| 角色 | 演員 | 備註 |
| Himself - Host (859 episodes, 2005-2011) | 史蒂芬·科拜爾（Stephen Colbert） | |
| Bobby (31 episodes, 2005-2008) | Eric Drysdale | |
| Russ Lieber (7 episodes, 2005-2007) | 大衛·克羅斯（David Cross） | |
| Tad (11 episodes, 2005-2011) | 保羅·迪耐羅（Paul Dinello） | |
| Himself (10 episodes, 2005-2011) | 喬恩·斯圖爾特（Jon Stewart） | |
| Himself (4 episodes, 2006-2009) | Frank Rich | |
| Jimmy (7 episodes, 2006-2011) | Peter Gwinn | |
| Himself (8 episodes, 2005-2011) | Neil Tyson | |
| Christina (3 episodes, 2005) | Christina Gausas | |
| Himself (3 episodes, 2006-2011) | Ric Ocasek | |
| Himself (4 episodes, 2006-2011) | 摩根·斯普爾洛克（Morgan Spurlock） | |
| Himself (2 episodes, 2006) | John Hall | |
| Himself (2 episodes, 2006) | Norm Ornstein | |
| Himself (2 episodes, 2006) | Mort Zuckerman | |
| Abraxxia (segment "Tek Jansen") (3 episodes, 2006-2010) | 艾米·塞德麗絲（Amy Sedaris） | |
| Himself (2 episodes, 2005-2006) | Stone Phillips | |
| Himself (2 episodes, 2005-2006) | 蒂姆·羅賓斯（Tim Robbins） | |
| Himself (3 episodes, 2005-2010) | 阿爾·夏普頓（Al Sharpton） | |
| Himself (3 episodes, 2006-2009) | Anthony Romero | |
| Herself (4 episodes, 2006-2009) | Arianna Stassinopo.. | |
| Herself (4 episodes, 2006-2009) | Eleanor Holmes Nor.. | |
| Herself (2 episodes, 2005-2007) | Katrina van den He.. | |
| Herself (2 episodes, 2006-2007) | Bay Buchanan | |
| Herself (2 episodes, 2006-2007) | 簡·方達（Jane Fonda） | |
| Himself (5 episodes, 2006-2011) | 托比·基思（Toby Keith） | |
| Himself (3 episodes, 2006-2008) | Robert Wexler | |
| Himself (2 episodes, 2005-2007) | Richard Clarke | |
| Himself (3 episodes, 2005-2008) | Lou Dobbs | |
| Himself (2 episodes, 2005-2007) | Richard Preston | |
| Himself (3 episodes, 2005-2008) | Eliot Spitzer | |
| Himself (2 episodes, 2006-2007) | Carl Bernstein | |
| Alan (2 episodes, 2006) | Jordan Carlos | |
| Himself (2 episodes, 2006) | Al Franken | |
| P.K. Winsome (9 episodes, 2006-2010) | 蒂姆·麥道斯（Tim Meadows） | |
| Himself (2 episodes, 2007) | Igor Dyachenko | |
| Himself (2 episodes, 2007) | Jann Wenner | |
| Jay the Intern (19 episodes, 2005-2011) | Jay Katsir | |
| Himself (8 episodes, 2011) | Trevor Potter | |
| Himself (7 episodes, 2006-2011) | Mike Huckabee | |
| Himself (5 episodes, 2006-2011) | Tom Brokaw | |
| Himself (5 episodes, 2005-2009) | Jim Cramer | |
| Benjamin Franklin (5 episodes, 2006-2008) | Ralph Archbold | |
| Meg the Intern (5 episodes, 2006-2008) | Meg DeFrancesco | |
| Himself (5 episodes, 2009-2010) | 傑夫·高布倫（Jeff Goldblum） | |
| Himself - Guest (4 episodes, 2005-2011) | Ken Burns | |
| Himself (4 episodes, 2006-2011) | Christopher Matthews | |
| Himself (4 episodes, 2006-2011) | Michael Pollan | |
| Himself (4 episodes, 2006-2010) | David Gergen | |
| Himself (4 episodes, 2007-2011) | James Martin | |
| Himself (4 episodes, 2007-2011) | Ron Paul | |
| Himself - Guest (4 episodes, 2007-2011) | 麥可·摩爾（Michael Moore） | |
| Herself (3 episodes, 2006-2011) | Christiane Amanpour | |
| Himself (3 episodes, 2011) | Simon de Pury | |
| Himself (3 episodes, 2011) | 傑克·懷特（Jack White） | |
| Himself (3 episodes, 2006-2011) | 麥可·劉易斯（Michael Lewis） | |
| Author, 'On China' (3 episodes, 2006-2011) | Henry Kissinger | |
| Himself (3 episodes, 2008-2011) | Richard Brookhiser | |
| Founder, AslanMedia.com (3 episodes, 2006-2011) | Reza Aslan | |
| Himself - Guest (3 episodes, 2006-2011) | David Brooks | |
| Himself (3 episodes, 2006-2011) | Jeff Greenfield | |
| Himself (3 episodes, 2006-2011) | Paul Krugman | |
| Herself - Guest (3 episodes, 2006-2011) | Gloria Steinem | |
| Himself (3 episodes, 2008-2011) | Niall Ferguson | |
| Herself (3 episodes, 2008-2011) | Robin Wright | |
| Himself (3 episodes, 2005-2011) | 安德森·庫珀（Anderson Cooper） | |
| Himself (3 episodes, 2005-2008) | Matt Taibbi | |
| Himself (3 episodes, 2006-2008) | Joe Quesada | |
| Himself (3 episodes, 2006-2008) | Andrew Sullivan | |
| Himself (3 episodes, 2007-2011) | Steven Pinker | |
| Himself (3 episodes, 2007-2008) | Malcolm Gladwell | |
| Himself - Guest (3 episodes, 2009-2011) | 史蒂夫·馬丁（Steve Martin） | |
| Himself (3 episodes, 2008-2011) | Mark Moffett | |
| Himself (3 episodes, 2005-2011) | Brian Greene | |
| Himself (3 episodes, 2006-2010) | Paul Begala | |
| Himself (3 episodes, 2007-2008) | Tony Snow | |
| Himself (3 episodes, 2007) | 比爾·奧雷利（Bill O'Reilly） | |
| Himself - Guest (3 episodes, 2008-2010) | Henry Louis Gates | |
| Himself (3 episodes, 2008-2010) | Brent Glass | |
| Himself (3 episodes, 2008-2010) | 約翰·傳奇（John Legend） | |
| Herself (3 episodes, 2008) | Susan Jacoby | |
| Gay Husband (3 episodes, 2009-2010) | Peter Grosz | |
| Himself (3 episodes, 2010-2011) | Hans Beinholt | |
| Veronica (3 episodes, 2010) | Jessica Ecklund | |
| Himself (3 episodes, 2011) | 約翰·利特高（John Lithgow） | |
| Himself (2 episodes, 2006-2011) | Robert Kennedy Jr. | |
| Himself (2 episodes, 2006-2009) | Bart D. Ehrman | |
| Himself (2 episodes, 2006-2009) | Jon Meacham | |
| Himself (2 episodes, 2006-2008) | Jonathan Alter | |
| Himself (2 episodes, 2008-2011) | Richard Haass | |
| Himself (2 episodes, 2008-2009) | Cory Booker | |
| Himself - Guest (2 episodes, 2009-2011) | 布萊恩·考克斯（Brian Cox） | |
| Author, 'A Singular Woman' (2 episodes, 2011) | Janny Scott | |
| Himself (2 episodes, 2011) | Hugo Vickers | |
| Himself (2 episodes, 2005-2010) | 巴尼·弗蘭克（Barney Frank） | |
| Himself (2 episodes, 2005-2008) | Fareed Zakaria | |
| Countdown, Current TV (2 episodes, 2006-2011) | Keith Olbermann | |
| Herself (2 episodes, 2006-2009) | Barbara Boxer | |
| Himself (2 episodes, 2006-2009) | Byron Dorgan | |
| Himself (2 episodes, 2006-2009) | David Gregory | |
| Himself (2 episodes, 2006-2009) | Alexi Lalas | |
| Himself (2 episodes, 2006-2009) | Paul Rieckhoff | |
| Herself (2 episodes, 2006-2008) | Madeleine Albright | |
| Himself (2 episodes, 2006-2008) | Surya Das | |
| Himself (2 episodes, 2006-2008) | Robert Greenwald | |
| Himself (2 episodes, 2006-2008) | Joe Scarborough | |
| Himself (2 episodes, 2006-2008) | Tyson Slocum | |
| China Correspondent, The New Yorker (2 episodes, 2007-2011) | Evan Osnos | |
| Author, 'The Believing Brain' (2 episodes, 2007-2011) | Michael Shermer | |
| Himself (2 episodes, 2008-2011) | Geoffrey Canada | |
| Documentary, Page One (2 episodes, 2008-2011) | David Carr | |
| Glenn (2 episodes, 2008-2011) | Glenn Eichler | |
| Himself (2 episodes, 2008-2011) | Yo-Yo Ma | |
| Himself (2 episodes, 2008-2011) | Grover Norquist | |
| Himself (2 episodes, 2008-2011) | Edward Rendell | |
| Himself (2 episodes, 2008-2010) | David Simon | |
| Himself (2 episodes, 2008-2010) | 保羅·西蒙（Paul Simon） | |
| Himself (2 episodes, 2008-2009) | Bob Graham | |
| Himself (2 episodes, 2008) | Bob Barr | |
| Himself (2 episodes, 2008) | 卡勒德·胡賽尼（Khaled Hosseini） | |
| Himself (2 episodes, 2008) | Andrew Young | |
| Herself - Council on Foreign Relations (2 episodes, 2009-2011) | Laurie Garrett | |
| Himself - Guest (2 episodes, 2010-2011) | Austan Goolsbee | |
| 'Reagan', HBO (2 episodes, 2010-2011) | Eugene Jarecki | |
| Himself (2 episodes, 2011) | 吉米·法倫（Jimmy Fallon） | |
| Himself - Economics writer, The New York Times (2 episodes, 2011) | David Leonhardt | |
| Himself (2 episodes, 2011) | Frank Luntz | |
| Himself (2 episodes, 2005-2011) | 馬克·庫班（Mark Cuban） | |
| Himself (2 episodes, 2005-2009) | 傑夫·丹尼爾斯（Jeff Daniels） | |
| Himself (2 episodes, 2006-2011) | Dan Rather | |
| Authour, 'My Father at 100' (2 episodes, 2006-2011) | Ron Reagan | |
| Former Governor of New Jersey (2 episodes, 2006-2011) | Christine Todd Whi.. | |
| Himself (2 episodes, 2006-2008) | Neal Katyal | |
| Himself (2 episodes, 2006-2008) | Rick Reilly | |
| Himself (2 episodes, 2006-2008) | David Sirota | |
| Himself (2 episodes, 2006-2007) | Markos Moulitsas | |
| Herself (2 episodes, 2007-2011) | 寶琳娜·普利茨科娃（Paulina Porizkova） | |
| Himself (2 episodes, 2007-2008) | Thomas Friedman | |
| Himself (2 episodes, 2008) | Roland Fryer | |
| Himself (2 episodes, 2010-2011) | Andres Serrano | |
| Himself (2 episodes, 2011) | Buddy Roemer | |
| Himself (2 episodes, 2006-2010) | 丹尼爾·艾斯伯格（Daniel Ellsberg） | |
| Himself (2 episodes, 2006-2008) | Rich Dahm | |
| Himself (2 episodes, 2007-2011) | Ben Cohen | |
| Herself (2 episodes, 2007-2011) | 凱蒂·柯麗克（Katie Couric） | |
| Himself (2 episodes, 2008-2011) | Bing West | |
| Himself (2 episodes, 2007-2011) | Jerry Greenfield | |
| Himself (2 episodes, 2005-2010) | Bob Costas | |
| Himself (2 episodes, 2006-2009) | Rick Nielsen | |
| Himself (2 episodes, 2006-2009) | Peter Singer | |
| Himself (2 episodes, 2006-2008) | Tony Campolo | |
| Himself (2 episodes, 2006-2008) | Kenneth Miller | |
| Himself (2 episodes, 2006-2008) | 柯南·奧布萊恩（Conan O'Brien） | |
| Himself (2 episodes, 2006-2008) | James Webb | |
| Himself (2 episodes, 2007-2011) | 理察·布蘭森（Richard Branson） | |
| Himself (2 episodes, 2007-2011) | Charlie Rose | |
| Himself (2 episodes, 2007-2011) | Jeffrey Toobin | |
| Himself (2 episodes, 2007-2010) | Tom Blanton | |
| Himself (2 episodes, 2007-2010) | Mark Frauenfelder | |
| Himself (2 episodes, 2007-2010) | Conn Iggulden | |
| Himself (2 episodes, 2007-2009) | J·J·艾布拉姆斯（J.J. Abrams） | |
| Himself (2 episodes, 2007-2009) | Howard Dean | |
| Himself (2 episodes, 2007-2009) | 沃爾特·肯（Walter Kirn） | |
| Himself (2 episodes, 2007-2009) | Ethan Nadelmann | |
| Himself (2 episodes, 2007-2009) | Simon Schama | |
| Herself (2 episodes, 2007-2008) | 瑪麗亞·巴提羅莫（Maria Bartiromo） | |
| Himself (2 episodes, 2007-2008) | Jackson Browne | |
| Himself (2 episodes, 2007-2008) | Nathan Gunn | |
| Himself (2 episodes, 2007-2008) | David Levy | |
| Herself (2 episodes, 2007-2008) | Ingrid Newkirk | |
| Herself (2 episodes, 2007-2008) | Lisa Randall | |
| Himself (2 episodes, 2007-2008) | 薩曼·拉什代（Salman Rushdie） | |
| Himself (2 episodes, 2007-2008) | Shashi Tharoor | |
| Himself (2 episodes, 2007) | Zbigniew Brzezinski | |
| Himself (2 episodes, 2007) | 湯米·鍾（Tommy Chong） | |
| Himself (2 episodes, 2007) | Jerry Miller | |
| Himself (2 episodes, 2007) | Spencer Wells | |
| Himself (2 episodes, 2007) | 布萊恩·威廉士（Brian Williams） | |
| Himself (2 episodes, 2008-2011) | 麥可·史帝普（Michael Stipe） | |
| Himself (2 episodes, 2008-2011) | Cornel West | |
| Himself (2 episodes, 2008-2011) | Jonathan Zittrain | |
| Himself (2 episodes, 2008-2010) | Nicholas Carr | |
| Himself (2 episodes, 2008-2010) | Jeffrey Goldberg | |
| Himself (2 episodes, 2008-2010) | Bob Inglis | |
| Himself (2 episodes, 2008-2009) | Stephen Moore | |
| Himself (2 episodes, 2008-2009) | 巴拉克·歐巴馬（Barack Obama） | |
| Justin (2 episodes, 2008-2009) | Justin Purnell | |
| Herself (2 episodes, 2008-2009) | Julia Sweig | |
| Maverick Bully (2 episodes, 2008) | Sean Clements | |
| Himself (2 episodes, 2008) | 凱文·科斯特納（Kevin Costner） | |
| Himself (2 episodes, 2008) | Tad Devine | |
| Himself (2 episodes, 2008) | 卡爾·希爾森（Carl Hiaasen） | |
| Himself (2 episodes, 2008) | Joe Salmonese | |
| Himself (2 episodes, 2009-2011) | 阿爾·戈爾（Al Gore） | |
| Himself - Guest (2 episodes, 2009-2010) | Elvis Costello | |
| Himself - Guest (2 episodes, 2009-2010) | Richard Engel | |
| Himself (2 episodes, 2009-2010) | 謝潑德·費瑞（Shepard Fairey） | |
| Body Double (2 episodes, 2009-2010) | Luke Guldan | |
| Himself (2 episodes, 2009-2010) | 湯姆·漢克斯（Tom Hanks） | |
| Himself (2 episodes, 2009-2010) | Biz Stone | |
| Himself - Guest (2 episodes, 2009) | 大衛·拜恩（David Byrne） | |
| Himself (2 episodes, 2009) | Harold Evans | |
| Homer (2 episodes, 2009) | Kumail Nanjiani | |
| Himself - Guest (2 episodes, 2009) | Cliff Sloan | |
| Himself (2 episodes, 2010-2011) | 凱文·克萊恩（Kevin Kline） | |
| Bing Bongavax (2 episodes, 2010-2011) | Eugene Mirman | |
| Himself - Guest (2 episodes, 2010-2011) | 史蒂芬·松德海姆（Stephen Sondheim） | |
| Himself (2 episodes, 2010) | Mike D'Antoni | |
| Himself - Guest (2 episodes, 2011) | Talib Kweli | |
