個人簡介
董四君，男，博士，研究員，博士生導師。從事環境荷爾蒙的分子作用機理研究，主要研究領域為傳統醫學的臨床套用及環境內分泌干擾物的分子機制的研究。承擔日本新能源和產業技術綜合開發機構(NEDO)研究項目及日本文部省科學技術振興會研究項目。發表論文10篇，其中SCI論文8篇，獲授權日本專利2項。
教育經歷
1990年獲得中國農業大學動物遺傳育種專業學士學位
2001年獲日本筑波大學生物系統學專業碩士學位
2004年獲東京農工大學生物工學專業博士學位
2004-2007年在日本產業技術綜合研究所從事博士後研究
2007-2008年任日本國際統合醫科學研究所研究員，從事環境荷爾蒙的分子作用機理研究。
研究領域：
環境分子毒理、複合污染的健康風險評價和致病機理，中醫藥在環境健康領域的套用研究
代表論著：
1. Dong S, Kiyama R. 2009. Characterization of Estrogenic Activity of Ginsenosides in MCF-7 Cells using a Customized DNA Microarray. Food Chem. 113: 672-678. .
2. Dong S, Ying S, Kojima T, Shiraiwa M, Mechin MC, Chavanas S, Serre G, Simon M, Kawada A, Takahara H. 2008. Crucial Role of MZF1 and Sp1 for the transcriptional regulation of the Peptidylarginine Deiminase Type I Gene (PADI1) in Human Keratinocytes. Journal of Investigative Dermatology 128(3):549-557.
3. Dong S, Inoue A, Zhu Y, Tanji M, Kiyama R.2007. Activation of rapid signaling pathways and the subsequent transcriptional regulation for the proliferation of breast cancer MCF-7 cells by the treatment with an extract of glycyrrhiza glabra root. Food and Chemical Toxicology 45: 2470–2478.
4. Dong S, Zhang Z, Takahara H. 2007. Estrogen-enhanced PADI4 expression in MCF-7 cells mediated by ER-promoted transfactors AP-1, NF-Y and SP1. Molecular Endocrinology 21: 1617-1629
5. Dong S, Kanno T, Yamaki A, Kojima T, Shirawa M, Kawada A, Mechin MC, Chavanas S, Serre G, Simon M, Takahara H. 2006. NF-Y and Sp1/Sp3 are involved in the transcriptional regulation of the peptidylarginine deiminase type III gene (PADI3) in human keratinocytes. Biochemical Journal 397(3):449-459
6. Dong S, Kojima T, Shiraiwa M, Mechin MC, Chavanas S, Serre G, Simon M, Kawada A, Kawada A, and Takahara H. 2005. Regulation of the expression of peptidylarginine deiminase type II gene (PADI2) in human keratinocytes involves Sp1 and Sp3 transcription factors. Journal of Investigative Dermatology 124(5):1026-1033.
7. Ying S, Dong S, Kawada A, Kojima T, Chavanas S, Mechin MC, Adoue V, Serre G, Simon M, Takahara H. 2009. Transcriptional Regulation of Peptidylargine Deiminase Expression in Human Keratinocytes. J Dermatol Sci. 53(1):2-9.
8. Chavanas S, Adoue V, Méchin MC, Ying S, Dong S, Duplan H, Charveron M, Takahara H, Serre G, Simon M. 2008. Long-range enhancer associated with chromatin looping allows AP-1 regulation of the peptidylarginine deiminase 3 gene in differentiated keratinocyte. PLoS ONE. 3(10):e3408.
9. Adoue V, Chavanas S, Coudane F, Méchin MC, Caubet C, Ying S, Dong S, Duplan H, Charveron M, Takahara H, Serre G, Simon M. 2008. Long-Range Enhancer Differentially Regulated by c-Jun and JunD Controls Peptidylarginine Deiminase-3 Gene in Keratinocytes. J Mol Biol. 384(5):1048-1057.
10. Zhou Y, Kogiso M, Asakawa M, Dong S, Kiyama R, Shimizu T. 2009. Antimicrobial Nanotubes as Delivery Vehicles Consisting of Ag-Embedded Peptidic Lipid-Bilayer Membranes. Adv. Mater. 21, 1-4.
