA Chemistry (Springer)青年工作委員會委員(2014.3-).
12.《藥學學報》英文刊 Acta Pharmaceutica Sinica B (Elsevier)編委(2014.7-).
13.國家自然科學基金委員會專家評審組專家（2012-）。
14.德國亥姆霍茲國家究中心生物材料研究所洪堡客座教授（2013 - 2015）
15.柏林自由大學洪堡客座教授（2013 - 2015）
16.中國材料研究學會高分子材料與工程分會常務理事（2014.7-）
17.江蘇省青年聯合會第十和第十一屆委員會委員
主要研究興趣
1) 功能性生物可降解高分子材料
2) 回響性聚合物納米載體（膠束、囊泡、納米粒）
3) 腫瘤的靶向治療
4) 可注射性水凝膠和微凝膠
5) 生物納米載體（聚合物囊泡和膠束）及腫瘤靶向治療
榮譽獎勵
1. 美國化學會期刊部和高分子委員會頒發的“2014年生物大分子/大分子青年研究者獎”（2014 Biomacromolecules/Macromolecules Young Investigator Award）。
2. 德國洪堡基金會頒發的“貝塞爾研究獎”（Bessel Research Award）（2013年）
3. 亞洲藥物釋放系統突破技術獎（日本藥物釋放系統學會和美國控制釋放學會聯合頒發，2013年）
4. 江蘇特聘教授（2013年）
5. 江蘇省333工程第二層次培養對象（2013年）
6. 蘇州市十佳魅力科技人物（2013年）
7. 國家傑出青年基金獲得者（2012年）
8. 教育部科學技術進步二等獎（2012年，排名2）
9. 江蘇省科學技術進步二等獎（2012年，排名2）
10. 2010-2011年度蘇州市自然科學優秀學術論文一等獎（2012年）
11. 蘇州市科學技術進步二等獎（2012年，排名1）
12. 2010年中國百篇最具影響國際學術論文（中國科學技術信息研究所，2011年）
13. 2009年中國百篇最具影響國際學術論文（中國科學技術信息研究所，2010年）
14. 2008-2009年度蘇州市自然科學優秀學術論文一等獎（2010年）
專利
1. 孟鳳華，徐海飛，鍾志遠，界面交聯的溫度敏感的聚合物囊泡及其套用。授權專利號：ZL 2009 1 0030113.5.
2. 李玉玲，劉兆忠，周磊，孟鳳華，鍾志遠，側鏈用硫辛酸修飾的親水性聚合物及其製備和套用。授權專利號：ZL 2009 1 0181922.6.
3. 朱彩虹，羅思彬，孟鳳華，朱秀林，鍾志遠，生物可降解陽離子聚合物及其套用。授權專利號：ZL 2009 1 0232056.9.
4. 陳維，王榮，孟鳳華，鍾志遠，含有丙烯酸酯類功能基團的環碳酸酯單體及其製備和套用。專利申請號：200910181912.2。
5. 劉桂景，李少科，孟鳳華，鍾志遠, 生物可降解聚合物囊泡及其製備和套用。專利申請號：200910264247.3。
6. 鍾志遠，劉兆忠，鄭蒙，孟鳳華，一種疏水基團修飾的聚乙烯亞胺衍生物及其套用。專利申請號：201110046746.2.
7. 鍾志遠, 李玉玲，劉兆忠，周磊，孟鳳華，一種側鏈用硫辛酸修飾的親水性聚合物。專利申請號：201110110986.4。
8. Zhiyuan Zhong，Rong Wang, Wei Chen, Fenghua Meng，Method for making an (alkyl) vinyl sulfone based polymer, such (alkyl) vinyl sulfone based polymer, a polymer article and biodevice, cyclic (alkyl) vinyl sulfone carbonate and pegylated cyclic (alkyl) vinyl sulfone carbonate，PCT, filed June 2011.
9. Wei Chen, Rong Wang, Fenghua Meng, and Zhiyuan Zhong, A method of making a polymer preferably an (alkyl)acryloyl polycarbonate, the polymer and (alkyl)acryloyl polycarbonate obtained, and a biodevice comprising same. International Application No. PCT/WO/2011/009478, filed December 2009.
10. Christine Hiemstra, Zhiyuan Zhong, and Jan Feijen, Stereo Photo Hydrogel, a Process of Making Said Stereo Photo Hydrogel, Polymers for Use in Making Such Hydrogel and a Pharmaceutical Comprising Said Polymers, International Application No. PCT/EP2007/002538, filing date: March 20, 2007.
Zhiyuan Zhong, Pieter J. Dijkstra, and Jan Feijen, Branched biodegradable polymers, a macromonomer, processes for the preparation of same, and their use, European Patent, 05.076302.8, filing date: June 3, 2005.
發表文章
1) Y.N. Zhong, C. Wang, R. Cheng, L. Cheng, F.H. Meng*, Z. Liu*, and Z.Y. Zhong*, cRGD-Directed, NIR-Responsive and Robust AuNR/PEG-PCL Hybrid Nanoparticles for Targeted Chemotherapy of Glioblastoma In Vivo, J. Control. Release 2014 (in revision)
2) W. Chen, F.H. Meng, R. Cheng, C. Deng, J. Feijen*, and Z.Y. Zhong*, Advanced Drug and Gene Delivery Systems Based on Functional Biodegradable Polycarbonates and Copolymers, J. Control. Release 2014, http://dx.doi.org/10.1016/j.jconrel.2014.05.023.
3) Y.N. Zhong, F.H. Meng, C. Deng*, and Z.Y. Zhong*, Ligand-Directed Active Tumor-Targeting Polymeric Nanoparticles for Cancer Chemotherapy, Biomacromolecules 2014, 15, 1955-1969.
4) Y. Zou, Y. Song, W.J. Yang, F.H. Meng*, H.Y.Liu, and Z.Y. Zhong*, Galactose-Installed Photo-Crosslinked pH-Sensitive Degradable Micelles for Active Targeting Chemotherapy of Hepatocellular Carcinoma in Mice, J. Control. Release 2014, http://dx.doi.org/10.1016/j.jconrel.2014.05.016
5) Y.J. Jiang, J. Chen, C. Deng*, E. Suuronen, and Z.Y. Zhong*, Click Hydrogels, Microgels and Nanogels: Emerging Platforms for Drug Delivery and Tissue Engineering, Biomaterials 2014, 35, 4969-4985.
6) C. Deng, J.T. Wu, R. Cheng, F.H. Meng, H.A. Klok, and Z.Y. Zhong*, Functional Polypeptide and Hybrid Materials: Precision Synthesis via α-Amino Acid N-Carboxyanhydride Polymerization and Emerging Biomedical Applications, Prog. Polym. Sci. 2014, 39, 330-364.
7) W. Chen, Y. Zou, F.H. Meng, R. Cheng, C. Deng, J. Feijen, and Z.Y. Zhong*, Glyco-Nanoparticles with Sheddable Saccharide Shells: A Unique and Potent Platform for Hepatoma-Targeting Delivery of Anticancer Drugs, Biomacromolecules 2014, 15, 900-907.
8) H.L. Sun, F.H. Meng*, R. Cheng, C. Deng, and Z.Y. Zhong*, Reduction and pH Dual-Bioresponsive Crosslinked Polymersomes for Efficient Intracellular Delivery of Proteins and Potent Induction of Cancer Cell Apoptosis, Acta Biomaterialia 2014, 10, 2159-2168
9) F.H. Meng, Y.N. Zhong, R. Cheng, C. Deng, and Z.Y. Zhong*, pH-sensitive polymer nanoparticles for tumor-targeting doxorubicin delivery: Concept and recent advances, Nanomedicine 2014, 9, 487-499. (invited review)
10) H.L. Sun, F.H. Meng*, R. Cheng, C. Deng, and Z.Y. Zhong*, Reduction-Responsive Polymeric Micelles and Vesicles for Triggered Intracellular Drug Release, Antioxidants & Redox Signaling 2014, doi:10.1089/ars.2013.5733 (invited forum article)
11) W.W. Guo, M. Zheng, Y.N. Zhong, F.H. Meng, C. Deng*, and Z.Y. Zhong*, Poly(ethylene oxide)-graft-methotrexate Macromolecular Drugs Conjugating via Aminopteridine Ring Exhibit Potent Anticancer Activity, Chinese Journal of Chemistry 2014, 32, 57-65.
12) Y.N. Zhong, W.J. Yang, H.L. Sun, R. Cheng, F.H. Meng, C. Deng*, and Z.Y. Zhong*, Ligand-Directed Reduction-Sensitive Shell-Sheddable Biodegradable Micelles Actively Deliver Doxorubicin into the Nuclei of Target Cancer Cells, Biomacromolecules 2013, 14, 3723-3730.
13) J.R. Zhou, P.P. Chen, C. Deng*, F.H. Meng, R. Cheng, and Z.Y. Zhong*, A Simple and Versatile Synthetic Strategy to Functional Polypeptides via Vinyl Sulfone-Substituted L-Cysteine N-Carboxyanhydride, Macromolecules 2013, 46, 6723–6730.
14) Y.P. Fan, C. Deng*, R. Cheng, F.H. Meng, and Z.Y. Zhong*, In Situ Forming Hydrogels via Catalyst-Free and Bioorthogonal “Tetrazole–Alkene” Photo-Click Chemistry, Biomacromolecules 2013, 14, 2814-2821.
15) X.Y. Wang, H.L. Sun, F.H. Meng*, R. Cheng, C. Deng, and Z.Y. Zhong*, Galactose-Decorated Reduction-Sensitive Degradable Chimaeric Polymersomes as a Multifunctional Nanocarrier To Efficiently Chaperone Apoptotic Proteins into Hepatoma Cells, Biomacromolecules 2013, 14, 2873-2882.
16) Y.D. Gu, Y.N. Zhong, F.H. Meng*, R. Cheng, C. Deng, and Z.Y. Zhong*, Acetal-Linked Paclitaxel Prodrug Micellar Nanoparticles as a Versatile and Potent Platform for Cancer Therapy, Biomacromolecules 2013, 14, 2772-2780.
17) Y.N. Zhong, W. Wang, L. Cheng, F.H. Meng, Z.Y. Zhong*, and Z. Liu*, Gold Nanorod-Cored Biodegradable Micelles as a Robust and Remotely Controllable Doxorubicin Release System for Potent Inhibition of Drug-Sensitive and -Resistant Cancer Cells, Biomacromolecules 2013, 14, 2411-2419.
18) L.L. Wu, Y. Zou, C. Deng*, R. Cheng, F.H. Meng, and Z.Y. Zhong*, Intracellular Release of Doxorubicin from Core-Crosslinked Polypeptide Micelles Triggered by Both pH and Reduction Conditions, Biomaterials 2013, 34, 5262-5272.
19) W. Chen, M. Zheng, F.H. Meng, R. Cheng, C. Deng, J. Feijen, and Z.Y. Zhong*, In Situ Forming Reduction-Sensitive Degradable Nanogels for Facile Loading and Triggered Intracellular Release of Proteins, Biomacromolecules 2013, 14, 1214-1222.
20) H.L. Sun, F.H. Meng*, R. Cheng, C. Deng, and Z.Y. Zhong*, Reduction-Sensitive Degradable Micellar Nanoparticles as Smart and Intuitive Delivery Systems for Cancer Chemotherapy, Expert Opin. Drug Deliv. 2013, 10, 1109-1122.
21) R. Cheng, F.H. Meng, C. Deng, H.A. Klok, and Z.Y. Zhong*, Dual and Multi-Stimuli Responsive Polymeric Nanoparticles for Programmed Site-Specific Drug Delivery, Biomaterials 2013, 34, 3647-3657.
22) J. Feijen, and Z.Y. Zhong*, The Second Symposium on Innovative Polymers for Controlled Delivery, September 11-14, 2012, Suzhou, China, J. Control. Release 201 3, 169, 163-164.
23) W. Chen, P. Zhong, F.H. Meng*, R. Cheng, C. Deng, J. Feijen, and Z.Y. Zhong*, Redox and pH-Responsive Degradable Micelles for Dually Activated Intracellular Anticancer Drug Release, J. Control. Release 201 3, 169, 171-179.
24) J. Feijen, W.E. Hennink, and Z.Y. Zhong*, Conference Scene: From Innovative Polymers To Advanced Nanomedicine: Key Challenges, Recent Progress and Future Perspectives, Nanomedicine 2013, 8, 177-180.
25) W. Chen, Y. Zou, J.N. Jia, F.H. Meng, R. Cheng, C. Deng, J. Feijen, and Z.Y. Zhong*, Functional Poly(ε-caprolactone)s via Copolymerization of ε‑Caprolactone and Pyridyl Disulfide-Containing Cyclic Carbonate: Controlled Synthesis and Facile Access to Reduction-Sensitive Biodegradable Graft Copolymer Micelles, Macromolecules 2013, 46, 699-707.
26) F.H. Meng, R. Cheng, C. Deng, and Z.Y. Zhong*, Intracellular Drug Release Nanosystems, Materials Today 2012, 15, 436-442 (invited review)
27) Y.L. Wu, W. Chen, F.H. Meng, Z.J. Wang, R. Cheng, C. Deng, H.Y. Liu, and Z.Y. Zhong*, Core-Crosslinked pH-Sensitive Degradable Micelles: A Promising Approach to Resolve the Extracellular Stability Versus Intracellular Drug Release Dilemma, J. Control. Release 201 2, 164, 338-345.
28) C. Deng, Y.J. Jiang, R. Cheng, F.H. Meng, and Z.Y. Zhong*, Biodegradable Polymeric Micelles for Targeted and Controlled Anticancer Drug Delivery: Promises, Progress and Prospects, Nano Today 2012, 7, 467-480 (invited review)
29) R.R. Wei, L. Cheng, M. Zheng, R. Cheng, F.H. Meng, C. Deng, and Z.Y. Zhong*, Reduction-Responsive Disassemblable Core-Cross-Linked Micelles Based on Poly(ethylene glycol)-b-poly(N-2-hydroxypropyl methacrylamide)–Lipoic Acid Conjugates for Triggered Intracellular Anticancer Drug Release, Biomacromolecules 2012, 13, 2429-2438.
30) S.K. Li, F.H. Meng, Z.J. Wang, Y.N. Zhong, M. Zheng, H.Y. Liu, and Z.Y. Zhong*, Biodegradable Polymersomes with An Ionizable Membrane: Facile Preparation, Superior Protein Loading, And Endosomal pH-Responsive Protein Release, Eur. J. Pharm. Biopharm. 2012, 82, 103-111 (invited article)
31) Y.F. Du, W. Chen, M. Zheng, F.H. Meng, and Z.Y. Zhong*, pH-Sensitive Degradable Chimaeric Polymersomes for the Intracellular Release of Doxorubicin Hydrochloride, Biomaterials 2012, 33, 7291-7299.
32) R. Cheng, X.Y. Wang, W. Chen, F.H. Meng, C. Deng, H.Y. Liu, and Z.Y. Zhong*, Biodegradable Poly(ε-caprolactone)-g-Poly(2-hydroxyethyl methacrylate) Graft Copolymer Micelles as Superior Nano-Carriers for “Smart” Doxorubicin Release, J. Mater. Chem. 2012, 22, 11730-11738.
33) M. Zheng, Z.H. Zhong, L. Zhou, F.H. Meng, R. Peng, and Z.Y. Zhong*, Poly(ethylene oxide) Grafted with Short Polyethylenimine Gives DNA Polyplexes with Superior Colloidal Stability, Low Cytotoxicity and Potent In Vitro Gene Transfection Under Serum Conditions, Biomacromolecules 2012, 13, 881–888.
34) W. Wang, H.L. Sun, F.H. Meng, S.B. Ma, H.Y. Liu, and Z.Y. Zhong*, Precise Control of Intracellular Drug Release and Anti-Tumor Activity of Biodegradable Micellar Drugs Via Reduction-Sensitive Shell-Shedding, Soft Matter 2012, 8, 3949-3956.
35) C.H. Zhu, M. Zheng, F.H. Meng, F.M. Mickler, N. Ruthardt, X.L. Zhu, and Z.Y. Zhong*, Reversibly Shielded DNA Polyplexes Based on Bioreducible PDMAEMA-SS-PEG-SS-PDMAEMA Triblock Copolymers Mediate Markedly Enhanced Nonviral Gene Transfection, Biomacromolecules 2012, 13, 769–778.
36) J.C. Zhang, L.L. Wu, F.H. Meng, Z.J. Wang, C.Deng, H.Y. Liu, and Z.Y. Zhong*, pH and Reduction Dual-Bioresponsive Polymersomes for Efficient Intracellular Protein Delivery, Langmuir 2012, 28, 2056–2065. (invited article)
37) M. Zheng, C.M. Yang, F.H. Meng, R. Peng, and Z.Y. Zhong*, pH-Sensitive Degradable Hydrophobe Modified 1.8 kDa Branched Polyethylenimine, as “Artificial Viruses” for Safe and Efficient Intracellular Gene Transfection, Macromol. Res. 2012, 20, 327-334 (Invited Article)
38) F.X. Zhan, W. Chen, Z.J. Wang, W.T. Lu, R. Cheng, C. Deng, F.H. Meng, H.Y. Liu and Z.Y. Zhong*, Acid-Activatable Prodrug Nanogels for Efficient Intracellular Doxorubicin Release, Biomacromolecules 2011, 12, 3612–3620.
39) R. Cheng, F.H. Meng, S.B. Ma, H.F. Xu, H.Y. Liu, X.B. Jing, and Z.Y. Zhong*, Reduction and Temperature Dual-Responsive Crosslinked Polymersomes for Targeted Intracellular Protein Delivery, J. Mater. Chem. 2011, 21, 19013-19020.
40) M. Zheng, Y.N. Zhong,F.H. Meng, R. Peng, and Z.Y. Zhong*, Lipoic Acid Modified Low Molecular Weight Polyethylenimine Mediates Nontoxic and Highly Potent In Vitro Gene Transfection, Mol. Pharmaceutics, 2011, 8, 2434-2443.
41) Z.Z. Liu, M. Zheng, F.H. Meng, and Z.Y. Zhong*, Non-Viral Gene Transfection In Vitro Using Endosomal pH-Sensitive Reversibly Hydrophobilized Polyethylenimine, Biomaterials 2011, 32, 9109-9119.
42) R. Wang, W. Chen, F.H. Meng, R. Cheng, C. Deng, J. Feijen, and Z.Y. Zhong*, Unprecedented Access to Functional Biodegradable Polymers and Coatings, Macromolecules 2011, 44, 6009–6016.
43) Y.H. Cong, H. Liu, D.L. Wang, B.J. Zhao, T.Z. Yan, L.B. Li , W. Chen, Z.Y. Zhong , M.-C. Lin, H.-L. Chen, and C.L. Yang, Stretch-Induced Crystallization through Single Molecular Force Generating Mechanism, Macromolecules 2011, 44, 5878-5882.
44) J. Chen, W. Chen, C. Deng, F.H. Meng, and Z.Y. Zhong*, Controlled Surface-Initiated Ring-Opening Polymerization of L-Lactide from Risedronate-Anchored Hydroxyapatite Nanocrystals: Novel Synthesis of Biodegradable Hydroxyapatite/Poly(L-lactide) Nanocomposites, J. Polym. Sci. Part A: Polym. Chem. 2011, 49, 4379-4386.
45) R. Yang, F.H. Meng, S.B. Ma, F.S. Huang, H.Y. Liu, and Z.Y. Zhong*, Galactose-Decorated Crosslinked Biodegradable Poly(Ethylene Glycol)- b-Poly(ε-Caprolactone) Block Copolymer Micelles for Enhanced Hepatoma-Targeting Delivery of Paclitaxel, Biomacromolecules 2011, 12, 3047–3055.
46) Y.X. Yu, C. Deng, F.H. Meng, Q. Shi, J. Feijen, and Z.Y. Zhong*, Novel Injectable Biodegradable Glycol Chitosan-Based Hydrogels Crosslinked by Michael-Type Addition Reaction with Oligo(acryloyl carbonate)-b-Poly(ethylene glycol)-b-Oligo(acryloyl carbonate) Copolymers, J. Biomed. Mater. Res. Part A 2011, 99A, 316-326.
47) S.B. Luo, R. Cheng, F.H. Meng, T.G. Park, and Z.Y. Zhong*, Water Soluble Poly(histamine acrylamide) with Superior Buffer Capacity Mediates Efficient and Nontoxic In Vitro Gene Transfection, J. Polym. Sci. Part A: Polym. Chem. 2011, 49, 3366–3373.
48) F.H. Meng, and Z.Y. Zhong*,Polymersomes Spanning from Nano to Micro Scales: Advanced Vehicles for Controlled Drug and Robust Vesicles for Virus and Cell-Mimicking J. Phys. Chem. Letters 2011, 2, 1533-1539. (Invited Perspective)
49) H.L. Sun, F.H. Meng, A.A. Dias, M. Hendriks, J. Feijen, and Z.Y. Zhong*, a-Amino Acid Containing Degradable Polymers as Functional Biomaterials: Rational Design, Synthetic Pathway and Biomedical Applications, Biomacromolecules 2011, 12, 1937-1955.
50) J. Xiong, F.H. Meng, C. Wang, R. Cheng, Z. Liu, and Z.Y. Zhong*, Folate-Conjugated Crosslinked Biodegradable Micelles for Receptor-Mediated Delivery of Paclitaxel, J. Mater. Chem. 2011, 21, 5786-5794.
51) L. Zhou, R. Cheng, H.Q. Tao, S.B. Ma, W.W. Guo, F.H. Meng, H.Y. Liu, Z. Liu, and Z.Y. Zhong*, Endosomal pH-Activatable Poly(ethylene oxide)-graft-Doxorubicin Prodrugs: Synthesis, Drug Release, and Biodistribution in Tumor-Bearing Mice, Biomacromolecules 2011, 12, 1460–1467.
52) Y.H. Wang, M. Zheng, F.H. Meng, J. Zhang, R. Peng, and Z.Y. Zhong*, Branched Polyethylenimine Derivatives with Reductively Cleavable Periphery for Safe and Efficient In Vitro Gene Transfer, Biomacromolecules 2011, 12, 1032-1040.
53) R. Cheng, F. Feng, F.H. Meng, C. Deng, J. Feijen, Z.Y. Zhong*, Glutathione-Responsive Nano-Vehicles as a Promising Platform for Targeted Intracellular Drug and Gene Delivery, J. Control. Release 201 1, 152, 2-12.
54) Z.Y. Zhong*, and J. Feijen, The First Symposium on Innovative Polymers for Controlled Delivery, September 14-17, 2010, Suzhou, China, J. Control. Release 2011, 152, 1-1.
55) G.J. Liu, S.B. Ma, S.K. Li, R. Cheng, F.H. Meng,*, H.Y. Liu, Z.Y. Zhong*, The highly efficient delivery of exogenous proteins into cells mediated by biodegradable chimaeric polymersomes, Biomaterials 2010, 31, 7575-7585.
56) R. Jin, L.S. MoreiraTeixeira, P.J. Dijkstra, Z.Y. Zhong, C.A. van Blitterswijk, M. Karperien, J. Feijen, Enzymatically crosslinked dextran-tyramine hydrogels as injectable scaffolds for cartilage tissue engineering, Tissue Engineering Part A. 2010,16, 2429-2440.
57) C.H. Zhu, S.Y. Jung, G.Y. Si, R. Cheng, F.H. Meng*, X.L. Zhu, T.G. Park, and Z.Y. Zhong*, Cationic methacrylate copolymers containing primary and tertiary amino side groups: controlled synthesis via RAFT polymerization, DNA condensation, and in vitro gene transfection, J. Polym. Sci. Part A: Polym. Chem. 2010, 48, 2869–2877.
58) H.L. Sun, F.H. Meng*, B.N. Guo, X.Q. Li, R. Cheng, H.Y. Liu, and Z.Y. Zhong*, Shell-sheddable micelles based on dextran-ss-poly(e-caprolactone) diblock copolymer for efficient intracellular release of doxorubicin, Biomacromolecules 2010, 11, 848–854.
59) R. Namgung, J.H. Brumbach, J.H. Jeong, J.W. Yockman, S.W. Kim, C. Lin, Z.Y. Zhong, J. Feijen, J.F.J. Engbersen, and W.J. Kim*, Dual bio-responsive gene delivery via reducible poly(amido amine) and survivin-inducible plasmid DNA, Biotechnol. Lett. 2010, 32, 755-764.
60) C.H. Zhu, S.Y. Jung, S.B. Luo, F.H. Meng, X.L. Zhu, T.G. Park, and Z.Y. Zhong*, Co-delivery of siRNA and Paclitaxel into Cancer Cells by Biodegradable Cationic Micelles Based on PDMAEMA-PCL-PDMAEMA Triblock Copolymers, Biomaterials 2010, 31, 2408–2416.
61) W. Chen, F.H. Meng*, R. Cheng, and Z.Y. Zhong*, pH-Sensitive Degradable Polymersomes for Triggered Release of Anticancer Drugs: a Comparative Study with Micelles, J. Control. Release 2010, 142, 40-46.
62) W. Chen, H.C. Yang, R. Wang, R. Cheng, F.H. Meng*, W.X. Wei, and Z.Y. Zhong*, Versatile Synthesis of Functional Biodegradable Polymers by Combining Ring-Opening Polymerization and Postpolymerization Modification via Michael-Type Addition Reaction, Macromolecules 2010, 43, 201–207.
63) J.M. Jukes, L.J. van der Aa, C. Hiemstra, T. van Veen, P.J. Dijkstra, Z.Y. Zhong, J. Feijen, C.A. van Blitterswijk, J. de Boer, A newly developed chemically crosslinked Dex-PEG hydrogel for cartilage tissue engineering, Tissue Engineering Part A. 2010, 16: 565-573.
64) Y.L. Li, L. Zhu, Z.Z. Liu, R. Cheng, F.H. Meng*, J.H. Cui, S.J. Ji, and Z.Y. Zhong*, Reversibly Stabilized Multifunctional Dextran Nanoparticles Efficiently Deliver Doxorubicin into the Nuclei of Cancer Cells, Angew. Chem. Int. Ed. 2009, 48, 9914-9918.
65) Y.M. Xu, F.H. Meng*, R. Cheng, Z.Y. Zhong*, Reduction-Sensitive Reversibly Crosslinked Biodegradable Micelles for Triggered Release of Doxorubicin, Macromol. Biosci. 2009, 9, 1254-1261.
66) H.Z. Du, A.H. Velders, P.J. Dijkstra, Z.Y. Zhong, X.S. Chen, J. Feijen, Chiral Salan Aluminum Ethyl Complexes and Their Application in Lactide Polymerization, Chem.-Eur. J. 2009, 15: 9836-9845.
67) H.L. Sun, B.N. Guo, R. Cheng, F.H. Meng *, H.Y. Liu, Z.Y. Zhong*, Biodegradable micelles with sheddable poly(ethylene glycol) shells for triggered intracellular release of doxorubicin, Biomaterials 200 9, 30: 6358-6366.
68) W. Chen, F.H. Meng, F. Li, S.-J. Ji, Z.Y. Zhong*, pH-Responsive Biodegradable Micelles Based on Acid-Labile Polycarbonate Hydrophobe: Synthesis and Triggered Drug Release, Biomacromolecules 2009, 10: 1727-1735.
69) H.F. Xu, F.H. Meng*, Z.Y. Zhong*, Reversibly crosslinked temperature-responsive nano-sized polymersomes: synthesis and triggered drug release, J. Mater. Chem. 2009, 19: 4183-4190.
70) F.H. Meng, W.E.Hennink, Z.Y. Zhong*, Reduction-Sensitive Polymers and Bioconjugates for Biomedical Applications, Biomaterials 2009, 30:2180-2198.
71) R. Jin, L.S. Moreira Teixeira, P.J. Dijkstra, M. Karperien, Z.Y. Zhong, J. Feijen, Injectable Chitosan-based Hydrogels for Cartilage Tissue Engineering, Biomaterials 2009, 30:2544-2551
72) H.Z. Du, A.H. Velders, P.J. Dijkstra, Z.Y. Zhong, X.S. Chen, J. Feijen, Polymerization of lactide using achiral bis(pyrrolidene) schiff base aluminum complexes, Macromolecules 2009, 42: 1058–1066.
73) F.H. Meng, Z.Y. Zhong*, J. Feijen, Stimuli-responsive polymersomes for programmed drug delivery. Biomacromolecules 2009, 10: 197-209.
74) C. Lin, C.-J. Blaauboer, M. Mateos Timoneda, M.C. Lok, M. van Steenbergen, W.E. Hennink, Z.Y. Zhong, J. Feijen, and J.F.J. Engbersen, Bioreducible poly(amido amine)s with oligoamine side chains: Synthesis, characterization, and structural effects on gene delivery, J. Control. Release, 2008, 126: 166-174.
75) C. Lin, Z.Y. Zhong, M.C. Lok, Holger K. de Wolf, W.E. Hennink, J. Feijen, J.F.J. Engbersen, Bioreducible poly(amido amine)s for gene delivery to ovarian cancer cells, J. Control. Release, 2008, 132: e9-e10.
76) R. Jin, L.S. Moreira Teixeira, P.J. Dijkstra, M. Karperien, Z. Zhong, J. Feijen, Fast in-situ formation of dextran-tyramine hydrogels for in vitro chondrocyte culturing, J. Control. Release, 2008, 132: e24-e26.
77) C. Hiemstra, W. Zhou, Z.Y. Zhong *, M. Wouters, and J Feijen*, Rapidly in situ forming biodegradable robust hydrogels by combining stereocomplexation and photopolymerization, J. Am. Chem. Soc. 2007, 129: 9918-9926.
78) M. Roerdink, T.S. van Zanten, M.A. Hempenius, Z.Y. Zhong, J. Feijen, and G.J. Vancso, Poly(ferrocenylsilane-block-lactide) Block copolymers, Macromol. Rapid Commun. 2007, 28: 2125-2130.
79) C. Lin, Z.Y. Zhong *, M.C. Lok, X.L. Jiang, W.E. Hennink, J. Feijen, and J.F.J. Engbersen*, Random and block copolymers of bioreducible poly(amido amine)s with high-and low-basicity amino groups: study of DNA condensation and buffer capacity on gene transfection, J. Control. Release, 200 7, 123: 67-75.
80) C. Hiemstra, Z.Y. Zhong *, M. J. van Steenbergen, W.E. Hennink, and J. Feijen*, Release of model proteins and basic fibroblast growth factor from in situ forming degradable dextran hydrogels, J. Control. Release 2007, 122: 71-78.
81) C. Hiemstra, Z.Y. Zhong *, S.R. van Tomme, M. J. van Steenbergen, J.J.L. Jacobs, W. den Otter, W.E. Hennink, and Jan Feijen*， In vitro and in vivo protein delivery from in situ forming poly(ethylene glycol)-poly(lactide) hydrogels, J. Control. Release 2007, 119: 320-327.
82) C. Hiemstra, L.J. van der Aa, Z.Y. Zhong *, and J. Feijen*, Rapidly in situ forming degradable hydrogels from dextran thiols through Michael addition, Biomacromolecules 2007, 8: 1548-1556.
83) F. Rusmini, Z.Y. Zhong *, and J. Feijen*, Protein immobilization strategies for protein biochips, Biomacromolecules 2007, 8: 1775-1789.
84) R. Jin, C. Hiemstra, Z.Y. Zhong *, and J. Feijen*, Enzyme-mediated fast in-situ formation of hydrogels from dextran-tyramine conjugates, Biomaterials 2007, 28: 2791-2800.
85) C. Hiemstra, L.J. van der Aa, Z.Y. Zhong *, P.J. Dijkstra, and J. Feijen*, Novel in situ forming, degradable dextran hydrogels by Michael addition chemistry: synthesis, rheology and degradation, Macromolecules 2007, 40: 1165-1173.
86) L.V. Christensen, C.W. Chang, J.W. Yockman, R. Conners, H. Jackson, D.A. Bull, Z.Y. Zhong, J. Feijen, and S.W. Kim, Reducible poly(amido ethylenediamine) for hypoxia-inducible VEGF delivery, J. Control. Release 2007, 118: 254-261.
87) J.H. Jeong, L.V. Christensen, J.W. Yockman, Z.Y. Zhong, J.F.J. Engbersen, W.J. Kim, J. Feijen, S.W. Kim, Reducible poly(amido ethylenimine) directed to enhance RNA interference, Biomaterials 2007, 28: 1912-1917.
88) C. Lin, Z.Y. Zhong *, M.C. Lok, X.L. Jiang, W.E. Hennink, J. Feijen, and J.F.J. Engbersen*, Novel bioreducible poly(amido amine)s for highly efficient gene delivery, Bioconjugate Chem. 2007，18: 138-145.
89) L.B. Li, F.H. Meng, Z.Y. Zhong, D. Byelov, W.H. de Jeu, and J. Feijen, Morphology of a highly asymmetric double crystallizable poly(e-caprolactone-b-ethylene oxide) block copolymer, J. Chem. Phys., 2007, 126: Art. No. 024904.
90) M.R. ten Breteler, Z.Y. Zhong, P.J. Dijkstra, and J. Feijen, Ring-opening polymerization of substituted e-caprolactones using a chiral (salen) AlOiPr-Complex, J. Polym. Sci. Part A, Polym. Chem. 2007, 45: 429-436.
91) C. Lin, Z.Y. Zhong *, M.C. Lok, X.L. Jiang, W.E. Hennink, J. Feijen, and J.F.J. Engbersen*, Linear poly(amido amine)s with secondary and tertiary amino groups and variable amounts of disulfide linkages: synthesis and in vitro gene transfer properties, J. Control. Release, 2006, 116: 130-137.
92) C. Hiemstra, Z.Y. Zhong, X. Jiang, W.E. Hennink, P.J. Dijkstra, and J. Feijen, PEG-PLLA and PEG-PDLA multiblock copolymers: synthesis and in situ hydrogel formation by stereocomplexation, J. Control. Release, 2006, 116: e17-e19.
93) C. Hiemstra, Z.Y. Zhong, S.R. van Tomme, W.E. Hennink, P.J. Dijkstra, and J. Feijen, Protein release from injectable stereocomplexed hydrogels based on PEG-PDLA and PEG-PLLA star block copolymers, J. Control. Release, 2006, 116: e19-e21.
94) C. Lin, T.M. Lammens, Z.Y. Zhong, H. Gu, M.C. Lok, X. Jiang, W.E. Hennink, J. Feijen, and J.F.J. Engbersen, Disulfide-containing poly(β-amino ester)s for gene delivery, J. Control. Release, 2006, 116: e79-e81.
95) Z.Y. Zhong *, C. Lin, Y. Ma, M.A. Hempenius, M.C. Lok, M.M. Fretz, J.F.J. Engbersen, G.J. Vancso, W.E. Hennink, and J. Feijen, Water-soluble cationic poly(ferrocenylsilane): an efficient DNA condensation and transfection agent, J. Control. Release, 2006, 116: e81-e83.
96) C. Hiemstra, Z.Y. Zhong *, L.B. Li, P.J. Dijkstra, and J. Feijen*, In situ formation of biodegradable hydrogels by stereocomplexation of PEG-(PLLA) and PEG-(PDLA) star block copolymers, Biomacromolecules 2006, 7: 2790-2795.
97) L.V. Christensen, C.W. Chang, W.J. Kim, S.W. Kim*, Z.Y. Zhong *, C. Lin, J.F.J. Engbersen*, and J. Feijen, Reducible poly(amido ethylenimine)s designed for triggered intracellular gene delivery, Bioconjugate Chem., 2006, 17: 1233-1240.
98) M. Leemhuis, C.F. van Nostrum, J.A.W. Kruijtzer, Z.Y. Zhong, M.R. ten Breteler, P.J. Dijkstra, J. Feijen, and W.E. Hennink, Functionalized poly( -hydroxy acid)s via ring-opening polymerization: toward hydrophilic polyesters with pendant hydroxyl groups, Macromolecules, 2006, 39: 3500-3508.
99) G. Engbers, A. Poot, D. Grijpma, Z.Y. Zhong, and P. Dijkstra, Professor Jan Feijen-30 years research in biomedical technology, J. Control. Release 2005, 109: 2-4.
100) Z.Y. Zhong, J. Feijen, M.C. Lok, W.E. Hennink, L. Christensen, J.W. Yockman, Y.-H. Kim, and S.W. Kim, Low molecular weight linear polyethylenimine-b-poly(ethylene glycol)-b-polyethylenimine triblock copolymers: synthesis, characterization and in vitro gene transfer properties, Biomacromolecules, 2005, 6: 3440-3448.
101) Z.Y. Zhong, Y. Song, J.F.J. Engbersen, M.C. Lok, W.E. Hennink, and J. Feijen, A versatile family of degradable non-viral gene carriers based on hyperbranched poly(ester amine)s. J. Control. Release 2005, 109: 317-329.
102) C. Hiemstra, Z.Y. Zhong, P. Dijkstra, and J. Feijen, Stereocomplex mediated gelation of PEG-(PLA)(2) and PEG-(PLA)(8) block copolymers. Macromol. Symp., 2005, 224: 119-131.
103) Z. Zhong, M.C. Lok, P.J. Dijkstra, W.E. Hennink, and J. Feijen, Structurally well-defined copolymers of poly(ethylene glycol) and low molecular weight linear polyethylenimine as vectors for gene delivery. J. Control. Release, 2005, 101(1-3): 406-408.
104) C. Hiemstra, Z. Zhong, P.J. Dijkstra, and J. Feijen, PEG-PLA hydrogels by stereocomplexation for tissue engineering of cartilage. J. Control. Release, 2005, 101(1-3): 332-334.
105) G. Becker, M. Niemeyer, O. Mundt, W. Schwarz, M. Westerhausen, M.W. Ossberger, P. Mayer, H. Noth, Z.Y. Zhong, P.J. Dijkstra, and J. Feijen, Crystal structures and spectroscopic properties of 2 lambda(3)-phospha-1,3-dionates and 1,3-dionates of calcium - Comparative studies on the 1,3-diphenyl and 1,3-Di(tert-butyl) derivatives. Z. Anorg. Allg. Chem., 2004, 630(15): 2605-2621.
106) Z.Y. Zhong, P.J. Dijkstra, and J. Feijen, Controlled synthesis of biodegradable lactide polymers and copolymers using novel in situ generated or single-site stereoselective polymerization initiators. J. Biomater. Sci.-Polym. Ed., 2004, 15(7): 929-946.
107) L.B. Li, Z.Y. Zhong, W.H. de Jeu, P.J. Dijkstra, and J. Feijen, Crystal structure and morphology of poly(L-lactide-b-D-lactide) diblock copolymers. Macromolecules, 2004, 37(23): 8641-8646.
108) M. Westerhausen, S. Schneiderbauer, A.N. Kneifel, Y. Soltl, P. Mayer, H. Noth, Z.Y. Zhong, P.J. Dijkstra, and J. Feijen, Organocalcium compounds with catalytic activity for the ring-opening polymerization of lactones. Eur. J. Inorg. Chem., 2003, (18): 3432-3439.
109) Z.Y. Zhong, P.J. Dijkstra, and J. Feijen, Determination of the Stereoselectivity Factor for an Asymmetric Enantiomer-Differentiating Polymerization: a Revisit. Macromolecules, 2003, 36(21): 8198-8200.
110) Z.Y. Zhong, S. Schneiderbauer, P.J. Dijkstra, W. M., and J. Feijen, Single-site calcium initiators for the controlled ring-opening polymerization of lactides and lactones. Polym. Bull., 2003, 51: 175-182.
111) Z.Y. Zhong, P.J. Dijkstra, and J. Feijen, controlled and stereoselective polymerization of lactide: kinetics, selectivity, and microstructures. J. Am. Chem. Soc., 2003, 125(37): 11291-11298.
112) A.P. Pego, Z.Y. Zhong, P.J. Dijkstra, D.W. Grijpma, and J. Feijen, Influence of catalyst and polymerization conditions on the properties of 1,3-trimethylene carbonate and epsilon- caprolactone copolymers. Macromol. Chem. Phys., 2003, 204(5-6): 747-754.
113) Z.Y. Zhong, P.J. Dijkstra, and J. Feijen, [(salen)Al]-mediated, controlled and stereoselective ring-opening polymerization of lactide in solution and without solvent: Synthesis of highly isotactic polylactide stereocopolymers from racemic D,L-lactide. Angew. Chem. Int. Edit., 2002, 41(23): 4510-4513.
114) Z.Y. Zhong, P.J. Dijkstra, J. Feijen, Y.M. Kwon, Y.H. Bae, and S.W. Kim, Synthesis and aqueous phase behavior of thermoresponsive biodegradable poly(D,L-3-methylglycolide)-block-poly(ethylene glycol)-block-poly(D,L-3-methylglycolide) triblock copolymers. Macromol. Chem. Phys., 2002, 203(12): 1797-1803.
115) Z.Y. Zhong, S. Schneiderbauer, P.J. Dijkstra, M. Westerhausen, and J. Feijen, Fast and living ring-opening polymerization of L-lactide initiated with in-situ-generated calcium alkoxides. J. Polym. Environ., 2001, 9(1): 31-38.
116) Z.Y. Zhong, M.J.K. Ankone, P.J. Dijkstra, C. Birg, M. Westerhausen, and J. Feijen, Calcium methoxide initiated ring-opening polymerization of epsilon-caprolactone and L-lactide. Polym. Bull., 2001, 46(1): 51-57.
117) Z.Y. Zhong, P.J. Dijkstra, C. Birg, M. Westerhausen, and J. Feijen, A novel and versatile calcium-based initiator system for the ring-opening polymerization of cyclic esters. Macromolecules, 2001, 34(12): 3863-3868.
118) Z.Y. Zhong, P.J. Dijkstra, and J. Feijen, Controlled ring-opening polymerization of omega- pentadecalactone with yttrium isopropoxide as an initiator. Macromol. Chem. Phys., 2000, 201(12): 1329-1333.
119) Z.Y. Zhong, D.H. Yu, F.H. Meng, Z.H. Gan, and X.B. Jing, Controlled synthesis of L-lactide-b-epsilon-caprolactone block copolymers using a rare earth complex as catalyst. Polym. J., 1999, 31(8): 633-636.
120) Z.H. Gan, D.H. Yu, Z.Y. Zhong, Q.Z. Liang, and X.B. Jing, Enzymatic degradation of poly(epsilon-caprolactone)/poly(DL- lactide) blends in phosphate buffer solution. Polymer, 1999, 40(10): 2859-2862.
121) J. Zhang, Z.H. Gan, Z.Y. Zhong, and X.B. Jing, A novel rare earth coordination catalyst for polymerization of biodegradable aliphatic lactones and lactides. Polym. Int., 1998, 45(1): 60-66.
部分國際會議邀請報告
1. Plenary lecture “Robust Biodegradable Nanoparticles with Active Tumor-Targeting and Programmed Drug Release”, 13 European Symposium on Controlled Drug Delivery (ESCDD 2014, April 16-18, 2014, Egmond aan Zee, The Netherlands)
2. Invited lecture “Design of Bio-Responsive Polymeric Nanosystems for Active Anticancer Drug, Protein, and Gene Delivery”, Seminar Nanobiotechnology Munich (January 28, 2014, Ludwig-Maximilians-University Munich, Germany)
3. Invited lecture “Design of Stimuli-Sensitive Biodegradable Polymeric Nanosystems for Precision Anticancer Drug Release”, The 13th Pacific Polymer Conference (PPC 2013, November 17-22, 2013, Kaohsiung,Taiwan)
4. Invited lecture “Biodegradable Nanoparticles for Targeted Anticancer Drug Delivery: Dilemma of Extracellular Stability versus Intracellular Drug Release”, 3rd Sino-German Symposium on Nanomaterials for Biomedical Applications (October 28-30, 2013, Hangzhou,China)
5. Invited lecture “Bioresponsive Biodegradable Micelles and Polymersomes for Targeted Intracellular Drug Delivery”, 246 ACS National Meeting (September 8 -12, 2013, Indianapolis,USA)
6. Invited lecture “From Functional Biodegradable Polymers To Targeted Drug and Protein Delivery” (August 16, 2013, Freie Universität Berlin,Germany)
7. Invited lecture “Bioresponsive Degradable Nanocarriers for Active Intracellular Anticancer Drug Delivery”, Controlled Release Society's 40th Annual Meeting and Exposition (July 21-24, 2013, Honolulu, Hawaii,USA)
8. Invited lecture “Bioresponsive Degradable Micelles and Polymersomes for Active Intracellular Drug Release in Cancer Cells”, Joint Symposium of the 5th Utah-Inha DDS & Advanced Therapeutics Research Center Symposium and the 7th International Symposium on Intelligent DDS (May 23-24, 2013, Incheon, Korea)
9. Invited lecture “Bioresponsive Nanosystems for Active Intracellular Drug and Protein Delivery”, 2013 MRS Spring Meeting & Exhibit (April 1-5, 2013, San Francisco,USA)
10. Invited lecture “From Functional Biodegradable Polymers To Controlled Drug Release Systems”, Symposium on Collaborations in Medical Bionics (December 8, 2012, Beijing,China)
11. Invited lecture “Novel Design and Synthesis of Functional Biodegradable Polymers and Nano-Carriers”, 244 ACS National Meeting (August 19-23, 2012, Philadelphia,USA)
12. Invited lecture “From Functional Biodegradable Polymers To Advanced Drug Delivery Systems”, 2012 World Polymer Congress (MACRO 2012, June 24-29, 2012, Virginia, USA)
13. Invited lecture “Nano-Carriers for Targeted Drug Delivery: Issues of Stability Versus Drug Release”, 12 European Symposium on Controlled Drug Delivery (ESCDD 2012, April 4-6, 2012, Egmond aan Zee, The Netherlands)
14. Invited lecture “Biodegradable Nano-Carriers for Drug, Protein and Gene Delivery: Promise, Problems and Prospects”, Seminar of Institute of Bioengineering and Nanotechnology (IBN) (January 4, 2012,Singapore)
15. Invited lecture “Versatile Synthesis and Biomedical Applications of Functional Biodegradable Polymers”, The 5th International Symposium on Polymer Chemistry (PC2012, June 2-6, 2012, Changchun,China)
16. Invited lecture “Bio-Responsive Nano-carriers for Efficient Intracellular Drug and Gene Delivery”, 12 Pacific Polymer Conference (PPC 12, November 13-17, 2011, Jeju Island,South Korea)
17. Invited lecture “Reduction-Responsive Nano-Carriers for Targeted Intracellular Drug Delivery”, 3 Asian Biomaterials Congress (September 15-17, 2011, Busan,South Korea)
18. Invited lecture “Multifunctional Biomaterials and Polymer-based Controlled Drug Release Systems”, 2 Sino-German Symposium on Multifunctional Biomaterials and Polymer-based Controlled Drug Release Systems (October 27-30, 2011, Berlin,Germany)
19. Invited lecture “Novel Synthesis of Functional Biodegradable Polymers based on Designed Cyclic Carbonate Monomers”, 3 International Conference on Bio-based Polymers (ICBP 2011, October 18-21, 2011, Beijing,China)
20. Invited lecture “Nano-Vehicles for Targeted Drug Delivery: Issues of Stability versus Drug Release”, The International Symposium on Functional Polymers and Nanomedicine (May 15-18, 2011, Hangzhou,China)
21. Invited lecture “Novel PDMAEMA and PEI-Based Gene Vectors”, 10 China-Japan-Korea Foresight Joint Symposium on Gene Delivery and International Symposium on Biomaterials（May 29-June 2, 2011, Guilin, China）
22. Invited lecture “pH and Reduction-Responsive Nano-Vehicles for Intracellular Protein and Drug Delivery”, 2011 International Advanced Drug Delivery Symposium (April 27-28, 2011,Taiwan)
23. Invited lecture “Reduction-Responsive Nano-Carriers for Intracellular Delivery of Anticancer Drugs”, The Third Sino-German Frontiers of Chemistry Symposium (August 12-15, 2010, Seeon,Germany)
24. Invited lecture “Bioresponsive Nano-Vehicles for Drug and Gene Delivery”, International Symposium on Polymer Chemistry (PC 2010, June 2-5, 2010, Suzhou,China)
25. Invited lecture “Reduction-Responsive Nano-Carriers for Targeted Intracellular Drug Delivery”, Sino-German Symposium on Bioinspired Systems for Drug, Protein and Gene Delivery (September 6-9, 2010, Chengdu, China)
26. Invited lecture “Stimuli-Sensitive Nano-carriers for Triggered Intracellular Drug Delivery”, 2 Sino-Canadian Conference of Advanced Materials (May 15-17, 2010, Suzhou,China)
27. Invited lecture “Stimuli-Responsive Biodegradable Micelles and Polymersomes for Triggered Drug Delivery”, 13 International IUPAC Conference on Polymers and Organic Chemistry (July 5 - 8, 2009, Montréal,Canada)
