簡介

研究興趣
蛋白質-蛋白質、蛋白質-小分子之間相互作用研究(有機)金屬配合物對膜受體介導的信號轉導過程的影響
多靶點抗癌藥物的設計、合成和分子作用機理研究
代表性論著
1.F.Y.Wang,S.Weidt,J.Xu,C.L.Mackay,P.R.R.Langridge-Smith,P.J.Sadler,identificationofclustersfromreactionsofrutheniumareneanticancercomplexwithglutathioneusingnanoscaleliquidchromatographyFouriertransformioncyclotronmassspectrometrycombinedwith18o-labeling,J.Am.Soc.MassSpectrom.2008,19,544-549.2.H.K.Liu,S.J.Berners-Price,F.Y.Wang,J.A.Parkinson,J.Xu,J.Bella,P.J.Sadler,diversityinG-selectiveDNAbindingmodesforanorganometallicrutheniumarenecomplex,Angew.Chem.Int.Ed.2006,45,8153-8156
3.H.K.Liu,F.Y.Wang,J.A.Parkinson,J.Bella,P.J.Sadler,ruthenationofduplexandsingle-strandedd(CGGCCG)byorganometallicanticancercomplexes,Chem.Eur.J.2006,12,6151-6165
4.F.Y.Wang,A.Habtemariam,E.P.L.vanderGeer,R.Fernández,M.Melchart,R.J.Deeth,R.Aird,S.Guichard,F.P.A.Fabbiani,P.Lozano-Casal,I.D.H.Oswald,D.I.Jodrell,S.Parsons,P.J.Sadler,controllingligandsubstitutionreactionsoforganometalliccomplexes:tuningcancercellcytotoxicity,Proc.Natl.Acad.Sci.U.S.A.2005,102,18269-18274.
5.F.Y.Wang,J.Xu,A.Habtemariam,J.Bella,P.J.Sadler,competitionbetweenglutathioneandguanineforaruthenium(II)areneanticancercomplex:detectionofasulfenatointermediate.J.Am.Chem.Soc.2005,127,17734-17743.
6.F,Y.Wang,J.Bella,J.A.Parkinson,P.J.Sadler,competitivereactionsofarutheniumareneanticancercomplexwithhistidine,cytochromecandanoligonucleotide.J.Biol.Inorg.Chem.2005,10,147-55.
7.F.YWang,H.M.Chen,S.Parsons,I.D.H.Oswald,J.E.Davidson,P.J.Sadler,kineticsofaquationandanationofruthenium(II)areneanticancercomplexes,acidityandX-raystructuresofaquaadducts.Chem.Eur.J.2003,9,5810-5820.
8.H.M.Chen,J.A.Parkinson,O.Novakova,J.Bella,F.Y.Wang,A.Dawson,R.Gould,S.Parsons,V.Brabec,P.J.Sadler,induced-fitrecognitionofDNAbyorganometalliccomplexeswithdynamicstereogeniccenters.Proc.Natl.Acad.Sci.U.S.A.2003,100,14623-14628.
9.F.Y.Wang,H.M.Chen,J.A.Parkinson,P.D.Murdoch,P.J.Sadler,reactionsofaruthenium(II)areneantitumorcomplexwithcysteineandmethionine.Inorg.Chem.2002,41,4509-4523.