研究方向
1. 針對特定靶點的小分子新藥研發及作用機理研究 ：主要針對惡性腫瘤及神經系統疾病包括急性腦損傷等進行針對特定靶點新藥研發套用基礎研究，研究內容包括高通量抗腫瘤藥物篩選，藥效，藥代動力學及安全性評價，基於代謝組學及蛋白組學等藥物作用機理及安全性研究。2. 抗腫瘤多藥耐藥及藥代動力學研究： 研究範圍包括藥物轉運載體包括腫瘤多藥耐藥相關藥物載體的調控機理研究，不同疾病狀態下藥物轉運載體的調控和藥代動力學特點研究。
代表性論著
· Huang Y , Gao H , Gou M , Ye H , Liu Y , Gao Y , Peng F , Qian Z , Cen X , Zhao Y *. Acute toxicity and genotoxicity studies on poly(varepsilon-caprolactone)-poly(ethylene glycol)-poly(varepsilon-caprolactone) nanomaterials. Mutat Res. 20 10 Jan 7.· Qian Bu, Guangyan Yan, Pengchi Deng, Feng Peng, Hongjun Lin, YouzhiXu, Zhixing Cao, Tian Zhou, Aiqin Xue, Yanli Wang, Xiaobo Cen and Ying-Lan Zhao * . NMR-based metabonomic study of the sub-acute toxicity of titanium dioxide nanoparticles in rats after oral administration. Nanotechnology. 2010, 21, 125105.
· Zheng-Guang Li, Ying-Lan Zhao, Xiaohua Wu, Hao-Yu Ye, Aihua Peng, Zhi-Xing Cao, Yong-Qiu Mao, Yu-Zhu Zheng, Pei-Du Jiang, Xia Zhao, Li-Juan Chen and Yu-Quan Wei. Barbigerone, a Natural Isoflavone, Induces Apoptosis in Murine Lung-Cancer Cells via the Mitochondrial Apoptotic Pathway. Cellular Physiology and Biochemistry. 2009;24:95-104.
· Yuzhu Zheng, Ying-Lan Zhao * , Xiaoqiang Deng, Shengyong Yang, Yongqiu Mao, Zhengguang Li, Peidu Jiang, Xia Zhao, and Yuquan Wei. Chloroquine Inhibits Colon Cancer Cell Growth In Vitro and Tumor Growth In Vivo via Induction of Apoptosis. Cancer Investigation. 2009 .27,286-292.
· Pei-du Jiang, Ying-Lan Zhao * , Wei Shi, Xiao-qiang Deng, Gang Xie, Yong-qiu Mao, Zheng-guang Li, Yu-zhu Zheng, Sheng-yong Yang and Yu-quan Wei. Cell Growth Inhibition, G2/M Cell Cycle Arrest, and Apoptosis Induced by Chloroquine in Human Breast Cancer Cell Line Bcap-37. Cellular Physiology and Biochemistry. 2008, 22,431-440.
· Ying-Lan Zhao , Qian Bu, Yan Zhou, Lei Lv, Guangyan Yan, Li Wang, Xiaobo Cen. Mechanism study of Aconitum -induced neurotoxicity in PC12 cells: Involvement of dopamine release and oxidative damage. Neurotoxicology . Accepted.
· Cen X, Nitta A, Ibi D, Zhao Y , Niwa M, Taguchi K, Hamada M, Ito Y, Ito Y, Wang L, Nabeshima T. Identification of Piccolo as a regulator of behavioral plasticity and dopamine transporter internalization. Mol Psychiatry . 2008 Jan 15; [Epub ahead of print]
· Cen X , Nitta A , Ohya S , Zhao Y , Ozawa N , Mouri A , Ibi D , Wang L , Suzuki M , Saito K , Ito Y , Kawagoe T , Noda Y , Ito Y , Furukawa S , Nabeshima T . An analog of a dipeptide-like structure of FK506 increases glial cell line-derived neurotrophic factor expression through cAMP response element-binding protein activated by heat shock protein 90/Akt signaling pathway. J Neurosci. 2006 Mar 22;26(12):3335-44.
· Xiao-Qiang Deng, Hui-Yuan Wang, Ying-Lan Zhao , Ming-Li Xiang, Pei-Du Jiang, Zhi-Xing Cao, Yu-Zhu Zheng, Shi-Dong Luo, Luo-Ting Yu, Yu-Quan Wei and Sheng-Yong Yang. Pharmacophore Modelling and Virtual Screening for Identification of New Aurora-A Kinase Inhibitors. Chem Biol Drug Des . 2008; 71: 533?C539. （ Contributed equally to first author ）
· Wang HY, Cao ZX, Li LL, Jiang PD, Zhao YL , Luo SD, Yang L, Wei YQ, Yang SY. Pharmacophore modeling and virtual screening for designing potential PLK1 inhibitors. Bioorg Med Chem Lett. 2008 Sep 15; 18 ( 18 ): 4972-7 .
· Yamaguchi S, Zhao YL , Nadai M, Yoshizumi H, Cen X, Torita S, Takagi K, Takagi K, Hasegawa T. Involvement of the drug transporters p glycoprotein and multidrug resistance-associated protein Mrp 2 in telithromycin transport. Antimicrob Agents Chemother. 2006 Jan;50(1):80-7. （ Contributed equally to first author ）
