主要研究內容
斑馬魚作為低等脊椎動物模式生物一直在發育生物學，比較內分泌學領域扮演重要角色。
二零零四年，王亞軍博士加入香港大學理學院長梁志清教授實驗室從事博士後研究。以鳥類模式生物-家雞為研究模型，圍繞神經內分泌生長軸（“下丘腦-垂體-靶器官”：調節生長發育的主要途徑）致力於新基因鑑定以及基因的網路調控分析。在此期間，王亞軍博士首次報導並闡明了家雞，兩棲類，及魚類中的新基因：GHRH基因（垂體生長激素生成與釋放的關鍵基因），該新基因的鑑定解釋了哺乳動物與低等脊椎動物垂體在應對生長激素釋放激素和垂體腺苷酸環化酶激活多肽上的差異。作為低等脊椎向高等脊椎動物的過渡，該基因的鑑定亦使得家雞垂體生長激素生成與釋放調控理論將獲重新闡釋。有鑒於家雞作為最重要的經濟動物，GHRH基因的鑑定為研究家禽的生長調節與品種選育提供重要理論依據。
回到四川大學後，王亞軍博士在四川大學引進人才基金支持下，組建畜禽功能基因組研究平台，以家雞，斑馬魚為主要研究模型，圍繞經濟動物之重要經濟性狀，開展新基因鑑定以及基因網路調控解析。
曾經主持項目：
國家自然科學基金：
《重新評估家雞下丘腦GHRH,GHRH-L以及PACAP在垂體生長激素生成與釋放中的重要作用》
項目主持， 2008年1月---2010年12月
《PrRP和C-RFa多肽在家雞垂體催乳素生成與釋放過程中的作用機理研究》
項目主持， 2009年1月---2011年12月
國家高科技發展計畫（863）:
《優質雞生長性狀主效基因的分子鑑別與多基因聚合育種》
項目副主持，2008年1月---2010年12月
國家轉基因生物新品種培育重大專項：
《豬控制生長與繁殖性狀重要基因及其調控元件克隆與功能驗證》
項目主持人，2009年1月---2011年12
代表性論文：
1. G. Huang, C. He, F. Meng, J. Li, J. Zhang, and Wang Y* (2014) Glucagon-Like Peptide (GCGL) Is a Novel Potential TSH-Releasing Factor (TRF) in Chickens: I) Evidence for Its Potent and Specific Action on Stimulating TSH mRNA Expression and Secretion. Endocrinology (接收) (*通訊) (IF = 4.644).
2. G Huang, J Li, H Wang, X Lan, and Wang Y* (2014) Discovery of a Novel Functional Leptin Protein (LEP) in Zebra Finches: Evidence for the Existence of an Authentic Avian Leptin Gene Predominantly Expressed in the Brain and Pituitary. Endocrinology 155: 3385-96 (*通訊, 封面論文) (IF = 4.644).
3. Meng F, Huang G, Gao S, Li J, Yan Z, Y. Wang* (2014). Identification of the receptors for somatostatin (SST) and cortistatin (CST) in chickens and investigation of the roles of cSST28, cSST14, and cCST14 in inhibiting cGHRH1–27NH2-induced growth hormone secretion in cultured chicken pituitary cells. Molecular and Cellular Endocrinology 384: 83-95. (*通訊) (IF= 4.241)
4. Mo C, Zhong Y, Wang Y*, Yan Z, Li J* (2014) Characterization of glucagon-like peptide 2 receptor (GLP2R) gene in chickens: functional analysis, tissue distribution, and developmental expression profile of GLP2R in embryonic intestine. Domestic Animal Endocrinology (doi:10.1016/j.domaniend. 2014.01. 002) (*通訊)
5. Zhang J., Cheng S, Wang Y*, Yu X, Li J*. (2014) Identification and characterization of the free fatty acid receptor 2 (FFA2) and a novel functional FFA2-like receptor (FFA2L) for short-chain fatty acids in pigs: Evidence for the existence of a duplicated FFA2 gene (FFA2L) in some mammalian species. Domestic Animal Endocrinology 47:108-118 (*通訊) (IF = 1.781).
6. He X, Meng F, Wang Y, Li J. (2014) Molecular Cloning and Characterization of Two Pig Vasoactive Intestinal Polypeptide Receptors (VPAC1-R and VPAC2-R). DNA Cell Biol. 33：259-270.
7. Bu G, Wang CY, Cai G, Leung FC*, Xu M, Wang H, Huang G, Li J,Wang Y* (2013) Molecular Characterization of Prolactin Receptor (cPRLR) Gene in Chickens: Gene Structure, Tissue Expression, Promoter Analysis, and Its Interaction with Chicken Prolactin (cPRL) and Prolactin-like Protein (cPRL-L). Molecular and Cellular Endocrinology 370: 149-62. （*通訊）(IF = 4.241).
8. Bu G, Huang G, Fu H, Li J, Huang S.Wang Y* （2013） Characterization of the novel duplicated PRLR gene at the late-feathering K locus in Lohmann chickens. Journal of Molecular Endocrinology 51, 261–276 （*通訊）(IF = 3.621).
9. Song X, Wang Y*, Tang Y* (2013) Rapid Diversification of FoxP2 in Teleosts through Gene Duplication in the Teleost-Specific Whole Genome Duplication Event. PLoS One.，8(12):e83858.（*通訊）(IF = 3.534).
10. Wang Y*, Meng F, Zhong Y, Huang G, Li J (2012) Discovery of a Novel Glucagon-like Peptide (GCGL) and its Receptor (GCGLR) in Chickens: Evidence for the Existence of GCGL and GCGLR Genes in Non-mammalian Vertebrates. Endocrinology 153, 5247-5260 (*通訊) (IF = 4.717)
11. Wang Y*, Wang CY, Wu Y, Huang G, Leung FC* (2012). Identification of the Receptors for Prolactin-releasing Peptide (PrRP) and Carassius RFamide Peptide (C-RFa) in Chickens. Endocrinology 153: 1861-1874 (*通訊) (IF = 4.717).
12.Wang Y*, Huang G, Li J., et al (2012) Characterization of Chicken Secretin (SCT) and Secretin Receptor (SCTR) Genes: A Novel Secretin-like Peptide (SCT-LP) and Secretin Encoded in a Single Gene. Molecular and Cellular Endocrinology, 348: 270-280 (*通訊) (IF=4.192).
13. Ho JCW, Jacobs T, Wang Y*, Leung FC* (2012) Identification and characterization of the chicken galanin receptor GalR2 and a novel GalR2-like receptor (GalR2-L). General and comparative endocrinology, 179: 305-312 (*通訊) (IF=3.267).
14. Kwok AHY, Wang Y*, Leung FC* (2012) Molecular characterization of prostaglandin F receptor (FP) and E receptor subtype 3 (EP3) in chickens. General and comparative Endocrinology. 179: 88-98 (*通訊) (IF=3.267).
15. Kwok AHY, Wang Y*, Leung FC* (2012) Molecular characterization of prostaglandin F receptor (FP) and E receptor subtype 1 (EP1) in zebrafish. General and comparative Endocrinology. 178: 216-226 (*通訊) (IF=3.267).
16. Huang G, Li J, Fu H, Yan Z, Bu G, He X, Wang Y* (2012) Characterization of glucagon-like peptide 1 receptor (GLP1R) gene in chickens: functional analysis, tissue distribution, and identification of its transrcipt variants. Domestic Animal Endocrinology 43: 1-15 (*通訊). (IF=2.056)
17. Li J, Meng F, Song C, Wang Y, Leung FC (2012) Characterization of chicken visfatin gene: cDNA cloning, Tissue expression, and promoter analysis. Poultry Science, 91: 2885-94 (IF=1.728)
18. Ho JC, Kwok AH, Zhao D, Wang Y*, et al. (2011) Characterization of the chicken galanin type I receptor (GalR1) and a novel GalR1-like receptor (GalR1-L). General and Comparative Endocrinology 170: 391-400, (*通訊) (IF=3.267).
19. Ruiqiang Li, Wei Fan, Geng Tian, Hongmei Zhu, Lin He, ……, Yajun Wang*… Lars Bolund, Karsten Kristiansen, Gane Ka-Shu Wong, Maynard Olson, Xiuqing Zhang, Songgang Li, Huanming Yang, Jian Wang & Jun Wang. The sequence and de novo assembly of the giant panda genome. Nature 463: 311-317, 2010 (IF=36.101)
20. Wang Y*, Li J, Kwok AHY, et al., (2010) A novel prolactin-like protein (PRL-L) gene in chickens and zebrafish: Cloning and Characterization of its tissue expression. General and Comparative Endocrinology 166: 200-210, (IF=3.108)
21. Wang Y*, Li J, C. Wang CY, et al., (2010) Characterization of the receptors for chicken GHRH and GHRH-related peptides: Identification of a novel receptor for GHRH and the receptor for GHRH-LP (PRP). Domestic Animal Endocrinology 38: 13-31 (IF=1.896).
22. Lynch VJ，Tanzer A, Wang Y*, et al. (2008), Adaptive changes in the transrciption factor HoxA-11 are essential for the evolution of pregnancy in mammals. Proc. Natl. Acad. Sci. U S A. 105: 14925-14933, (IF=9.598)
23. Wang J, Wang Y*, Li X, et al., (2008) Cloning, tissues distribution and functional characterization of chicken glucagon receptor. Poultry science 87: 2678-2688, (IF=1.603)
24. Kwok AHY, Wang Y*, Wang CY, et al. (2008), Molecular cloning and characterization of chicken prostaglandin E receptor subtypes 2 and 4 (EP2 and EP4). General and Comparative Endocrinology, 157: 99-106, (IF=3.108)
25. Wang Y*, Li J, Wang CY, et al., (2007) Identification of the endogenous ligands for chicken growth hormone-releasing hormone (GHRH) receptor. Evidence for a separate gene encoding GHRH in submammalian vertebrates. Endocrinology 148: 2405-2416 (IF=5.045)
26. Wang Y*, Li J，Wang CY, et al., (2007) Epidermal growth factor receptor (EGFR) ligand in the chicken ovary: I) Evidence for heparin binding epidermal growth factor-like growth factor (HB-EGF) as a potential oocyte-derived factor to control granulosa cell proliferation and HB-EGF and Kit ligand expression. Endocrinology 148: 3426 – 3440. (IF=5.045).
27. Wang Y, Wang Z, Li J, Wang Y*, et al., (2007) A database for chicken full-length cDNAs. Physiological Genomics 28:141-5, (IF=3.368).
28. Kwok AHY, Wang Y*, Wang CY, et al. (2007), Cloning of chicken glucocorticoid receptor (GR) and characterization of its expression in pituitary and extra-pituitary tissues. Poultry Science 86: 423-430 (IF=1.603).
29. Wang CY*, Wang Y*, Kwok AHY et al., (2007). Identification of two novel chicken GHRH receptor splice variants: implications for the roles of aspartate 56 in the receptor activation and direct ligand receptor interaction. Journal of Endocrinology 195: 525-536, (IF=2.636) (同等貢獻).
30. Wang CY, Wang Y, Li J et al. (2006) Expression profiles of chicken growth hormone-releasing hormone (GHRH) and growth hormone-releasing hormone receptor (GHRHR) during chicken embryonic pituitary development. Poultry Science, 85: 569-576, (IF=1.603).
31. Kwok HF, So WK, Wang Y* et al (2005) Zebrafish gonadotropins and their receptors: I. Cloning and characterization of zebrafish follicle-stimulating hormone and luteinizing hormone receptors: Evidence for their distinct functions in follicle development. Biology of Reproduction, 72: 1370-1381, (IF=3.670).
32. Wang Y* & Ge W (2004) Cloning of Epidermal growth factor (EGF) and EGF receptor from the zebrafish ovary: evidence for EGF as a potential paracrine factor from the oocyte to regulate activin/follistatin system in the follicle cells. Biology of Reproduction, 71: 749-760 (IF=3.670).
33. Wang Y* & Ge W (2004). Developmental profiles of activin βA, βB, and follistatin expression in the zebrafish ovary: evidence for their differential roles during sexual maturation and ovulatory cycle. Biology of Reproduction, 71: 2056-2064, (IF=3.670).
34. Wang Y* & Ge W (2004). Cloning of zebrafish ovarian P450c17 (CYP17, 17α-hydroxylase/ 17,20- lyase) and characterization of its expression in gonadal and extra-gonadal tissues. General and Comparative Endocrinology, 135: 241-249 (IF=3.108)
35. Wang Y* & Ge W (2003) Involvement of cyclic adenosine 3’,5’-monophosphate in the differential regulation of activin βA and βB expression by gonadotropin in the zebrafish ovarian follicle cells. Endocrinology, 144: 491-499 (IF=5.045).
36. Wang Y*, Wong AOL & Ge W (2003) Cloning, regulation of mRNA expression and function of a new isoform of pituitary adenylate cyclase-activating polypeptide (PACAP) in the zebrafish ovary. Endocrinology, 144: 4799-4810 (IF=5.045).
37. Wang Y* & Ge W (2003) Spatial expression patterns of activin and its signaling system in the zebrafish ovarian follicle: Evidence for paracrine action of activin on the oocytes. Biology of Reproduction, 69: 1998-2006 (IF=3.670)
38. Wang Y* & Ge W (2003) Gonadotropin regulation of follistatin expression in the cultured ovarian follicle cells of zebrafish, Danio rerio. General and Comparative Endocrinology, 134: 308-315 (IF=3.108)
39. Wang Y* & Ge W (2002) Cloning of zebrafish ovarian carbonyl reductase-like 20β-hydroxysteroid dehydrogenase and characterization of its spatial and temporal expression. General and Comparative Endocrinology, 127: 209-216 (IF=3.108).
