王陽[上海交通大學醫學院副教授]

王陽，上海交通大學醫學院附屬新華醫院，副教授，碩士生導師。2011年獲上海交通大學博士學位，2015年在美國哈佛大學醫學院完成博士後研究工作。2013年、2017年兩次入選上海交通大學“SMC-晨星優秀青年教師獎勵計畫”，2012年入選上海高校優秀青年教師培養資助計畫。發表SCI論文40多篇，主持國家自然科學基金面上項目等多個課題。

研究方向

1. 腸神經系統分子調控機制

2. 先天性巨結腸分子遺傳機制

發表論文

Wang Y, Yan W, Wang J, Zhou Y, Chen J, Gu B, Cai W. Common genetic variants in GAL, GAP43 and NRSN1 and interaction networks confer susceptibility to Hirschsprung disease. J Cell Mol Med.2018;22(7):3377-3387.

Wang Y, Veremeyko T, Wong AH, El Fatimy R, Wei Z, Cai W, Krichevsky AM.Downregulation of miR-132/212 impairs S-nitrosylation balance and induces tau phosphorylation in Alzheimer's disease.Neurobiol Aging. 2017;51:156-166.

Wen J, Zhou Y, Wang J, Chen J, Yan W, Wu J, Yan J, Zhou K, Xiao Y, Wang Y, Xia Q, Cai W.Interactions between Th1 cells and Tregs affect regulation of hepatic fibrosis in biliary atresia through the IFN-γ/STAT1 pathway. Cell Death Differ.2017;51:156-166

Wang Y, Cao Y, Huang X, Yu T, Wei Z, McGrath J, Xu F, Bi Y, Li X, Yang F, Li W, Zou X, Peng Z, Xiao Y, Zhang Y, He L, He G. Allele-specific expression of mutated in colorectal cancer (MCC) gene and alternative susceptibility to colorectal cancer in schizophrenia. Sci Rep. 2016;6:26688

Teplyuk NM, Uhlmann EJ, Gabriely G, Volfovsky N, Wang Y, Teng J, Karmali P, Marcusson E, Peter M, Mohan A, Kraytsberg Y, Cialic R, Chiocca EA, Godlewski J, Tannous B, Krichevsky AM. Therapeutic potential of targeting microRNA-10b in established intracranial glioblastoma: first steps toward the clinic. EMBO Mol Med. 2016;8(3):268-87

Wang Y, Wang J, Zhou Y, Wei Z, Xiao Y, Zhou K, Wen J, Yan J, Cai W. Contribution of common variants in GABRG2, RELN and NRG3 and interaction networks to the risk of Hirschsprung disease. Cell Physiol Biochem. 2016;40(3-4):509-26.

Xiao Y, Wang J, Yan W, Zhou Y, Chen Y, Zhou K, Wen J, Wang Y, Cai W. Dysregulated miR-124 and miR-200 expression contribute to cholangiocyte proliferation in the cholestatic liver by targeting IL-6/STAT3 signalling. J Hepatol. 2015;62(4):889-96

Wang Y, Wang J, Pan W, Zhou Y, Xiao Y, Zhou K, Wen J, Yu T, Cai W. Common genetic variations in Patched1 (PTCH1) gene and risk of hirschsprung disease in the Han Chinese population. PLoS One. 2013;20;8(9):e75407

Wang Y, He G, He L, McGrath J. Do shared mechanisms underlying cell cycle regulation and synaptic plasticity underlie the reduced incidence of cancer in schizophrenia? Schizophr Res. 2011;130(1-3):282-4

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