譚英[清華大學講師]

個人資料

譚英，清華大學講師， 主要從事化學生物學領域研究。

研究方向

1、 酶動力學及作用機制研究，蛋白結構及功能研究

2、 化學小分子與生物大分子(蛋白、多肽、核酸)相互作用及構象關係研究

3、 蛋白信號通路及細胞生物學研究

個人作品

[1] Ying Tan, Xin Zhang, Yonghua Xie, Rui Zhao, Chunyan Tan and Yuyang Jiang. Label-Free Fluorescent Assays Based on Aptamer-Target Recognition. Analyst. 2012, 137, 2309-2312.

[2] Yonghua Xie1, Ying Tan1, Renxuan Liu, Rui Zhao, Chunyan Tan and Yuyang Jiang. Continuous and Sensitive Acid Phosphatase Assay Based on A Conjugated Polyelectrolyte. ACS Appl. Mater. Interfaces. 2012, 4 (8), 3784–3787. (1The two authors contributed equally to this work)

[3] Xin Zhang1, Ying Tan1, Rui Zhao, Bizhu Chu, Chunyan Tan and Yuyang Jiang. Site-directed mutagenesis study of the Ile140 in conserved hydrophobic core of Bcl-xL. Protein & Peptide Lett. 2012, in press. (1The two authors contributed equally to this work)

[4] Xiaohong Qin1，Ying Tan1, Lele Wang, Zhifang Wang, Baifan Wang, Xin Wen, Guangfu Yang, Zhen Xi, and Yuequan Shen. Structural insight into human Variegated Porphyria disease. FASEB J. 2011, 25, 653-64. (1The two authors contributed equally to this work)

[5] Jiang Lili1，Tan Ying1, Zhu Xiao-Lei, Wang Zhi-Fang, Yang Zuo, Chen Qiong, Zhen Xi, Guang-Fu Yang, Design, Synthesis and 3D-QSAR Analysis of Novel 1,3,4-Oxadiazol-2(3H)-ones as Protoporphyrinogen oxidase Inhibitors. J. Agric. Food Chem. 2010, 58, 2643-2651. (1The two authors contributed equally to this work)

[6] Ying Tan, Lu Sun, Zhen Xi, Guang-Fu Yang, Dong-Qing Jiang, Xiu-Ping Yan, Xing Yang, He-Yang Li. A capillary electrophoresis assay for recombinant Bacillus subtilis protoporphyrinogen oxidase. Anal. Biochem. 2008, 383, 200-204.

[7] Ge-Fei Hao, Ying Tan, Ning-Xi Yu, Guang-Fu Yang. Structure–activity relationships of diphenyl-ether as protoporphyrinogen oxidase inhibitors: insights from computational simulations. J. Comput. Aid. Mol. Des. 2011, 25, 213–222.

[8] Li Zhang, Ying Tan, Neng-Xue Wang, Qiong-You Wu, Zhen Xi, Guang-Fu Yang. Design, syntheses and 3D-QSAR studies of novel N-phenyl pyrrolidin-2-ones and N-phenyl-1H-pyrrol-2-ones as protoporphyrinogen oxidase inhibitors. Bioorgan. Med. Chem. 2010, 18, 7948–7956.

[9] Wei Huang, Ying Tan, Ming-Wu Ding, and Guang-Fu Yang. An Improved Synthesis of 2-(3H)Benzo-thiazolethiones Under Microwave Irradiation. Synthetic. Commun. 2007, 37, 369-376.

[10] Rui Zhao, Yonghua Xie, Ying Tan, Chunyan Tan, Yuyang Jiang. Binding of a bcl-2 family inhibitor to bovine serum albumin: fluorescence quenching and molecular docking study. Protein & Peptide Lett. 2012, in press.

[11] Yonghua Xie, Rui Zhao, Ying Tan, Xin Zhang, Feng Liu, Yuyang Jiang, Chunyan Tan. Conjugated Polymer-Based Real-Time Fluorescence Caspase Assays. ACS Appl. Mater. Inter. 2012, 4, 405–410.

[12] Lu Sun, Xin Wen, Ying Tan, Heyang Li, Zhen Xi. Site-directed mutagenesis and computational study of the Y366 active site in Bacillus subtilis proprotoporphyrinogen oxidase. Amino Acids, 2009, 37, 523-530.

[13] Li Zhang, Ge-Fei Hao, Ying Tan, Zhen Xi, Ming-Zhi Huang, Guang-Fu Yang. Bioactive conformation analysis of cyclic imides as protoporphyrinogen oxidase inhibitor by combining DFT calculations, QSAR and molecular dynamic simulations. Bioorgan. Med. Chem. 2009, 17, 4935-4942.

[14] Li-Li Jiang, Yang Zuo, Zhi-Fang Wang, Ying Tan, Qiong-You Wu, Zhen Xi, and Guang-Fu Yang. Design and Syntheses of Novel N-(Benzothiazol-5-yl)-4,5,6,7– tetrahydro-1H-isoindole -1,3(2H)-dione and N-(Benzothiazol-5-yl)isoindoline-1,3- dione as Potent Protoporphyrinogen Oxidase Inhibitors. J. Agric. Food Chem. 2011, 59, 6172–6179.

[15] Wei Huang, Ming-Zhen Liu, Yan Li, Ying Tan, and Guang-Fu Yang, Design, syntheses, and antitumor activity of novel chromone and aurone derivatives，Bioorgan. Med. Chem. 2007, 15, 5191–5197.

[16] Xiaohong Qin, LuSun, Xin Wen, Xue Yang, Ying Tan, Hao Jin, Qiongyao Cao, Weihong Zhou, Zhen Xi, Yuequan Shen. Structural insight into unique properties of protoporphyrinogen oxidase from Bacillus subtilis. J. Struct. Biol. 2010, 170, 76-82.

[17] Feng Zhu, Chu Qin, Lin Tao, Xin Liu, Zhe Shi, Xiaohua Ma, Jia Jia, Ying Tan, Cheng Cui, Jinshun Lin, Chunyan Tan, Yuyang Jiang, and Yuzong Chen. Clustered patterns of species origins of nature-derived drugs and clues for future bioprospecting. Proc. Natl. Acad. Sci. 2011, 108, 12943–12948.