研究方向
生物材料與微納醫學1.納米生物學及腫瘤微納醫學工程2.腫瘤細胞力學與細胞信號轉導
科研項目
近年主持的主要科研項目：
1. 葉酸受體靶向的超順磁/螢光/VEGF siRNA 多功能矽納米載體的抗腫瘤作用及其成像規律研究，國家自然科學基金(no. 81201192)
2.基因/化療藥物共輸送的氧化還原回響性PLGA超聲納米泡協同抗腫瘤作用及其超聲成像研究，國家自然科學基金(no. 31470959)
3. 發光/磁性雜合靶向納米膠束聯合阿黴素和miR-34a治療腫瘤協同增敏和雙模態成像研究，國家自然科學基金（no. 81671821）
4. 生物多功能化螢光矽納米靶向載體的構建及其生物學套用，中央高校基本業務費（no. ZYGX2010J101）
論文列表
已經發表SCI收錄論文20餘篇，
代表性論文如下：
01. Yang H, Guan L, Li S, Jiang Y, Xiong N, Li L, Wu C, Zeng H, Liu Y*. (2016) Mechanosensitive caveolin-1 activation-induced PI3K/Akt/mTOR signaling pathway promotes breast cancer motility, invadopodia formation and metastasis in vivo. Oncotarget. 7(13): 16227-16247.
02. Yang H, Xu M, Shen X, Li T, Yan J, Zhang C, Wu C, Zeng H, Liu Y*. (2016) Chitosan hybrid nanoparticles as a theranostic platform for targeted doxorubicin/VEGF shRNA co-delivery and dual-modality fluorescence imaging. RSC Advances. 6: 29685-29696
.03. Yang H, Deng L, Li T, Shen X, Yan J, Zuo L, Wu C, Liu Y*. (2015) Multifunctional PLGA nanobubbles as theranostic agents: Combining doxorubicin and P-gp siRNA co-delivery into human breast cancer cells and ultrasound cellular imaging. Journal of Biomedical Nanotechnology. 11: 2124-2136
. 04. Yang H, Li T, Chen Y, Xu M, Li Y*. (2015) VCAM-1-targeted silica nanoparticles doped with FITC and Fe3O4 for dual-mode cellular imaging of LPS-induced inflammatory endothelial cell. J Control Release. 213:e40-41. DOI: 10.1016.
05. Yang H, Li Y, Chen Y, Wu C, Dong X, Li T, Xu M, Liu Y*. (2014) Multifunctional core/shell nanoparticles cross-linked polyetherimide-folic acid as effecient Notch-1 siRNA carrier for targeted killing of breast cancer. Scientific Reports. 4: 7072, DOI: 10.1038/srep07072
.06. Yang H, Shi M, Xu M, Li Y, Wu C, Liu Y*. (2013) Multifunctional silica nanoparticles as theranostic agents: combining VEGF gene delivery and dual-modality cellular imaging. Journal of Controlled Release. 172(1): e120-e121
.07. Yang H, Zhao F, Li Y, Xu M, Li L, Wu C, Miyoshi H, Liu Y*. (2013) VCAM-1-targeted core/shell nanoparticles for selective adhesion and delivery to endothelial cells with lipopolysaccharide-induced inflammation under shear flow and cellular magnetic resonance imaging in vitro. International Journal of Nanomedicine. 8: 1897-1906
.08. Yang H, Zhang L, Xiong X, Liu Y*. (2011) Specific adhesion and accumulation of VCAM-1-targeted ultrasound microbubbles to inflammatory endothelial cells under hemodynamic shear flow simulation. Journal of Controlled Release. 152(s1): e227-e229.0
09. Yang H, Lou C, Xu M, Wu C, Miyoshi H, Liu Y*. (2011) Investigation of folate conjugated fluorescent silica nanoparticles for targeting delivery to folate receptor-positive tumors and their internalization mechanism. International Journal of Nanomedicine. 6: 2023-2032.
10. Yang H, Xiong X, Zhang L, Wu C, Liu Y*. (2011) Adhesion of bio-functionalized ultrasound microbubbles to endothelial cells by targeting to vascular cell adhesion molecule-1 under shear flow. International Journal of Nanomedicine. 6: 2043-2051.
