![王育才[中國科學技術大學教授]](/img/3/e68/nBnauM3XzATM1EjM2EzN2YTM1UTM1QDN5MjM5ADMwAjMwUzLxczL3QzLt92YucmbvRWdo5Cd0FmLxE2LvoDc0RHa.jpg "王育才[中國科學技術大學教授]")
學術成果
多年來一直從事納米材料在癌症治療及成像領域的研究，在國際學術期刊發表研究論文50餘篇，引用次數超過2600次，還為Advanced Functional Materials及Macromolecular Bioscience撰寫邀請綜述，並為Nature Materials撰寫論文評論 。
主要研究
1.可降解生物材料
2.納米藥物用於癌症診療
主要論文
[1]H. X. Wang, Z. Q. Zuo, J. Z. Du, Y. C. Wang*, R. Sun, Z. T. Cao, X. D. Ye, J. L. Wang, K. W. Leong*, J. Wang*. Surface Charge critically affects tumor penetration and therapeutic efficacy of cancer nanomedicines. Nano Today, 2016, accepted
[2]Z. T. Cao, Z. Y. Chen, C. Y. Sun, H. J. Li, H. X. Wang, Q. Q. Cheng, Z. Q. Zuo, J. L. Wang, Y. Z. Liu, Y. C. Wang*, J. Wang*. Overcoming tumor resistance to cisplatin by cationic lipid-assisted prodrug nanoparticles. Biomaterials, 2016, accepted, 2016, DOI:10.1016/j.biomaterials.2016.04.001
[3]Z. Q. Zuo, K. G. Chen, X. Y. Yu, G. Zhao, S. Shen, Z. T. Cao, Y. L. Luo, Y. C. Wang, J. Wang*. Promoting Tumor Penetration of Nanoparticles for Cancer Stem Cell Therapy by TGF-β Signaling Pathway Inhibition. Biomaterials, 2016, 82, 48-59
[4]Y. C. Ma, J. X. Wang, W. Tao*, C. Y. Sun, Y. C. Wang*, D. D. Li, F. Fan, H. S. Qian, X. Z. Yang*. Redox-Responsive Polyphosphoester-Based Micellar Nanomedicines for Overriding Chemoresistance in Breast Cancer Cells. ACS Applied Materials & Interfaces,2015, 7, 26315-26325
[5]Z. Luo#, Y. Jiang#, B. Myers, D. Isheim, J. Wu, J. Zimmerman, Z. Wang, Q. Li, Y. C. Wang, X. Chen, V. P. Dravid, D. N. Seidman, B. Tian*. Atomic Gold–Enabled Three-Dimensional Lithography for Silicon Mesostructures. Science, 2015, 348, 1451-1455.
[6]J. Zimmerman, M. Murray, Y. C. Wang, J. Jumper, J. Austin, B. Tian*, Free-Standing Kinked Silicon Nanowires for Probing Inter-and Intracellular Force Dynamics. Nano Letters, 2015, 15, 5492-5498.
[7]Y. C. Wang#, M. S. Shim#, N. S. Levinson, H-W. Sung, Y. Xia*.Stimuli-Responsive Materials for Controlled Release of Theranostic Agents. Advanced Functional Materials, 2014, 24, 4206-4220
[8]K. C. L. Black#, Y. C. Wang#, H. P. Luehmann, X. Cai, W. X. Xing, B. Pang, Y. F. Zhao, C. S. Cutler, L. V. Wang, Y. Liu*,Y. Xia*. Radioactive 198Au-Doped Nanostructures with Different Shapes forin vivoAnalyses of Their Biodistribution, Tumor Uptake, and Intratumoral Distribution. ACS Nano, 2014, 8, 4385-4394
[9]T. M. Sun#, Y. C. Wang#, F. Wang, J. Z. Du, C. Q. Mao, C. Y. Sun, R. Z. Tang, Y. Liu, J. Zhu, Y. H. Zhu, X. Z. Yang, J. Wang*. Cancer Stem Cell Therapy Using Doxorubicin Conjugated to Gold Nanoparticles via Hydrazone Bonds. Biomaterials,2014, 35, 836-845.
[10]T. M. Sun, Y. Wang, Y. C. Wang, Y. Xia*. Using SV119-Gold Nanocage Conjugates to Eradicate Cancer Stem Cells through a Combination of Photothermal and Chemo Therapies. Advanced Healthcare Materials, 2014, 3, 1283-1291
[11] Y. C. Wang#, Y. Liu#, H. Luehamn, X. Xia, D. Wan, C. Cutler, Y. Xia*. Radioluminescent Gold Nanocages with Controlled Radioactivity for Real-Time in Vivo Imaging. Nano Letters, 2013, 13, 581-585.
[12] Y. C. Wang#,K. C. L. Black#, H. Luehmann, W. Li, Y. Zhang, X. Cai, D. Wan, S. Liu, M. Li, P. Kim, Z. Li, L. V. Wang, Y. Liu*, Y. Xia*. Comparison Study of Gold Nanohexapods, Nanorods, and Nanocages for Photothermal Cancer Treatment. ACS Nano,2013, 7, 2068-2077.
[13]D. Wan, X. Xia, Y. C. Wang, Y. Xia*. Robust Synthesis of Gold Cubic Nanoframes through a Combination of Galvanic Replacement, Gold Deposition, and Silver Dealloying. Small,2013, 9, 3111-7
[14]K. J. Chen, H. F. Liang, H. L. Chen; Y. C. Wang; P. Y. Cheng; Liu, H. L. Liu; Y. Xia*, H. W. Sung*.A Thermoresponsive Bubble-Generating Liposomal System for Triggering Localized Extracellular Drug Delivery. ACS Nano,2013, 7, 438-446.
[15]Y. Zhang, Y. Wang, L. Wang, Y. C.Wang, X. Cai, C. Zhang, L. V. Wang, Y. Xia*. Labeling Human Mesenchymal Stem Cells with Au Nanocages for in vitroand in vivoTracking by Two-Photon Microscopy and Photoacoustic Microscopy. Theranostics, 2013, 3, 532-543.
[16]W. Li#, F. Wang#, Z. Liu, Y. C. Wang, J. Wang*, F. Sun*. Gold Nanoparticles Elevate Plasma Testosterone Levels in Male Mice without Affecting Fertility. Small, 2013, 9, 1708-1714.
[17]W. Li#, C. Sun#, F. Wang, Y. C. Wang, Y. Zhai, M. Liang, W. Liu, Z. Liu, J. Wang*, F. Sun*. Achieving a New Controllable Male Contraception by the Photothermal Effect of Gold Nanorods. Nano Letters, 2013, 13, 2477-2484.
[18]H. X. Wang#, M. H. Xiong#, Y. C. Wang, J. Zhu. J. Wang*. N-Acetylgalactosamine Functionalized Mixed Micellar Nanoparticles for Targeted Delivery of siRNA to Liver. Journal of Controlled Release, 2013, 166, 106-114.
[19]J. Wu#, T. M. Sun#, X. Z. Yang*, J. Zhu, X. J Du, Y. D. Yao, M. H. Xiong, H. X. Wang, Y. C Wang, J. Wang*. Enhanced Drug Delivery to Hepatocellular Carcinoma with a Galactosylated Core–Shell Polyphosphoester Nanogel. Biomaterial Sciences, 2013, 1, 1143-1150.
[20] Y. C. Wang#, Y. Liu#，*, H. Luehmann, X. Xia, P. Brown, C. Jarreau, M. Welch, Y. Xia*. Evaluating the Pharmacokinetics and In VivoCancer Targeting Capability of Au Nanocages by Positron Emission Tomography Imaging. ACS Nano,2012, 6, 5880-5888.
[21] Y. C. Wang, Y. Wang, F. Zhou, P. Kim, Y. Xia*. Protein-Protected Au Clusters as a New Class of Nanoscale Biosensor for Label-Free Fluorescence Detection of Proteases. Small, 2012, 8, 3769-3773.
[22]S. Xie, M. Jin, J. Tao, Y. C. Wang, Z. Xie, Y. Zhu, Y. Xia*. Synthesis and Characterization of Pd@MxCu1-x (M=Au, Pd, and Pt) Nanocages with Porous Walls and a Yolk-Shell Structure through Galvanic Replacement Reactions. Chemistry of Materials, 2012, 18, 14974–14980.
[23]X. Xia, M. X. Yang, Y. C. Wang, Y. Zheng, Q. Li, J. Cheng*, Y. Xia*. Quantifying the Coverage Density of Poly(ethylene glycol) Chains on the Surface of Gold Nanostructures. ACS Nano,2012, 6, 512–522.
[24]X. Z. Yang, S. Dou, Y. C. Wang, H. Y. Long, M. H. Xiong, C. Q. Mao, Y. D. Yao. J. Wang*. Single-Step Assembly of Cationic Lipid-Polymer Hybrid Nanoparticles for Systemic Delivery of siRNA. ACS Nano, 2012, 6, 4955–4965.
[25]M. H. Xiong#, Y. Bao#, X. Z. Yang, Y. C. Wang, B. Sun*, J. Wang*. Lipase-Sensitive Polymeric Triple-Layered Nanogel for "On-Demand" Drug Delivery. Journal of the American Chemical Society2012, 134, 4355–4362.
[26] Y. C. Wang, J. Xu, X. Xia, M. Yang, S. Vangverarong, J. Chen, R. H. Mach, Y. Xia*. SV119-Gold Nanocage Conjugates: a New Platform for Targeting Cancer Cells viaSigma-2 Receptors. Nanoscale, 2011, 4, 421–424.
[27] Y. C. Wang, P. Brown, Y. Xia*. Swarming to the Target. Nature Materials, 2011, 10, 482–483(News & Views)
[28] Y. C. Wang#,F. Wang#, T. M. Sun, J. Wang*. Redox-Responsive Nanoparticles from the Single Disulfide Bond-Bridged Block Copolymer as Drug Carriers for Overcoming Multi-Drug Resistance in Cancer Cells. Bioconjugate Chemistry, 2011, 22, 1939–1945
[29]F. Wang#, Y. C. Wang#, S. Dou, M. H. Xiong, T. M. Sun, J. Wang*. Doxorubicin-Tethered Responsive Gold Nanoparticles Facilitate Intracellular Drug Delivery for Overcoming Multidrug Resistance in Cancer Cells. ACS Nano, 2011, 5, 3679–3692
[30] Y. C. Wang,Y. Y. Yuan, F. Wan g, J. Wang*,Syntheses and Characterization of Block Copolymers of Poly(aliphatic ester) with Clickable Polyphosphoester. Journal of Polymer Science Part A: Polymer Chemistry, 2011, 49, 487–494.
