學習經歷:
1998年-2003年 黑龍江中醫藥大學,臨床醫學本科;
2003年-2006年 黑龍江中醫藥大學,醫學碩士;
2006年-2009年 哈爾濱醫科大學,醫學博士。
工作經歷:
2009年-2012年,北京協和醫學院 病原生物學研究,博士後;
2012年-2013年,廣州泰諾迪生物科技有限公司,項目經理;
2013年-至今,暨南大學,副研究員。
研究方向:
基因工程人源化抗體
主要論文:
1. Yuan XiaoHui, QuZhangYi, Wu XiaoMin, et al. Molecular modeling and epitopes mapping of human adenovirus type 3 hexonprotein.Vaccine, 2009; 27:5103–5110.
2. Yuan Xiaohui, QuZhangyi, Wu Xiaomin, et al. Homology Modeling and Evolution Trace Analysis of Human Adenovirus Type 3 Hexon. Chem J Chinese Universities,2009; 30:1636-1640.
3. Xiaohui Yuan,Yingchen Wang,ZhangyiQu, et al. Novel Rapid Molecular Modeling Method Based on Evolutional Tree for Human Adenovirus Hexon Proteins Family.Chem. J. Chinese Universities, 2011; 32:1838-1844.
4. Yuan Xiaohui,Yingchen Wang, Jin Wenjing, He Youwen, et al. Structure based High throughput Epitope Analysis of Hexon Proteins in B and C species of Human Adenoviruses (HAdVs). PLoS One. 2012, 7(3): e32938.
5. Yuan Xiaohui, Wang Yingchen, QuZhangyi, et al. Phylogenetic and Structural Analysis of Major Surface Proteins Hemagglutinin (HA) and Neuraminidase (NA) of Novel Avian Influenza Virus A H7N9 From Chinese Patient, Chem Res Chinese Universities, 2013, 29(5): 934-940.
6. Ding Zhang, Cai-Feng Chen, Bin-Bin Zhao, Lu-Lu Gong, Wen-Jing Jin, Jing-Jun Liu, Jing-Fei Wang, Tian-Tian Wang, Xiao-Hui Yuan, You-Wen He, A Novel Antibody Humanization Method Based on Epitopes Scanning and Molecular Dynamics Simulation. PLoS ONE, 2013, 8(11): e80636. (Corresponding Author)
7. ZhiweiYang, FeiWu, Junxing Liu, Shuqiu Wang, Xiaohui Yuan*,Susceptibility of Commercial Neuraminidase Inhibitors Against 2013 A/H7N9 Influenza Virus: A Docking and Molecular Dynamics Study. Journal of Theoretical and Computational Chemistry.Vol. 12, No. 8,1350069 (2013)(*Corresponding Author)
8. Wang Peng, Wang Qunxing, Luo Chunhua, Tan Chao, Yuan Xiaohui*,Iridoid glycosides extracted from Zhizi(FructusGardeniae ) decrease collagen-induced platelet aggregation and reduce carotid artery thrombosis in an invivo rat model. J Tradit Chin Med. 2013, 33(4):531-534(*Corresponding Author)
9. Wang Peng, Wang Qunxing, Luo Chunhua, Tan Chao, Yuan Xiaohui*, Antithrombotic Effect of Ligustrazine Hydrochloride Injection on the model of induced arteriovenous shunt thrombosis.J Res Med Sci. 2013, 18(8): 704-706(*Corresponding Author)
承擔課題:
1. 國家自然科學基金青年基金:基於虛擬突變與結合自由能計算的抗體親和力體外成熟(批准號:31400795),主持人;
2. 廣東省第四批引進創新創業團隊專項:高通量全人源單克隆抗體綜合研發技術平台建設與套用(批准號:2013Y113),團隊核心成員;
3. 廣州市珠江科技新星專項:計算機輔助的抗體親和力體外成熟(批准號:201506010097),主持人。
社會職務:
廣東省高性能計算學會 理事。
簡介:
授權專利:一種抗體人源化改造方法,授權專利號:201310016799.9,第一發明人