研究方向
生物大分子相互作用,蛋白質結構,鐵蛋白納米結構自組裝
獲獎情況
主持或參與課題
(1)國家自然科學基金(青年項目):鐵蛋白殼狀結構的完全去對稱化及利用小分子促使殼狀結構形成的研究(31200564),2013-2015,項目主持;
(2)南京林業大學引進高層次人才和高層次留學回國人員科研基金:鐵蛋白殼狀結構的合理去對稱化(YJ2012-05),2013-2015,項目主持;
(3)國家自然科學基金(面上項目):木聚糖高溫水解關鍵酶分子改造及其熱穩定性和耐糖機理,2014-2017,項目參與。
發表論文 (代表性或近三年)
1. Yu Zhang, Siti Raudah Mohamed Lazim, Huihian Teo, Gwenda W. S. Teo, Rongli Fan, Xiaoming Sun, Brendan P. Orner . Alanine-shaving Mutagenesis to Determine Key Interfacial Residues Governing the Assembly of a Nano-cage Maxi-ferritin ( 2010) J.Bio.Chem. 285, 12078-12086. (Paper of the week)
2. Yu Zhang, Brendan P. Orner. Self-assembly in the ferritin nano-cage protein superfamily ( 2011). Int. J. Mol. Sci. 12, 5406-5421.
3. Yu Zhang, Jing Fu, Sze Y. Chee, Emmiline X. W. Ang, Brendan P. Orner . Rational disruption of the oligomerization of the Mini-Ferritin E. coli DPS through protein-protein interface mutation ( 2011). Protein Sci . 20, 1907-1917. (Cover paper)
4. Hao Shi, Yu Zhang, Xun Li, Yingjuan Huang, Liangliang Wang, Ye Wang, Huaihai Ding, Fei Wang. A novel highly thermostable xylanase stimulated by Ca from Thermotoga thermarum: cloning, expression and characterization ( 2013). Biotechnology for Biofuels. 6, 26.