![李陶[幹細胞工程技術領域科學家]](/img/c/570/nBnauM3XzgDO3AzN1gzNzgzNxUTMwczM3kDN0QTNwAzMwIzL4czLyYzLt92YucmbvRWdo5Cd0FmLyE2LvoDc0RHa.jpg "李陶[幹細胞工程技術領域科學家]")
研究領域
CTCF介導的染色體間相互作用(Science)，臍帶間充質幹細胞治療對乙醯氨基酚致肝衰（Cytothrapy），腫瘤細胞核移植誘導再編程與異常Igf2印跡的矯正(EMBO)，表觀遺傳性狀的修飾與癌症治療(JCI)，腫瘤細胞中PEG1和PEG1反義基因印跡(JBC)，胚胎幹細胞分化（StemcellsDev.）等。[2]
社會任職
深圳中美賽爾生物科技有限公司董事長、首席科學家
李陶深圳市幹細胞工程技術研究開發中心主任[1]
深圳北科生物科技有限公司研發部總監、IPS首席科學家[1]
“未來生命醫養科學城”首席科學家[3]
深圳市生物工程國家級領軍人物[3]
原美國史丹福大學高級研究員[1]
日本東京大學博士[1]
原日本岩手生物工學研究中心研究員[1]
科研成果
1.JiaLiu.LinggaiCao.YueFeng.YuhuaLi.TaoLiMiR-338-3pinhibits
李陶2.WeihongYi,DazhiYang,HuangCao,ChuangLi,JingHan,Ji-FanHu,TaoLi(correspondingauthor)RepairofdegenerativeintervertebraldiscsinrabbitsbyhumanumbilicalcordmesenchymalstemcellsembeddedintypeIcollagenhydrogel.StemCellResearch&Therapy2016,Vol.1,(2)53-63
3.DehaiYu,ZhonghuaDu,LinglingPian,TaoLi,XueWen,WeiLi,Su-JeongKim,JialinXiao,PinchasCohen,JiuweiCui,AndrewR.Hoffman,andJi-FanHuMitochondrialDNAHypomethylationIsaBiomarkerAssociatedwithInducedSenescenceinHumanFetalHeartMesenchymalStemCellsVol.2017,ArticleID1764549
4.YunxiaTang,QiongshuLi,FanweiMeng,XingyuHuang,ChanLi,XinZhou,XiaopingZeng,YixinHe,JiaLiu,XiangHu,Ji-FanHu,andTaoLi(correspondingauthor)TherapeuticPotentialofHGF-ExpressingHumanUmbilicalCordMesenchymalStemCellsinMicewithAcuteLiverFailureInternationalJournalofHepatology2016Vol.131-13
5.ChanLi,XinZhou,XiaopingZeng,YixinHe,GuifangZeng,JiaLiu,ChunfengWu,TenglongYan,QiongshuLiJiuweiCui,XiangHu,Ji-FanHu,TaoLiHumanumbilicalcordmesenchymalstemcellssuppresssystemiclupuserythematosuslesionsbyrebalancingCD4+/CD8+cellpopulationStemcellBiologyandTransplantation2016Vol.31-13
6.GuifangZeng,QiongshuLi,HongfangJu,XinZhou,JiaolianZhuXiaopingZeng,YixinHe,ChanLi,JiaLiu,ChunfengWu,TenglongYan,ManWu,JingyiGan,WeiLi,JiuweiCui,XiangHu,Ji-FanHu,TaoLi(correspondingauthor)Therapeuticalcomparisonofhumanplacenta-derivedmesenchymalstemcellsinthetreatmentofmicewithacutehepaticfailureStemCellResearch&Therapy2016Vol.678-90
7.JingyiGan,FanweiMeng,XinZhou,ChanLi,ZongcaiLiu,XiaopingZeng,XingenJiang,YuanzhiLao,XiangjunZhou,XiangHu,JifanHu,TaoLi.(correspondingauthor)Hematopoieticrescueofradiation-inducedacutedeathbyhumansuperoxidedismutase-modifiedumbilicalcordmesenchymalstemcellsCytotherapy2014Vol.17403-417
8.ZongcaiLiu,FanweiMeng,ChanLi,XinZhou,XiaopingZeng,YixinHe,RandallJ.Mrsny,XiangHu,JifanHu,TaoLi(correspondingauthor)Humanumbilicalcordmesenchymalstemcellsrescueanimalsfromacetaminophen-inducedacuteliverfailure.Cytotherapy201416:1207-1219
9.ZhangH,JiaoW,SunL,FanJ,ChenM,WangH,XuX,ShenA,LiT,NiuB,GeS,LiW,CuiJ,WangG,SunJ,FanX,HuX,MrsnyRJ,HoffmanAR,HuJF.Intrachromosomalloopingisrequiredforactivationofendogenouspluripotencygenesduringreprogramming,CellStemCell.2013Jul3;13(1):30-5
10.TaoLi,Ji-FanHu,JianqunLing,ThanhH.Vu,AndrewR.Hoffman.AberrantIGF2imprintinginhumanmalignancyisassociatedwiththealteredCTCF-PRC2-IGF2promoterintrachromosomalloopcomplex.HumanMolecularGenetics201433：117-128
11.MengfeiChen,HeZhang,JieWu,LiangXu,DiXua,JingnanSun,YixinHe,
李陶12.ZhangH,NiuB,HuJF,GeS,WangH,LiT,LingJ,SteelmanBN,QianG,HoffmanAR.InterruptionofintrachromosomalloopingbyCTCFdecoyproteinsabrogatesgenomicimprintingofhumaninsulin-likegrowthfactorII.JournalofCellBiology2011;193:475-487
13.MaAN,HuangWL,WuZN,HuJF,LiT,ZhouXJ,WangYX.Inducedepigeneticmodificationsofthepromoterchromatinsilencesurvivinandinhibittumorgrowth.BiochemBiophysResCommun.2010;393:592-597
14.PanYQ,HeBS,LiT,ZhuC,ZhangLR,WangB,XuYF,QuLL,1HoffmanAR,WangSK,HuJH*.TargetedtumorgenetherapybasedonlossofIGF2imprinting.CancerBiology&Therapy2010;10;290-298
15.TaoLi,Ji-FanHu,XinwenQiu,JianqunLing,HuilingChen,ShukuiWang,AijuHou,ThanhH.Vu,AndrewR.Hoffman.2008CTCFregulatesallelicexpressionofIgf2byorchestratingapromoter-polycombrepressivecomplex-2intrachromosomalloop.MolecularCellularBiology，Vol.28,No.20.
16.XinwenQiu,ThanhH.Vu,QiuchengLu,JianQunLing,TaoLi,AijuHou,ShuKuiWang,HuiLingChen,JiFanHu,andAndrewR.Hoffman(2008)AComplexDeoxyribonucleicAcidLoopingConfigurationAssociatedwiththeSilencingoftheMaternalIgf2Allele.MolecularEndocrinology22(6):1476–1488
17.TheresaL.Chen,Wen-JunShen,Xin-WenQiu,TaoLi,AndrewR.HoffmanandFredricB.Kraemer(2007).Generationofnoveladipocytemonolayerculturesfromembryonicstemcell.StemcellsandDevelopment,16:371–380,
18.HuiLingChen*,TaoLi*(*equalcontribution),XinWenQiu,JieWu,JianQunLing,ZhiHongSun,WeiboWang,WeiChen,AijuHou,ThanhHVu,AndrewRHoffmanandJi-FanHu(2006).CorrectionofaberrantimprintingofIGF2inhumantumorsbynucleartransfer-inducedepigeneticreprogramming.TheEMBOJournal25,5329–5338.
19.JianqunLing,TaoLi,JiFanHu,1ThanhH.Vu,HuiLingChen,XinWenQiu,AthenaM.Cherry,AndrewR.Hoffman(2006).CTCFMediatesInterchromosomalColocalizationBetweenIgf2/H19andWsb1/Nf1.ScienceVol.312:269-272.
20.TaoLi,ThanhH.Vu,GaryA.Ulaner,EvaLittman,Jian-QunLing,Hui-LingChen,Ji-FanHu,BarryBehr,LindaGiudiceandAndrewR.Hoffman(2005).IVFresultsindenovoDNAmethylationandhistonemethylationatanIgf2-H19imprintingepigeneticswitch.MolHumReprod11(9):631-640
21.ThanhHVu*,TaoLi*(*equalcontribution)andAndrewRHoffman(2004).Promoter-specifichistonecodemarksimprintingstatusofIGF2receptorinhumanandmouse.HumanMolecularGenetics13(19):2233-2245.
22.XiaomingYao,Ji-FanHu,TaoLi,YouwenYang,ZhihongSun,GaryUlaner,ThanhHVu,andAndrewR.Hoffman(2004).Epigeneticregulationofthetaxolresistance-associatedgeneTRAG-3inhumantumors.CancerGeneticsandCytogenetics.151(1):1-13
23.TaoLi,ThanhH.Vu,GaryA.Ulaner,YouwenYang,Ji-FanHuandAndrewR.Hoffman(2004).ActivatingandsilencinghistonemodificationsformindependentallelicswitchregionsintheimprintedGnasgene.HumanMolecularGenetics13:741–750.
24.YouwenYang,Ji-FanHu,GaryA.Ulaner,TaoLi,XiaomingYao,ThanhH.Vu,andAndrewR.Hoffman(2003).EpigeneticRegulationofIgf2/H19ImprintingatCTCFInsulatorBindingSites.JournalofCellularBiochemistry90:1038–1055.
25.YouwenYang*,TaoLi*(*equalcontribution),ThanhH,GaryA.Ulaner,JifanHuandAndrewR.Hoffman(2003).TheHistoneCodeRegulatingExpressionoftheImprintedMouseIgf2rGene.Endocrinology144:5658–5670.
26.ThanhH.Vu*,TaoLi*(*equalcontribution),ChuyenV.NguyenandAndrewR.Hoffman(2003).LossofImprintingofIGF2SenseandAntisenseTranscriptsinWilms’Tumor.CancerResearch63:1900–1905.
27.XiaomingYao,Ji-FanHu,MarkDaniels,HuifanYien,HongqiLu,HadasSharan,XiangjunZhou,ZhilanZeng,TaoLi,YouwenYang,andAndrewR.Hoffman(2003).Anovelorthotopictumormodeltostudygrowthfactorsandoncogenesinhepatocarcinogenesis.ClinicalCancerResearch.9:2719-2726.
28.GaryA.Ulaner,ThanhH.Vu,TaoLi,Ji-FanHu1,Xiao-MingYao,YouwenYang,RichardGorlick,PaulMeyers,JohnHealey,MarcLadanyiandAndrewR.Hoffman(2003).LossofimprintingofIGF2andH19inosteosarcomaisaccompaniedbyreciprocalmethylationchangesofaCTCF-bindingsite.HumanMolecularGenetics12:535–549.
29.XiaomingYao,Ji-FanHu,MarkDaniels,XingjunZhou,HuifanYien,HongqiLu,ZhilanZeng,TaoLi,andAndrewR.Hoffman(2002).AmethylatedoligonucleotideinhibitsIGF2expressionandenhancessurvivalinamodelofhepatocellularcarcinoma.J.Clin.Invest.111:265–273.
30.TaoLi,ThanhH.Vu,Kok-Onn.Lee,ChuyenV.Nguyen,HuyQ.Bui,Zhi-LanZeng,BinhT.Nguyen,Ji-FanHu,SusanK.Murphy,RandyL.Jirtle,andAndrewR.Hoffman(2002).ImprintedPEG1/MESTAntisenseExpressedPredominantlyinHumanTestisandinMatureSpermatozoa.JournalofBiologicalChemistry16:13518-13527.
31.KillianJK,NolanCM,WylieAA,LiT,VuTH,HoffmanAR,JirtleRL(2001).DivergentevolutioninM6P/IGF2RimprintingfromtheJurassictotheQuaternary.HumanMolecularGenetics10:1721-1728.
32.TaoLi,ThanhH.Vu,DanielleNguyen,BinhT.Nguyen,JifanHuandAndrewHoffman(2000).Tissue-specificexpressionofantisenseandsensetranscriptattheimprintedGnaslocus.Genomics69:295-304.
33.Ji-fanHu,JungPham,IndiralDey,TaoLi,ThanhH.VuandAndrewR.Hoffman(2000).Allele-specifichistoneAcetylationaccompaniesgenomicimprintingoftheinsulin-likegrowthfactorIIreceptorgene.Endocrinology.141:4428-35.
34.TaoLi,ThanhH.Vu,DanielleNguyen,BinhT.Nguyen,XiaomingYao,JifanHuandAndrewHoffman(2000).SymmetricandAsymmetricDNAmethylationintheHumanIGF2-H19imprintedregion.Genomics.64,132-143.
35.OkamuraK,Hagiwara-TakeuchiY,LiT,VuTH,HiraiM,HattoriM,SakakiY,HoffmanAR,ItoT.(2000).ComparativegenomeanalysisofthemouseimprintedgeneimpactanditsnonimprintedhumanhomologIMPACT:towardthestructuralbasisforspecies-specificimprinting.GenomeResearch.10:1878-1889.
36.HuJF,BalaguruKA,IvaturiRD,OrugantiH,LiT,NguyenBT,VuTHandHoffmanAR(1999).LackofreciprocalgenomicimprintingofsenseandantisenseRNAofmouseinsulin-likegrowthfactorIIreceptorinthecentralnervoussystem.BiochemBiophysResCommun.257:604-608.[1]
InJapan
1.TaoLi,T.Aoki,N.Kameya,T.Tata,I.Nakamura(1998).Molecularanalysisofexpressedricegenesinducedbyinfectionofriceblastfungus.Japan.J.Breed.48,Suppl.1:122.
2.TaoLi,NanakoKameya,YoshimichiHukuta,IkuoNakamura(1997).MolecularcloningandlinkageanalysisofOSDIMcDNAinrice.RiceGeneticsNewsletter14:130-133.
3.TaoLi,N.Kameya,T.Takano,Z.You,M.Yamada1(1997).StructureanalysisandexpressionofDIMgeneinrice.Japan.J.Breed.48,Suppl.2:122.
4.TaoLiN.Kameya,Y.Fukuta,H.Kitano,I.Nakamura(1997).MolecularanalysisofDIM(diminuto)geneinrice.Japan.J.Breed.47,Suppl.1:239.
5.Aoki,T.,N.Kameya,T.Li,I.Nakamura(1996).cDNAclonesencodingpolysaccharide-modifyingenzymesinelongatinginternodesofriceaomutant.Japan.J.Breed.46,Suppl.2:128.
6.TaoLi,TetsuoTakanoandKeisukeKitamura(1995).CloningofGlymBd30Kgenesforanallergenicproteininazukibean.Japan.J.Breed.45,Suppl.2:454.
7.TakanoTetsuo,TaoLiandKeisukeKitamura(1995).Cloningofthegenesforanallergenicproteininsoybean.Japan.J.Breed.45,Suppl.1:27.
8.TaoLi,TetsuoTakanoandKeisukeKitamura(1995).Distributionofasoybeanallergicprotein(GlymBd30K)anditsgeneinlegumespecies.Japan.J.Breed.45,Suppl.1:268.
9.TaoLi,TetsuoTakano,NagamuraAtsusiandGenkichiTakeda(1993).Linkageanalysisofricelactatedehydrogenasegene.RiceGeneticsNewsletter1:109-111.
10.TaoLi,TetsuoTakano,NagamuraAtsusiandGenkichiTakeda(1994).CharacterizationandRFLPmappingofricelactatedehydrogenasegene.Japan.J.Breed.44,Suppl.1:19.
11.TaoLi,TetsuoTakano,HideoMatsumuraandGenkichiTakeda(1993).MolecularcloningofricelactatedehydrogenasecDNA.Japan.J.Breed.Vol.43No.1:129-133.
12.TaoLi,TetsuoTakano,HideoMatsumuraandGenkichiTakeda(1993).Anaerobicexpressionandstructuralanalysisofricelactatedehydrogenasegene.Japan.J.Breed.43,Suppl.2:38.
13.TaoLi,TetsuoTakano,HideoMatsumuraandGenkichiTakeda(1993).MolecularcloningofricelactatedehydrogenasecDNAanditsgene.Japan.J.Breed.43,Suppl.1:84.
14.HideoMatsumura,TaoLi,TetsuoTakanoandGenkichiTakeda(1992).Lactatedehydrogenase(LDH)inriceunderanaerobiccondition.Japan.J.Breed.42,Suppl.2:292-293.
15.KadowakiK.,S.,Kazama,TaoLi,T.andK.Harada(1990).AnalysisofachimericATPasesubunit6genegeneratedbyintramolecularrecombinationinricemitochondria.Japan.J.Breed.40,Suppl.2:138-139.[1]
人物影響
李陶博士從事生物醫學理論研究及產業轉化近30年，先後服務多家國際知名科研機構和行業龍頭企業，率先對臍帶間充質幹細胞進行基因改造，解決了多個關鍵性工藝環節中的重大技術難題。
李陶博士在工程化幹細胞系的構建和新型腫瘤治療技術開發、腫瘤靶向治療新靶點的篩查等新產品、新技術領域的研究水平和研究成果都處於國際前列。
近期以來，依託生命原點公司承建的河北省幹細胞庫和河北省細胞組織低溫生物保存套用工程技術研究中心兩大研發平台，李陶帶領團隊在幹細胞工程技術開發及臨床轉化研究領域取得重大進展，率先建立了臍帶間充質幹細胞工程化技術平台，構建了多個基因修飾的臍帶間充質幹細胞系，完成了工程化幹細胞移植治療急性肝衰、肝硬化的藥效學研究及治療系統性紅斑狼瘡、心肌梗塞的臨床前有效性研究，為臍帶間充質幹細胞製劑的開發、規模化生產製備及臨床套用攻克了多個關鍵性工藝難題，相關核心技術正在申請國家發明專利。[4]
部分專利
1、ZL200680046641.4體內和體外再生細胞的方法
2、ZL201110243239.8細胞轉核誘導體細胞成多能二倍體幹細胞的方法
3、ZL201110221115.X單個核細胞培養液
4、ZL201110243239.8通過mRNA誘導體細胞為多能幹細胞的方法
5、ZL201010593844.3一種高效誘導人類體細胞重編程為多潛能幹細胞的方法
6、201410836460.8發明專利經血間充質幹細胞的培養方法
7、201410841610.4一種可用於肝衰竭治療的經HGF基因修飾的UCMSC製備方法
8、201410795197.2一種製備蛻膜間充質幹細胞的方法
9、201410841531.3牙齒來源間充質幹細胞體外分離與培養方法
10、201410795200.0一種製備絨毛膜間充質幹細胞的方法
11、2015109740167一種抗CD16A和抗MUC1抗原的雙特異性抗體
12、201510963795.一種用於免疫治療的EB病毒LMP2A串聯表位肽及其套用
13、201611066874.2CD16A/GPC3雙抗病慢病毒表達載體及其構建方法和套用
14、201611266589.5一種抗原表位肽組合物及其使用
15、PCT/US2006/040723Methodsforrejuvenatingcellsinvitroandinvivo[4]
