主要成就
1990年獲美國南卡羅萊納大學博士學位。現任東北師範大學生命科學院教授。長期從事基因的克隆、基因的表達及基因的調節研究工作，完成了多個基因的克隆工作，建立了多種細胞模型、轉基因動物模型，以及多個基因的定位敲除動物模型。先後在Nature, Science，PNAS，BLOOD，JBC等權威雜誌上發表了多篇論文。1993年開始從事與心血管病有關的凝血蛋白酶（血栓素）受體的研究工作，在血栓素受體基因克隆、基因表達，以及利用轉基因動物和最新的基因敲除技術在血管內皮細胞生長因子（VEGF）基因的功能等方面進行了大量的、深入的研究，並取得了一系列科研成果，在國際血栓素受體和血管內皮生長因子研究領域內占有重要學術地位。
個人經歷
1978 — 1982 山西大學生命科學院植物生理學學生，獲得學士學位；
1985 — 1990 美國南卡羅萊納大學生命科學系分子遺傳學研究生，獲得博士學位；
1990 — 1993 美國加州大學舊金山分校病理系，博士後；
1982 — 1984 山西大學生命科學院助教
1985 — 1990 美國南卡羅萊納大學生命科學系，研究助教
1990 — 1993 美國加州大學舊金山分校 心血管研究所，專職助研究員
1993 — 1996 美國加州大學舊金山分校 心血管研究所，專職副研究員
2000 — 2003 美國加州大學舊金山分校 心血管研究所，專職研究員一級
2003 — 2006 美國加州大學舊金山分校心血管研究所，專職研究員二級
2006 — 現在 美國加州大學舊金山分校心血管研究所，專職研究員三級
2005 — 現在 東北師範大學生命科學院膜通道實驗室，教授
社會學術兼職
現任北美生物科技學會（SCBA)會員，華園科技學會會員(HYSTA)會員，美西醫藥協會(SAPA- West)會員，以及中國細胞生物學學會（CSCB）會員。
教學工作
主要講授課程：
本科：《細胞生物工程》
主要科研方向
研究領域：
分子生物學、細胞生物學、基因工程、心血管病學
研究方向：
基因的克隆、基因的表達調控；細胞工程和基因工程；心血管病的相關基因的功能研究
發表論文：
1. Pappu R,Schwab SR,Comelissen I,Pereira JP,Regard JB,Xu Y,Camerer E,Zheng YW,Huang Y,Cyster JG,Coughlin SR.
Promotion oflymphocyteegressinto Blood and Lymph by Distinct Sources of Sphingosine-1-Phosphate.
Science. 2007 Mar 15； [Epub ahead of print]
2. DE Candia E, Pecci A, Ciabattoni G, DE Cristofaro R, Rutella S, Yao-Wu Z, Lazzareschi I, Landolfi R, Coughlin S, Balduini CL.
platelet responsiveness to thrombin and protease-activated receptors agonists in a novel case of gray platelet syndrome: correlation between the platelet defect and the alpha-granule content in the patient and four relatives.
J Thromb Heamost.2007 Mar；5(3):551-9. Epub 2006 Nov 1
3. Griffin CT*, Srinivasan Y*, Zheng YW, Huang W, Coughlin SR.
A role for thrombin receptor signaling in endothelial cells during embryonic development.
Science. 2001 Aug 31；293(5535):1666-70.
*Equal contributors
4. Sambrano GR*, Weiss EJ*, Zheng YW*, Huang W, Coughlin SR.
Role of thrombin signaling in platelets in haemostasis andthrombosis.
Nature. 2001 Sep 6；413(6851):74-8.
*Equal contributors
5.NAKANISHI-Matsui M, Zheng YW, Sulciner DJ, Weiss EJ, Ludeman MJ, Coughlin SR.
PAR3 is a cofactor for PAR4 activation by thrombin.
Nature. 2000 Apr 6；404(6778):609-13.
6. Camerer E, Cornelissen I, Kataoka H, Duong DN, Zheng YW, Coughlin SR.
Roles of protease-activated receptors in a mouse model of endotoxemia.
Blood. 2006 Jan 24； [Epub ahead of print]
7. Ruppel KM, Willison D, Kataoka H, Wang A, Zheng YW, Cornelissen I, Yin L, Xu SM, Coughlin SR.
Essential role for Galpha13 in endothelial cells during embryonic development.
Proc Natl Acad Sci U S A. 2005 Jun 7;102(23):8281-6. Epub 2005 May 26.
8. Ludeman MJ, Zheng YW, Ishii K, Coughlin SR.
Regulated shedding of PAR1 N-terminal exodomain from endothelial cells.
J Biol Chem. 2004 Feb 24 [Epub ahead of print]
9. Kataoka H, Hamilton JR, McKemy DD, Camerer E, Zheng YW, Cheng A, Griffin C, Coughlin SR.
Protease-activated receptors 1 and 4 mediate thrombin signaling in endothelial cells.
Blood. 2003 Nov 1；102(9):3224-31. Epub 2003 Jul 17.
10. Camerer E, Kataoka H, Zheng YW, Kahn M, Lease K, Coughlin SR.
Genetic evidences that protease-activated receptors mediate factor Xa signaling in endothelial cells.
J Biol Chem. 2002 May 3；277(18):16081-7.
11. Cases S, Smith SJ, Zheng YW, Myers HM, Lear SR, Sande E, Novak S, Collins C, Welch CB, Lusis AJ, Erickson SK, Farese RV Jr.
Identification of a gene encoding an acyl CoA:diacylglycerol acyltransferase, a key enzyme in triacylglycerol synthesis.
Proc Natl Acad Sci U S A. 1998 Oct 27；95(22):13018-23.
12. Cases S, Novak S, Zheng YW, Myers HM, Lear SR, Sande E, Welch CB, Lusis AJ, Spencer TA, Krause BR, Erickson SK, Farese RV Jr.
ACAT-2, a second mammalian acyl-CoA: cholesterol acyltran-sferase. Its cloning, expression, and characterization.
J Biol Chem. 1998 Oct 9；273(41):26755-64.
13. Kahn ML, Zheng YW, Huang W, Bigornia V, Zeng D, Moff S, Farese RV Jr, Tam C, Coughlin SR.
A dual thrombin receptor system for platelet activation.
Nature. 1998 Aug 13；394(6694):690-4.
14. Ishihara H, Connolly AJ, Zeng D, Kahn ML, Zheng YW, Timmons C, Tram T, Coughlin SR.
Protease-activated receptor 3 is a second thrombin receptor in humans.
Nature. 1997 Apr 3；386(6624):502-6.
15. Cases, S； Zheng, YW；Novak， S； et al.
Identification and cloning of two new mammalian ACAT gene family members
Circulation, 96 (8): 1264-1264 Suppl. S OCT 21 1997
16. Zheng YW, Felder MR.
Genetic mapping of a possible new alcohol dehydrogenase sequence to mouse chromosome 3 at the Adh-1/Adh-3 complex.
Biochem Genet. 1997 Apr；35(3-4):105-17.
17. Xie D, Narasimhan P, Zheng YW, Dewey MJ, Felder MR.
Ten kilobases of 5'-flanking region confers proper regulation of the mouse alcohol dehydrogenase-1 (Adh-1) gene in kidney andadrenalof transgenic mice.
Gene. 1996 Nov 28；181(1-2):173-8.
18. Ishii K, Gerszten R, Zheng YW, Welsh JB, Turck CW, Coughlin SR.
Determinants of thrombin receptorcleavage. Receptor domains involved, specificity, and role of the P3 aspartate.
J Biol Chem. 1995 Jul 7；270(27):16435-40.
19. Zheng YW, Riegler J, Wu J, Yen TS.
Novel short transcripts of hepatitis B virus X gene derived from intragenic promoter.
J Biol Chem. 1994 Sep 9；269(36):22593-8.
20Yen, Tsb; Zheng, Yw
Novel Small Transcripts Of The Hepatitis-B Virus X-Gene
Journal Of Cellular Biochemistry, 218-218 Suppl. 18c Feb 13 1994
21. Zheng YW, Yen TS.
Negative regulation of hepatitis B virus gene expression and replication by oxidative stress.
J Biol Chem. 1994 Mar 25；269(12):8857-62.
22. Zheng YW, Bey M, Liu H, Felder MR.
Molecular basis of the alcohol dehydrogenase-negative deer mouse. Evidence for deletion of the gene for class I enzyme and identification of a possible new enzyme class.
J Biol Chem. 1993 Nov 25；268(33):24933-9.
23. Ceci JD, Zheng YW, Felder MR.
Molecular analysis of mouse alcohol dehydrogenase: nucleotide sequence of the Adh-1 gene and genetic mapping of a related nucleotide sequence to chromosome 3.
Gene. 1987；59(2-3):171-82.
