人物經歷
學習經歷
1984.9—1989.6中國科技大學生物系生物物理學專業,獲學士學位。
1989.9—1994.6中國科學院上海生理所(今中國科學院神經科學研究所)神經生物學專業,獲博士學位(導師李朝義院士)。
1994.8-1996.6,美國加州大學伯克利分校,博士後(合作導師:Prof Gerald Westheimer)。
工作經歷
1996.7-1999.5年,德國馬克思普朗克學會生物控制論研究所,訪問學者。
1999.6-2007.6,美國洛克菲勒大學,研究助理教授(合作導師:Charles Gilbert 院士)。
2007.3-現在,北京師範大學認知神經科學與學習國家重點實驗室,主任、教授、博士生導師。
現任職務:
教育部長江學者特聘教授。
國家傑出青年科學基金獲得者。
新世紀百千萬人才工程國家級人選。
研究方向
視知覺的神經機制。
主要貢獻
學術成果
通過在獼猴大腦皮層中植入微電極陣列,研究猴子在執行各種視覺檢測和分辨任務時神經元的反應特性,探討視知覺的神經機制。主要研究興趣在於視覺及其皮層加工過程的自適應性,包括各種動態特性和可塑性,著重研究以下問題:(1)視皮層神經元如何根據特定的圖形上下文,動態地對各種圖象信息進行整合和分割,從而形成知覺表象上的圖形和背景;(2)選擇性注意等高級認知功能如何動態地調節視覺神經元的反應特性,從而最為有效地處理視覺圖象中與行為密切相關的信息;(3)過去的經驗如何影響視覺神經元對刺激的編碼以及知覺學習的神經機制,即知覺訓練過程中所產生的內隱記憶是如何被存儲和提取的。
發表論文
Journal Papers
Gilbert, C.D., and Li, W. (2013). Top-down influences on visual processing. Nat. Rev. Neurosci. 14, 350-363.
McFarland, R., Roebuck, H., Yan, Y., Majolo, B., Li, W., and Guo, K. (2013). Social interactions through the eyes of macaques and humans. PLos One 8, e56437.
Ramalingam, N., McManus, J.N.J., Li, W., and Gilbert, C.D. (2013). Top-down modulation of lateral interactions in visual cortex. J. Neurosci. 33, 1773-1789.
Gilbert, C.D., and Li, W. (2012). Adult visual cortical plasticity. Neuron 75, 250-264.
Xing, D., Shen, Y., Burns, S., Yeh, C.-I., Shapley, R., and Li, W. (2012). Stochastic generation of gamma-band activity in primary visual cortex of awake and anesthetized monkeys. J. Neurosci. 32.
Pan, Y., Chen, M., Yin, J., An, X., Zhang, X., Lu, Y., Gong, H., Li, W., and Wang, W. (2012). Equivalent representation of real and illusory contours in macaque V4. J. Neurosci. 32, 6760-6770.
McManus, J.N.J., Li, W., and Gilbert, C.D. (2011). Adaptive shape processing in primary visual cortex. Proc. Natl. Acad. Sci. U. S. A. 108, 9739-9746.
Zhang, E., and Li, W. (2010). Perceptual learning beyond retinotopic reference frame. Proc. Natl. Acad. Sci. U. S. A. 107.
Gilbert, C.D., Li, W., and Piech, V. (2009). Perceptual learning and adult cortical plasticity. J. Physiol. (Lond). 587, 2743-2751.
Li, W., Piech, V., and Gilbert, C.D. (2008). Learning to link visual contours. Neuron 57, 442-451.
Li, W., Piech, V., and Gilbert, C.D. (2006). Contour saliency in primary visual cortex. Neuron 50, 951-962.
Stettler, D.D., Yamahachi, H., Li, W., Denk, W., and Gilbert, C.D. (2006). Axons and synaptic boutons are highly dynamic in adult visual cortex. Neuron 49, 877-887.
Li, W., Piech, V., and Gilbert, C.D. (2004). Perceptual learning and top-down influences in primary visual cortex. Nat. Neurosci. 7, 651-657.
Li, W., and Gilbert, C.D. (2002). Global contour saliency and local colinear interactions. J. Neurophysiol. 88, 2846-2856.
Crist, R.E., Li, W., and Gilbert, C.D. (2001). Learning to see: experience and attention in primary visual cortex. Nat. Neurosci. 4, 519-525.
Li, W., Thier, P., and Wehrhahn, C. (2001). Neuronal responses from beyond the classic receptive field in V1 of alert monkeys. Exp. Brain Res. 139, 359-371.
Li, W., Thier, P., and Wehrhahn, C. (2000). Contextual influence on orientation discrimination of humans and responses of neurons in V1 of alert monkeys. J. Neurophysiol. 83, 941-954.
Li, W., and Westheimer, G. (1997). Human discrimination of the implicit orientation of simple symmetrical patterns. Vision Res. 37, 565-572.
Westheimer, G., and Li, W. (1997). Classifying illusory contours: Edges defined by ''pacman'' and monocular tokens. J. Neurophysiol. 77, 731-736.
Westheimer, G., and Li, W. (1996). Classifying illusory contours by means of orientation discrimination. J. Neurophysiol. 75, 523-537.
Wehrhahn, C., Li, W., and Westheimer, G. (1996). Patterns that impair discrimination of line orientation in human vision. Perception 25, 1053-1064.
Li, C.Y., and Li, W. (1994). Extensive integration field beyond the classical receptive field of cat's striate cortical neurons-classification and tuning properties. Vision Res. 34, 2337-2355.
Book Chapters
Li, W., and Gilbert, C.D. (2009). Visual cortical plasticity and perceptual learning. In The cognitive neurosciences, M.S. Gazzaniga, ed. (Cambridge, Massachusetts: The MIT Press), pp. 129-140.
Li, W., and Gilbert, C.D. (2008). Perceptual Learning: neural mechanisms. In Encyclopedia of Neuroscience, L.R. Squire, ed. (Oxford: Academic Press), pp. 535-541.
Li, W., and Gilbert, C.D. (2007). Perceptual learning. In The Senses: A comprehensive reference, A.I. Basbaum et al., eds. (New York: Academic Press), pp. 303-328.
Li, C.Y., and Li, W. (1994). Extensive integration field beyond the classical receptive field of cat's striate cortical neurons-classification and tuning properties. Vision Res.34, 2337-2355.編寫專著
Li, W., and Gilbert, C.D. (2009). Visual cortical plasticity and perceptual learning. In The cognitive neurosciences, M.S. Gazzaniga, ed. (Cambridge, Massachusetts: The MIT Press), pp. 129-140.
Li, W., and Gilbert, C.D. (2008). Perceptual Learning: neural mechanisms. In Encyclopedia of Neuroscience, L.R. Squire, ed. (Oxford: Academic Press), pp. 535-541.
Li, W., and Gilbert, C.D. (2007). Perceptual learning. In The Senses: A comprehensive reference, A.I. Basbaum et al., eds. (New York: Academic Press), pp. 303-328.
Li, W., and Gilbert, C.D. (2009). Visual cortical plasticity and perceptual learning. In The cognitive neurosciences, M.S. Gazzaniga, ed. (Cambridge, Massachusetts: The MIT Press), pp. 129-140.
Li, W., and Gilbert, C.D. (2008). Perceptual Learning: neural mechanisms. In Encyclopedia of Neuroscience, L.R. Squire, ed. (Oxford: Academic Press), pp. 535-541.
Li, W., and Gilbert, C.D. (2007). Perceptual learning. In The Senses: A comprehensive reference, A.I. Basbaum et al., eds. (New York: Academic Press), pp. 303-328.